Abstract: An object of the present invention is to provide a sensor in which a molecularly imprinted polymer is immobilized on the surface, the sensor having homogeneous performance and excellent reproducibility of measurement. The present invention provides a sensor comprising: a conductive particle having a molecularly imprinted polymer on the surface; and a support.

Abstract: The present disclosure provides a buffer circuit and a buffer. The buffer circuit includes: an input follower circuit for following the voltage change of the first input signal; an input follower linearity boosting circuit for improving follower linearity of the input follower circuit; a first voltage bootstrap circuit for bootstrapping the voltage of the first input signal; a second voltage bootstrap circuit for bootstrapping the voltage of the second input signal; a third voltage bootstrap circuit for providing corresponding quiescent operation point voltage; a compensation follower circuit for following the compensation voltage; a compensation follower linearity boosting circuit for improving follower linearity of the compensation follower circuit; a first load for collecting the buffered voltage; a bias circuit for providing a bias current for the buffer; a bias linearity boosting circuit for improving linearity of the bias circuit; a second load for generating a nonlinear compensation current.

Abstract: The invention described herein is directed to methods of isolation and detection of target analytes in a sample. The target analytes are coupled to analyte detection particles which comprise base particles having labels and affinity agents coupled thereto by linker arms. The linker arms form bonds with the labels and target analytes and are cleavable under different label and affinity cleavable conditions. Systems and methods for preparing and using the analyte detection particles are also disclosed.

Abstract: The present invention discloses a phthalide derivative, the structure of said derivative is represented by Formula (I) or Formula (II). The present invention also discloses the preparation method and use of said derivative. The phthalide compound obtained through structure modifications in the present invention enhances the chemical stability and pharmacological activity of the phthalide compound, facilitating the improvement of the druggability of such compounds.

Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems. In particular the present invention comprehends engineered new guide architectures to be used in optimized CRISPR-Cas enzyme systems.

Abstract: The present invention relates to a process for preparing 3-pyrrolidine carboxylic acid derivatives, and particularly a simple process for preparing 5-substituted 3-pyrrolidine carboxylic acid derivatives. In addition, the present invention relates to a novel pyrrolidine carboxylic acid derivative, its manufacture, pharmaceutical compositions containing it and its use as a catalyst.

Abstract: A method for additive manufacturing a three-dimensional article may comprise simulating the three-dimensional article based on at least one parameter characterizing the three-dimensional article such that the three-dimensional article comprises a first region comprising a first base material and a second region comprising a second base material. The method may further comprise generating a set of print instructions based on a conformation of the three-dimensional article, preparing an additive manufacturing feedstock comprising the first base material and the second base material based on the three-dimensional article, and supplying the set of print instructions and the additive manufacturing feedstock to an additive manufacturing device. The additive manufacturing device may then fabricate the three-dimensional article using the additive manufacturing feedstock based on the set of print instructions.

Abstract: A high frequency push-push oscillator is disclosed. The high frequency push-push oscillator includes a resonant circuit, including tank transmission lines or an inductor capacitor (LC) tank circuit, for generating a differential signal having a resonant frequency, and a Gm-core circuit for converting the differential signal to an output signal having an output frequency that is higher than the resonant frequency. The Gm-core circuit includes cross-coupled first and second transistors having first and second gates, drains, and sources, respectively, and first and second gate transmission lines. The first and second drains are in electrical communication with the resonant circuit. The first gate transmission line is joined with the first gate and the resonant circuit and the second gate transmission line is joined with the second gate and the resonant circuit. The Gm-core circuit includes a differential transmission line positioned between the first and second gates of the first and second transistors.

Abstract: An encoding apparatus extracts features of an image by applying multiple padding operations and multiple downscaling operations to an image represented by data and transmits feature information indicating the features to a decoding apparatus. The multiple padding operations and the multiple downscaling operations are applied to the image in an order in which one padding operation is applied and thereafter one downscaling operation corresponding to the padding operation is applied. A decoding method receives feature information from an encoding apparatus, and generates a to reconstructed image by applying multiple upscaling operations and multiple trimming operations to an image represented by the feature information. The multiple upscaling operations and the multiple trimming operations are applied to the image in an order in which one upscaling operation is applied and thereafter one trimming operation corresponding to the upscaling operation is applied.

Abstract: The present invention provides a thermoelectric material excellent in heat resistance with less degradation of thermoelectric characteristics even in a high temperature environment. The thermoelectric material comprises a compound represented by a chemical formula Mg2Si1?xSnx(0<x<1) wherein at least one of the Si site and the Sn site of the compound is replaced with at least one of Sb and Bi, and an added Fe.

Abstract: Disclosed is a terahertz wave generating apparatus. The terahertz wave generating apparatus includes a dual mode laser including a first single mode laser that generates a first beating signal, a gain adjustment region that modulates the first beating signal, and a second single mode laser that generates a second beating signal, and a photomixer that mixes the modulated first beating signal and the second beating signal, and that modulates a current supplied based on a beating frequency of the mixed beating signals to generate a terahertz wave signal, and the gain adjustment region is formed between the first single mode laser and the second single mode laser, and the first beating signal is output from the first single mode laser to the gain adjustment region and is modulated based on a reverse bias voltage supplied to the gain adjustment region.

Abstract: Disclosed are a target holder assembly of an ion probe and a method for preparing a sample target thereof. Specifically, the target holder assembly includes a body and sheets, a middle part of the body is provided with a sample target hole, and limiting portions are symmetrically arranged at an opening of the sample target hole away from a sample target entry side; and the sheets match the limiting portions in shape and dimension to form recesses on a sample target for receiving the limiting portions.

Abstract: The present disclosure generally relates in certain embodiments to a combined cycle power plant system comprising an electrochemical compressor. For instance, in one set of embodiments, the electrochemical compressor is may separate oxygen from a flow of air from an air source to provide a pressurized flow of oxygen to a combustor. In some embodiments, the resulting combustion products may only include oxygen and water without any substantial fraction of other combustion products or contaminants which may facilitate the separation of carbon dioxide (CO2) for subsequent processes including compression and/or storage.

Abstract: An exhaust gas dilution device according to an exemplary embodiment of the present invention includes a head part, ejector unit, a nozzle part, and a dilution part. The head part has a space part into which an exhaust gas flows and a through-hole formed through the center axis direction to be connected to the space part. The ejector unit is coupled to the head part and has a first discharge hole formed passing through the center axis direction to be connected to the through-hole and connected to a first inlet to which primary dilution air is supplied. The nozzle part is inserted into a first discharge hole through the through-hole and has a second discharge hole that penetrates in the center axis direction so that the exhaust gas flowed into the space part is sucked and ejected into the first discharge hole as the primary dilution air moves through the first discharge hole.

Abstract: Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.

Abstract: The present invention relates to a relationship between microbial metagenomic structure and function and clinical remission with anti-integrin therapy induction; longitudinal trajectory of changes in the microbiome with maintenance treatment; and a comprehensive predictive model incorporating clinical and microbiome-related data to accurately classify treatment response.

Abstract: Disclosed is an intelligent micromanipulation system based on machine vision, including a base, wherein a microscope, a rotating table and two lifting tables are arranged on the base, the microscope is located right above the rotating table, the two lifting tables are arranged at two sides of the rotating table, respectively, and each is provided with a mechanical arm, each of the two manipulators is provided with an end effector, the mechanical arm is capable of driving the corresponding end effector to perform fine adjustment in x, y and z directions, one of the end effectors clamps a suction holding needle in communication with a suction pump, while the other end effector clamps an injection needle in communication with an injection pump; and the rotating table includes a tray, a rotating mechanism and a driving device, and the driving device drives the tray to rotate via the rotating mechanism.

Abstract: The invention provides methods and devices for determining molecular signatures in a cancer that predict response to a MARPK pathway inhibitor and methods of use of such signatures.

Abstract: A subpixel structure includes a substrate and a light emitting diode chip. The light emitting diode chip is disposed on the substrate. The light emitting diode chip has a chip area and a light emitting area, and the light emitting area is less than or equal to one tenth of the chip area.

Abstract: Provided are an object tracking system and an object tracking method.