Abstract: An image analysis apparatus rectifies a first image and a second image to generate a first rectified image and a second rectified image respectively. A first container door in the first rectified image and a second container door in the second rectified image have the same sizes and the same pixel coordinates. The image analysis apparatus divides the first rectified image into a plurality of first blocks and divides the second rectified image into a plurality of second blocks in a same manner. The image analysis apparatus calculates respective correlations between every first block and its corresponding second block. Each of the correlations includes a grayscale correlation and at least one color correlation. The image analysis apparatus determines whether the first container door and the second container door represent the same container door based on the correlations.

Abstract: Embodiments of the present disclosure relate generally to single molecule arrays. More particularly, the present disclosure provides materials and methods for generating single molecule arrays using bottom-up self-assembly processes. Materials and methods of the present disclosure can be used to generate single molecule arrays with nanoapertures (e.g., zero mode waveguides) and for carrying out rapid, point-of-care biomolecule detection and quantification.

Abstract: A boltless fastener assembly for a heavy haul railway with an axle load of 35-40 tons includes a pre-embedded steel holder, an e-clip, an insulated gauge block and a rubber pad. A clamping leg-heel end of the e-clip is provided with an L-shaped retaining end. The pre-embedded steel holder is improved to adapt to the e-clip, and an opening is formed at a portion of the pre-embedded steel holder close to the clamping leg-heel end of the e-clip, so that the e-clip can be installed normally. During normal installation, the L-shaped retaining end of the e-clip does not contact the pre-embedded steel holder. When the rail undergoes large torsional deformation, the L-shaped retaining end on one side of a rail moves upward to contact an upper edge of the opening of the pre-embedded steel holder or engages with a second heel end.

Abstract: Anti-heparanase compounds for the treatment of cancer are described. The anti-heparanase compounds are high affinity, synthetic glycopolymers that result in minimal anticoagulant activity. Stereoselective fluorinated forms of these compounds are also provided.

Abstract: A membrane distillation (MD) system includes a membrane module and reduced graphene oxide-carbon nanotube immobilized membrane for organic solvent separation. The MD module could include a feed inlet and outlet, a sweep gas inlet, and a sweep gas outlet. Thermostats are positioned at the feed inlet and outlet to measure the change in temperature. Preferential sorption of the organic, specifically tetrahydrofuran (THF), on a hybrid reduced graphene oxide-carbon nanotube immobilized membrane contributes to enhanced solvent removal of the MD system.

Abstract: Disclosed is a neural network accelerator including a maximum value determiner outputting a maximum value based on a first magnitude component corresponding to first input data and a second magnitude component corresponding to second input data, a sign determiner outputting a sign component corresponding to the maximum value among a first sign component corresponding to the first input data and a second sign component corresponding to the second input data, as an output sign component, an offset operator quantizing a difference between the first magnitude component and the second magnitude component and outputting an output offset based on the first sign component, the second sign component, and the quantization result, and a magnitude operator calculating an output magnitude component of an output data based on the maximum value and the output offset. Each of the first input data and the second input data is data on a logarithm domain.

Abstract: One aspect of the disclosure describes a lipid conjugated cationic molecule. Other aspects of the disclosure describes nanoparticle delivery systems and methods of making the systems are disclosed. An embodiment of the nanoparticle delivery system has sustained gene delivery properties, the nanoparticle delivery system can be synthesized using biodegradable and biocompatible polymers via self-assembly. The nanoparticle delivery system comprises a plurality of nanoparticle depots, each of which has a particle-in-particle structure, and is composed of a polymeric nanoparticle, which encapsulates cationic molecule/nucleic acid complexes, facilitating enhanced retention and prolonged release of the gene payload. The polymeric nanoparticle comprises a shell, and a nanocomplex of the cationic molecule and a polynucleotide, the nanocomplexes are distributed within the shell and/or embedded in the shell. Another embodiment of the nanoparticle delivery system has one or more nanocomplexes.

Abstract: A solid-liquid separation device includes a kettle body, a piston, a stirrer, a separation plate having filtration pores, and a filtration mesh. The kettle body is hollow along an axial direction to form a chamber body. The separation plate is fitly installed in the chamber body, and divides the chamber body into a washing chamber and a draining chamber. The piston and the stirrer are fitly disposed in the washing chamber. The filtration mesh is attached on a side of the separation plate to cover the filtration pores. The kettle body is further provided with a feed inlet, a water inlet, a material outlet, and a liquid outlet. The feed inlet and material outlet are communicated with the washing chamber, and the water inlet and the liquid outlet are communicated with the draining chamber. The method includes the following steps: feeding, solid-liquid separation, washing, and material discharge.

Abstract: The present disclosure relates to an electrode for supercapacitor, preparation method and use thereof. The electrode comprises an electrode terminal, an active layer and a coating layer from inside to outside. A material for preparing the coating layer comprises an oxygenated compound, which contains at least one of transition metal elements or is doped with a substance containing a transition metal element. Providing the coating layer on the surface of the active layer prevents organic electrolytes from being easily adsorbed and nucleated in the porous structure of the electrode surface due to interface defects, and facilitates to weaken the interface problems existing between the electrolyte and the electrode surface. The capacitor prepared by means of the electrode according to the embodiments of the present disclosure can significantly increase the operating voltage window (may be up to above 4V) and capacitance of the supercapacitor, and further increase energy density thereof.

Abstract: Disclosed herein are compounds comprising an electrophilic moiety and rigid moiety for use in modulating an activity of Pin1. The rigid moiety comprises at least one functional group that is capable of forming hydrogen bonds with hydrogen atoms, wherein the electrophilic moiety and the rigid moiety are arranged such that the electrophilic moiety is capable of covalently binding to the Cys113 residue of Pin1, and the rigid moiety is capable of forming hydrogen bonds with the Gln131 and His 157 residues of Pin1. Further disclosed are novel compounds having Formula Id: wherein the dashed line, W, X, Y, Z, Ra-Rc, R1, R2, L1, L2 and n are as defined herein, and libraries comprising such compounds. Further disclosed are methods of identifying a compound capable of modulating an activity of Pin1, by screening a library of compounds.

Abstract: A system and method for developing a treatment plan using multi-stage machine learning. A method includes determining a treatment plan for a patient based on at least one mental health disorder of a patient, wherein the treatment plan includes a plurality of digital therapeutics exercise tasks, wherein each digital therapeutics exercise task is selected from among a category of digital therapeutics exercise tasks corresponding to a type of mental health disorder of the at least one mental health disorder of the patient; and administering treatment to the patient by prescribing the treatment plan to the patient and causing data for administering the treatment plan to a user device of the patient.

Abstract: Disclosed are information transmission method, apparatus, device and medium for medical imaging application. The method includes: an imaging device corresponding to an application authorization request is determined according to the received application authorization request, and an application permission profile of the imaging device is acquired; and a medical imaging application corresponding to the imaging device is determined according to the application permission profile of the imaging device, and medical imaging application information corresponding to the medical imaging application is transmitted to the imaging device.

Abstract: The sample introduction device includes a nebulizer that atomizes a sample liquid; a spray chamber that has one end into which a spray port part of the nebulizer is inserted and the other end from which at least a part of liquid droplets of the sample liquid sprayed from the spray port part is discharged to an outside; and a heating electromagnetic wave radiation unit that is arranged outside the spray chamber, wherein the heating electromagnetic wave radiation unit performs radiation of heating electromagnetic waves from the outside of the spray chamber toward at least a part of the spray chamber other than a part into which the spray port part of the nebulizer is inserted.

Abstract: A system and a process for co-producing dimethyl carbonate and ethylene glycol. The system comprises an interconnected ethylene carbonate preparation unit and an ethylene carbonate alcoholysis unit. The ethylene carbonate preparation unit comprises a fixed bed reactor and a light-component stripping column connected to each other. The fixed bed reactor is filled with a supported ionic liquid catalyst. The process comprises the steps of: reacting carbon dioxide and ethylene oxide as raw materials in the fixed bed reactor to produce ethylene carbonate, purifying the ethylene carbonate and then mixing it with an alcoholysis reaction catalyst, and reacting the mixture with methanol in a reactive distillation tower, producing dimethyl carbonate and ethylene glycol. The process increases the conversion rate of ethylene oxide and avoids the need for a process of separating conventional homogeneous catalysts from ethylene carbonate, thereby reducing process energy consumption and simplifying process procedures.

Abstract: A method for fabricating a nano-structure includes: providing a phase mask having an uneven lattice structure to contact a photoresist film; exposing the photoresist film to a light through the phase mask such that the light is obliquely incident on a surface of the photoresist film; and developing the photoresist film to form a nano-structure.

Abstract: A method for route planning for an autonomous vehicle includes receiving a request to autonomously navigate to a destination. The method also includes identifying a stall factor on a route to the destination prior to departing to the destination, the stall factor delaying a time for arriving at the destination. The method further includes determining whether an occupant of the autonomous vehicle is capable of manually operating the autonomous vehicle in a manual operating mode or a semi-manual operating mode. The method still further includes identifying an alternate route to the destination based on identifying the stall factor and the occupant being incapable of manually operating the autonomous vehicle. The method also includes controlling the autonomous vehicle to drive on the alternate route instead of the route.

Abstract: The present invention relates to an isoindolin-1-on derivative, a method for preparing same, and a pharmaceutical composition comprising same as an effective component for preventing or treating tumors, wherein the isoindolin-1-on derivative exhibits a high inhibitory effect on EGFR mutations, and thus can be beneficially used for the treatment of EGFR-mutated tumors, and the isoindolin-1-on derivative exhibits a significant synergistic effect when co-administered, and thus can be beneficially used in concomitant therapy.

Abstract: A probe for use with an imaging system, including a scanning device configured to receive a first light beam from a light source, a beam-divider configured to split the first light beam into a plurality of second light beams, and a focusing device configured to focus each of the second light beams on respective locations in an object of interest is disclosed.

Abstract: The present disclosure provides a flexible hinge structure including: a rigid driving member; a mounting fixed member which is connected to an upper surface of the rigid driving member through a first flexible portion at one end in a longitudinal direction of the upper surface, a first fixing structure being provided on a surface of the mounting fixed member; a displacement output member connected to the upper surface of the rigid driving member through a second flexible portion at the other end in the longitudinal direction of the upper surface; and a pair of guiding fixed members symmetrically disposed on both sides of the displacement output member through third flexible portions, the both sides being parallel to the longitudinal direction of the upper surface of the rigid driving member and a second fixing structure being provided on a surface of each of the guiding fixed members.

Abstract: Reversible phase-change materials (PCMs) can be added to or incorporated into meta-lenses, wave plates, waveguides, gratings, and other optical components to form active optical devices with controllable and adjustable optical characteristics. Local heating can be used to induce solid-state phase changes and large refractive index changes in the PCMs. The phase and index changes can provide large changes in the device's optical characteristics. Optical devices with PCM can be used for imaging applications, orbital angular momentum control, photonic integrated circuits and optical communication systems, beam steering, and other application.