Abstract: Early detection of lysosomal storage diseases (LSDs) including Mucopolysaccharidosis Type I (MPS I) and Pompe Disease can greatly improve patient outcome as each disease can be fatal once symptoms emerge. Screening for MPS I and Pompe Disease using biological samples including dried blood spots (DBS), buccal swab, peripheral blood mononuclear cells (PBMCs), or white blood cells (WBCs) is described. The disclosed methods and assays provide a robust way to screen newborns for LSDs. The disclosed methods and assays can also allow rapid prediction of whether a patient with LSD will develop an immune response to enzyme replacement therapy (ERT), thus improving treatment for patients with LSDs. The disclosed methods and assays can also further reduce the number of false positives caused by pseudo deficiency cases of LSD, such as MPS I and Pompe Disease.

Abstract: Provided are an electrode sensor and a method for fabricating the same. According to embodiments, an electrode sensor includes: an organic substrate including a polymer; an organic insulating pattern which is disposed on the organic substrate and has an opening through which the organic substrate is exposed; a conductive layer which is disposed on the organic substrate and within the opening of the organic insulating pattern; and a passivation pattern which is disposed on the organic insulating pattern and through which a portion of the conductive layer is exposed. The conductive layer may include a conductive polymer, and the conductive layer may be coupled to the organic substrate by a covalent bond.

Abstract: Provided are a method for fabricating a highly elastic porous polymer membrane, a method for manufacturing a cell culture system using a porous polymer membrane fabricated by the fabrication method, and a cell culture system manufactured by the manufacturing method. The porous polymer membrane can be fabricated by spin coating a mixture solution containing a biodegradable elastomeric polymer and a water-soluble moisture absorbent in an optimum ratio while maintaining a high relative humidity. The porous polymer membrane has a uniform thickness and a uniform pore size and is highly elastic. In addition, the thickness and pore size of the porous polymer membrane can be controlled. The porous polymer membrane can induce active cell-cell interaction during cell co-culture due to its high porosity. The porous polymer membrane enables control over cell alignment or array due to its high biocompatibility and elasticity.

Abstract: Disclosed are degraders, pharmaceutical compositions containing them, and methods of making and using the degraders to treat diseases and disorders characterized by aberrant protein activity that can be targeted by cereblon.

Abstract: The present invention discloses an image decoding method, the method including generating a candidate list including motion information derived from a spatial neighboring block and a temporal neighboring block adjacent to a current block; deriving motion information of the current block using the candidate list; generating a prediction block of the current block using the derived motion information; and updating the derived motion information in a motion information list, wherein the generating of the candidate list is performed in such a manner as to include at least one information of the motion information included in the updated motion information list in a block decoded before the current block.

Abstract: A data transmission method of a source node in a cooperative communication system includes: performing a beamforming to a relay node; transmitting data to the relay node; performing a beamforming to a destination node; and transmitting data to the destination node.

Abstract: In accordance with one or more embodiments of the present disclosure, a method of starting a fuel reformer including a heating element and a subsequent autothermal reformer includes contacting a first fluid comprising oxygen with the heating element, passing the first fluid into the autothermal reformer to preheat a reformer catalyst within the autothermal reformer to a first temperature, reducing flow of the first fluid into the autothermal reformer, introducing a fuel into the autothermal reformer subsequent to preheating the reformer catalyst to initiate a partial oxidation reaction and generating additional heat, increasing flow of the fuel and first fluid to initiate autothermal reforming, and controlling the temperature of the reformer catalyst by supplying a cooling fluid, the first fluid, and the fuel and adjusting flow of each.

Abstract: A method of manufacturing a composite member including an aluminum member and a resin member that are bonded to each other, the method including: performing blasting on a surface of the aluminum member; modifying the surface of the aluminum member into aluminum hydroxide, the modifying including causing the surface of the aluminum member having undergone blasting to react with water vapor by applying a pressure exceeding an atmospheric pressure; and directly bonding the resin member to the surface of the aluminum member modified to aluminum hydroxide.

Abstract: Articles and methods related to passivation materials on alkaline earth metals are generally described.

Abstract: A method for controlling a driving behavior performed by a first agent includes navigating, by the first agent, according to a trajectory and a velocity. The method also includes receiving, from a second agent, a risk identification message identifying a third agent as a potential risk based on the third agent performing a behavior associated with a probability that is less than a threshold. The method further includes autonomously engaging a defensive driving mode in response to receiving the risk identification message. The method still further includes adjusting one or both of the trajectory or the velocity in response to autonomously engaging the defensive driving mode.

Abstract: Disclosed is a neural network computing device. The neural network computing device includes a neural network accelerator including an analog MAC, a controller controlling the neural network accelerator in one of a first mode and a second mode, and a calibrator that calibrating a gain and a DC offset of the analog MAC. The calibrator includes a memory storing weight data, calibration weight data, and calibration input data, a gain and offset calculator reading the calibration weight data and the calibration input data from the memory, inputting the calibration weight data and the calibration input data to the analog MAC, receiving calibration output data from the analog MAC, and calculating the gain and the DC offset of the analog MAC, and an on-device quantizer reading the weight data, receiving the gain and the DC offset, generating quantized weight data, based on the gain and the DC offset.

Abstract: Systems and methods for semi-autonomously controlling a vehicle are disclosed. In one embodiment, a method includes determining a trajectory of a semi-autonomous vehicle based on data received from one or more vehicle sensors, determining a state of the vehicle based on data received from the vehicle sensors, determining an optimal trajectory of the vehicle based on the state of the vehicle, determining a level of confidence in the determined state of the vehicle and in the determined optimal trajectory of the vehicle, determining a plurality of possible future states of the vehicle based on the state of the vehicle, the trajectory of the vehicle, and the level of confidence, determining whether a subset of the possible future states of the vehicle are recoverable, and when it is determined that the subset of the possible future states of the vehicle are recoverable, issuing a security certificate.

Abstract: The present invention relates to compositions which may comprise a non-naturally occurring or engineered artificial transcription factor, wherein the transcription factor may comprise a sequence specific DNA binding domain, a sliding domain, and one or more linkers, wherein the DNA binding domain and the sliding domain are operably connected by the one or more linkers, and uses thereof. Methods involving the use of a non-naturally occurring or engineered artificial transcription factors and pharmaceutical compositions, methods for treating cancer, a degenerative disease, a genetic disease or an infectious disease as well as diagnostic methods are also contemplated by the present invention.

Abstract: An apparatus for analyzing a biological material component may include an impedance sensor comprising a first electrode having a first contact surface that contacts an analysis target, and a second electrode having a second contact surface that contacts the analysis target and that faces the first contact surface. The apparatus may include an impedance measurement assembly configured to measure impedance of the analysis target using the first electrode and the second electrode. The apparatus may include a processor configured to model the measured impedance as an equivalent circuit, and analyze a biological material component based on a modeling result.

Abstract: The present invention provides novel compounds according to Formula (I): where Ring A, Ring B, X, L1, L2, RA, RC, RD, RE, m, n, and p are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of human diseases associated with kinase activity, for example, proliferative diseases, neurodegenerative diseases, metabolic disorders, inflammatory diseases, and cardiovascular diseases.

Abstract: A method includes encapsulating a current state of a road portion into a voxel grid, a first dimension of the voxel grid being associated with a first spatial dimension of the road portion, a second dimension of the voxel grid being associated with a second spatial dimension of the road portion, and a third dimension of the voxel grid comprising a plurality of feature layers, wherein each feature layer is associated with a feature of the road portion. The voxel grid may be input into a trained neural network and a future state of the road portion may be predicted based on an output of the neural network.

Abstract: A preparation method for a metal-doped gallium oxide transparent conductive thin film for ultraviolet waveband includes: growing a contact layer thin film (2) on a substrate (1) first, and annealing the grown contact layer thin film (2) in a nitrogen-oxygen atmosphere at 400° C. to 600° C. through a rapid thermal annealing furnace; growing a first Ga2O3 thin film (31) by sputtering through magnetron sputtering under argon conditions; growing a doped thin film (4) by sputtering through magnetron sputtering under argon conditions; growing a second Ga2O3 thin film (32) by sputtering through magnetron sputtering under argon conditions; and annealing the grown thin films in a nitrogen-oxygen atmosphere at 500° C. to 600° C. through a rapid thermal annealing furnace, so that permeation, diffusion and fusion occur between thin film materials to form a metal-doped Ga2O3 thin film (5). A metal-doped gallium oxide transparent conductive thin film for ultraviolet waveband is provided.

Abstract: Devices, systems, and methods for adjusting the high flex point of a deformable sensor are disclosed herein. A deformable sensor may include an enclosure comprising a housing and a deformable membrane coupled to an upper portion of the housing, where the enclosure is configured to be filled with a medium, a contact mechanism coupled to the housing and selectively adjustable such that adjusting a position of the contact mechanism causes a change in a location of a high flex point of the deformable membrane, and an internal sensor, disposed within the enclosure, having a field of view configured to be directed through the medium and toward a bottom surface of the deformable membrane, where the internal sensor is configured to output a deformation region within the deformable membrane when placed in contact an object.

Abstract: This invention is in the area of compositions and methods for regulating chimeric antigen receptor immune effector cell, for example T-cell (CAR-T), therapy to modulate associated adverse inflammatory responses, for example, cytokine release syndrome and tumor lysis syndrome, using targeted protein degradation.

Abstract: An actuator capable of attaining high output. The actuator includes a frame structure part that forms a frame structure surrounding a housing part, and a volume change part housed in the housing part. The volume change part increases a volume thereof by input of external energy. The frame structure part has a higher Young's modulus than a Young's modulus of the volume change part. The housing part has an anisotropic shape, with a maximum width in first direction of the housing part longer than a maximum width in second direction different from the first direction of the housing part.