Patents Assigned to Institute Pasteur
  • Cytotoxic T lymphocyte-inducing lipopeptides and methods of use
    Patent number: 5993823
    Abstract: Cytotoxic lymphocyte-inducing lipopeptides comprising a peptide fragment having approximately between 10 and 40 amino acids and comprising at least one antigenic determinant and also comprising one or more chains derived from fatty acids and one or more modified steroid groups useful for immunizing a human or animal body against pathogenic agents such as viruses or parasites which fragment is preferably a fragment of the protein encoded by the ENV gene, by the NEF gene or by the GAG gene of HIV viruses.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 30, 1999
    Assignee: Institut Pasteur de Lille
    Inventors: Christophe Boutillon, Frederic Martinon, Christian Sergheraert, Remy Magne, Helene Gras-Masse, Elisabeth Gomard, Andre Tartar, Jean-Paul Levy
  • Polypeptides and nucleic acids derived from Salmonella typhi and detection of Salmonella using thereof
    Patent number: 5989841
    Abstract: Nucleic sequences from the genome of Salmonella Typhi include all or part of the genetic information required for the in vitro infection of cultured HeLa cells by Salmonella bacteria. Polypeptides encoded by these nucleic sequences are also described, as is the use of said polypeptides and nucleic sequences for implementing methods of in vitro Salmonella detection in biological samples which are thought to contain it.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 23, 1999
    Assignees: Institut Pasteur, Institut National de la Sante et de la Recherche Medicale
    Inventors: Michel Yvan Popoff, Michel Dion
  • .beta.-(1-3)-glucanosyltransferase, oligonucleotides encoding this enzyme, and molecules having effects on this enzyme
    Patent number: 5989895
    Abstract: Protein having a .beta.-(1-3) glucanosyltransferase activity. This protein can be used for screening molecules for their antifungal activities.
    Type: Grant
    Filed: September 2, 1997
    Date of Patent: November 23, 1999
    Assignee: Institut Pasteur
    Inventors: Thierry Fontaine, Robbert Hartland, Isabelle Mouyna, Jean-Paul Latge
  • Genes of Helicobacter pylori necessary for the regulation and maturation of urease and their use
    Patent number: 5986051
    Abstract: This invention relates to Helicobacter polypeptides, particularly UreE, UreF, UreG, UreH, and UreI, immunogenic fragments of those polypeptides, and compositions containing those polypeptides or fragments. This invention also relates to purified antibodies that bind to the polypeptides of this invention and to compositions comprising those antibodies.
    Type: Grant
    Filed: July 1, 1994
    Date of Patent: November 16, 1999
    Assignees: Institut Pasteur, Institut National de la Santa et de la Recherche Medicale
    Inventors: Agnes Labigne, Valerie Cussac, Richard Ferrero
  • Bordetella strains
    Patent number: 5985286
    Abstract: The invention relates to an immunogenic composition, characterized in that it comprises an adenyl cyclase-hemolysin (AC-Hly) protein, or an immunogenic portion of this AC-Hly, of a strain of Bordetella chosen from B. pertussis, B. parapertussis or B. bronchiseptica, and in that it comprises, in addition, a bacterial extract containing the expression products of the vrg genes of a strain of Bordetella chosen from B. pertussis, B. parapertussis or B. bronchiseptica, or a portion of these expression products which is sufficient to induce an immune response in a host to which the extract might be administered.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: November 16, 1999
    Assignee: Institut Pasteur
    Inventors: Pascale Gueirard, Nicole Guiso
  • Amino acid DNA sequences related to genomic RNA of human immunodeficiency virus (HIV-1)
    Patent number: 5980900
    Abstract: This invention is in the field of lymphadenopathy virus which has been desogmated Human Immunodeficiency Virus Type 1 (HIV-1) This invention relates to a diagnostic means and method to detect the presence of DNA, RNA or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates to the DNA fragments, vectors comprising them and the proteins expressed.
    Type: Grant
    Filed: August 28, 1991
    Date of Patent: November 9, 1999
    Assignee: Institut Pasteur and Centre National de la Recherche Scientifique
    Inventors: Marc Alizon, Pierre Sonigo, Cole Stewart, Oliver Danos, Simon Wain-Hobson
  • Genital human papillomavirus type 68a (HPV-68a), related to the potentially oncogenic HPV-39
    Patent number: 5981173
    Abstract: The genomes of two novel human papillomavirus (HPV) types, HPV68 and HPV70, were cloned from a low grade cervical intraepithelial neoplasia and a vulvar papilloma, respectively, and sequenced. Both types are related to HPV39, a potentially oncogenic virus. HPV68 and HPV70 were also detected in genital intraepithelial neoplasia from three patients and one patient, respectively. Comparison with sequence data in the literature indicates that the subgenomic ME180-HPV DNA fragment, cloned from a carcinoma cell line, corresponds to an HPV68 subtype and that several HPV DNA fragments amplified by PCR from genital neoplasia represent worldwide distributed variants of HPV68 and HPV70.
    Type: Grant
    Filed: February 11, 1997
    Date of Patent: November 9, 1999
    Assignees: Institut Pasteur, Institut Nationale de la Sante Et de la Recherche Medicale
    Inventors: Gerard Orth, Sylvie Beaudenon, Michele Longuet
  • Competitive assays for determining the effectiveness of a human immunodeficiency virus type 2 (HIV-2) antiviral agent, employing peptides and proteins of HIV-2
    Patent number: 5976785
    Abstract: A method for diagnosing an HIV-2 (LAV-II) infection and a kit containing reagents for the same is disclosed. These reagents include cDNA probes which are capable of hybridizing to at least a portion of the genome of HIV-2. In one embodiment, the DNA probes are capable of hybridizing to the entire genome of HIV-2. These reagents also include polypeptides encoded by some of these DNA sequences.
    Type: Grant
    Filed: December 20, 1991
    Date of Patent: November 2, 1999
    Assignee: Institut Pasteur
    Inventors: Marc Alizon, Luc Montagnier, Denise Guetard, Francois Clavel, Pierre Sonigo, Mireille Guyader
  • Altered major histocompatibility complex (MHC) determinant and method of using the determinant
    Patent number: 5976551
    Abstract: An altered MHC class II determinant comprises .alpha..sub.1, .alpha..sub.2, .beta..sub.1, .beta..sub.2, domains of a mammalian MHC class II locus in which the domains are covalently linked to form a construct comprising the .beta..sub.2 -.alpha..sub.2 -.alpha..sub.1 .beta..sub.1 domains in sequence. The altered class II determinants can be associated with an antigen to elicit an immune response. In addition, the altered determinants may be used to prepare antibodies. The antibodies so produced have various diagnostic and therapeutic uses.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 2, 1999
    Assignee: Institut Pasteur and Institut Nationale de la Sante et de la Recherche Medicale
    Inventors: Estelle Mottez, Jean-Pierre Abastado, Philippe Kourilsky
  • Immunogenic compositions and antibodies directed against human papillomavirus type 49 (HPV 49), type 50 (HPV 50), type 54 (HPV 54), and type 55 (HPV 55).
    Patent number: 5968522
    Abstract: The invention relates to papillomavirus probes derived from new DNA-HPVs deposited with the CNCM on the May 6, 1988 under the following filing numbers:PGEM 4 HPV49: I-754PSP 65 HPV50: I-755PSP 64 HPV54: I-756PGEM 4 HPV55A: I-757PGEM 4 HPV55B: I-758These probes can be used for in vitro detection of:in the case of HPV49: warts of the skin (in particular, common and plantar warts) and the differential diagnosis of epidermodysplasia verruciformis,in the case of HPV50: epidermodysplasia verruciformis, intra-epithelial neoplasias and cutaneous cancers,in the case of HPV55: genital neoplasias and cancers of the uterine cervix,in the case of HPV55: genital neoplasias and cancers of the uterine cervix, condylomas and papillomas.
    Type: Grant
    Filed: August 20, 1998
    Date of Patent: October 19, 1999
    Assignees: Institut Pasteur, Institut Nationale de la Sante et de la Recherche Medicale
    Inventors: Gerard Orth, Michel Favre, Dina Kremsdorf, Gerard Pehau-Arnaudet
  • Promoter of M. paratuberculosis and its use for the expression of immunogenic sequences
    Patent number: 5968815
    Abstract: The invention relates to a nucleotide sequence which is present at a position adjacent to the 5' end of the reverse sequence complementary to the open reading frame coding for a potential transposase contained in the insertion element IS900 in Mycobacterium paratuberculosis. The nucleotide sequence has promoter functions and contains important signals for the regulation of transcription and translation. The invention also relates to methods for cloning and expressing heterologous proteins using such regulatory sequences, to vectors and transformed host cells containing these sequences, and to immunogenic compositions prepared by expression of nucleotide sequences placed under control of these regulatory sequences.
    Type: Grant
    Filed: October 6, 1994
    Date of Patent: October 19, 1999
    Assignees: Institut Pasteur, Massey University
    Inventors: Alan Murray, Marina Gheorghiu, Brigitte Gicquel
  • Nucleotide sequence encoding the enzyme I-SceI and the uses thereof
    Patent number: 5962327
    Abstract: An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-directed insertion of genes.
    Type: Grant
    Filed: April 5, 1995
    Date of Patent: October 5, 1999
    Assignee: Institut Pasteur Universite Paris-VI
    Inventors: Bernard Dujon, Andre Choulika, Laurence Colleaux, Cecile Fairhead, Arnaud Perrin, Anne Plessis, Agnes Thierry
  • Mycobacterium proteins and applications
    Patent number: 5962240
    Abstract: Mycobacterium proteins, in particular those of M. bovis, having molecular weights between approximately 44.5 and 47.5 kD. These proteins can have molecular weights of approximately 45 kD or 47 kD and isoelectric pH of approximately 3.7 (45 and 47 kD proteins) and 3.9 (47 kD proteins).These proteins or hybrid proteins containing a part of their sequences can be used as vaccines or as drugs, or for the detection and monitoring of tuberculosis in particular in man and in cattle.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: October 5, 1999
    Assignee: Institut Pasteur
    Inventors: Gilles Marchal, Felix Romain, Pascale Pescher
  • Probes for papillomaviruses and an in vitro diagnostic procedure for papilloma infections
    Patent number: 5958674
    Abstract: The invention relates to papillomaviruses, particularly to DNA-HPVs isolated from the papillomaviruses IP5 and IP6, the restriction maps of papillomaviruses IP5 and IP6, and also to probes containing these DNA-HPVs or fragments obtained from them. The invention relates, in addition, to "kits" containing distinct groups of probes, containing one of these DNA-HPVs or DNA-HPV fragments, as well as a procedure for the detection and identification of papillomaviruses which makes use of these different probes.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 28, 1999
    Assignees: Institut Pasteur, Institut Nationale de la Sante et de la Recherche Medicale
    Inventors: Sylvie Beaudenon, Dina Kremsdorf, Odile Croissant, Gerard Orth
  • Nucleotide sequences and proteins conferring cycloheximide resistance
    Patent number: 5958687
    Abstract: The invention relates to a nucleotide sequence coding for a cycloheximide resistance protein sensitive to concatenation of amino acids A, or coding for all or part of said optionally modified concatenation A, in as much as the formed protein confers cycloheximide resistance to a recombinant eucaryotic host transformed by the nucleotide sequence coding for said protein, in conditions appropriate for its production. The invention also relates to a sequence containing the DNA coding for the concatenation A and capable of conferring a high level of resistance to cycloheximide in a given host.
    Type: Grant
    Filed: March 14, 1997
    Date of Patent: September 28, 1999
    Assignee: Institut Pasteur
    Inventors: Pierre Dehoux, Julian Davies
  • Method of detecting and characterizing a nucleic acid or reactant for the application of this method
    Patent number: 5955262
    Abstract: Method for detecting the possible presence of a DNA fragment, notably of a gene, in the midst of a complex sample of nucleic acids.It comprises the hybridization of the sought fragment with a RNA probe, this being, prior or subsequent to the hybridization reaction, modified by an enzyme.Application to seeking of particular genes or DNA fragments in the midst of a biological sample.
    Type: Grant
    Filed: September 8, 1992
    Date of Patent: September 21, 1999
    Assignee: Institut Pasteur
    Inventors: Philippe Kourilsky, Stratis Avrameas, Brigitte Cami Contamine, Jean-Luc Guesdon
  • Polypeptides and antibodies characteristics of papillomavirus, and diagnostic procedures and vaccines making use of them
    Patent number: 5955260
    Abstract: The invention relates to the DNAs of papillomaviruses, and more particularly to the probes derived from these papillomaviruses, as well as procedures for their implementation in the in vitro diagnosis of papillomavirus infections.
    Type: Grant
    Filed: April 21, 1995
    Date of Patent: September 21, 1999
    Assignee: Institut Pasteur and Institut National de la Sante et de la Recherche Medicale
    Inventors: Carol Ann Komly, Odile Croissant, Francoise Breitburd
  • DNA sequences of the papillomavirus HPV42 for use in diagnosis
    Patent number: 5952487
    Abstract: DNA sequences derived from human papillomavirus HPV42 are disclosed. Also disclosed are methods of using these sequences as hybridization probes in diagnostic assays.
    Type: Grant
    Filed: February 10, 1994
    Date of Patent: September 14, 1999
    Assignee: Institut Pasteur
    Inventors: Wolfgang Philipp, Martin Sapp, Stewart Cole, Nadine Honore
  • Nucleotide sequence encoding the enzyme I-SceI and the uses thereof
    Patent number: 5948678
    Abstract: An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-directed insertion of genes.
    Type: Grant
    Filed: July 20, 1998
    Date of Patent: September 7, 1999
    Assignees: Institut Pasteur, Universite Peirre et Marie Curie
    Inventors: Bernard Dujon, Andre Choulika, Arnaud Perrin, Jean-Francois Nicolas
  • Genetic markers used jointly for the diagnosis of Alzheimer's disease, and diagnostic method and kit
    Patent number: 5942392
    Abstract: Combined use of at least two genetic markers selected from apolipoprotein E, D19S178 and apolipoprotein CII, for the diagnosis of Alzheimer's disease, especially apolipoprotein .epsilon.4, long apolipoprotein CII (30.+-.3 repeat patterns (CA) and short D19S178 (less than 167.+-.4 nucleotides) alleles. The invention also concerns a method for the diagnosis of Alzheimer's disease and a kit for carrying out said method.
    Type: Grant
    Filed: January 2, 1997
    Date of Patent: August 24, 1999
    Assignees: Institut Pasteur de Lille, Institut National de la Sante et de la Recherche Medicale
    Inventors: Philippe Amouyel, Marie-Christine Chartier-Harlin