Patents Assigned to Institute of Technology
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Publication number: 20250181955Abstract: According to one aspect of the disclosure, a system for performing quantum computations includes: a first environment for being maintained at an ambient temperature, having a classical computing processor; and a second environment for being maintained at a cryogenic temperature, having a plurality of qubits and a multiplexing circuit coupled to the plurality of qubits, each of the plurality of qubits having a gap transition frequency; wherein the classical computing processor is configured to change the states of each of the plurality of qubits by controlling the multiplexing circuit to couple particular ones of the plurality of qubits to a pulsed baseband waveform.Type: ApplicationFiled: February 8, 2023Publication date: June 5, 2025Applicant: Massachusetts Institute of TechnologyInventors: William D. Oliver, Simon Gustavsson
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Publication number: 20250180962Abstract: A device useful as a spectrometer or a sensor, comprising a source of a short electromagnetic pulses at a first wavelength and having a full width at half maximum in a range of 1 femtosecond-1 nanosecond; a sample holder in which the short pulses interact with the sample in the sample holder so as to form an output signal comprising a background residual of the short pulses and a sample response signal in the time domain, and an amplifier comprising nonlinear medium. The nonlinear medium comprises an input for receiving the output signal and a pump pulse at a second wavelength, and a second-order nonlinearity configured for a nonlinear process selectively amplifying the sample response signal, for example by temporally overlapping the pump pulse and the sample response signal.Type: ApplicationFiled: November 27, 2024Publication date: June 5, 2025Applicant: California Institute of TechnologyInventors: Alireza Marandi, Mingchen Liu, Robert M. Gray
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Patent number: 12322497Abstract: Techniques for detecting embolic information for a patient. The techniques may include obtaining data identifying an ultrasound signal associated with the patient, identifying a set of candidate embolic regions in the data, identifying a set of embolic regions from among the set of candidate embolic regions, and outputting embolic information corresponding to the set of embolic regions.Type: GrantFiled: April 8, 2020Date of Patent: June 3, 2025Assignees: Massachusetts Institute of Technology, Children's Medical Center CorporationInventors: Thomas Heldt, Syed Muhammad Imaduddin, Kerri Larovere, Barry Kussman
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Patent number: 12318315Abstract: Methods and systems are provided for decoding movement intentions using functional ultrasound (fUS) imaging of the brain. In one example, decoding movement intentions include determining a memory phase of a cognitive state of the brain, the memory phase between a gaze fixation phase and movement execution phase, and determining one or more movement intentions including one or more of intended effector (e.g., hand, eye) and intended direction (e.g., right, left) according to a machine learning algorithm trained to classify one or more movement intentions simultaneously.Type: GrantFiled: May 12, 2021Date of Patent: June 3, 2025Assignees: California Institute of Technology, INSERM (Institut National de la Santé et de la Recherche Médicale), CNRS-CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de ParisInventors: Sumner L Norman, David Maresca, Vasileios Christopoulos, Mikhail Shapiro, Richard A Andersen, Mickael Tanter, Charlie Demene
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Patent number: 12311194Abstract: Devices, systems, and methods for a treating dementia or Alzheimer's disease in a subject in need thereof. In one example, combined auditory and visual stimuli having a frequency of about 20 Hz to about 60 Hz, and more specifically about 40 Hz, are non-invasively delivered to the subject to induce synchronized gamma oscillations in at least one brain region of the subject. In particular, pursuant to various treatment and exposure protocols, combined auditory and visual stimulation (as opposed to auditory or visual stimulation alone) promotes a microglia response in the medial prefrontal cortex (mPFC). More generally, combined auditory and visual stimulation induces an extended microglia clustering response in the auditory cortex, the visual cortex, and the mPFC.Type: GrantFiled: February 7, 2022Date of Patent: May 27, 2025Assignee: Massachusetts Institute of TechnologyInventors: Li-Huei Tsai, Anthony James Martorell, Ho-Jun Suk, Ed Boyden
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Patent number: 12312583Abstract: The present disclosure, at least in part, relates to a miRNA based logic gate that comprises an engineered RNA carrier that comprises an nuclear export signal, a target site for a first miRNA and a pre-miRNA sequence for a second miRNA. Also provided by the disclosure are recombinant viruses (e.g., recombinant adeno-associated viruses (rAAV)) for delivery of the miRNA based logic gates.Type: GrantFiled: November 1, 2022Date of Patent: May 27, 2025Assignee: Massachusetts Institute of TechnologyInventors: Ron Weiss, Giulio Alighieri
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Patent number: 12314734Abstract: According to embodiments of the present disclosure, a system includes: a microkernel having a low-level application programming interface (API) and providing memory protection domains to user-level processes; and an abstraction layer running on top of the microkernel and comprising a plurality of service extensions to the microkernel and configured to provide a high-level operating system (OS) API for use by one or more application processes running in user space, wherein different ones of the service extensions are configured to run within different ones of the memory protection domains provided by the microkernel.Type: GrantFiled: May 17, 2022Date of Patent: May 27, 2025Assignee: Massachusetts Institute of TechnologyInventors: Richard W. Skowyra, Samuel Jero, Juliana Furgala, Bryan C. Ward, Roger Khazan
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Patent number: 12317741Abstract: The teachings herein pertain to hole transporting compounds containing a cyclobutyl moiety, which can be made into organic hole conductors and into hole transporting material. Additionally, optoelectronic and photoelectrochemical devices comprising such hole transporting material or hole transporting compound are described, in particular photovoltaic devices, organic-inorganic perovskite films, layered photovoltaic devices, p-n heterojunctions, dye-sensitized solar cells, organic solar cells and solid-state solar cells. Notably, a fabricated perovskite solar cell module using a disclosed HTM compound exhibited a record efficiency over 19.0% with an active area of 30.24 cm2.Type: GrantFiled: November 12, 2021Date of Patent: May 27, 2025Assignees: Kaunas University of Technology, EPFL-Swiss Federal Institute of Technology LausanneInventors: Vytautas Getautis, Kasparas Rakstys, Maryte Daskeviciene, Sarune Daskeviciute-Geguziene, Yi Zhang, Mohammad Khaja Nazeeruddin
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Patent number: 12311113Abstract: Techniques for non-invasively controlling targeted neural activity of a subject are provided herein. The techniques include applying a stimulus input to the subject, the stimulus input being formed by a deep artificial neural network (ANN) model and being configured to elicit targeted neural activity within a brain of the subject. The stimulus input may be a pattern of luminous power generated by the deep ANN model and applied to retinae of the subject. The stimulus input may be generated by the deep ANN model based on a mapping of the subject's neural responses to neurons of the deep ANN model.Type: GrantFiled: October 6, 2023Date of Patent: May 27, 2025Assignee: Massachusetts Institute of TechnologyInventors: James Dicarlo, Pouya Bashivan, Kohitij Kar
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Publication number: 20250168048Abstract: Systems and methods for transmitting data using various Modulation on Zeros schemes are described. In many embodiments, a communication system is utilized that includes a transmitter having a modulator that modulates a plurality of information bits to encode the bits in the zeros of the z-transform of a discrete-time baseband signal. In addition, the communication system includes a receiver having a decoder configured to decode a plurality of bits of information from the samples of a received signal by: determining a plurality of zeros of a z-transform of a received discrete-time baseband signal based upon samples from a received continuous-time signal, identifying zeros that encode the plurality of information bits, and outputting a plurality of decoded information bits based upon the identified zeros.Type: ApplicationFiled: November 22, 2024Publication date: May 22, 2025Applicants: California Institute of Technology, MOXZ GmbHInventors: Philipp Walk, Babak Hassibi, Peter Jung
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Publication number: 20250165827Abstract: Quantum Phased Array(s) of emitters and receivers that generate, modulate, emit, receive, and detect any quantum field. Quantum phased arrays include particle source(s) sourcing any quantum field, transmit modulator element(s) modulating any quantum observable and the associated quantum field, emitting elements radiating one or more quantum fields spatiotemporally, a propagation medium with one or more modulator elements for complete control of the quantum field, receiver(s) receiving one or more quantum fields, receive modulator element(s) modulating any quantum observable and the associated quantum field, detector(s) resolving one or more received quantum fields.Type: ApplicationFiled: April 8, 2024Publication date: May 22, 2025Applicant: California Institute of TechnologyInventors: Baris Volkan Gurses, Samantha I. Davis, Maria Spiropulu, Seyed Ali Hajimiri
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Publication number: 20250162036Abstract: A method and apparatus used in preparing a recrystallized metal alloy involve a cooling medium and a heating element to create a cold zone and a hot zone. An additively manufactured metal alloy preform is drawn in a draw direction from the cold zone towards the hot zone to form the recrystallized metal alloy. The cold zone and the hot zone create a surface temperature gradient on at least a portion of the preform of at least about 104 K m?1. The step of drawing causes an average grain size of at least a portion of the preform to increase in a direction parallel to the draw direction.Type: ApplicationFiled: May 5, 2022Publication date: May 22, 2025Applicant: Massachusetts Institute of TechnologyInventors: Zachary C. Cordero, Dominic David. R. Peachey, Christopher Pratt Carter, Andres Garcia Jimenez
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Publication number: 20250155826Abstract: A reticle stage for a photolithography scanner is disclosed having a direct-drive ironless linear motor to actuate a short-stroke stage during a turnaround operation. The reticle stage may include a long stroke stage, an array of permanent magnets coupled to a beam, and at least one conductive coil mounted to the short-stroke stage without a ferromagnetic core. The beam may pass through the short-stroke stage and be coupled to one of the long-stroke stage or a balance mass, both of which may be disposed about the perimeter of the short-stroke stage. An electrical current applied to the coil may interact with the magnetic field from the permanent magnets to provide a force on the short-stroke stage.Type: ApplicationFiled: November 8, 2024Publication date: May 15, 2025Applicant: Massachusetts Institute of TechnologyInventors: Charles Byron Seaberg, David L. Trumper
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Publication number: 20250155827Abstract: A reticle stage for a photolithography scanner having a pneumatic actuation system is disclosed. The pneumatic actuation system may provide a restoring force to a long-stroke stage during scan and turnaround operations. The reticle stage may have or define dual-chamber pneumatic pistons as energy storage devices to create turnaround forces for stage acceleration. As the long-stroke stage is driven by a linear motor a pressure differential is formed between the two pistons providing a net force opposing the direction of the long-stroke stage movement.Type: ApplicationFiled: November 8, 2024Publication date: May 15, 2025Applicant: Massachusetts Institute of TechnologyInventors: Charles Byron Seaberg, David L. Trumper
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Publication number: 20250155825Abstract: A photolithography system with an actuatable reticle stage is disclosed. Mechanical actuators coupled to a long-stroke reticle stage are driven to extend and mechanically contact a short-stroke stage during reticle stage turnaround. The actuators may be piezoelectric stack pushers or pneumatic bellows pushers. The pusher devices are controlled and driven to enable higher acceleration turnaround trajectories by applying forces via mechanical contact engaging during turnaround and disengaging before exposure begins during a scan.Type: ApplicationFiled: November 8, 2024Publication date: May 15, 2025Applicant: Massachusetts Institute of TechnologyInventors: Charles Byron Seaberg, David L. Trumper
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Patent number: 12301016Abstract: A primary resonant coil (22) and a secondary resonant coil (23) are different in the proposed improved coreless power transformer design, wherein the differences between the two resonant coils are achieved in two ways: (1) in the first difference, the two resonant coil windings are made to be different; for example, to have different number of turns, turn spacing and/or different wire sizes, and (2) the second difference is with the capacitance values of the two parallel capacitors each used to resonate their respective coils.Type: GrantFiled: August 17, 2021Date of Patent: May 13, 2025Assignee: Massachusetts Institute of TechnologyInventors: Chathan M. Cooke, Daniel Schemmel
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Patent number: 12295799Abstract: Surgical marker systems and methods for delineating a lesion margin of a subject are provided. An example system includes a handheld probe device configured to capture an optical coherence tomography (OCT) image and a processor coupled to a memory. The handheld probe device includes a handheld probe including a fiber-optic probe assembly and a marker assembly. The processor is configured to: segment, by a neural network, each pixels of the OCT into different tissue-type categories; generate one or more feature vectors based at least in part on the segmented pixels; determine, by a one-class classifier, a boundary location in the OCT image between a normal tissue and an abnormal tissue of the tissue structure; and control the marker assembly to selectively create a visible label on a tissue location of the subject, the tissue location corresponding to the boundary location.Type: GrantFiled: June 23, 2022Date of Patent: May 13, 2025Assignee: New Jersey Institute of TechnologyInventors: Xuan Liu, Yuwei Liu
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Patent number: 12297230Abstract: Disclosed herein include methods, compositions, and kits suitable for use in thresholding of protein signals. There are provided, in some embodiments, synthetic protein circuits that respond to inputs only above or below a certain threshold concentration. In some embodiments, the threshold value itself is tunable. Methods of treating a disease or disorder characterized by aberrant signaling are provided in some embodiments.Type: GrantFiled: May 11, 2023Date of Patent: May 13, 2025Assignee: California Institute of TechnologyInventors: Lucy S. Chong, Ronghui Zhu, Xiaofei Ge, Michael B. Elowitz, Mark W. Budde
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Patent number: 12297236Abstract: Disclosed herein include methods, compositions, and kits suitable for robust and tunable control of payload gene expression. Some embodiments provide rationally designed circuits, including miRNA-level and/or protein-level incoherent feed-forward loop circuits, that maintain the expression of a payload at an efficacious level. The circuit can comprise a promoter operably linked to a polynucleotide encoding a fusion protein comprising a payload protein, a protease, and one or more self-cleaving peptide sequences. The payload protein can comprise a degron and a cut site the protease is capable of cutting to expose the degron. The circuit can comprise a promoter operably linked to a polynucleotide comprising a payload gene, a silencer effector cassette, and one or more silencer effector binding sequences.Type: GrantFiled: October 4, 2023Date of Patent: May 13, 2025Assignee: California Institute of TechnologyInventors: Michael J. Flynn, Michael B. Elowitz, Acacia Hori, Viviana Gradinaru
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Patent number: 12295742Abstract: In various aspects, a photoacoustic endoscopic probe and methods for measuring a hydration of a connective tissue in vivo using the photoacoustic endoscopic probe are disclosed.Type: GrantFiled: December 3, 2020Date of Patent: May 13, 2025Assignees: Washington University, California Institute of TechnologyInventors: Lihong Wang, Konstantin Maslov, Methodius Tuuli, Molly Stout, George Macones, Junhui Shi, Peinan Zhao, Yuan Qu, Peng Hu