Abstract: The invention relates to a manganese (II) complex, its preparation method and use. The structure of the complex is (R1R2R3R4A)2[MnX4], wherein R1, R2, R3 and R4 are identical or different, independently selected from alkyl, aryl, or heteroaryl; said alkyl, aryl, or heteroaryl can be optionally substituted with a substituent, and the substituent is preferably alkyl, aryl or heteroaryl; A is N, P, or As; X is optionally F, Cl, Br, or I. The present invention also relates to an organic light emitting diode, its preparation method and use, wherein the manganese (II) complex of the invention is used as a dopant in the light-emitting layer. The prepared organic light emitting diode exhibits high electrical-to-optical conversion efficiency which can be used for flat-panel displays and illuminations.
Type:
Grant
Filed:
May 19, 2017
Date of Patent:
March 22, 2022
Assignee:
FUJIAN INSTITUTE OF RESEARCH ON THE STRUCTURE OF MATTER, CHINESE ACADEMY OF SCIENCES
Inventors:
Zhongning Chen, Liangjin Xu, Jinyun Wang
Abstract: A laser protection system includes a high-power laser source, an optical diffuser, a photo detector, a signal-processing device, and a control module. The high-power laser source generates a first laser light beam, and the optical diffuser attenuates a laser power of the first laser light beam to form a second laser light beam. The photo detector obtains an optical detection signal from the second laser light beam. The signal-processing device includes a signal conversion module, a processor, and an encoder. The signal conversion module transforms the optical detection signal into a measurement data eigenvalue. The encoder encodes the measurement data eigenvalue into a measured encoded data, and the setting data eigenvalue into a set encoded data. The control module evaluates the set encoded data and the measured encoded data to determine whether or not the high-power laser source needs to be stopped.
Type:
Grant
Filed:
December 26, 2019
Date of Patent:
March 22, 2022
Assignee:
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventors:
Chih-Chun Chen, Fu-Shun Ho, Chun-Chieh Yang, Yu-Cheng Song
Abstract: Provided herein is an apparatus for assessing a color characteristic of a gemstone. The apparatus comprises an optically opaque platform for supporting a sample gemstone to be assessed, a daylight-approximating light source to provide uniform illumination to the gemstone, an image capturing component, and a telecentric lens positioned to provide an image of the illuminated gemstone to the image capturing component. Also provided are methods of color analysis based on images collected using such an apparatus.
Type:
Grant
Filed:
November 26, 2019
Date of Patent:
March 22, 2022
Assignee:
Gemological Institute of America, Inc. (GIA)
Abstract: Disclosed are methods for diagnosing a myelodysplastic syndrome (MDS) in a subject. In some embodiments, the method involves assaying a sample from the subject to detect inflammasome activation, wherein an increase in inflammasome activation in the sample compared to a control is an indication of MDS in the subject. The disclosed methods can further involve treating the subject for MDS if an increase in inflammasome activation is detected.
Type:
Grant
Filed:
November 11, 2019
Date of Patent:
March 22, 2022
Assignee:
H. Lee Moffitt Cancer Center and Research Institute, Inc.
Abstract: Disclosed is an in situ method for detecting spatial proximity relationships between nucleic acid sequences, such as DNA, in a cell. The method includes: providing a sample of one or more cells comprising nucleic acids; fragmenting the nucleic acids present in the cells that leaves 5? overhanging ends; filling in the overhanging ends with at least one labeled nucleotide; joining the filled in end of the fragmented nucleic acids that are in close physical proximity to create one or more end joined nucleic acid fragments having a junction; isolating the one or more end joined nucleic acid fragments using the labeled nucleotide; and determining the sequence at the junction of the one or more end joined nucleic acid fragments.
Type:
Grant
Filed:
December 1, 2015
Date of Patent:
March 22, 2022
Assignees:
THE BROAD INSTITUTE, INC., BAYLOR COLLEGE OF MEDICINE
Inventors:
Erez Lieberman-Aiden, Suhas Rao, Elena Stamenova, Olga Dudchenko, Eric Lander
Abstract: A computing system creates interaction features from variable values in a transformed dataset that includes a variable value computed for each variable of transformed variables computed from a prior execution of a transformation flow applied to an input dataset. An interaction transformation flow definition indicates a subset of the transformed variables, a synthesis definition, and interaction transformation operations to apply to the transformed variables. The synthesis definition describes how the subset of the transformed variables are combined to compute a value input to the interaction transformation operations. A plurality of variable combinations of the subset is defined. A computation is defined for each combination and interaction transformation operation. An operation data value is computed for each computation from the transformed dataset. An observation vector is read from the transformed dataset and a current interaction variable value is synthesized for each combination.
Abstract: Disclosed is a method of preparing a catalyst having a conductive oxide protective layer. The method may include providing (e.g., supplying) a carbon support having a metal catalyst supported thereon to a fluidized bed reactor, and forming a conductive oxide protective layer using atomic layer deposition (ALD). Particularly, the atomic layer deposition may include supplying a conductive oxide precursor to the fluidized bed reactor, conducting a first purging by supplying an inert gas to the fluidized bed reactor, converting the conductive oxide precursor to conductive oxide by supplying a reactive gas to the fluidized bed reactor, and conducting a second purging by supplying an inert gas to the fluidized bed reactor.
Type:
Grant
Filed:
February 25, 2020
Date of Patent:
March 22, 2022
Assignees:
Hyundai Motor Company, Kia Motors Corporation, Institute for Research & Industry Cooperation Pusan National University
Inventors:
Seung Jeong Oh, Woong Pyo Hong, Woo Jae Lee, Se Hun Kwon
Abstract: The present disclosure relates to an apparatus and a method for extracting genome, capable of acquiring a sufficient amount of genome for genetic analysis with high extraction efficiency, even with a small amount of target sample.
Type:
Grant
Filed:
September 30, 2019
Date of Patent:
March 22, 2022
Assignee:
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Abstract: A bit-interleaved coded modulation (BICM) reception device and a BICM reception method are disclosed herein. The BICM reception device includes a demodulator, a bit deinterleaver, and a decoder. The demodulator performs demodulation corresponding to 1024-symbol mapping. The bit deinterleaver performs group-unit deinterleaving on interleaved values. The interleaved values are generated after the demodulation. The decoder restores information bits by LDPC-decoding deinterleaved values generated based on the group-unit deinterleaving. The deinterleaved values corresponds to a LDPC codeword having a length of 64800 and a code rate of 2/15.
Type:
Grant
Filed:
May 1, 2020
Date of Patent:
March 22, 2022
Assignee:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Inventors:
Sung-Ik Park, Sun-Hyoung Kwon, Jae-Young Lee, Heung-Mook Kim, Nam-Ho Hur
Abstract: A semiconductor device that includes a SiC semiconductor substrate; a SiC epitaxial layer having an impurity concentration lower than that of the SiC semiconductor substrate; a first semiconductor layer including first semiconductor pillars and second semiconductor pillars; a second semiconductor layer; a device active region; a termination region; a channel stopper region having an impurity concentration higher than that of the SiC epitaxial layer; and a plurality of first chip end portions and a plurality of second chip end portions, and a surface of the first side surface is covered with an impurity region having an impurity concentration higher than those of the first semiconductor pillar and the SiC epitaxial layer and is connected to the channel stopper region.
Type:
Grant
Filed:
February 15, 2019
Date of Patent:
March 22, 2022
Assignees:
NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, FUJI ELECTRIC CO., LTD., MITSUBISHI ELECTRIC CORPORATION
Abstract: A novel Lactobacillus paracasei AO356 strain according to the present disclosure, which is a strain isolated from the human body, has high stability, exhibits the activity of inhibiting adipogenic differentiation in vitro and inducing the differentiation of M1 and M0 macrophages into M2 macrophages, and has excellent activity of alleviating, preventing, or treating obesity, such as the activity of reducing body weight and a reduction in blood lipid concentration through the browning of white fat in animal experiments. Thus, the novel strain of the present disclosure has a low possibility of causing side effects, and therefore, unlike conventional diet functional foods or drugs, which have side effect problems, a diet effect can be exhibited without controlling the dose thereof. Accordingly, the novel strain can be used as a pharmaceutical composition for treating or preventing obesity or a food composition for alleviating or preventing obesity.
Type:
Grant
Filed:
June 17, 2020
Date of Patent:
March 22, 2022
Assignee:
KOREA FOOD RESEARCH INSTITUTE
Inventors:
Young Do Nam, So Young Lee, Hee Soon Shin, So Lim Park, Won Hyong Chung, Eun Sook Lee, Eun Ji Song, Dong Uk Shin
Abstract: The present disclosure provides an epoxy resin wave-absorbing composite material and a preparation method thereof. The method includes: heating an epoxy resin to 50° C.˜70° C., and adding carbon black, to obtain a mixture of the epoxy resin and the carbon black; heating the mixture of the epoxy resin and the carbon black to 100° C.˜120° C., adding a curing agent, and stirring and dissolving them to obtain a mixture of the epoxy resin, the carbon black, and the curing agent; and adding surface-treated hollow glass microbeads into the mixture of the epoxy resin, the carbon black, and the curing agent, and curing them to obtain the epoxy resin wave-absorbing composite material.
Type:
Grant
Filed:
November 26, 2019
Date of Patent:
March 22, 2022
Assignees:
LUOYANG INSTITUTE OF CUTTING-EDGE TECHNOLOGY, LUOYANG CUTTING EDGE EQUIPMENT TECHNOLOGY LTD
Inventors:
Ruopeng Liu, Zhiya Zhao, Miao Yin, Lu Zhang, Yan Hou, Yunxiang Zhang, Zhonghao Qiu, Xue Li
Abstract: A device for high-speed real-time sampling of mid-infrared ultrafast light signals includes a time domain amplification unit and a detection unit. The time domain amplification unit is used to perform sampling and time domain amplification on signal light incident to the time domain amplification unit, and convert the signal light of a mid-infrared band into a near-infrared/visible band. The detection unit is used to receive and record information of the to-be-detected signal light processed by the time domain amplification unit to realize high-speed real-time sampling and measurement of the mid-infrared ultrafast light signal. The present disclosure can accurately obtain subpicosecond transient characteristics of the light signal, breaks through the capacity limit to the response rate of a traditional photoelectric detector, the bandwidth of the oscilloscope and the like, and is applicable to femtosecond-level mid-infrared ultrafast light signals.
Type:
Grant
Filed:
December 2, 2019
Date of Patent:
March 22, 2022
Assignee:
Xi'an Institute of Optics and Precision Mechanics of CAS
Abstract: A light-emitting module includes: a semiconductor light-emitting element which emits deep ultraviolet light; a liquid sealing the semiconductor light-emitting element; and a package for accommodating the semiconductor light-emitting element and the liquid. The liquid is transparent to the deep ultraviolet light. The package has a transparent member transparent to the deep ultraviolet light. For that reason, a highly reliable light-emitting module provided with the semiconductor light-emitting element that emits the deep ultraviolet light can be provided.
Type:
Grant
Filed:
November 22, 2016
Date of Patent:
March 22, 2022
Assignee:
NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY
Abstract: Provided herein are, inter alia, methods, compositions, and kits for producing adipocyte populations such as beige adipocyte populations. Also included are methods and compositions for increasing the level of adipocyte populations (e.g., beige adipocyte populations) in a subject, as well as methods and compositions for treating subjects who are overweight, obese, or who have diabetes.
Abstract: Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
Type:
Grant
Filed:
February 22, 2019
Date of Patent:
March 22, 2022
Assignees:
The Board of Trustees of the University of Arkansas, The Kitasato Institute, Montefiore Medical Center, National University Corporation Kagawa University
Inventors:
Tulasi Ponnapakkam, Sagaya Theresa Leena Philominathan, Joshua Sakon, Ranjitha Katikaneni, Takaki Koide, Osamu Matsushita, Robert C. Gensure, Nozomu Nishi
Abstract: A hydrothermal liquefaction (HTL) system can comprise a biomass slurry source, a first pump in fluid communication with the slurry source and configured to pressurize a biomass slurry stream from the slurry source to a first pressure, a first heat exchanger in fluid communication with the first pump and configured to heat a slurry stream received from the first pump to a first temperature, a second pump in fluid communication with the first heat exchanger and configured to pressurize a slurry stream received from the first heat exchanger to a second pressure higher than the first pressure, a second heat exchanger in fluid communication with the second pump and configured to heat a slurry stream received from the second pump to a second temperature higher than the first temperature, and a HTL reactor configured to produce biocrude from a slurry stream received from the second heat exchanger.
Type:
Grant
Filed:
January 10, 2020
Date of Patent:
March 22, 2022
Assignee:
Battelle Memorial Institute
Inventors:
Michael R. Thorson, Lesley J. Snowden-Swan, Andrew J. Schmidt, Todd R. Hart, Justin M. Billing, Daniel B. Anderson, Richard T. Hallen
Abstract: The present application relates to treatment of myeloproliferative neoplasms using the JAK1/JAK2 inhibitor, ruxolitinib, in combination with a low dose of a Pim inhibitor, N-{(7R)-4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide, wherein the combination is unexpectedly synergistic at a very low dose of the Pim inhibitor.
Type:
Grant
Filed:
February 6, 2020
Date of Patent:
March 22, 2022
Assignees:
Incyte Corporation, H. Lee Moffitt Cancer Center and Research Institute, Inc.
Abstract: Present disclosure provides a cooling device with safety features and methods for controlling temperature of the cooling device for safe cooling of target surface.
Type:
Grant
Filed:
July 12, 2021
Date of Patent:
March 22, 2022
Assignees:
RECENSMEDICAL, INC., Ulsan National Institute of Science and Technology
Inventors:
Gun-Ho Kim, Jae Bum Cho, Dae Hyun Kim, Chul Ho Lee
Abstract: Systems and methods for obtaining simultaneous X-ray-magnetic resonance imaging (MRI) images are provided. A magnetic resonance X-ray CT (MRX) system can combine X-ray imaging and MRI in a cost-effective and relatively simple solution for improved imaging. During imaging of a subject, the X-ray source and X-ray detector can be simultaneously rotated around the subject, and the means for generating a magnetic field can also be rotated around the subject. The means for generating a magnetic field can be a plurality of permanent magnets.