Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in prokaryotic and eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity.

Abstract: The present application discloses a construction method for pouring concrete in a karst cave. Concrete streaming is pumped into a hollow passage of a drill stem, then opens the one-way openable sealing cover with a pre-tensioned spring on a reaming drill bit and enters the karst cave to complete pouring of the concrete. When the karst cave is relatively low, low-slump plain concrete mixed with quick-setting agents is injected through a drilling rig and the hollow drill stem to form a concrete pier; when the karst cave is relatively high, the hollow drill stem is sleeved into a thin-walled steel shell, and the thin-walled steel shell is synchronously sunk into the drilled hole while drilling, enters the karst cave and is socketed into a stable rock stratum, then concrete is pumped into the thin-walled steel shell from the bottom of the pile, and finally, a reinforcement cage is inserted to form a cast-in-place pile.

Abstract: The present Disclosure is directed to methods for inhibiting or suppressing metastasis of a tumor in a mammalian subject using a cysteamine product, e.g., cysteamine or cystamine or a derivative thereof. Also described herein is a method for treating pancreatic cancer in a mammalian subject by administering a cysteamine product described herein.

Abstract: The invention relates to a comprehensive monitoring and data mining system and method for algae bloom of lake, wherein, the method comprises acquiring monitoring indicator data related to algae bloom of lake by three ways, i.e., remote sensing monitoring, automatic monitoring and manual surveying, and transmitting the acquired data to a data center by Internet; performing data backup and data preprocessing of the received data in the data center, including temporal interpolation, spatial interpolation and outlier determination and processing; transmitting the preprocessed data to a database for storage; performing computation of 3D numerical model of lake according to the data source stored in the database, assessing the risk of algae bloom of the lake to be monitored according to the simulation data of the numerical model, and displaying predictive warning information on algae bloom of the lake on a public platform.

Abstract: The present disclosure, at least in part, relates to an engineered incoherent feed forward loop (iFFL) comprising a first transcription unit encoding an endoribonuclease and a second transcription unit encoding an output molecule and an endoribonuclease target site located in the 5? UTR of the output molecule coding sequence. The engineered iFFL, at least in part, can be used for sustained expression of an output molecule despite of transcription resource disturbance in a given environment.

Abstract: Provided herein are prenatal methods comprising administering an effective amount of a biocompatible microsphere comprising a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic.

Abstract: Detection reagent is formed by reacting a catalyst and xanthydrol. The catalyst includes an active component loaded on a support, wherein the active component includes Pt, Ru, Rh, or a combination thereof, and the support includes carbon material, silica, alumina, or calcium carbonate. The detection reagent can be used to detect the primary amide compound.

Abstract: An inverted nanocone structure of the present disclosure includes a first surface, a second surface spaced apart from the first surface by a predetermined distance and having a greater area than the first surface, and a body having an inverted cone shape between the first surface and the second surface, wherein at least one activated point defect center is provided in the body.

Abstract: Provided are a conductive composite resin composition for photocurable 3D printing and a preparation method thereof. The conductive composite resin composition for photocurable three-dimensional (3D) printing includes 10 to 90 wt % of a photoreactive viscosity decreasing agent and 10 to 90 wt % of a photocurable resin based on 100 wt % of the conductive composite resin composition, wherein the conductive composite resin composition further comprises 0.01 to 1 wt % of conductive nanostructures, and the conductive composite resin composition has a viscosity of 400 cP or less at a shear rate of 58 s?1.

Abstract: A method for scene perception using video captioning based on a spatio-temporal graph model is described. The method includes decomposing the spatio-temporal graph model of a scene in input video into a spatial graph and a temporal graph. The method also includes modeling a two branch framework having an object branch and a scene branch according to the spatial graph and the temporal graph to learn object interactions between the object branch and the scene branch. The method further includes transferring the learned object interactions from the object branch to the scene branch as privileged information. The method also includes captioning the scene by aligning language logits from the object branch and the scene branch according to the learned object interactions.

Abstract: An image encoding/decoding method is disclosed. Present invention of the method of decoding an image comprises determining a prediction mode for a current block and performing prediction on the current block on the basis of the determined prediction mode.

Abstract: The present invention provides methods and compositions based on a non-naturally occurring nucleic acid construct encoding a fusion protein for quantitating levels of secretion in a single cell which may comprise a protein sequence which may comprise a cytoplasmic domain, a transmembrane domain and a vesicular domain, wherein the vesicular domain may comprise a protein tag sequence, wherein upon expression of the fusion protein by a cell, the fusion protein localizes to the membrane of a secretory vesicle such that the protein tag localizes to the lumen of the secretory vesicle, and wherein the protein tag binds to a cell-impermeable marker, whereby upon secretion of the contents of the secretory vesicle, the protein tag is exposed to the cell-impermeable marker, the fusion protein is recycled back into the cell, and the single cell becomes labeled with the marker relative to the amount of secretion.

Abstract: Geospatial data can be converted into audio outputs. For example, a system can receive a dataset indicating geospatial locations of objects within a region. Based on the dataset, the system can generate a virtual map representing the region and including virtual points representing the objects. The virtual points can be spatially positioned at locations in the virtual map corresponding to the geospatial locations of the objects in the region. The system can receive a user input via a user input device for interacting with a particular virtual point among the virtual points in the virtual map. The system can determine one or more sound characteristics for a sound based on receiving the user input. The system can then transmit an audio signal to an audio device for causing the audio device to generate the sound having the one or more sound characteristics, which may assist with exploring the virtual map.

Abstract: Disclosed are compounds with immunomodulatory activity, methods of making the compounds, pharmaceutical compositions containing the compounds, and methods of using the compounds to treat diseases or disorders characterized or mediated by dysfunctional protein activity.

Abstract: The invention relates to a method for computationally designing re-usable silicone molds for the reproduction of an object, wherein the silicone mold is fillable with casting material, for example, but not limited to, resin, to form the object.

Abstract: Disclosed is a hydrogen production and storage system using solar energy which converts solar energy into electric energy through a solar panel, operates a water electrolysis reactor using the electric energy to produce hydrogen, and stores the hydrogen at a high pressure in a hydrogen storage tank through a water tank, a pressure control valve, etc.

Abstract: The present invention relates to a system for determining a posture of an operator of a device that transmits vibrations to the operator, wherein the system comprises at least one vibration sensor for measuring vibrations at at least one location on the body of the operator and/or the device, and a posture determining means for detecting one or more characteristics of the measured vibrations assigned to a predetermined posture and for determining the predetermined posture as the posture of the operator when the characteristic is detected.

Abstract: Provided herein are compounds of Formula (I?) or (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing diseases (e.g., proliferative diseases (e.g., cancers (e.g., carcinoma); lung cancer, breast cancer, liver cancer, pancreatic cancer, gastric cancer, ovarian cancer, colon cancer, colorectal cancer)), metabolic disorders (e.g., diabetes), autoimmune diseases, and neurological diseases (e.g., Alzheimer's disease, gliosis, spinal cord injury)) in a subject, as well as for male contraception (e.g., reducing or inhibiting spermatogenesis, or reducing the rate of male fertility in a healthy fertile male subject). Provided are methods of inhibiting a CDK (e.g., CDK14, CDK15, CDK16, CDK17, CDK18) in a subject.

Abstract: An apparatus includes processor(s) to: use an acoustic model to generate a first set of probabilities of speech sounds uttered within speech audio; derive at least a first candidate word most likely spoken in the speech audio using the first set; analyze the first set to derive a degree of uncertainty therefor; compare the degree of uncertainty to a threshold; in response to at least the degree of uncertainty being less than the threshold, select the first candidate word as a next word most likely spoken in the speech audio; in response to at least the degree of uncertainty being greater than the threshold, select, as the next word most likely spoken in the speech audio, a second candidate word indicated as being most likely spoken based on a second set of probabilities generated by a language model; and add the next word most likely spoken to a transcript.

Abstract: Provided is a means for promoting electron transfer between nanocarbon and other substances. An electron transfer accelerator for nanocarbon comprising a compound having an aromatic ring skeleton.