Patents Assigned to Indiana University Research and Technology Corporation
  • Modified Tamm-Horsfall protein and related compositions and methods of use
    Patent number: 11053290
    Abstract: Embodiments of the present disclosure provide polypeptides, related materials and compositions, and methods for their use. In certain embodiments, the present disclosure provides a monomeric Tamm-Horsfall Protein polypeptide, or a biologically active truncation thereof. Other embodiments provide polynucleotides encoding a polypeptide described herein, nucleic acid expression vectors including the polynucleotides, and recombinant host cells including the expression vector. Yet other embodiments provide pharmaceutical compositions including a polypeptide described herein. Also provided are methods for treating a renal disease, disorder, or condition in a subject and/or modulating an immune response in a subject.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: July 6, 2021
    Assignees: Indiana University Research and Technology Corporation, The United States Government as Represented by the Department of Veterans Affair
    Inventors: Tarek Maurice Ashkar, Radmila Micanovic
  • GENETICALLY MODIFIED MOUSE MODELS OF ALZHEIMER'S DISEASE
    Publication number: 20210195879
    Abstract: The present disclosure provides a genetically modified mouse comprising a genomic nucleic acid encoding human APOE4, a genomic nucleic acid encoding mouse TREM2 modified to include a R47H substitution, and at least one genomic modification selected from the group consisting of: (a) a genomic nucleic acid encoding mouse ABCA7 modified to include an A 1541 G substitution; (b) a genomic nucleic acid encoding mouse APP modified to include G601R, F606Y, and R609H substitutions; (c) a genomic nucleic acid encoding mouse PLCG2 modified to include a M28L substitution; (d) a genomic nucleic acid encoding mouse MTHFR modified to include a A262V substitution; (e) an inactivated Ceacam1 allele; and (f) an inactivated Il1rap allele. Methods of producing the genetically modified mouse and methods of using the genetically modified mouse are also provided.
    Type: Application
    Filed: June 21, 2019
    Publication date: July 1, 2021
    Applicants: The Jackson Laboratory, Indiana University Research and Technology Corporation, Sage Bionetworks
    Inventors: Gareth Howell, Gregory Carter, Michael Sasner, Stacey Rizzo, Harriet Williams, Bruce Lamb, Paul Territo, Adrian Oblak, Ben Logsdon, Lara Mangravite, Leah Graham
  • Blood biomarkers for suicidality
    Patent number: 11047009
    Abstract: Biomarkers and methods for screening expression levels of the biomarkers for predicting and tracking suicidality, as well as for monitoring response to a treatment for suicidal risk and for determining suicidal risk as a side-effect of an antidepressant are disclosed.
    Type: Grant
    Filed: April 6, 2016
    Date of Patent: June 29, 2021
    Assignee: Indiana University Research and Technology Corporation
    Inventor: Alexander B. Niculescu
  • ANTIBIOTIC GEL FORMULATION AND METHODS OF PREPARING THE ANTIBIOTIC GEL FORMULATION
    Publication number: 20210145827
    Abstract: Antibiotic gel formulations for use in dental applications are disclosed. More particularly, the present disclosure is directed to antibiotic gel formulations including low concentrations of antibiotics that are capable of killing root canal pathogens without harming the stem cells inside the root canal. Additionally, the present disclosure is directed to delivery systems and methods for applying the antibiotic gel formulations into a subject's intracanal region.
    Type: Application
    Filed: January 25, 2021
    Publication date: May 20, 2021
    Applicant: Indiana University Research and Technology Corporation
    Inventors: Ghaeth H. Yassen, Jeffrey A. Platt, Richard L. Gregory
  • SOLUBILITY ENHANCING PROTEIN EXPRESSION SYSTEMS
    Publication number: 20210139920
    Abstract: Embodiments disclosed herein provide compositions, methods, and uses for solubility-enhancing protein (SEP) tags. Certain embodiments provide expression vectors for the production of a soluble protein or polypeptide of interest (i.e., a target protein) having a molecular mass of about 100 kDa or greater. In some embodiments, the SEP tags enable expression of large and often difficult to express proteins, with yields appropriate for further protein study. Also described are nucleic acid cassettes that include a SEP tag, and fusion proteins expressed from the SEP expression vectors or nucleic acid cassettes. Kits including SEP expression vectors are also provided.
    Type: Application
    Filed: August 21, 2018
    Publication date: May 13, 2021
    Applicant: Indiana University Research and Technology Corporation
    Inventors: Yuichiro Takagi, Tsuyoshi Imasaki
  • Position determining system
    Patent number: 11002526
    Abstract: An XYZ flexural mechanism comprising an X-axis flexural mechanism comprising a first voice coil actuator, a motion stage platform, a plurality of flexural bearings, and a plurality of guide rods, a Y-axis flexural mechanism comprising a second voice coil actuator, a plurality of flexural bearings, a plurality of guide rods, and a frame, and a Z-axis flexural mechanism comprising a third voice coil actuator, a plurality of flexural bearings, a plurality of guide rods, and a frame, the frame supporting the XYZ flexural mechanism.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: May 11, 2021
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Hrishikesh Balasaheb Zambare, Ali Razban, Suhas Pandurang Deshmukh, Mahesh Shivaji Shewale, Sharad S. Mulik
  • POLYMER INFRARED POLARIZER
    Publication number: 20210132276
    Abstract: A polymer infrared polarizer (100) comprising a transparent polymer substrate (110) formed of a high sulfur content polymeric material, and a metal layer (130) fixed to an upper surface (120) of the transparent polymer substrate (110).
    Type: Application
    Filed: October 18, 2018
    Publication date: May 6, 2021
    Applicant: Indiana University Research and Technology Corporation
    Inventor: Jong Eun Ryu
  • DEVICE AND METHOD FOR SCAR SUBCISION
    Publication number: 20210128187
    Abstract: A scar subcision devices comprising a first elongated element comprising a pivotal connection to a second elongated element, the first elongated element having a blunt distal end, the second elongated element having a proximal-facing cutting edge at a distal end thereof, the device having a first state wherein the cutting edge is retracted to a location within an outer perimeter of the first elongated element, and a second state wherein the cutting edge is exposed outside of the outer perimeter of the first elongated element and the device transitioning between the first state and the second state by the first elongated element and the second elongated element rotating relative to each other about the pivotal connection are disclosed. Methods are also disclosed.
    Type: Application
    Filed: January 11, 2021
    Publication date: May 6, 2021
    Applicant: Indiana University Research and Technology Corporation
    Inventors: Luke G. Gutwein, Rajiv Sood, Barry Davignon
  • Predicting suicidality using a combined genomic and clinical risk assessment
    Patent number: 10991449
    Abstract: Biomarkers and methods for screening expression levels of the biomarkers for predicting suicidality (referred herein to suicidal ideation and actions, future hospitalizations and suicide completion) are disclosed. Also disclosed are quantitative questionnaires and mobile applications for assessing affective state and for assessing socio-demographic and psychological suicide risk factors, and their use to compute scores that can predict suicidality. Finally, an algorithm that combines biomarkers and computer apps for identifying subjects who are at risk for committing suicide is disclosed, as well as methods to mitigate and prevent suicidality based on the biomarkers and computer apps.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: April 27, 2021
    Assignee: Indiana University Research and Technology Corporation
    Inventor: Alexander Bogdan Niculescu
  • Hydrodynamic method and apparatus for delivering fluids to kidney tissues
    Patent number: 10980985
    Abstract: The invention provides a catheter and control box apparatus and related methods that are useful in delivering liquids, including liquids comprising nucleic acid molecules into cells. In particular, the invention provides a catheter that stabilizes fluid flow within a vein to deliver a volume, pressure charge of saline solution, exogenous compositions, and isolated vectors to kidney cells, using the renal vein as a guide and under hydrodynamic pressure. The catheter and control box apparatus and related methods described herein are useful to research, prognose, ameliorate symptoms of kidney injury, and treat kidney pathologies.
    Type: Grant
    Filed: September 2, 2014
    Date of Patent: April 20, 2021
    Assignees: Indiana University Research and Technology Corporation, United States Government as Represented by the Department of Veterans Affairs
    Inventor: Robert Bacallao
  • Hepatitis B core protein modulators
    Patent number: 10968211
    Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: April 6, 2021
    Assignees: Assembly Biosciences, Inc., INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
    Inventors: William W. Turner, Jr., Lee D. Arnold, Hans Maag, Leping Li, Mark G. Bures, Simon Nicolas Haydar, Samson Francis
  • DOUBLE KNOCKOUT (GT/CMAH-KO) PIGS, ORGANS AND TISSUES
    Publication number: 20210076647
    Abstract: The invention provides double knockout transgenic pigs (GT/CMAH-KO pigs) lacking expression of any functional ?GAL and CMAH. Double knockout GT/CMAH-KO transgenic organs, tissues and cells are also provided. Methods of making and using the GT/CMAH-KO pigs and tissue are also provided.
    Type: Application
    Filed: April 22, 2020
    Publication date: March 18, 2021
    Applicant: Indiana University Research and Technology Corporation
    Inventor: A. Joseph Tector
  • Hepatitis B core protein allosteric modulators
    Patent number: 10947224
    Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: March 16, 2021
    Assignees: Indiana University Research and Technology Corporation, Assembly Biosciences, Inc.
    Inventors: William W. Turner, Jr., Lee Daniel Arnold, Hans Maag, Adam Zlotnick
  • Tube securing device
    Patent number: 10946174
    Abstract: A tube securing device is provided comprising: a base including a lower plate and a pair of inner walls, each of the inner walls including a ledge extending therefrom which forms a notch between the ledge and the lower plate, the base further including a groove between the inner walls sized to receive a tube in communication with a cavity of a patient; and a retainer including an upper plate and a pair of retention beams, each of the retention beams including a ridge extending therefrom, the retainer further including a groove between the retention beams sized to receive the tube. The tube is retained in the groove of the base and the groove of the retainer when the retainer is attached to the base by forcing the ridges over the ledges until the ridges snap into notches.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: March 16, 2021
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Samer Abu-Sultaneh, Terri Bogue
  • MATERIALS AND METHODS FOR SUPPRESSING AND/OR TREATING BACTERIAL INFECTIONS AND RELATED SYMPTOMS
    Publication number: 20210069221
    Abstract: Various aspects and embodiments disclosed herein relate generally to the modelling, treatment, reducing resistence to the treatment, prevention, and diagnosis of diseases/symptoms induced by infectious bacteria. Embodiments include methods of treating a bacterial infection, comprising the steps of: providing to a patient diagnosed with staphylococcal infection at least one therapeutically effective dose of a compound having an anti-virulence effect.
    Type: Application
    Filed: August 20, 2020
    Publication date: March 11, 2021
    Applicant: Indiana University Research and Technology Corporation
    Inventors: Taeok Bae, WonSik Yeo, Hyunyoung Jeong
  • Ink reinforcement for printed electronics
    Patent number: 10934446
    Abstract: Reinforced conductive nanoink formulations are disclosed including a carrier, metallic nanostructures dispersed in the carrier, and a reinforcement fiber. Methods of depositing and manufacturing using reinforced nanoinks are also disclosed.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: March 2, 2021
    Assignee: Indiana University Research and Technology Corporation
    Inventor: Jong Eun Ryu
  • Materials and methods for suppressing and/or treating bacterial infections and related symptoms
    Patent number: 10933075
    Abstract: Various aspects and embodiments disclosed herein relate generally to the modelling, treatment, reducing resistence to the treatment, prevention, and diagnosis of diseases/symptoms induced by infectious bacteria. Embodiments include methods of treating a bacterial infection, comprising the steps of: providing to a patient diagnosed with staphylococcal infection at least one therapeutically effective dose of a compound having an anti-virulence effect.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: March 2, 2021
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Taeok Bae, WonSik Yeo, Hyunyoung Jeong
  • PRECISION MEDICINE FOR PAIN: DIAGNOSTIC BIOMARKERS, PHARMACOGENOMICS, AND REPURPOSED DRUGS
    Publication number: 20210047689
    Abstract: Disclosed are methods for treating pain and tracking response to treatment. Also disclosed are methods for determining pain, including predicting future medical care facility visits for pain.
    Type: Application
    Filed: March 14, 2019
    Publication date: February 18, 2021
    Applicants: Indiana University Research and Technology Corporation, The United States Government as Represented by the Department of Veterans Affairs
    Inventor: Alexander Bogdan Niculescu
  • MOLECULAR ROTOR-BASED D-AMINO ACIDS AS TOOLS FOR IMAGING PEPTIDOGLYCAN BIOSYNTHESIS
    Publication number: 20210047308
    Abstract: Disclosed herein are compositions for assessing peptidoglycan (PG) biosynthesis in bacteria using modified D-amino acids covalently attached to a molecular rotor and visualizing the labeled PG in bacteria based upon the enhanced fluorescence of the molecular rotor incorporated in the PG. The resultant, labeled peptidoglycan structures are amenable for identification by microscopic visualization, flow cytometry or other suitable methods.
    Type: Application
    Filed: February 7, 2019
    Publication date: February 18, 2021
    Applicant: Indiana University Research and Technology Corporation
    Inventors: Michael VanNieuwenhze, Yves Brun, Erkin Kuru, Edward Hall
  • Antibacterials and/or modulators of biofilm formation and methods of using the same
    Patent number: 10919844
    Abstract: Amides substituted with aromatic groups were synthesized and some were purified to create enantiomer pure compounds. The compounds were tested to determine their ability to inhibit the growth of bacteria and the formation of biofilms created by bacteria. Some of these compounds were found to be effective antibacterials and to effectively inhibit the formation of biofilms.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: February 16, 2021
    Assignee: Indiana University Research and Technology Corporation
    Inventors: William L. Scott, Martin J. O'Donnell, Jack Geno Samaritoni