Abstract: The present invention features improved methods of identifying patients having cancer (e.g., melanoma, adenocarcinoma, lung, cervical, liver or breast cancer) using biomarkers (e.g., PDE3A, SLFN12) that correlate with drug sensitivity and consequently treating a stratified patient population with an agent of the invention (e.g., DNMDP, zardaverine, and anagrelide).
Type:
Grant
Filed:
August 12, 2016
Date of Patent:
December 28, 2021
Assignees:
The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc., Bayer Pharma Aktiengesellschaft
Inventors:
Luc De Waal, Matthew Meyerson, Heidi Greulich, Monica Schenone, Alex Burgin, Xiaoyun Wu, Ulrike Sack
Abstract: The present application relates generally to systems and methods for using machine vision to provide information on one or more aspects of an additive fabrication device, such as calibration parameters and/or an object formed by the device or in the process of being formed by the device. According to some aspects, a method is provided for calibrating an additive fabrication device. According to some aspects, a method is provided for assessing at least a portion of an object formed using an additive fabrication device. According to some aspects, a method is provided for fabricating a second object in contact with a first object using an additive fabrication device. According to some aspects, an additive fabrication device configured to perform one or more of the above methods may be provided.
Type:
Grant
Filed:
July 30, 2019
Date of Patent:
December 28, 2021
Assignee:
Massachusetts Institute of Technology
Inventors:
Javier E. Ramos, Pitchaya Sitthi-Amorn, Wojciech Matusik, Yuwang Wang
Abstract: A radar includes a transmitter that generates a first signal that is a frequency modulated continuous wave (FMCW) signal and radiates the generated first signal to an outside, a receiver that receives a second signal based on the first signal and generates a baseband signal of the second signal, a signal processor that extracts a target frequency signal from the baseband signal, and a signal converter that outputs the target frequency signal that is controlled as a digital signal, and wherein the signal processor includes a high pass filter connected to the receiver, that receives the baseband signal, and attenuates a low frequency signal present in the received baseband signal, based on a first cutoff frequency, an amplifier that amplifies the attenuated baseband signal, and a signal controller that removes a direct current component of the amplified baseband signal, based on a second cutoff frequency.
Type:
Grant
Filed:
May 22, 2020
Date of Patent:
December 28, 2021
Assignee:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Abstract: A method for forecasting an agricultural irrigation water requirement includes: selecting a baseline period and crops each with a sown area larger than a set proportion as typical crops; calculating an irrigation water quota of the typical crop during a growth stage according to meteorological information; obtaining ten-day rainfall in a water-saving area from weather stations; and calculating effective rainfall in a sown region of the typical crop based on the ten-day rainfall; calculating an irrigation water requirement per unit area of the typical crop; and determining whether the irrigation water requirement per unit area of at least one typical crop is greater than an average of actual irrigation water usage per unit area measured in consecutive years, if yes, correcting the irrigation water requirement per unit area of all typical crops according to actual irrigation water usage; otherwise calculating a total water requirement for a next year.
Type:
Grant
Filed:
June 10, 2020
Date of Patent:
December 28, 2021
Assignee:
CHINA INSTITUTE OF WATER RESOURCES AND HYDROPOWER RESEARCH
Inventors:
Guiyu Yang, Hao Wang, Juncang Tian, Wanli Shi, Lin Wang, Zhaohui Yang
Abstract: Chimeric protein constructs including a herpesvirus glycoprotein D (gD) and a heterologous polypeptide that interact with herpes virus entry mediator (HVEM) and enhance and enhance an immune response against the heterologous polypeptide and methods for their use are provided.
Type:
Grant
Filed:
May 10, 2019
Date of Patent:
December 28, 2021
Assignee:
The Wistar Institute of Anatomy and Biology
Inventors:
Hildegund C. J. Ertl, Marcio O. Lasaro, Luis C. S. Ferreira
Abstract: Disclosed herein are a video decoding method and apparatus and a video encoding method and apparatus. Encoding and decoding of a target block are performed using intra-prediction. The intra-prediction is intra-prediction that uses bidirectional intra-prediction and a remaining mode. In bidirectional intra-prediction, a prediction value for a target pixel in the target block is determined based on reference pixels in two directions of bidirectional intra-prediction. In intra-prediction using a remaining mode, the remaining mode indicates remaining intra-prediction modes other than MPMs present in an MPM list.
Type:
Grant
Filed:
November 28, 2018
Date of Patent:
December 28, 2021
Assignees:
Electronics and Telecommunications Research Institute, HANBAT NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
Inventors:
Hyunsuk Ko, Jung-Won Kang, Sung-Chang Lim, Jin-Ho Lee, Ha-Hyun Lee, Dong-San Jun, Hae-Chul Choi, Hui-Yong Kim, A-Ram Back
Abstract: The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of proteinopathies, particularly MUC1-associated kidney disease (ADTKD-MUC1 or MKD), Retinitis Pigmentosa (e.g., due to rhodopsin mutations), autosomal dominant tubulo-interstitial kidney disease due to UMOD mutation(s) (ADTKD-UMOD), and other forms of toxic proteinopathies resulting from mutant protein accumulation in the ER or other secretory pathway compartments and/or vesicles, among others. The disclosure also identifies and provides TMED9-binding agents as capable of treating or preventing proteinopathies of the secretory pathway, and further provides methods for identifying additional TMED9-binding agents.
Type:
Grant
Filed:
January 28, 2021
Date of Patent:
December 28, 2021
Assignees:
The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc., The Brigham and Women's Hospital, Inc.
Inventors:
Anna Greka, Moran Dvela-Levitt, Maria Alimova, Eric Lander, Todd R. Golub, Florence Wagner, Brian Chamberlain, Valeria Padovano, Joseph Growney
Abstract: In one aspect, a composition can include an organelle, and a nanoparticle having a zeta potential of less than ?10 mV or greater than 10 mV contained within the organelle. In a preferred embodiment, the organelle can be a chloroplast and the nanoparticle can be a single-walled carbon nanotube associated with a strongly anionic or strongly cationic polymer.
Type:
Grant
Filed:
August 7, 2014
Date of Patent:
December 28, 2021
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventors:
Michael S. Strano, Juan Pablo Giraldo Gomez, Sean Mitchell Faltermeier, Markita P. Landry
Abstract: A water-air amphibious cross-medium bio-robotic flying fish includes a body, pitching pectoral fins, variable-structure pectoral fins, a caudal propulsion module, a sensor module and a controller. The caudal propulsion module is controlled to achieve underwater fish-like body-caudal fin (BCF) propulsion, and the variable-structure pectoral fins is adjusted to achieve air gliding and fast splash-down diving motions of the bio-robotic flying fish. The coordination between the caudal propulsion module and the pitching pectoral fins is controlled to achieve the motion of leaping out of water during water-air cross-medium transition. The ambient environment is detected by the sensor module, and the motion mode of the bio-robotic flying fish is controlled by the controller.
Type:
Grant
Filed:
April 16, 2020
Date of Patent:
December 28, 2021
Assignee:
INSTITUTE OF AUTOMATION, CHINESE ACADEMY OF SCIENCES
Inventors:
Junzhi Yu, Zhengxing Wu, Di Chen, Min Tan
Abstract: Disclosed is a fuel cell filter including a body including therein an internal space in which a fluid flows, an inlet port provided in the body and configured to receive a fluid discharged from a fuel cell stack, a gas-water separating membrane disposed in the internal space and configured to block a liquid fluid included in a fluid absorbed in the inlet port from flowing upwards, a discharge port provided in the body and configured to externally discharge the liquid fluid blocked in the gas-water separating membrane, a water absorbent disposed in the internal space and configured to absorb water included in a gaseous fluid passing through the gas-water separating membrane, and a gas outlet port provided in the body and configured to externally discharge gas separated in the gas-water separating membrane.
Type:
Grant
Filed:
February 11, 2019
Date of Patent:
December 28, 2021
Assignee:
KOREA INSTITUTE OF ENERGY RESEARCH
Inventors:
Young-jun Sohn, Hwan Yeong Oh, Dong Won Shin, Seung-gon Kim, Byungchan Bae, Min-jin Kim, Sung-dae Yim, Tae-hyun Yang, Gu-gon Park, Won-yong Lee, Chang-soo Kim, Seok-hee Park
Abstract: The embodiments of the present disclosure are applicable to the technical field of computer science and application technology, and disclose a wireless body area network, a key generation method and a key distribution method in the wireless body area network, and a related device. The gait acceleration signal is extracted synchronously through the respective acceleration acquisition devices integrated with the coordinator and the wearable equipment, the position information corresponding to the peak value and the valley value in the gait acceleration signal is correspondingly extracted and is taken as the gait common information, and the gait common information is used to perform key distribution in the wireless body area network, the security and the consistency are higher, the calculation is simplified, the key distribution method is suitable for wearable devices having limited resources.
Type:
Grant
Filed:
September 29, 2020
Date of Patent:
December 28, 2021
Assignee:
SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES
Abstract: A modular structure may comprise multiple mechanical linkages. The structure may undergo two-dimensional or three-dimensional shape transformations, such as bending, twisting, shearing, uniform scaling, and anisotropic scaling. These shape transformations may be actuated by applying force to one or more specific locations in the structure. Each of the linkages in the modular structure may comprise a four-bar linkage. The exact shape transformation that the structure undergoes may be determined by the type and location of the linkages in the structure.
Abstract: The present application is directed to the use of a VEGF-C inhibitor, a VEGFR-2 inhibitor and/or a VEGFR-3 inhibitor as a prophylactic or therapeutic for the treatment of eye disorders such as a maculopathy and pathogenic ocular neovascularisation. The application is also directed to the use of a VEGF-C measurement from a biological sample from a mammalian subject as a predictive marker, a selected marker, a responsive marker or a tracking marker for a disease or condition selected from the group consisting of a maculopathy and pathogenic ocular neovascularization.
Type:
Grant
Filed:
March 25, 2019
Date of Patent:
December 28, 2021
Assignees:
VEGENICS PTY LIMITED, THE SCHEPENS EYE RESEARCH INSTITUTE, INC.
Inventors:
Megan E. Baldwin, Kameran Lashkari, Jie Ma
Abstract: The supporter material for catalyst includes a main body alumina and a rod-shaped alumina. The main body alumina is provided with micron-sized pore channels, at least part of the rod-shaped alumina is distributed on the exterior surface of the main body alumina and/or in the micron-sized pore channels with a pore diameter D within a range of 3-10 ?m; the rod-shaped alumina has a length of 1-12 ?m and a diameter of 80-300 nm. The alumina supporter material is used as a residual oil hydrogenation catalyst supporter to facilitate a long period operation of the residual oil hydrogenation, and has high demetalization rate, desulfurization rate and denitrification rate.
Type:
Grant
Filed:
October 26, 2018
Date of Patent:
December 28, 2021
Assignees:
CHINA PETROLEUM & CHEMICAL CORPORATION, DALIAN RESEARCH INSTITUTE OF PETROLEUM AND PETROCHEMICALS, SINOPEC CORP.
Inventors:
Honghai Ji, Huicheng Zhang, Fengxiang Ling, Shaojun Wang, Zhiqi Shen, Weiya Yang, Lihua Wang
Abstract: A thermal management system includes a refrigerant system, which includes a compressor, a flow control device, a valve member, a first heat exchanger, a second heat exchanger, and a third heat exchanger. The flow control device includes a first throttle unit, a second throttle unit, and a valve assembly; the flow control device includes a first port, a second port, and a third port; a first connection port of the first heat exchanger is in communication with the second port, and a first connection port of the second heat exchanger is in communication with the third port, while a first connection port of the third heat exchanger is in communication with the first port. The thermal management system includes a first operating state and a second operating state.
Type:
Grant
Filed:
June 25, 2018
Date of Patent:
December 28, 2021
Assignee:
Hangzhou Sanhua Research Institute Co., Ltd.
Abstract: A multi-stable electroresponsive smart window and preparation method thereof are disclosed. The multi-stable electroresponsive smart window comprises a first light transmitting conductive substrate, a parallel orientation layer, a positive polymer stabilized cholesteric texture layer, a positive cholesteric texture layer and a second light transmitting conductive substrate disposed in stack successively. The multi-stable electroresponsive smart window of the present disclosure can realize a diversified light transmission state such as colored and transparent state, colored and blur state, colorless and blur state, and colorless and transparent state by changing the magnitude of the access voltage, thereby satisfying the various demands in people's work and life.
Type:
Grant
Filed:
June 15, 2021
Date of Patent:
December 28, 2021
Assignees:
South China Normal University, Electronic Paper Display Institute, South China Normal Univ
Inventors:
Guofu Zhou, Xiaowen Hu, Wei Zhao, Haitao Sun
Abstract: A method for processing, by a base station, an interference in a wireless communication system includes determining a first base station group and a second base station group based on network topology information, determining a first precoder vector for the first base station group and a second precoder vector for the second base station group, the first precoder vector being linearly independent of the second precoder vector, and transmitting the first precoder vector and a first decoder vector to the first base station group and transmitting the second precoder vector and a second decoder vector to the second base station group, wherein the first decoder vector is included in a null space of the second precoder vector, and the second decoder vector is included in a null space of the first precoder vector.
Type:
Grant
Filed:
January 12, 2017
Date of Patent:
December 28, 2021
Assignees:
LG Electronics Inc., Korea Advanced Institute of Science and Technology
Inventors:
Heejin Kim, Changho Suh, Jaewoong Cho, Jiwon Kang