Patents Assigned to Institute of Technology
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Patent number: 9426429Abstract: A scanning projective lensless microscope device comprises a specimen surface, a scanning illumination source with a light element, a light detector outside the specimen surface, and a processor. The scanning illumination source scans the light element to a plurality of scanning locations to provide illumination to an object on the specimen surface. The light detector samples a sequence of sub-pixel shifted projection object images corresponding to the plurality of scanning locations. The processor constructs a high resolution image of the object based on the sequence of sub-pixel shifted projection images and a motion vector of the projections at a plane of interest.Type: GrantFiled: October 25, 2011Date of Patent: August 23, 2016Assignee: California Institute of TechnologyInventors: Guoan Zheng, Samuel Yang, Seung Ah Lee, Changhuei Yang
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Publication number: 20160235870Abstract: Multifunctional chelators, metal complexes thereof, compositions thereof, and methods of making and use in diagnostic imaging and treatment of cellular disorders.Type: ApplicationFiled: October 6, 2014Publication date: August 18, 2016Applicant: Illinois Institute of TechnologyInventor: Hyun-Soon CHONG
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Publication number: 20160238591Abstract: Various aspects and embodiments provided herein are directed to compositions that include at least one nanoparticle linked to a first polypeptide, and a biologically synthesizable polymer linked to at least one second polypeptide that binds covalently to the first polypeptide. Other aspects and embodiments provided herein are directed to methods of producing the foregoing compositions and components therein.Type: ApplicationFiled: January 15, 2015Publication date: August 18, 2016Applicant: Massachusetts Institute of TechnologyInventors: ZHENGTAO DENG, Timothy Kuan-Ta Lu
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Publication number: 20160238455Abstract: The present invention generally relates to composition and methods for downconverting light. In some embodiments, the composition and methods comprise an organic material, a nanocrystal, and a ligand capable of facilitating energy transfer between the organic material and the nanocrystal. In certain embodiments, the nanocrystal has a first excited energy state with an energy less than a triplet energy state of the organic material. The organic material, in some embodiments, may be aromatic and/or include one or more pi-conjugated carbon-carbon double bonds. In some cases, incident light may be absorbed by the organic material to produce two triplet excitons. The triplet excitons may then transfer to the nanocrystal via the ligand, where they can undergo recombination, resulting in the formation low energy photons.Type: ApplicationFiled: February 16, 2016Publication date: August 18, 2016Applicant: Massachusetts Institute of TechnologyInventors: Daniel N. Congreve, Nicholas John Thompson, Mark W.B. Wilson, Mengfei Wu, Marc A. Baldo, Moungi G. Bawendi, Vladimir Bulovic
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Publication number: 20160237343Abstract: The present invention generally relates to composition and methods for upconverting light. In some embodiments, the composition and methods comprise an organic material, a nanocrystal, and a ligand capable of facilitating energy transfer between the nanocrystal and the organic material. In certain embodiments, the nanocrystal has a first excited energy state with an energy greater than a triplet state of the organic material. The organic material, in some embodiments, may be aromatic and/or include one or more pi-conjugated carbon-carbon double bonds. In some cases, incident light may be absorbed by the nanocrystal to produce triplet excitons. The triplet excitons may then transfer from the nanocrystal to the organic material and undergo triplet-triplet annihilation, creating a singlet state of approximately twice the energy of the triplet exciton. In certain embodiments, the singlet state fluoresces, resulting in the formation of a high energy photon.Type: ApplicationFiled: February 16, 2016Publication date: August 18, 2016Applicant: Massachusetts Institute of TechnologyInventors: Marc A. Baldo, Daniel N. Congreve, Nicholas John Thompson, Mark W.B. Wilson, Mengfei Wu, Moungi G. Bawendi, Vladimir Bulovic
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Publication number: 20160238593Abstract: A programmable modular protein architecture for RNA binding comprises a set of modules, derived from RNA-binding protein Pumilio, that can be concatenated into chains of varying composition and length. When bound into a chain, each module has a preferred affinity for a specific RNA base. The chains can bind arbitrary RNA sequences with high specificity and fidelity by varying the sequence of modules within the chains. Each module contains at least 6 amino acids, with the amino acids in positions 1 and 5 providing the preferred affinity for the specific base, and the amino acid at position 2 serving as a stacking unit between concatenated modules. The modules may have four canonic forms, each having a preferred affinity for a different base and characterized by the base with which it has affinity, the two amino acids that provide the affinity, and the amino acid that serves as a stacking unit.Type: ApplicationFiled: January 13, 2016Publication date: August 18, 2016Applicant: Massachusetts Institute of TechnologyInventors: Edward S. Boyden, Katarzyna P. Adamala, Daniel Alberto Martin-Alarcon
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Patent number: 9419824Abstract: An equalizer provided in a digital transmitter compensates for attenuation in a signal channel to a digital receiver. The equalizer generates signal levels as a logical function of bit history to emphasize transition signal levels relative to repeated signal levels. The preferred equalizer includes an FIR transition filter using a look-up table. Parallel circuits including FIR filters and digital-to-analog converters provide a high speed equalizer with lower speed circuitry. The equalizer is particularly suited to in-cabinet and local area network transmissions where feedback circuitry facilitates adaptive training of the equalizer.Type: GrantFiled: February 25, 2015Date of Patent: August 16, 2016Assignee: Massachusetts Institute of TechnologyInventor: William J. Dally
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Patent number: 9415070Abstract: The invention provides compositions and methods for delivering an agent to virally infected tissues and/or cells of a subject by conjugating agent-loaded nanoparticles to virus-specific T cells, such as cytotoxic T lymphocytes. The agent may be a latency-reversing drug (LRD), an antiviral agent and/or an agent that enhances cytotoxic efficacy of T lymphocytes.Type: GrantFiled: November 8, 2013Date of Patent: August 16, 2016Assignees: Massachusetts Institute of Technology, The General Hospital CorporationInventors: Darrell J. Irvine, Bruce D. Walker, Richard Bradley Jones
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Patent number: 9419147Abstract: A method and apparatus for making analog and digital electronics which includes a composite including a squishable material doped with conductive particles. A microelectromechanical systems (MEMS) device has a channel made from the composite, where the channel forms a primary conduction path for the device. Upon applied voltage, capacitive actuators squeeze the composite, causing it to become conductive. The squishable device includes a control electrode, and a composite electrically and mechanically connected to two terminal electrodes. By applying a voltage to the control electrode relative to a first terminal electrode, an electric field is developed between the control electrode and the first terminal electrode. This electric field results in an attractive force between the control electrode and the first terminal electrode, which compresses the composite and enables electric control of the electron conduction from the first terminal electrode through the channel to the second terminal electrode.Type: GrantFiled: January 9, 2015Date of Patent: August 16, 2016Assignee: Massachusetts Institute of TechnologyInventors: Vladimir Bulovic, Jeffrey H. Lang, Sarah Paydavosi, Annie I-Jen Wang, Trisha L. Andrew, Apoorva Murarka, Farnaz Niroui, Frank Yaul, Jeffrey C. Grossman
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Patent number: 9416800Abstract: A carrier-gas mixture is directed through a fluid flow path in a combined heat and mass transfer device, which can be operated at sub-atmospheric pressure. Heat and mass are transferred from or to the carrier-gas mixture via interaction with a liquid composition that includes a vaporizable component in a liquid state to substantially change the content of the vaporizable component in the carrier-gas mixture via evaporation or condensation. The mass flow rate of the carrier-gas mixture is varied by extracting or injecting the carrier-gas mixture from at least one intermediate location in the fluid flow path, and/or the mass flow rate of the liquid composition is varied by extracting or injecting the liquid composition from at least one intermediate location in the fluid flow path; and the flow of the carrier-gas mixture or the liquid composition is regulated to reduce the average local enthalpy pinch in the device.Type: GrantFiled: June 24, 2013Date of Patent: August 16, 2016Assignees: Massachusetts Institute of Technology, King Fahd University of Petroleum MineralsInventors: Prakash Narayan Govindan, Gregory P. Thiel, Ronan K. McGovern, John H. Lienhard, Sarit K. Das, Karim M. Chehayeb, Syed M. Zubair, Mohammed A. Antar
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Publication number: 20160231267Abstract: Embodiments described herein provide devices and methods for the determination of analytes. The device typically includes an absorbent material that allows for an analyte sample to be concentrated and analyzed simultaneously and within a short period of time (e.g., less than 10 seconds). Embodiments described herein can provide portable and easily operable devices for on-site, real time field monitoring with high sensitivity, selectivity, and fast response time.Type: ApplicationFiled: September 5, 2014Publication date: August 11, 2016Applicant: Massachusetts Institute of TechnologyInventors: Timothy M. Swager, Jisun Im, Alexander R. Petty, Jan Schnorr, Cindy Schmädicke
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Publication number: 20160229714Abstract: A carrier gas and a combined feed liquid are directed through a humidifier, where water vaporizes from the combined feed liquid into the carrier gas, and through a dehumidifier, where the combined feed liquid cools the carrier gas to condense water from the carrier gas. At least a portion of the concentrated brine stream from the humidifier is directed through a pressure-retarded osmosis unit, while an initial feed solution is directed, in counter-flow, through the osmosis unit. Water from the initial feed solution flows through a membrane in the osmosis chamber into the concentrated brine stream to dilute and increase the volumetric flow rate of the brine stream. The diluted brine stream is extracted from the osmosis chamber and depressurized to produce power, while the concentrated initial feed solution is combined with the depressurized, diluted brine stream to form the combined feed liquid.Type: ApplicationFiled: February 10, 2016Publication date: August 11, 2016Applicant: Massachusetts Institute of TechnologyInventors: Gregory Parker Thiel, Leonardo David Banchik, John H. Lienhard
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Publication number: 20160228045Abstract: A method including a dosimetry device having at least one sensor in a housing and a dosimetry processing device with a memory. The dosimtery processing device is coupled to the at least one sensor in the housing. The dosimetry processing device is configured to execute programmed instructions stored in the memory comprising: obtaining readings from the sensor; storing the readings; conducting an analysis of the stored readings to determine an injury risk assessment; and outputting at least one of the conducted analysis of the determined injury risk assessment or the stored readings.Type: ApplicationFiled: April 15, 2016Publication date: August 11, 2016Applicant: Rochester Institute of TechnologyInventors: David A. Borkholder, Gregory T.A. Kovacs, Jeffrey Rogers
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Publication number: 20160233959Abstract: A multiplexed optical communication system comprising a carrier optical fiber, a plurality of launching light sources, and a matching plurality of multiplexer/demultiplexers and photodetectors is described and claimed. Optical communication channel separation by Spatial Domain Multiplexing (SDM), Optical Angular Momentum (OAM) multiplexing, and Wavelength Division Multiplexing (WDM) is used in combination to achieve significant increase in optical communication channel bandwidth over the prior art. The launching light sources may be positioned such that the light beams are incident on the receiving end of the carrier optical fiber at desired angles including complementary angles. Crosstalk between optical communication channels is minimal. The communication bandwidth of a TDM system may be increased by an order of magnitude due the layered WDM/SDM/OAM data multiplexing of the invention.Type: ApplicationFiled: February 8, 2016Publication date: August 11, 2016Applicant: Florida Institute of Technology, Inc.Inventors: Syed H. Murshid, Saud Alanzi, Bilas Chowdhury
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Patent number: 9413461Abstract: A method, systems, apparatus and device enable high bandwidth satellite communications. An onboard tracking detector, installed in a low-earth orbit satellite, detects a position of an incoming optical beam received/transmitted from a first ground station of one or more ground stations. Tracker electronics determine orientation information of the incoming optical beam based on the position. Control electronics receive the orientation information from the tracker electronics, and control a waveguide drive electronics. The waveguide drive electronics control a voltage that is provided to an electro-optic waveguide beam steering device. The electro-optic waveguide beam steering device steers an outgoing optical beam to one of the one or more ground stations based on the voltage.Type: GrantFiled: November 4, 2014Date of Patent: August 9, 2016Assignee: California Institute of TechnologyInventors: Tien-Hsin Chao, Keith E. Wilson, Keith Coste
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Patent number: 9411010Abstract: A system for introspection and annotation of electronic design data includes a tracked probe that interacts with an electronic circuit, a tracking system, schematics, design files, or models for the circuit, electronic design system software, and a user interface. The probe has a sensor that tracks the position of the probe within the circuit. The tracking system receives data from the sensor and translates it into coordinates reflecting the location of the probe within the circuit. The software uses the probe coordinates to locate the position of the probe on the circuit schematic, identify the circuit component at the probe location, and display information about the identified component. The displayed information preferably includes an annotated version of the circuit schematic. The system may include a measurement or instrumentation device, the probe may include at least one parameter measurement device, and the display may include information derived from the parameter measurements.Type: GrantFiled: October 3, 2014Date of Patent: August 9, 2016Assignee: Massachusetts Institute of TechnologyInventors: Pragun Goyal, Joseph A. Paradiso
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Patent number: 9408890Abstract: This disclosure provides compositions, kits, and methods useful for treating or preventing viral and bacterial infection and reducing or preventing the effects of toxins. The methods comprise administering to a subject an effective amount of a liposomal composition.Type: GrantFiled: January 22, 2014Date of Patent: August 9, 2016Assignees: The Charles Stark Draper Laboratory, Inc., The Massachusetts Institute of Technology, University of California, Santa Barbara (UCSB), University of Massachusetts Medical SchoolInventors: James Comolli, Jose Trevejo, Ram Sasisekharan, Zachary Shriver, Karthik Viswanathan, Deborah Fygenson, Robert Finberg, Jennifer Wang
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Patent number: 9410142Abstract: One aspect of the invention is a salt comprising guanidinium groups, as shown in formula I. Another aspect of the invention is a salt comprising guanidinium groups, as shown in formula II. Another aspect of the invention is a salt comprising guanidinium groups, as shown in formula III. Another aspect of the invention is a salt comprising guanidinium groups, as shown in formula IV. Yet another aspect of the invention is a salt comprising guanidinium groups, as shown in formula I, II, III, and IV further comprising independently for each occurrence citrate, phosphate, or sulfate anion. Also disclosed are compositions comprising a protein and a salt comprising guanidinium groups, as shown in formula I, II, III, and IV. Also provided are methods of increasing shelf life of an aqueous solution of a protein and decreasing the amount of protein aggregation in an aqueous solution of a protein.Type: GrantFiled: November 11, 2011Date of Patent: August 9, 2016Assignee: Massachusetts Institute of TechnologyInventors: Bernhardt L. Trout, II, Diwakar Shukla, Curtiss P. Schneider
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Patent number: 9412173Abstract: A method for mapping an environment comprises moving a sensor along a path from a start location (P0) through the environment, the sensor generating a sequence of images, each image associated with a respective estimated sensor location and comprising a point cloud having a plurality of vertices, each vertex comprising an (x,y,z)-tuple and image information for the tuple. The sequence of estimated sensor locations is sampled to provide a pose graph (P) comprising a linked sequence of nodes, each corresponding to a respective estimated sensor location. For each node of the pose graph (P), a respective cloud slice (C) comprising at least of portion of the point cloud for the sampled sensor location is acquired. A drift between an actual sensor location (Pi+1) and an estimated sensor location (Pi) on the path is determined.Type: GrantFiled: April 22, 2014Date of Patent: August 9, 2016Assignees: National University of Ireland, Maynooth, Massachusetts Institute of TechnologyInventors: John Joseph Leonard, Michael Kaess, John McDonald, Thomas John Whelan
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Patent number: 9409023Abstract: Described are devices including stimulation assemblies connectable to a plurality of electrodes. The plurality of electrodes can be configured to connect to a spinal cord at a location below a lesion of the spinal cord. The stimulation assembly can be configured to deliver stimulation to selected ones of the plurality of electrodes when the stimulation assembly is connected to the plurality of electrodes when located below the lesion of the spinal cord. Methods of using the devices are also described.Type: GrantFiled: March 26, 2012Date of Patent: August 9, 2016Assignees: California Institute of Technology, University of Louisville Research Foundation, Inc., The Regents of the University of CaliforniaInventors: Joel W. Burdick, Yu-Chong Tai, John F. Naber, Robert S. Keynton, Victor Reggie Edgerton, Roland R. Roy, Yury Gerasimenko, Susan J. Harkema, Jonathan Hodes, Claudia A. Angeli, Mandheerej S. Nandra, Thomas Anthony Desautels, Steven L. Upchurch, Douglas J. Jackson, Nicholas A. Terrafranca, Yangshen Chen