Abstract: A system and method for developing a treatment plan using multi-stage machine learning. A method includes identifying at least one cognitive distortion of a user by applying a first machine learning model to a first portion of features extracted from data related to the user, wherein the first machine learning model is a cognitive distortions model trained using training user-created content; determining a plurality of digital therapeutics exercise tasks for the user based on the at least one cognitive distortion by applying a second machine learning model to a second portion of the features extracted from the data related to the user and to the output of the first machine learning model, wherein the second machine learning model is a task recommender model trained using training cognitive distortions and the training user-created content; and generating a treatment plan including the plurality of digital therapeutics exercise tasks for the user.

Abstract: A composition can photocatalytically reduce carbon dioxide.

Abstract: A vascular interventional instrument control device capable of operating double guide wires or balloons, includes a main finger assembly, a first sub-finger assembly, a second sub-finger assembly, a driving assembly and a clamping assembly, wherein the main finger assembly, the sub-finger assembly, the driving assembly and the clamping assembly are separately installed to the body structural member and separately connected to the controller through a communication link, one of the operated double guide wires or balloons is clamped by the main finger assembly and the first sub-finger assembly, and the other is clamped by the main finger assembly and the second sub-finger assembly; and the operated double guide wires or double balloons can be separately moved axially or rotated about its own axial direction.

Abstract: A method for automatically generating hierarchical exploded views based on assembly constraints and collision detection, in which parts to be exploded are layered in explosion sequence according to a design result of the 3D assembly process planning, and the parts to be exploded in each layer are grouped based on the type and the disassembly direction; a feasible explosion direction of the parts in each layer is determined according to assembly constraints and collision detection; the explosion sequence and explosion direction of the parts in each layer are determined; and then the layered explosion is performed at a certain distance. Ball markers and a part-list are generated after all the parts are exploded.

Abstract: The combination of 3D printing technology plus the additional dimension of transformation over time of the printed object is referred to herein as 4D printing technology. Particular arrangements of the additive manufacturing material(s) used in the 3D printing process can create a printed 3D object that transforms over time from a first, printed shape to a second, predetermined shape.

Abstract: The invention discloses a monosubstituted or polysubstituted amphiphilic hypocrellin derivative, and a preparation method and application thereof. The amphiphilic hypocrellin derivative substituted by a group containing PEG, a quaternary ammonium salt or the like prepared according to the invention has an obvious red shift in its absorption spectrum and a significantly enhanced molar extinction coefficient, compared with the parent hypocrellin, can efficiently produce singlet state oxygen and other reactive oxygen species under photosensitive conditions; has different amphiphilicities and increased biocompatibility with cells or tissues by regulating its hydrophilicity and hydrophobicity; can meet the requirements of different clinical drugs, and solves the requirements of different drug delivery methods for different drug hydrophilicity and lipophilicity.

Abstract: A method for simultaneous design of a hybrid transceiver in an OFDM-based wideband multi-antenna system is provided. The method comprises: designing transmission/reception analog beamforming commonly used for each subcarrier by using product information of subcarrier channel information; and designing baseband beamforming for an effective channel of each subcarrier.

Abstract: A memory system includes a memory device including a plurality of memory cells, and a controller configured to access the plurality of memory cells. The controller includes a data read block configured to read first data from one or more pages included in first memory cells, determine a target memory cell subject to a compensation based on the first data, and read second data from one or more pages of second memory cells adjacent to the target memory cell, and an equalizer configured to convert the second data into symbol interfering data, check a probability of the first data from a lookup table according to the symbol interfering data, and determine the compensation on the first data based on the probability.

Abstract: Probe embodiments for targeting, identifying, and isolating enzymes exhibiting BSH activity as well as devices and kits that use the probes are described herein. Methods of making and using the probes, devices, and kits are also described. In some embodiments, probes, devices, and kits for targeting, identifying, and isolating enzymes in a biological sample are disclosed. In some embodiments, compositions and methods of treatment using the probes, devices, and kits disclosed herein are described.

Abstract: Macromolecules comprising triazoles and related compositions and methods are provided. In some embodiments, a macromolecule may comprise one or more repeat units including a triazole and a functionalizable pendant group. The macromolecule may also comprise one or more orthogonally addressable end groups. In some embodiments, one or more repeat units may be formed by a synthetic process that allows for precise control over stereochemistry, pendant functionality, and/or the spatial relationship (e.g., distance) between groups in the repeat unit(s). Such precise control over pendant group and repeat unit structure allows for the macromolecule functionality, stereochemistry, and spacing between groups (e.g., pendant groups) to be precisely controlled. Macromolecules described herein may be used for a wide variety of applications, including the delivery of active agents.

Abstract: Methods of the invention treat, reduce, or reverse fibrosis of a bodily tissue by administering to the local affected tissue a composition comprising an inhibitor of p38 MAP kinase, which treatment leads to a reduction or reversal of fibrosis.

Abstract: A millimeter wave imaging apparatus, including: a crystal oscillator, a power divider, a millimeter wave transceiver, a local-oscillation signal processor, a second frequency mixer and an image processor; the power divider performs power distribution on an oscillation signal generated by the crystal oscillator, and outputs a clock trigger signal and a local-oscillation signal; the local-oscillation signal processor processes the local-oscillation signal and outputs a second local-oscillation signal; the millimeter wave transceiver unit processes an echo signal reflected by an object to be detected, and outputs a first intermediate-frequency signal; the second frequency mixer mixes the second local-oscillation signal and the first intermediate-frequency signal, and outputs a second intermediate-frequency signal; the image processor processes the second intermediate-frequency signal, and images the object to be detected.

Abstract: An operation method of a terminal in a communication system includes receiving a message from a base station, the message including physical random access channel (PRACH) configuration information indicating a PRACH slot; determining a start symbol to which a PRACH is mapped among symbols constituting the PRACH slot based on a type of the PRACH slot; mapping the PRACH from the start symbol in the PRACH slot; and transmitting the PRACH mapped to the PRACH slot to the base station.

Abstract: Disclosed herein are chimeric antigen receptor (CAR) polypeptides that can be used with adoptive cell transfer to target and kill TAG-72-expressing cancers. Also disclosed are immune effector cells, such as T cells or Natural Killer (NK) cells, that are engineered to express these CARs. Therefore, also disclosed are methods of providing an anti-tumor immunity in a subject with a TAG-72-expressing cancer that involves adoptive transfer of the disclosed immune effector cells engineered to express the disclosed CARs.

Abstract: The present invention relates to a novel azole derivative as an apelin receptor agonist and a method for treating cardiovascular disease, diabetic disease, renal disease, hypertension, and arteriosclerosis, etc., using the same. The present invention provides a compound represented by formula (I) or a pharmacologically acceptable salt thereof wherein X1 represents —N? or —CH?, X2 represents —CH? or —N?, R1 and R2 each represent a C1 to C6 alkoxy group or the like, R3 represents a heteroaryl group (the heteroaryl group is optionally substituted by a methyl group or the like) or the like, and R4 represents a C1 to C6 alkylthio group or a C2 to C6 alkenyl group (the C1 to C6 alkylthio group and the C2 to C6 alkenyl group are each optionally substituted by one carboxy group or the like) or the like.

Abstract: An isolated peptide consisting of FKCRRWQWRMKKL (SEQ ID NO: 1) for preserving the natural color of the hair, or slowing the decay in the natural pigment production of the hair follicle, or reducing the appearance of hair graying is provided. Also disclosed herein are methods and compositions for preserving the natural color of the hair, or slowing the decay in the natural pigment production of the hair follicle, or reducing the appearance of hair graying in a mammal subject.

Abstract: Antibody molecules that specifically bind to TIM-3 are disclosed. The anti-TIM-3 antibody molecules can be used to treat, prevent and/or diagnose immune, cancerous, or infectious conditions and/or disorders.

Abstract: Ooids, microabrasive compositions containing ooids and methods of making microabrasive compositions containing ooids are described. Generally, ooids represent small particles, which are selectable for size, size distribution, and other characteristics and can be used as a microabrasive particle. Ooids generally show a high level of symmetry, sphericity, roundness and a low aspect ratio. As described here, these characteristics generally yield a predictable and highly effective abrasive.

Abstract: A method for efficiently producing PHA comprising: inoculating PHA fermentation strains into a fermentation medium for fermentation under the condition of being capable of producing PHA through fermentation; subjecting the fermentation broth to a solid-liquid separation to obtain fermentation supernatant and thallus precipitate; breaking the cell walls of the thallus precipitate, and subjecting the wall-broken products to a plate and frame filtration to prepare PHA; pre-coating a filter cloth for the plate and frame filtration with a PHA layer; at least part of the water of the fermentation medium is PHA process wastewater. The method utilizes the PHA process wastewater as at least part of the water of the fermentation medium, and filters and separates the broken thallus with the plate and frame filtration equipment pre-coated with PHA layer to prepare PHA, thereby recycling the high-salt wastewater, reducing costs, and potentially separating PHA on a large scale for industrial production.

Abstract: This invention relates to the field of ribonucleic acid (RNA) regulation of intracellular activity. In particular, the invention relates to compositions and methods of identifying and tracking specific intracellular RNAs. For example, a fluorescently tagged RNA probe may be tracked by in vivo live imaging throughout its intracellular lifetime in order to determine its purpose and identify regulatory targets to modify its effects. Alternatively, an RNA probe may carry a therapeutic payload for treatment of medical condition or disorder.