Abstract: Disclosed are bifunctional compounds (degraders) that target HAT EP300 for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the compounds to treat disease.

Abstract: The present disclosure provides a composition for preventing or treating a benign tumor. Provided is a composition for preventing or treating a benign tumor that comprises a WT1 peptide or an analog thereof, or a nucleic acid molecule encoding a WT1 peptide or an analog thereof. In a specific embodiment, the present disclosure provides a composition for preventing or treating a benign tumor that comprises a WT1 peptide or an analog thereof, or a nucleic acid molecule encoding a WT1 peptide or an analog thereof. In a preferred embodiment, the composition for preventing or treating a benign tumor (e.g. familial adenomatous polyposis) according to the present disclosure comprises a killer type WT1 peptide and/or a helper type WT1 peptide. In a further preferred embodiment, the WT1 peptide is WT1126 killer peptide and/or WT135 helper peptide.

Abstract: A photonic parallel network can be used to sample combinatorially hard distributions of Ising problems. The photonic parallel network, also called a photonic processor, finds the ground state of a general Ising problem and can probe critical behaviors of universality classes and their critical exponents. In addition to the attractive features of photonic networks—passivity, parallelization, high-speed and low-power—the photonic processor exploits dynamic noise that occurs during the detection process to find ground states more efficiently.

Abstract: Aspects of the application relate to methods and systems for evaluating treatment response by measuring treatment-induced changes at the single cell level. The disclosure provides methods for isolating single cells that are primary cancer cells, including primary cancer cells from solid tumors, and detecting in minutes to hours from their removal from the body the response of such cells to anti-cancer agents such as radiation, small molecules, biologies, DNA damaging agents and the like.

Abstract: A laser ignition device includes an excitation light source that generates excitation light, and a pulsed laser oscillator connected to the excitation light source, wherein the pulsed laser oscillator generates a plurality of pulsed light beams at a time of one ignition to produce an initial flame.

Abstract: In a method of manufacturing a highly stretchable three-dimensional (3D) percolated conductive nano-network structure, a 3D nano-structured porous elastomer including patterns distributed in a periodic network is formed. A surface of the 3D nano-structured porous elastomer is changed to a hydrophilic state. A polymeric material is conformally adhered on the surface of the 3D nano-structured porous elastomer. The surface of the 3D nano-structured porous elastomer is wet by infiltrating a conductive solution in which a conductive material is dispersed. A 3D percolated conductive nano-network coupled with the 3D nano-structured porous elastomer is formed by evaporating a solvent of the conductive solution and removing the polymeric material.

Abstract: An image decoding method is disclosed in the present specification. A method of decoding an image, the method may comprises determining whether to perform a context update for a first syntax element of a current block, updating, on the basis of the determination, a context for entropy decoding of the first syntax element and generating, on the basis of the updated context, a bin for the first syntax element, and wherein whether to perform the context update is determined on the basis of the number of pre-decoded predetermined syntax elements for the current block.

Abstract: The present disclosure provides a novel method for monitoring the conversion of oral precancerous lesions to oral cancers, including monitoring changes in oral exosome concentrations in a subject, thereby determining the state of the disease and the risk of carcinogenesis. The disclosure also relates to a detection kit for use in the above method.

Abstract: An image encoding/decoding method and apparatus are provided. An image decoding method performed by an image decoding apparatus according to the present invention may comprise deriving an intra-prediction mode of a current block, and performing intra-prediction for the current block based on the intra-prediction mode. The deriving of the intra-prediction mode may comprise decoding a predetermined mode sameness indicator.

Abstract: A method for etching a surface including obtaining a structure comprising a plurality of nanowires on or above a substrate and a dielectric layer on or above the nanowires, wherein the dielectric layer comprises protrusions formed by the underlying nanowires; reacting a surface of the dielectric layer with a reactant, comprising a gas or a plasma, to form a reactive layer on the dielectric layer, wherein the reactive layer comprises a chemical compound including the reactant and elements of the dielectric layer and the reactive layer comprises sidewalls defined by the protrusions; and selectively etching the reactive layer, wherein the etching etches the protrusions laterally through the sidewalls so as to planarize the surface and remove or shrink the protrusions.

Abstract: A spherical body drive type movement device 10 includes rotary bodies 14, 15, and 16 rotating n number of driving spherical bodies 11, 12, and 13 by being rotationally driven in a state of being in contact from two different directions with each of the driving spherical bodies 11, 12, and 13, and moves on a traveling surface G. The rotary bodies 14, 15, and 16 come into contact with the driving spherical bodies 11, 12, and 13 at positions higher than centers P1, P2, and P3 of the driving spherical bodies 11, 12, and 13 in contact and inside a virtual inverted n-gonal pyramid H or, at positions higher than the centers P1, P2, and P3 of the driving spherical bodies 11, 12, and 13 in contact and on lateral faces ?, ?, and ? of the virtual inverted n-gonal pyramid H.

Abstract: The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of cancers, particularly cancers that exhibit elevated expression of SLC26A2, such as certain ovarian, endometrial, brain, bone, and lung cancers, as well as melanoma. A previously identified vanadium-containing compound, bis(maltolato)oxovanadium(IV) (BMOV), specifically provided for killing of SLC26A2 expressing cancer cells in a SLC26A2-dependent manner. The instant disclosure therefore provides for selecting and/or administering BMOV and related vanadium-containing compounds as a therapeutic agent to target a cancer cell and/or subject having or at risk of developing a cancer. Methods and compositions for therapies that include such compounds are also provided.

Abstract: An efficient simulated moving bed device and an efficient simulated moving bed process are provided. The efficient simulated moving bed device comprises an adsorption bed, a raw material feeding system, a desorbent feeding system, a circulating system, an extract system, a raffinate system, a program-controlled valve group, and an automatic control system.

Abstract: Systems and methods related to reconfigurable medical devices are described. In some embodiments, a reconfigurable medical device may include a central core and a plurality of arms. The arms may be rotatably coupled to the central core such that the plurality of arms may rotate outwards away from the central core to selectively reconfigure the reconfigurable device between a retracted configuration and an expanded configuration. In an initial state, the arms may be biased outwards away from the central core into the expanded configuration. When the reconfigurable device is exposed to a temperature greater than a threshold temperature, the arms may be biased towards the central core into the retracted configuration. In some embodiments, a reconfigurable medical device may include therapeutic compound-loaded needles coupled to distal portions of the arms.

Abstract: Disclosed is an integrated circuit, which includes a DTC block including DTCs, receiving a first reference signal and a first division signal, and outputting a second reference signal and a second division signal based on the first reference signal, the first division signal, and control codes, a TDC comparing phases of the second reference signal and the second division signal and outputting a comparison signal, a digital loop filter filtering the comparison signal, an oscillator generating an output signal based on the filtered comparison signal, a delta-sigma modulator outputting a first signal and a quantized noise signal based on first and second division ratio signals, a divider dividing a frequency of the output signal based on the first signal and outputting the first division signal, and a probability modulator generating the control codes based on the quantized noise signal. Probability density functions of the control codes are time-invariant.

Abstract: Provided are a smart barn system and smart barn control method for detecting an abnormal sign of livestock and a tag attachable to livestock. The smart barn system includes a plurality of tags attached to ears of livestock bred in a pigsty and configured to measure temperatures of the livestock and transmit the measured temperature information of the livestock, a plurality of antennas configured to transmit and receive wireless signals to and from the tags, a reader configured to collect tag information of the livestock, which approaches an apparatus for providing feed and water, through any one of the plurality of antennas and measure an access frequency of the tag, which is collected through each of the antennas, through the collected tag information of the livestock, and a plurality of wireless power switching modules provided between the antennas and the reader and connected in a cascade.

Abstract: In this invention, we propose a convolutional neural network (CNN) based architecture designed for the ITM to HDR consumer displays, called ITM-CNN, and its training strategy for enhancing the performance based on image decomposition using the guided filter. We demonstrate the benefits of decomposing the image by experimenting with various architectures and also compare the performance for different training strategies. To the best of our knowledge, this invention first presents the ITM problem using CNNs for HDR consumer displays, where the network is trained to restore lost details and local contrast. Our ITM-CNN can readily up-convert LDR images for direct viewing on an HDR consumer medium, and is a very powerful means to solve the lack of HDR video contents with legacy LDR videos.

Abstract: A method and a system for simultaneously tracking several 6 DoF poses of a movable object and a movable camera are provided. The method the following steps: A series of images are captured by a movable camera, several environmental feature points are extracted from the images and are matched to compute several camera matrixes of the movable camera, and the 6 DoF poses of the movable camera are computed using the camera matrixes. At the same time, several feature points of the movable object are inferred from the images captured by the movable camera, the coordinates of the feature points of the movable object are corrected using the camera matrixes corresponding to the images as well as the predefined geometric and temporal constraints. Then, the 6 DoF poses of the movable object are computed using the coordinates of the corrected feature points and their corresponding camera matrixes.

Abstract: A method, a processing device and a display system for information display are provided. The system includes a display being light transmissive, at least one first information extraction device, at least one second information extraction device, and a processing device. The processing device is connected to the display, the first information extraction device and the second information extraction device. The first information extraction device is configured to extract a user's position information and posture information. The second information extraction device is configured to extract a target object's position information and posture information.

Abstract: The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of cancers, particularly cancers that exhibit arm-level loss of chromosome 16q, focal copy loss of 16q13 and/or low expression of metallothionein proteins, such as certain uterine, ovarian, gastroesophageal and lung cancers. Three known drugs, disulfiram, elesclomol and thiram, as well as certain disulfiram metabolites, are specifically provided for killing cancer cells characterized by arm-level loss of chromosome 16q, focal copy loss of 16q13 and/or low expression of metallothioneins. The instant disclosure therefore provides for selecting and/or administering disulfiram, elesclomol and thiram and/or active metabolites or derivatives of disulfiram, elesclomol and thiram as a therapeutic agent(s) to target a cancer cell and/or subject having or at risk of developing a cancer. Methods and compositions for therapies that include such compounds are also provided.