Patents Assigned to Incept
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Patent number: 6689148Abstract: Methods and apparatus of forming hydrogel systems in situ are provided using a delivery system configured to deliver two or more fluent prepolymer solutions without premature crosslinking. The delivery system comprises separate first and second lumens coupling first and second inlet ports and first and second outlet ports, respectively, and may include a balloon, flexible distal region, mixing chamber or steerable distal end. Multi-component hydrogel systems suitable for use with the inventive methods and apparatus are also described.Type: GrantFiled: November 21, 2001Date of Patent: February 10, 2004Assignee: Incept LLCInventors: Amarpreet S. Sawhney, John Spiridigliozzi
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Publication number: 20040023842Abstract: Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants.Type: ApplicationFiled: February 24, 2003Publication date: February 5, 2004Applicant: InceptInventors: Chandrashekhar P. Pathak, Amarpreet S. Sawhney, Peter G. Edelman
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Publication number: 20040009205Abstract: Pharmaceutically acceptable hydrogel polymers of natural, recombinant or synthetic origin, or hybrids thereof, are introduced in a dry, less hydrated, or substantially deswollen state and rehydrate in a physiological environment to undergo a volumetric expansion and to affect sealing, plugging, or augmentation of tissue, defects in tissue, or of organs. The hydrogel polymers may deliver therapeutic entities by controlled release at the site. Methods to form useful devices from such polymers, and to implant the devices are provided.Type: ApplicationFiled: July 9, 2003Publication date: January 15, 2004Applicant: Incept LLCInventor: Amarpreet S. Sawhney
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Patent number: 6673093Abstract: Methods and apparatus of forming in situ tissue adherent barriers are provided using a sprayer capable of applying two or more viscous crosslinkable components to tissue. The sprayer comprises separate spray nozzles for each of two or more crosslinkable solutions, with each nozzle surrounded by an annular gas flow outlet. Crosslinkable solutions are stored in separate compartments and communicated under pressure to the spray nozzles. In the presence of gas flow through the annular gas flow outlets, the crosslinkable solutions are atomized and mixed in the gas flow to form a spray. Multi-component hydrogel systems suitable for use with the inventive methods and apparatus are also described.Type: GrantFiled: April 21, 2000Date of Patent: January 6, 2004Assignee: Incept LLCInventor: Amarpreet S. Sawhney
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Publication number: 20040002456Abstract: Materials, methods, and compositions for making crosslinked albumin hydrogels are included in the application. Embodiments include a biocompatible material of albumin crosslinked with an n-functional crosslinking agent wherein n is at least 3. Other embodiments include a cross-linking agent having a polyalkylene oxide member. Other embodiments include a system for administering an albumin material, the system having albumin and a crosslinking agent that reacts with the albumin to form a crosslinked material made of crosslinked albumin. Another embodiment is a method of making a biocompatible material that includes a step of mixing albumin with an n-functional crosslinking agent wherein n is at least 3.Type: ApplicationFiled: February 11, 2003Publication date: January 1, 2004Applicant: Incept LLCInventor: Chandrashekhar P. Pathak
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Patent number: 6663651Abstract: Apparatus and methods for retrieving a vascular filter from a vessel are provided wherein a retrieval adapter is delivered to a treatment site concurrently along with an interventional device to reduce the number of steps required to remove the vascular filter. The retrieval adapter also reduces the possibility of entangling the vascular filter with a stent disposed within the vessel during removal of the vascular filter. A separate retrieval catheter is also described for use in conjunction with the retrieval adapter.Type: GrantFiled: January 16, 2001Date of Patent: December 16, 2003Assignee: Incept LLCInventors: Jeff A. Krolik, Amr Salahieh, Jackson F. Demond, Farhad Khosravi
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Patent number: 6632457Abstract: Compositions and methods are provided to control the release of relatively low molecular weight therapeutic species through hydrogels by first dispersing or dissolving such therapeutic species within relatively hydrophobic rate modifying agents to form a mixture. The mixture is formed into microparticles that are dispersed within bioabsorbable hydrogels, so as to release the water soluble therapeutic agents in a controlled fashion. Methods of using the compositions of the present invention in therapeutic systems are also provided.Type: GrantFiled: August 14, 1998Date of Patent: October 14, 2003Assignee: Incept LLCInventor: Amarpreet S. Sawhney
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Patent number: 6620182Abstract: Apparatus and methods are provided for use in filtering emboli from a vessel such as the ascending aorta, wherein a vascular device comprises a support hoop having an articulation region connected near a distal end of an elongated member, a blood permeable sac affixed to the support hoop so that the support hoop forms a mouth of the blood permeable sac, a guide wire, and a delivery sheath. The articulation region comprises a reduced thickness region of the support hoop that prevents kinks from forming in the support hoop when the apparatus is contracted to its delivery state, and curved regions that close the mouth of the sac to prevent material escaping from the sac when the apparatus is collapsed for removal.Type: GrantFiled: August 9, 2000Date of Patent: September 16, 2003Assignee: Incept LLCInventors: Farhad Khosravi, L. N. Hopkins, Amr Salahieh, Jackson F. Demond, Jeff A. Krolik
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Patent number: 6616679Abstract: Apparatus and methods are provided for use in filtering emboli from a vessel and performing thrombectomy and embolectomy, wherein a vascular device comprises a support hoop having an articulation region connected near a distal end of a guide wire, and a blood permeable sac affixed to the support hoop, and a delivery sheath that permits the vascular device to be deployed in a “rapid exchange” mode. The articulation region comprises a reduced thickness region of the support hoop that prevents kinks from forming in the support hoop when the apparatus is contracted to its delivery state, and curved regions that close the mouth of the sac to prevent material escaping from the sac when the apparatus is collapsed for removal.Type: GrantFiled: July 7, 2000Date of Patent: September 9, 2003Assignee: Incept, LLCInventors: Farhad Khosravi, Richard Renati
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Publication number: 20030162841Abstract: Biocompatible crosslinked-polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants.Type: ApplicationFiled: February 25, 2003Publication date: August 28, 2003Applicant: InceptInventors: Chandrashekhar P. Pathak, Amarpreet S. Sawhney, Peter G. Edelman
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Patent number: 6610033Abstract: The present invention provides apparatus and methods for making and using a medicinal polymer formed from two components. The apparatus includes a double syringe holder housing first and second syringes that is adapted to be coupled with a predetermined orientation to a double vial holder housing first and second vials. The double syringe holder and double vial holder have mating key features that prevent the first syringe from being coupled to the second vial and the second syringe from being coupled to the first vial. The apparatus also includes a delivery device having first and second inlet ports and a key feature that prevents the first syringe from being coupled to the second inlet port and the second syringe from being coupled to the first inlet port.Type: GrantFiled: October 13, 2000Date of Patent: August 26, 2003Assignee: Incept, LLCInventors: David A. Melanson, Michelle D. Lyman, Peter G. Edelman, Amarpreet S. Sawhney
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Patent number: 6605294Abstract: Pharmaceutically acceptable hydrogel polymers of natural, recombinant or synthetic origin, or hybrids thereof, are introduced in a dry, less hydrated, or substantially deswollen state and rehydrate in a physiological environment to undergo a volumetric expansion and to affect sealing, plugging, or augmentation of tissue, defects in tissue, or of organs. The hydrogel polymers may deliver therapeutic entities by controlled release at the site. Methods to form useful devices from such polymers, and to implant the devices are provided.Type: GrantFiled: August 14, 1998Date of Patent: August 12, 2003Assignee: Incept LLCInventor: Amarpreet S. Sawhney
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Patent number: 6589263Abstract: Apparatus and methods are provided for use in filtering emboli from a vessel and performing thrombectomy and embolectomy, wherein a vascular device comprises one or more support hoops, each having an articulation region connected near a distal end of a guide wire, and a blood permeable sac affixed to the one or more support hoops so that the support hoops form a mouth of the blood permeable sac. Each articulation region comprises a reduced thickness region of the support hoop that prevents kinks from forming in the support hoop when the apparatus is contracted to its delivery state, and curved regions that close the mouth of the sac to prevent material escaping from the sac when the apparatus is collapsed for removal.Type: GrantFiled: October 29, 1999Date of Patent: July 8, 2003Assignee: Incept LLCInventors: Leo N. Hopkins, Farhad Khosravi, Amr Salahieh, Jeff A. Krolik, Jackson F. Demond
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Publication number: 20030100919Abstract: Apparatus and methods are provided for use in filtering emboli from a vessel and/or performing thrombectomy and embolectomy, wherein a vascular device comprises one or more support hoops connected near a distal end of a guide wire, each support hoop having an articulation region, and a blood permeable sac affixed to the support hoop or hoops to form a mouth of the blood permeable sac. The mouth of the sac closes when the apparatus is collapsed for removal to prevent material from escaping from the sac.Type: ApplicationFiled: November 22, 2002Publication date: May 29, 2003Applicant: INCEPT LLCInventors: L. N. Hopkins, Farhad Khosravi, Amr Salahieh, Jackson F. Demond, Jonah Lepak, Stephen Ramee, Jeff A. Krolik, Richard Renati
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Patent number: 6566406Abstract: Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants.Type: GrantFiled: December 3, 1999Date of Patent: May 20, 2003Assignee: Incept, LLCInventors: Chandrashekhar P. Pathak, Amarpreet S. Sawhney, Peter G. Edelman
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Publication number: 20030077272Abstract: Proteinaceous gels having visualization agents and methods of use thereof are disclosed herein. Further, polymeric crosslinking agents are disclosed that have an inert water soluble polymeric component, biodegradable components, functional components reactive with chemical groups on a protein, for example, amine or thiol groups. The inert polymeric component may be flanked at each end with a biodegradable component which is flanked at each end with a protein reactive functional component. A polymeric crosslinking agent is disclosed having a biodegradable component, polyalkylene oxide, and at least three reactive functional groups that are each capable of forming a covalent bond in water with at least one functional group such as an amine, thiol, or carboxylic acid.Type: ApplicationFiled: November 13, 2002Publication date: April 24, 2003Applicant: Incept LLCInventor: Chandrashekhar P. Pathak
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Publication number: 20030077242Abstract: Methods are provided for forming hydrogel barriers in situ that adhere to tissue and prevent the formation of post-surgical adhesions or deliver drugs or other therapeutic agents to a body cavity. The hydrogels are crosslinked, resorb or degrade over a period of time, and may be formed by free radical polymerization initiated by a redox system or thermal initiation, or electrophilic-neutrophilic mechanism, wherein two components of an initiating system are simultaneously or sequentially poured into a body cavity to obtain widespread dispersal and coating of all or most visceral organs within that cavity prior to gelation and polymerization of the regional barrier. The hydrogel materials are selected to have a low stress at break in tension or torsion, and so as to have a close to equilibrium hydration level when formed.Type: ApplicationFiled: October 8, 2002Publication date: April 24, 2003Applicant: Incept LLCInventor: Amarpreet S. Sawhney
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Patent number: 6544279Abstract: Apparatus and methods are provided for use in filtering emboli from a vessel and/or performing thrombectomy and embolectomy, wherein a vascular device comprises one or more support hoops connected near a distal end of a guide wire, each support hoop having an articulation region, and a blood permeable sac affixed to the support hoop or hoops to form a mouth of the blood permeable sac. The mouth of the sac closes when the apparatus is collapsed for removal to prevent material from escaping from the sac.Type: GrantFiled: August 9, 2000Date of Patent: April 8, 2003Assignee: Incept, LLCInventors: L. N. Hopkins, Farhad Khosravi, Amr Salahieh, Jackson F. Demond, Jonah Lepak, Stephen Ramee, Jeff A. Krolik, Richard Renati
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Patent number: 6530939Abstract: Apparatus and methods are provided for use in filtering emboli from a vessel and performing thrombectomy and embolectomy, wherein a vascular device comprises a support hoop having an articulation region connected near a distal end of a guide wire, and a blood permeable sac affixed to the support hoop so that the support hoop forms a mouth of the blood permeable sac. The articulation region comprises a reduced thickness region of the support hoop that prevents kinks from forming in the support hoop when the apparatus is contracted to its delivery state, and curved regions that close the mouth of the sac to prevent material escaping from the sac when the apparatus is collapsed for removal.Type: GrantFiled: July 30, 1999Date of Patent: March 11, 2003Assignee: Incept, LLCInventors: Leo N. Hopkins, Farhad Khosravi, Amr Salahieh, Jeff A. Krolik, Jackson F. Demond
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Patent number: 6514534Abstract: Methods are provided for forming hydrogel barriers in situ that adhere to tissue and prevent the formation of post-surgical adhesions or deliver drugs or other therapeutic agents to a body cavity. The hydrogels are crosslinked, resorb or degrade over a period of time, and may be formed by free radical polymerization initiated by a redox system or thermal initiation, or electrophilic-nucleophilic mechanism, wherein two components of an initiating system are simultaneously or sequentially poured into a body cavity to obtain widespread dispersal and coating of all or most visceral organs within that cavity prior to gelation and polymerization of the regional barrier. The hydrogel materials are selected to have a low stress at break in tension or torsion, and so as to have a close to equilibrium hydration level when formed.Type: GrantFiled: August 14, 1998Date of Patent: February 4, 2003Assignee: Incept LLCInventor: Amarpreet S. Sawhney