Abstract: Disclosed herein are systems, methods and computer-program products to create synthetic immunohistochemistry (IHC) stained digital slides generated using artificial neural networks (ANNs). In some implementations, the created digital slides can be used as a ground truth to evaluate a method of analyzing IHC stained tissues.

Abstract: Disclosed herein are high Tm RNA nanostructures that can be composed of one or more modules or motifs to build RNA nanostructures with or without layers. The RNA nanostructures can have a core domain and three or more double-stranded arms and formulations thereof to conjugate high copy numbers of therapeutics, pH responsive or enzyme cleavable drug cargo. Also described herein is a design strategy for generation of synthetic RNA oligonucleotides that can self assemble into highly thermostable RNA structures. Also described herein are uses of the RNA nanostructures described herein.

Abstract: Disclosed herein are methods and apparatus for making a determination about an eye comprising detecting light reflected out of an eye of a subject from a retina of the eye of the subject and making a determination about the eye of the subject based upon the reflected light, wherein the light is adjusted for color temperature when making the determination about the eye.

Abstract: Disclosed herein are methods and apparatus for making a determination about a cataract in an eye in ambient lighting conditions.

Abstract: A T-breaker is an all-in-one solution for dc microgrid fault protection, power flow control, and power quality improvement. A T-breaker features a modular multilevel “T” structure with integrated energy storage devices. The two horizontal arms of the T-breaker realize fault current breaking, load voltage compensation, and power flow control; and the vertical arm of the T-breaker realizes shunt compensation. The configuration provides excellent voltage scalability and relaxes the requirements on the switching signal synchronization during fault transients. The local energy storage in sub-modules eases the fault energy dissipation requirement placed on the traditionally-adopted surge arrestors. The modular multilevel structure also offers immense control flexibility for all types of targeted functions of the provided T-breaker.

Abstract: Provided herein are aptamers capable of inhibiting the activity of Von Willebrand Factor (VWF). Pharmaceutical compositions comprising these aptamers are also provided. Methods of preventing blood clot formation in a subject by administering the aptamers are provided and methods of treating a blood clot by administering a VWF-targeting agent are also provided.

Abstract: The disclosed technology relates to redox flow batteries (“RFB”), and particularly to electrolytes useful in RFBs based on 2,5-dimercapto-1,3,4-thiadiazole (“DMTD”) and derivatives thereof.

Abstract: Various implementations include a fluidic oscillator having at least one control port. The at least one control port is for introducing a control fluid into the fluidic oscillator or suctioning the fluid stream from the fluidic oscillator. The introduction of a control fluid into the fluidic oscillator or suction of the fluid stream from the fluidic oscillator alters the frequency and sweeping angle of the oscillating fluid stream as it exits the fluidic oscillator. Various other implementations include a fluidic oscillator having a first control port defined by the first portion of the outlet nozzle and a second control port defined by the second portion of the outlet nozzle. The introduction of a control fluid into the fluidic oscillator or suction of the fluid stream from the fluidic oscillator through the control ports alters the exit angle of the oscillating fluid stream as it exits the fluidic oscillator.

Abstract: Disclosed herein is a contact lens comprising a rounded, minus-carrier, lenticular-like curve over a central, upper portion of the lens that allows the contact lens to translate upwards in downgaze.

Abstract: Disclosed herein is a contact lens comprising a lenticular in a superior portion of the contact lens wherein the contact lens attaches to an upper eyelid of a wearer by the lenticular interacting with an upper tarsal plate of the upper eyelid of a wearer, said interaction allows the contact lens to translate upwards in downgaze and maintain rotational stability. In one aspect, the lenticular has a top surface, said top surface having a shape selected from the group consisting of flat, flat with rounded corners, concave, convex or tapered having a thicker portion closer to an edge of the contact lens, or combinations thereof. In another aspect, the lenticular is comprised of a plurality of lenticular sections. In yet another aspect, the lenticular is anatomically-shaped.

Abstract: In one aspect, the disclosure relates to methods and compositions for treatment of cancer cachexia. In a further aspect, the composition is a pharmaceutical composition comprising a class I/IIB HDAC inhibitor and an androgen. In a still further aspect, the method of treatment comprises administering a class I/IIB HDAC inhibitor and an androgen to a subject or patient who has been diagnosed as having cancer cachexia. In some aspects, the class I/IIB HDAC inhibitor is a compound known as AR-42.

Abstract: Disclosed are aluminum alloys with high iron content and methods of making and using.

Abstract: The disclosure provides a method of isolating one or more compounds present in fruit seed extracts that have anti-ty-rosinase or whitening activity, compositions having one or more fruit seed extracts that have anti-tyrosinase or whitening (lightening) activity.

Abstract: In a non-contact pressure measurement system of a balloon catheter and a non-contact pressure measurement method of the balloon catheter using the same, the system includes a chamber part, a balloon, a tube part, a pump part and a displacement sensor. The chamber part stores a saline solution. The balloon is disposed inside of a body and is configured to be expanded with supply of the saline solution. The tube part is configured to connect the chamber part with the balloon. The pump part is configured to control the supply of the saline solution via the tube part. The displacement sensor is configured to measure an amount of the expansion of the tube part expanded with the supply of the saline solution, in a predetermined section of the tube part.

Abstract: An example assembly for use with a vacuum system and an esophageal positioning device esophageal positioning device includes an introducer, in which the esophageal positioning device includes a handle, a first segment, a second segment and an articulation driving mechanism. The first segment being coupled to the handle. The second segment being pivotally connected to the first segment. The articulation driving mechanism being configured to pivot the second segment about the first segment upon articulation.

Abstract: In one aspect, the disclosure relates to compositions and methods for dispersing exiting Salmonella biofilms and inhibiting formation of Salmonella biofilms. In various aspects, the disclosed compositions can be used in methods of treating a persistent Salmonella infection, including an asymptomatic infection. Such infections can colonize a variety of tissues, including the gall-bladder. Also disclosed are methods of treating typhoid fever. Also disclosed are methods for mitigating or preventing secondary outbreaks of typhoid fever by treating asymptomatic subjects who had been symptomatic for typhoid fever at a previous time. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: A multiband antenna comprises a dielectric substrate with a first surface defining an annular ledge and a central recess with a plurality of pockets. A MIMO radiator body is disposed in the central recess having a first surface defining a plurality of lobes which are disposed in respective ones of the plurality of pockets and having a second surface defining an outer rim and a central shelf A radiator ring is disposed at the annular ledge so that the radiator ring and the outer rim converge along an annular gap therebetween. A plurality of MIMO feed lines provide external connection to respective lobes. The MIMO radiator body and the radiator ring provide a substantially horizontally-directed radiation pattern (e.g., for terrestrial signals). At least one low-profile radiator on the central shelf provides a substantially circularly polarized or vertically-directed radiation pattern for receiving signals radiated from a satellite.

Abstract: The present disclosure relates to synthetic oncolytic viruses comprising a lipid nanoparticle comprising one or more types of lipid and a self-amplifying replicon RNA comprising a sequence that encodes an immunomodulatory molecule.