Patent number: 9540372
Abstract: The present invention pertains generally to the field of therapeutic compounds for treating proliferative disorders, cancer, etc., and more specifically to certain pyrido[2,3-b]pyrazin-8-substituted compounds, as described herein, which, inter alia, inhibit RAF (e.g.,B-RAF) activity. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit RAF (e.g., BRAF) activity, to inhibit receptor tyrosine kinase (RTK) activity, to inhibit cell proliferation, and in the treatment of diseases and disorders that are ameliorated by the inhibition of RAF, RTK, etc., proliferative disorders such as cancer (e.g., colorectal cancer, melanoma), etc.
Type:
Grant
Filed:
September 14, 2015
Date of Patent:
January 10, 2017
Assignees:
INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE), CANCER RESEARCH TECHNOLOGY LIMITED
Inventors:
Caroline Joy Springer, Dan Niculescu-Duvaz, Ion Niculescu-Duvaz, Richard Marais, Bartholomeus Marinus Josephus Marie Suijkerbuijk, Alfonso Zambon, Arnaud Nourry, Delphine Menard
Patent number: 9543571
Abstract: Disclosed are a precursor for a rechargeable lithium battery, a positive active material including the same, a preparation method thereof, and a rechargeable lithium battery including the positive active material. More particularly, the present invention relates to a precursor including a sheet-shaped plate having a thickness of about 1 nm to about 30 nm and that is represented by the following Chemical Formula 1. NixCoyMn1-x-y-zMz(OH)2??[Chemical Formula 1] In the above Chemical Formula 1, 0<x<1, 0?y<1, 0.5?1-x-y-z, and 0?z<1, and M is at least one kind of metal selected from the group consisting of Al, Mg, Fe, Cu, Zn, Cr, Ag, Ca, Na, K, In, Ga, Ge, V, Mo, Nb, Si, Ti, and Zr.
Type:
Grant
Filed:
September 18, 2012
Date of Patent:
January 10, 2017
Assignee:
KOREA ELECTRONICS TECHNOLOGY INSTITUTE
Inventors:
Jun Ho Song, Young Jun Kim, Jeom-Soo Kim, Woo Suk Cho, Jae-Hun Kim, Jun Sung Lee, Jin Hwa Kim, Kyoung Joon Lee