Abstract: Expression of proteolytically active, high molecular weight ADAM10 protease is relatively increased in tumour cells that also express the putative tumour stem cell marker CD133. A recombinant humanized antibody or antibody fragment based on 8C7 monoclonal antibody may be used to selectively bind to proteolytically active, high molecular weight ADAM10 protease to thereby detect tumour cells and also as a therapeutic agent for treating cancers, tumours and other malignancies inclusive of leukemia, lymphoma, lung cancer, colon cancer, adenoma, neuroblastoma, brain tumour, renal tumour, prostate cancer, sarcoma and/or melanoma.

Abstract: A sensing chip attached to a bandage monitors the healing process of a wound by detecting growth factors, thrombin and fibrinogen. The complementary metal-oxide semiconductor includes a functionalized working electrode, functionalized counter electrode and functionalized reference electrode. The healing progress is stimulated by generating oxygen in the wound.

Abstract: The present invention relates to compounds of formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity: Formula I wherein X1, X2, X3, R1, R2, R3, R4 and R5 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.

Abstract: A method for the treatment of silicon-containing wastewater from the preparation of a molecular sieve or a catalyst includes the step of contacting the silicon-containing wastewater with at least one acid or at least one alkali, so that at least a part of the silicon elements in the silicon-containing wastewater form a colloid. A mixture containing a colloid is thus obtained. A silicon-containing solid phase and a first liquid phase are produced by a solid-liquid separation. A solid phase and a second liquid phase are produced by a solid-liquid separation after at least a part of the metal elements in the first liquid phase form a precipitate. At least a part of the second liquid phase is subjected to electrodialysis to produce an acid liquor and/or an alkali liquor. The silicon-containing solid phase can be used as the raw material for a molecular sieve synthesis.

Abstract: A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.

Abstract: A turbulent fluidized bed reactor, device and method for preparing para-xylene and co-producing light olefins from methanol and/or dimethyl ether and benzene, resolving or improving the competition problem between an MTO reaction and an alkylation reaction during the process of producing para-xylene and co-producing light olefins from methanol and/or dimethyl ether and benzene, and achieving a synergistic effect between the MTO reaction and the alkylation reaction. By controlling the mass transfer and reaction, competition between the MTO reaction and the alkylation reaction is coordinated and optimized to facilitate a synergistic effect of the two reactions, so that the conversion rate of benzene, the yield of para-xylene, and the selectivity of light olefins are increased.

Abstract: Disclosed herein are a method and apparatus for video decoding and a method and apparatus for video encoding. A prediction block for a target block is generated by predicting the target block using a prediction network, and a reconstructed block for the target block is generated based on the prediction block and a reconstructed residual block. The prediction network includes an intra-prediction network and an inter-prediction network and uses a spatial reference block and/or a temporal reference block when it performs prediction. For learning in the prediction network, a loss function is defined, and learning in the prediction network is performed based on the loss function.

Abstract: Described here are systems and methods for visualizing thermal ablation lesions by imaging specific chemical compounds that are created during thermal ablation procedures, such as cardiac ablation procedures. When a cardiac ablation procedure is performed, a central area of coagulative necrosis is created at the treatment site. This necrotic region is surrounded by layers of tissues with ultra-structural and electrophysiological changes. Two particular changes include the denaturation of proteins and the formation of ferric iron containing chemical compounds, such as methemoglobin and metmyoglobin. The formation of and distribution of such chemical compounds can be imaged with the appropriate systems and methods. Accordingly, these chemical compounds can be utilized as biomarkers that indicate the presence and physical characteristics of thermal ablation lesions. Imaging can be performed using magnetic resonance imaging, optical imaging, or photoacoustic imaging, as examples.

Abstract: The present disclosure relates to a carbon-based porous material microscopically exhibiting a three-dimensional cross-linked net-like hierarchical pore structures with micropores nested in mesopores that are in turn nested in macropores. Such material provides for accelerated adsorption and desorption rates and lower desorption temperatures for recovery of organic gas molecules.

Abstract: The present application provides bifunctional compounds of Formula (I): which act as protein degradation inducing moieties for EGFR and/or a mutant thereof. The present application also describes methods for the targeted degradation of EGFR and/or a mutant thereof through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to EGFR and/or a mutant thereof which can be utilized in the treatment of disorders modulated by EGFR or a mutant thereof.

Abstract: The present invention relates to an apparatus for the mass production of polymeric nanofibres and their uniform deposition over any substrate. The present invention also provides a method for the manufacture of droplet free polymeric nanofibres by electrospinning process using multi-hole spinnerets. The droplet free polymeric nanofibres of the present invention are preferably of a diameter in the range of 50 nm to 850 nm.

Abstract: The present invention provides a method for the preparation of an insensitive high enthalpy explosive Dihydroxylammonium 5,5?-bistetrazole-1,1?-diolate (TKX-50) in the presence of N,N-dimethylformamide, N,N-dimethylacetamide, or N-Methyl-2-pyrrolidone as a solvent via a four-step, one-pot reaction route to obtain a final product after four reaction steps. The more dangerous intermediate diazidoglyoxime may be solved by the one-pot method without the need of isolation. Further, the cyclization reaction is carried out in the presence of dropwisely added concentrated sulfuric acid to replace hydrochloric gas so no hydrochloric gas generator is needed to greatly reduce the amount of waste acid so as to effectively reduce the cost by avoiding using hydrochloric gas steel cylinders which require much safety equipment.

Abstract: A boron-nitrogen ligand with a chiral 1,2-ethylenediamine backbone, a preparing method and used thereof are provided. The structural formula of the boron-nitrogen ligand is as shown in formula (I): wherein R1, R2 and R3 are respectively at least independently selected from substituted or unsubstituted C3-C10 cycloalkyl, C1-C10 alkyl or aryl; R4, R5, R6, R7, R8, R9, R10, R11 and R12 are respectively at least independently selected from hydrogen, halogen, substituted or unsubstituted C1-C10 alkyl, C1-C4 alkoxy, C3-C30 cycloalkyl or aryl; Ar1 and Ar2 are respectively at least independently selected from substituted or unsubstituted C6-C30 aryl. The preparation method of the present application is simple, and can be used for preparing a racemic or chiral boron-nitrogen ligand, which can be used as a catalyst for an asymmetric catalytic reaction and has economic practicability and industrial application prospects.

Abstract: The present invention relates to a method for regulating localization of CCNY protein to synapses, comprising palmitoylation of CCNY protein. Specifically, the present invention relates to a method for regulating targeting of CCNY protein to synapses by regulating addition of a palmitoyl group to cysteine at position 7 and/or 8 on the CCNY protein. Therefore, the palmitoylation of CCNY, a postsynaptic protein known to be implicated in synaptic plasticity and learning and memory, is a critical process for CCNY to be localized in postsynaptic spines, and thus it can be found that CCNY plays an important role in synaptic functions.

Abstract: A measuring program compiling device and a measuring program compiling method thereof are provided. The method includes analyzing a first measuring program to obtain a plurality of first measuring parameters corresponding to the first measuring program, and converting the first measuring parameters into a plurality of second measuring parameters corresponding to a plurality of planning operations; generating a plurality of standardized measuring parameters according to the second measuring parameters and a plurality of computer aided design (CAD) image parameters; receiving a plurality of parameter input operations corresponding to the planning operations to update the second measuring parameters; generating a standardized measuring program corresponding to a CAD file according to the standardized measuring parameters; and converting the standardized measuring program into a target measuring program executed on a target measuring device according to specification data of the target measuring device.

Abstract: A system includes a first camera having a first field of view of an environment and a first machine learning model associated with the first camera, where the first machine learning model is trained to identify object or semantic information from image data captured by the first camera. The system further includes a second camera having a second field of view of the environment. An electronic controller communicatively coupled to the first camera and the second camera is configured to receive object or semantic information from the image data captured by the first camera as identified by the first machine learning model and train the second machine learning model, where training data utilized for training the second machine learning model comprises the object or semantic information identified by the first machine learning model.

Abstract: Provided is an air conditioning system including: a case including a first sub-case including an outdoor air inlet and a discharge outlet, and a second sub-case including an air returning inlet and an air supply inlet; a desiccant rotor module; a heat exchanger including a first sub-heat exchanger and a second sub-heat exchanger, a ventilator including a first sub-ventilator and a second sub-ventilator; and a damper including a first sub-damper and a second sub-damper, wherein the first sub-damper is installed downstream of the first region of the desiccant rotor module, and the second sub-damper is installed downstream of the second region of the desiccant rotor module, wherein the desiccant rotor module and the heat exchanger are integrally assembled so as to be detachably installed in the case, wherein the outdoor air and the indoor air do not mix with each other.