Abstract: Disclosed herein are compounds and methods for reducing the risk of developing, preventing, or treating graft versus host disease (GVHD) in a subject. The compounds can concurrently block Aurora kinase A and JAK2 signal transduction which synergistically suppresses alloreactive human T-cells in vitro, prevents xenogeneic graft-versus-host disease without impairing anti-tumor responses, and promotes the development and suppressive potency of CD39+ inducible Treg. In certain aspects, disclosed are compounds of Formula I-V.

Abstract: The present disclosure provides a 1S1R memory integrated structure and a method for fabricating the same, wherein the 1S1R memory integrated structure includes: a word line metal, a resistive material layer, a selector lower electrode, a selector material layer, a selector upper electrode, an interconnection wire, and a bit line metal; wherein the selector material layer is in a shape of a groove, and the selector upper electrode is formed in the groove. According to the 1S1R memory integrated structure and its fabricating method in the present disclosure, by the change of the integrated position of the selector, the device area of the selector is much larger than the device area of the memory, which significantly reduces the requirement for the on-state current density of the selector.

Abstract: A test method for an eye tracking algorithm creatively defines indicators for eye tracking algorithm performance test, and proposes a general environment and an overall process for the eye tracking algorithm performance test to realize the versatility of the eye tracking algorithm test, improve the algorithm development efficiency, shorten the development cycle, and provide a direction and reference for the algorithm development and iteration. The test method decouples the performance test of an eye tracking algorithm from development of the eye tracking algorithm itself, so that a test environment is not limited to a specific eye tracking algorithm and a general performance test environment for the eye tracking algorithm is established. The test method includes: defining indicators for the eye tracking algorithm performance test, defining an overall architecture of a performance test environment of the eye tracking algorithm, and proposing steps for performing the eye tracking algorithm performance test.

Abstract: Disclosed herein are an apparatus and method for booting a virtual machine. The apparatus for booting a virtual machine includes: an access unit for accessing a virtual disk, corresponding to a virtual machine that exists in a virtualization area, using a trap generated by a trap generation unit, and for controlling the input and output of data stored in the virtual disk; an extraction unit for extracting data used for booting from the virtual disk; and a verification unit for extracting a trusted boot image from image storage and verifying the integrity of the data used for booting based on a result of comparing the trusted boot image with the data used for booting.

Abstract: Distributed Bragg reflectors are incorporated into the compositionally graded buffers of metamorphic solar cells, adding functionality to the buffer without adding cost. The reflection aids in collection in subcells that are optically thin due to low diffusion length, high bulk recombination, radiation hardness, partially-absorbing quantum structures, or simply for cost savings. Performance enhancements are demonstrated in GaAs subcells with QWs, which is beneficial when GaAs is not the ideal bandgap.

Abstract: A three-degree-of-freedom parallel mechanism, includes a fixed platform, a movable platform, and three kinematic chains, where at least one of the three kinematic chains is a flexible chain; and the flexible chain includes a first connecting rod, a second connecting rod, and an axis-variable revolute pair, the axis-variable revolute pair includes a fixed member, a movable member, and a spherical pair, one end of the fixed member is fastened on the fixed platform, the other end of the fixed member fits and abuts against an inclined surface of the movable member, the spherical pair is accommodated in the fixed member, a spherical hinge connecting rod of the spherical pair penetrates the movable member, the first connecting rod is rotatably connected to the spherical hinge connecting rod and the second connecting rod, and the second connecting rod is spherically hinged to the movable platform.

Abstract: The present disclosure relates to an L-shaped header of a steam generator including a spiral heat transfer tube, and a coupling structure between the L-shaped header and the heat transfer tube, wherein an upper end and a lower end of a heat transfer tube assembly configured with a plurality of heat transfer tubes are vertically formed, and the upper and lower ends of the heat transfer tube assembly are vertically coupled to a bottom side or a top side of the header. Therefore, the heat transfer tubes constituting the same concentric circle may use the heat transfer tubes formed with the same shape, thereby improving the manufacturability of parts and reducing the manufacturing cost.

Abstract: The invention relates to PGT121-germline-targeting designs, trimer stabilization designs, combinations of those two, trimers designed with modified surfaces helpful for immunization regimens, other trimer modifications and on development of trimer nanoparticles and methods of making and using the same.

Abstract: Provided are a processing method and a processing apparatus for efficacy of a combined drug. The processing method includes: obtaining dose-effect curve band of expected additive effect of the combined drug; obtaining actual dose-effect relationship curve formed by actual effect value of the combined drug with a dose change of one target component drug in the combined drug; comparing a positional relationship between the actual dose-effect relationship curve and the dose-effect curve band; and outputting the efficacy of the combined drug as a synergistic effect when the actual dose-effect relationship curve is located above the dose-effect curve band, outputting the efficacy of the combined drug as an antagonistic effect when the actual dose-effect relationship curve is located below the dose-effect curve band, and outputting the efficacy of the combined drug as an additive effect when the actual dose-effect relationship curve is located within a range of the dose-effect curve band.

Abstract: Provided a method for separating PHA and PHA prepared therefrom. The method comprises the following steps: subjecting a PHA fermentation broth to solid-liquid separation to obtain a thallus precipitate; breaking cell walls of the thallus precipitate, and subjecting obtained wall-broken products to a plate and frame filtration to obtain PHA; a filter cloth for the plate and frame filtration is pre-coated with a PHA layer. The method adopts a plate and frame separation to replace the traditional centrifugal separation to prepare PHA, and the PHA layer is pre-coated on the filter cloth for the plate and frame filtration, thereby overcome the defects in the prior art such as high cost and operational difficulty caused by adopting multiple centrifugal separations; in addition, the method of the present disclosure also exhibits the advantages of high recovery rate of PHA and high purity of the prepared PHA product.

Abstract: The present disclosure relates to 2?3? cyclic phosphonate dinucleotides of general formula (J), their pharmaceutically acceptable salts, their pharmaceutical composition and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.

Abstract: A method of performing carrier frequency offset (CFO) estimation and/or time offset (TO) estimation at a radio equipment in a mobile communications system. The method allows, for each of a plurality of synchronization signal (SS) blocks (SSBs) in a SS Burst detected at said radio equipment, determining a CFO estimation and/or a TO estimation based on network information signal prediction. The method includes selecting at least some of said detected SSBs in said SSB Burst and combining the CFO estimations and/or the TO estimations to obtain improved CFO compensation and/or TO compensation for signal processing at said radio equipment.

Abstract: The present invention relates to a semiconductor device. The semiconductor device based on the spin orbit torque (SOT) effect, according to an example of the present invention, comprises the first electrode; and the first cell and the second cell connected to the first electrode, wherein the first and the second cells are arranged on the first electrode separately; the magnetic tunnel junction (MTJ) having a free magnetic layer and a pinned magnetic layer with a dielectric layer in between them; the magnetization direction of the free magnetic layer is changed when the current applied on the first electrode exceeds critical current value of each cell; and the critical current value of the first cell is different from that of the second cell.

Abstract: An advanced nitrogen removal method using partial nitrification-denitrification coupled two-stage autotrophic denitrification. Sewage is introduced into a first pool for partial nitrification-denitrification treatment, and then introduced into a first regulating reservoir. Dissolved oxygen content in the first pool is kept at 0.4-0.6 mg/L. Water is discharged when a molar ratio of nitrite nitrogen to ammonia nitrogen in the first regulating reservoir is 1.0-1.3:1. Effluent in the regulating reservoir is introduced into a second pool for anaerobic ammonia oxidation treatment, and then introduced into a second regulating reservoir. In the second pool, pH is 7.0-7.4, a temperature is 22-28° C. Effluent in the second regulating reservoir and sulfides are introduced into a third pool for denitrification treatment. Water is discharged. In the third pool, pH is 7.5-8.0, a temperature is 28-32° C., a mass ratio of sulfur to nitrogen is 1.9-2.0:1.

Abstract: An inter prediction method according to the present invention comprises: a step for deriving reference motion information related to a unit to be decoded in a current picture; and a step for performing motion compensation for the unit to be decoded, using the reference motion information that has been derived. According to the present invention, image encoding/decoding efficiency can be enhanced.

Abstract: A simultaneous emission-transmission tomography in an MRI hardware framework is described. A method of multimodality imaging includes reconstructing, by a simultaneous emission transmission (SET) circuitry, a concentration image based, at least in part, on a plurality of selected ?-rays; and reconstructing, by the SET circuitry, an attenuation image based, at least in part, on the plurality of selected ?-rays. The plurality of selected ?-rays is emitted by a polarized radio tracer included in a test object. The selected ?-rays are selected based, at least in part, on a radio frequency (RF) pulse and based, at least in part, on a gradient magnetic field.

Abstract: Disclosed is a method of encoding and decoding an audio signal using linear predictive coding (LPC) and an encoder and a decoder that perform the method. The method of encoding an audio signal to be performed by the encoder includes identifying a time-domain audio signal block-wise, quantizing a linear prediction coefficient obtained from a block of the audio signal through the LPC, generating an envelope based on the quantized linear prediction coefficient, extracting a residual signal based on the envelope and a result of converting the block into a frequency domain, grouping the residual signal by each sub-band and determining a scale factor for quantizing the grouped residual signal, quantizing the residual signal using the scale factor, and converting the quantized residual signal and the quantized linear prediction coefficient into a bitstream and transmitting the bitstream to a decoder.

Abstract: Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize poly (?-amino ester) (PBAE) polymers, which are synthesized via Michael addition reactions of diacrylates and amines disclosed herein. Various embodiments utilize lactones and lactone derivatives to generate the diacrylate compounds. The PBAE polymers are shown to be effective biodegradable carriers for the delivery of an agent such as an organic molecule, inorganic molecule, nucleic acid, protein, peptide, polynucleotide, targeting agent, an isotopically labeled chemical compound, vaccine, or an immunological agent.

Abstract: In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. Additionally, the disclosure demonstrates that inhibitors of ALK1 may be used to increase pericyte coverage in vascularized tissues, including tumors and the retina. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and describes antibodies that inhibit receptor-ligand interaction.

Abstract: Disclosed herein are an apparatus and method for calculating a multiplicative inverse. The apparatus for calculating a multiplicative inverse includes a data input unit for receiving input data, a multiplicative inverse calculation unit for dividing an input degree-8 finite field corresponding to the input data into two first degree-4 finite fields so as to perform Advanced Encryption Standard (AES) encryption on the input data, and for performing a multiplicative inverse calculation on the first degree-4 finite fields in consideration of a circuit depth value (T-Depth) and qubit consumption of quantum gates in a quantum circuit, and a data output unit for outputting result data obtained by performing the multiplicative inverse calculation.