Abstract: Disclosed herein are chimeric antigen receptors (CAR) that can specifically recognize tumor-associated antigens (TAA) on multiple myeloma (MM) cells. Also disclosed are immune effector cells, such as T cells or Natural Killer (NK) cells, that are engineered to express these CARs. Therefore, also disclosed are methods of providing an anti-tumor immunity in a subject with MM that involves adoptive transfer of the disclosed immune effector cells engineered to express the disclosed CARs.

Abstract: Methods for automated calibration adaptation of a gearshift controller are disclosed. In one aspect, the method automates calibration of a gearshift controller in an automatic transmission having one or more speed sensors, each configured to generate a signal, and allowing one or more gearshifts with associated gearshift output sets ji that are functions of speed sensor signals and the desired gearshift output sets ?i. The gearshift controller has one or more gearshift control parameter sets Urji to be calibrated, each set including gearshift control parameters for an allowed gearshift at one operating condition, and learning controllers Li sets of system models Hr, and positive definite matrices Pi for updating Urji during sequences of allowed gearshifts. The method incudes acquiring speed sensor signals, computing the gearshift output set jj; and updating the gearshift control parameter set pi.

Abstract: Devices and methods for surface-induced dissociation (SID) are disclosed. In one aspect, a device for SID is disclosed which, in one embodiment includes a collision surface, a deflector configured to guide precursor ions from a pre-SID region to the collision surface to cause SID, and an ion carpet having applied electrical properties configured to guide product ions resulting from collision with the collision surface to a post-SID region. In another aspect, a method for SID is disclosed which, in one embodiment includes guiding, by a deflector, precursor ions from a pre-SID region to a collision surface to cause SID, and guiding, by an ion carpet having selected applied electrical properties, product ions resulting from collision with the collision surface to a post-SID region.

Abstract: Disclosed herein are laser-assisted metal-organic chemical vapor deposition devices and methods of use thereof for suppressing background carbon incorporation.

Abstract: The present disclosure generally relates to genome editing systems and methods and compounds and compositions for use in Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) genome editing systems. Disclosed herein are modified nucleic acids that modulate the activity of genome editing.

Abstract: A hybrid Schottky diode is described herein where the forward characteristics are determined by the metal-semiconductor junction, and the reverse characteristics and breakdown are determined by the metal/dielectric/semiconductor junction. Experimental demonstration of such hybrid Schottky diodes shows significant improvement in the breakdown performance with average breakdown field up to 2.22 MV/cm with reduced turn on of 0.47 V and enable state-of-art power switching figure of merit for GaN lateral Schottky diodes.

Abstract: A method for evaluating for the presence of the COVID disease by detecting one or more biomarkers using a breathalyzer (138). The breath sample (2) taken from the subject (10) is passed over a sensor (140) which changes resistance in the presence of nitric oxide as a function of concentration. The resistance pattern of the subject (10) having the COVID disease will have a distinct shape, approximating the appearance of the small Greek letter omega (?). Test results can be generated in less than a minute.

Abstract: Mid-infrared spectroscopic analysis of tissue specimens can include training a learning model and using the trained learning model to classify tissue into at least two (or more than two) categories such as a tumor category, a non-tumor category, and a histology category. Resulting richer diagnostic indication can be provided and can optionally be mapped to a schema for RGB or other display. Efficient and accurate classification can employ an efficient linear SVM model representation. The model representation can include a ? spectrum including the fuller wavelength set, a central tendency indicator (?) of the training set, a spread indicator (?) of the training set, and a scaling factor. Various types of illuminators and response detectors can include one or more Quantum Cascade Lasers, broadband light source configured to permit spectral separation, a thermal or other imaging array, among others.

Abstract: Systems, devices, and methods for generating a unique fingerprint are described herein. For example, an example integrated circuit (IC) chip includes a physically unclonable function (PUF) and an auxiliary circuit. The PUF is a hybrid Boolean network. Additionally, the auxiliary circuit is configured to receive a transient response enable signal.

Abstract: An exemplary axial cladding magnet magnetically-geared machine is disclosed comprising Halbach array cladding magnets located on the axial ends of the magnetically-geared machine. The Halbach array cladding magnets can be used to increase the magnetic efficiency and torque transmission of the magnetically-geared machine by mitigating end-effect losses.

Abstract: A method of preparing a colorless transparent copolyamide-imide resin solution and its fabrication as a thin film has been disclosed. The method details formulations derived from a reaction between one or more units of dianhydride and one or more units of diamine monomers with one or more of the monomers containing fluorine atoms in their structural unit. It enables the fabrication of thin films with superior thermal and mechanical properties along with co-efficient of thermal expansion values as low as 2 ppm/° C. and a tensile modulus as high as 9 GPa. The transparent copolyamide-imide film thus prepared has the potential for utilization in flexible displays such as substrates for thin film transistors (TFT), touch sensor panels (TSP) and cover window in organic light emitting diode (OLED) and liquid crystal display (LCD) applications.

Abstract: Systems and methods use bimetallic alloy particles for converting hydrogen sulfide (H2S) to hydrogen (H2) and sulfur (S), typically during multiple operations. In a first operation, metal alloy composite particles can be converted to a composite metal sulfide. In a second operation, composite metal sulfide from the first operation can be regenerated back to the metal alloy composite particle using an inert gas stream. Pure, or substantially pure, sulfur can also be generated during the second operation.

Abstract: Methods for automated calibration adaptation of a gearshift controller are disclosed. In one aspect, the method automates calibration of a gearshift controller in an automatic transmission having one or more speed sensors, each configured to generate a signal, and allowing one or more gearshifts with associated gearshift output sets ji that are functions of speed sensor signals and the desired gearshift output sets ?i. The gearshift controller has one or more gearshift control parameter sets Urji to be calibrated, each set including gearshift control parameters for an allowed gearshift at one operating condition, and learning controllers Li sets of system models Hr, and positive definite matrices Pi for updating Urji during sequences of allowed gearshifts. The method incudes acquiring speed sensor signals, computing the gearshift output set jj; and updating the gearshift control parameter set pi.

Abstract: The present invention relates to a novel method for preparing inotodiol, which is different from the existing method for preparing inotodiol and has a high yield of inotodiol, so it can be effectively used for preparing and mass-producing inotodiol.

Abstract: Disclosed are compounds that can penetrate the mitochondrial membrane and that are able to deliver cargo (e.g., therapeutic agents) specifically to the mitochondria.

Abstract: In an image processing-based system for measuring moisture and light transmittance and a method for measuring moisture and light transmittance using the same, the image processing-based system includes a coating paper, a photographing box, a microscope and an RGB decision program. The coating paper is coated with coating conditions substantially same as the coating conditions for a metal material. The photographing box is configured to photograph the coating paper, to obtain a first image. The microscope is configured to photograph the coating paper, to obtain a second image. The RGB decision program is configured to obtaining an RGB value of each of the first and second images. Moisture transmittance is evaluated using the RGB value of the first image, and light transmittance is evaluated using the RGB value of the second image.

Abstract: Apparatus and methods for a market-based control framework to coordinate a group of autonomous thermostatically controlled loads (TCL) to achieve system-level objectives with pricing incentives is disclosed. In one example of the disclosed technology, a method of providing power to a load via a power grid by submitting bids to a coordinator includes determining an energy response relating price data for one or more energy prices to quantity data for power to be consumed by the load, sending a bid for power for a finite time period based on the energy response to the coordinator, and receiving a clearing price based on: the bid, on bids received from a plurality of additional loads, and a feeder power constraint. In some examples, the energy response is based at least in part on an equivalent thermal parameter model and a control policy indicating one or more power states for the load.

Abstract: Frequency stabilization is provided in a microelectromechanical systems (MEMS) oscillator via tunable internal resonance (IR). A device comprises a MEMS resonator comprising a stepped-beam structure that is a thin-layer structure. The resonator may be configured to implement IR. The stepped-beam structure may be configured to provide flexibility to adjust modal frequencies into a n:m ratio, wherein n and m are integers. The thin-layer structure provides frequency tunability by controlling the mid-plane stretching effect with an applied DC bias. The thin-layer structure compensates for a frequency mismatch from a n:m ratio due to a fabrication error. The MEMS resonator may be an oscillator.

Abstract: Documents from a set of related documents in a domain are processed to identify keywords associated with each document. The documents are then further processed to identify the documents that are the most similar to each other. For each document, some or all of the keywords that are associated with the similar documents, but not the document itself, are selected as semantic tags for the document. These semantic tags determined for a document represent novel or hidden concepts and contexts that may relate to the document, but that do not actually appear in the document. The documents are used to train a model that generate semantic tags for a document or for keywords associated with the document. The generated model can then be used for a variety of purposes such the creation of an index for a set of documents or for query expansion.

Abstract: Described herein, in various embodiments, are peptides comprising: (i) a cyclic cell-penetrating peptide sequence (cCPP) and (ii) a CAL-PDZ binding sequence, which is conjugated, directly or indirectly, to an N-terminus of an amino acid in the cCPP, to a C-terminus of an amino acid on the cCPP, or on a side chain of an amino acid in the cCPP. In other embodiments, the peptides further comprise a physiologically cleavable group, wherein after entering the cell, the physiologically cleavable group is reduced, thereby providing a linear peptide. Without being bound by theory, the inventors discovered that the amino acid sequence in the cCPP, which facilities cytosolic delivery of the CAL-PDZ binding sequence also, surprisingly and unexpectedly, synergistically improves binding of CAL-PDZ binding sequence to the CAL-PDZ binding domain. Additionally, the cCPP sequence may also improve selectivity of the CAL-PDZ binding sequence for the CAL-PDZ domain relative to other PDZ binding domains.