Abstract: Potassium chloride cotransporter-2 (KCC2) plays a critical role in brain function, and deficiency in KCC2 has been linked to neurological diseases, psychiatric disorders, and central nervous system injuries. In particular, Rett syndrome (RTT), a severe neurodevelopmental disorder caused by mutations in the X-linked gene Methyl CpG binding Protein 2 (MECP2), has been linked to deficits in KCC2. The disclosure reports the use of CRISPR/Cas9 genome-editing technology to generate stem cell-derived, genetically defined KCC2 reporter human neurons for large-scale compound screening. This screening platform has been utilized to identify a number of small molecule compounds that are capable of enhancing KCC2 expression in both wild-type and RTT neurons, as well as organotypical brain slices cultured from wild-type mice.

Abstract: Disclosed herein is a method of manufacturing a micro-supercapacitor with an increased storage capacity of electrical energy. The method is a method of manufacturing a high-capacity micro-supercapacitor including an anode and a cathode separated from each other, which includes forming a pair of current collectors by discharging conductive ink on a substrate surface with a 3D printer, and forming an electrode consisting of an anode and a cathode by stacking an electrode constituting material in the form of a plurality of layers on each of the pair of current collectors using the 3D printer.

Abstract: Disclosed herein are a hardware security module, a device having the hardware security module, and a method for operating the device. The method for verifying integrity of executable code in a device includes dividing, by a Micro-Control Unit (MCU), executable code into multiple blocks, generating, by the MCU, hash values corresponding to the blocks resulting from the division, storing, by a Hardware Security Module (HSM), the generated hash values, calculating, by the MCU, at least one hash value, among hash values of the multiple blocks when the executable code boots, and comparing, by the HSM, the calculated hash value with a hash value corresponding to the calculated hash value, among the hash values stored in the HSM.

Abstract: Systems and methods for generating efficient planning routes for vehicles, including autonomous and semi-autonomous vehicles are presented. A route planner may generate dynamic maps and routes that reduces the uncertainty of road-agent environmental and behavioral data in an efficient manner. Route planning may be accomplished using a statistical approach in which known data from one geographic or behavioral feature set may be used and relied upon by a vehicle in another geographical and behavioral context to estimate the environmental and behavioral data relevant to the vehicles current operation.

Abstract: The present disclosure provides a method for assessing hot coal fallout propensity of burning cigarettes based on human behavior features of ash-flicking action. The method is characterized in that the method is accomplished through an apparatus for detecting hot coal fallout propensity based on human behavior features of ash-flicking action, which include behavior features of human action of flicking cigarette ash, features of holding a cigarette, and features of force applying process and other aspects. This method can provide objective and accurate test basis for evaluation of cigarette fallout performance.

Abstract: An electronic device comprises: a first plate configured to face one surface of the electronic device; a second plate configured to face in a direction opposite to the first plate; a side bezel structure connected to the first plate and the second plate and configured to surround the side of the electronic device; and a printed circuit board mounted in the electronic device and configured to be connected to the side bezel structure, wherein the printed circuit board comprises: a ground area; a first conductive pad, disposed in one area of the printed circuit board, and configured to couple the side bezel structure and the printed circuit board; and a second conductive pad electrically connected to the ground area and disposed between the first conductive pad and the ground area, wherein the first conductive pad and the second conductive pad may be disposed at an interval through which a current, having a voltage equal to or greater than a threshold voltage between the first conductive pad and a second electro

Abstract: The present invention provides methods and tools for analyzing genetic interactions. The subject matter disclosed herein is generally directed to single cell genomics and proteomics. In one embodiment provided is a method of cell and nuclei hashing using sample barcodes. In another embodiment are method of performing genomewide CRISPR perturbation screens.

Abstract: Provided is a lithium-conductive solid-state electrolyte material that comprises a sulfide compound of a composition that does not deviate substantially from a formula of Li9S3N. The compound's conductivity is greater than about 1×10?7 S/cm at about 25° C. and is in contact with a negative electroactive material. Also provided is an electrochemical cell that includes an anode layer, a cathode layer, and the electrolyte layer between the anode and cathode layers. In an example, the material's activation energy can be no greater than about 0.52 eV at about 25° C.

Abstract: A computing system receives as candidate predictors, for a model set, a list of terms for computer identification in dataset(s). The system receives initial user selections in the graphical user interface (GUI) of a term set, a response variable, and target value(s) for the response variable. The term set comprises candidate predictors from the list. The response variable is for a response to input to an initial model of the model set. The system generates the initial model that estimates a relationship between the target value(s) and the term set. The system displays in the GUI a performance representation of the initial model for user comparison of models and an indication of a contribution, to the initial model, of terms of a subset of the term set. The system receives a subsequent user selection, in the GUI, to change an aspect of the initial model.

Abstract: Provided herein are methods and systems and related compositions comprising an effective amount of one or more zwitterionic polysaccharide possibly in combination with one or more antibiotics, for treatment and/or prevention of sepsis or a condition associated thereto in an individual.

Abstract: The magnesium alkoxide particle contains the reaction product of the following components: 1) a magnesium powder; 2) a mixed alcohol; 3) a halogenating agent; and 4) a titanate compound. The magnesium alkoxide particle is used for preparing a catalyst for olefin polymerization.

Abstract: Provided is a fluorescent signal detection apparatus including a reaction unit including a kit loading part in which a diagnostic kit is inserted to one area, a light source unit including a light source and a first barrel configured to surround the light source, a light receiving unit provided at one side of the light source unit and including a detection part and a second barrel configured to surround the detection part, and a case configured to surround the reaction unit, the light source unit, and the light receiving unit. Here, the diagnostic kit includes measuring parts and microstructures configured to accommodate a target to be measured, which is labeled by a fluorescent dye, and the microstructures are provided on the measuring parts.

Abstract: The present invention is directed to a copolymer of styrene and ?-methylstyrene comprising an alternating sequence of styrene and ?-methylstyrene residues, and a method to make the copolymer.

Abstract: A finger device including a finger segment, a finger base, a first steering control mechanism, a first actuator, a second steering control mechanism, a universal joint and a second actuator is provided. The finger base is connected to one end of the finger segment, and the first steering control mechanism is disposed on the finger base. The first actuator is configured to provide a first moment to the first steering control mechanism, so that the finger segment and the finger base have a degree of freedom in a first moving direction. The second steering control mechanism is disposed on the finger base. The second actuator is configured to provide a second moment to the universal joint. The universal joint is rotatably connected between the second actuator and the second steering control mechanism, so that the finger segment has a degree of freedom in a second moving direction.

Abstract: The invention relates to multiple epitope constructs, immunogenic and vaccine compositions comprising recombinant molecules presenting inserted multiple and different epitopes from a variety of antigens. The antigenic determinants being associated with different pathways leading to atherosclerosis. In particular, the invention relates to such compositions for eliciting an immune response against antigens and pathogens involved in the development of atherosclerosis the invention includes inter alia methods of treating and/or preventing the disease and recombinant protein products.

Abstract: Disclosed is a composite polymer electrolyte membrane comprising: a support membrane; a metal ion-blocking layer stacked on the support membrane; a stabilization layer; and a protecting layer, wherein the support membrane includes a cation conductive polymer.

Abstract: The present disclosure is directed to lenses, devices, methods and/or systems for addressing refractive error. Certain embodiments are directed to changing or controlling the wavefront of the light entering a human eye. The lenses, devices, methods and/or systems can be used for correcting, addressing, mitigating or treating refractive errors and provide excellent vision at distances encompassing far to near without significant ghosting. The refractive error may for example arise from myopia, hyperopia, or presbyopia with or without astigmatism. Certain disclosed embodiments of lenses, devices and/or methods include embodiments that address foveal and/or peripheral vision. Exemplary of lenses in the fields of certain embodiments include contact lenses, corneal onlays, corneal inlays, and lenses for intraocular devices both anterior and posterior chamber, accommodating intraocular lenses, electro-active spectacle lenses and/or refractive surgery.

Abstract: The present invention discloses a method for rapidly estimating for a remaining capacity of a battery, comprising performing a constant current charge to the battery in a first period, instantly capturing a voltage/temperature of the battery in a frequency, and generating a voltage-time graph; after leaving the battery along for a second period, instantly capturing the voltage/temperature of the battery in the frequency; calculating a voltage rising rate during the first period; calculating a voltage drop rate during a leaving-along period; calculating a critical sample time; applying the critical sample time, and comparing the voltage-time graph measured in the first period, to obtain a critical sampling voltage; calculating a voltage difference slope; calculating a charging time, which is consumed by charging the battery from a lower-bound voltage to an upper-bound voltage with the constant current; calculating a compensation ratio value; and calculating the remaining capacity of the battery.

Abstract: A sheet metal hemming device is provided. The sheet metal hemming device includes a frame and a rolling wheel, a bearing wheel, a first rotating shaft, a second rotating shaft, a sliding block, an arc-shaped guide rail and a driver which are disposed on the frame. The rolling wheel is disposed on the first rotating shaft, the bearing wheel is disposed on the second rotating shaft, and an angle is formed between the rolling wheel and the bearing wheel. The sliding block is slidable relative to the arc-shaped guide rail and is connected to the rolling wheel via the first rotating shaft. The driver is connected to the sliding block for driving the sliding block to slide along the arc-shaped guide rail to adjust the angle between the rolling wheel and the bearing wheel.