Patents Assigned to INSTITUTE
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Publication number: 20250103751Abstract: A computing circuit with a de-identified architecture, a data computing method, a data processing system, and a data de-identification method are provided. The computing circuit includes an arithmetic array and a de-identification circuit. The computing circuit may perform an accumulation operation on input data to generate accumulated data by the arithmetic array. The de-identification circuit has an analog offset error determined based on an analog physical unclonable function. The computing circuit may operate the accumulated data according to the analog offset error to generate de-identification data by the de-identification circuit. It can not only provide the analog offset error through the transistors in the de-identification circuit, but also be combined with obfuscated code settings to dynamically adjusting the degree of de-identification of data.Type: ApplicationFiled: September 26, 2024Publication date: March 27, 2025Applicant: Industrial Technology Research InstituteInventors: Bo-Cheng Chiou, Chih-Sheng Lin, Tuo-Hung Hou, Chih-Ming Lai, Yun-Ting Ho, Shan-Ming Chang
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Publication number: 20250101364Abstract: Disclosed herein are aspects of a system for coupling electrochemical marine carbon capture with photosynthesis. In some aspects of the present disclosure, the system comprises an electrochemical cell that converts saline water into (i) a base stream, (ii) an at least partially deionized water stream, and (iii) an acid stream. In some aspects, the system further comprises a biomass cultivation unit in fluid communication with the acid stream, the biomass cultivation unit comprising a photosynthetic organism. The acid stream catalyzes release of CO2 in a growth medium for the photosynthetic organism to accelerate growth of the photosynthetic organism relative to growth without the acid stream and facilitates CO2 storage by the photosynthetic organism. Also disclosed herein are aspects of a method for coupling electrochemical marine carbon capture with photosynthesis.Type: ApplicationFiled: September 26, 2024Publication date: March 27, 2025Applicant: Battelle Memorial InstituteInventors: Chinmayee V. Subban, Scott J. Edmundson, Christopher R. Myers, Charles F. Hibbeln
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Publication number: 20250099458Abstract: Provided is a use of nintedanib or a pharmaceutically acceptable salt thereof in preparing a drug for treating tuberculosis. The nintedanib or the pharmaceutically acceptable salt thereof is used in combination with a further anti-tuberculosis drug for treating tuberculosis, or used as an adjuvant drug for the treating tuberculosis, where the further anti-tuberculosis drug is selected from a group consisting of: rifampicin, isoniazid, pyrazinamide, ethambutol, fluoroquinolone, streptomycin, kanamycin, amikacin, capreomycin, sodium para-aminosalicylate, ethionamide, cycloserine, clofazimine, and linezolid.Type: ApplicationFiled: March 16, 2023Publication date: March 27, 2025Applicants: Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis Chest Cancer InstituteInventors: Yu LU, Xiaoyou CHEN, Xueting QI, Luyao ZHENG, Lei FU, Weiyan ZHANG, Ning WANG
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Publication number: 20250101454Abstract: Disclosed herein are a pharmaceutical composition comprising an inhibitor of Olfr164 for the prevention or treatment of sepsis, a method for the prevention or treatment of sepsis, a use of Olfr164 as a marker for selecting sepsis therapeutic agents, a screening method for sepsis therapeutics using same, and a transgenic animal in which Olfr164 is knocked out. The composition comprising Olfr164 inhibitor can effectively prevent or treat sepsis. Additionally, sepsis therapeutics can be effectively screened by comparing the expression level or activity of Olfr164 before and after administering the candidate substance.Type: ApplicationFiled: March 21, 2024Publication date: March 27, 2025Applicants: Research & Business Foundation Sungkyunkwan University, Daegu Gyeongbuk Institute of Science and TechnologyInventors: JaeHyung KOO, Yoe Sik BAE, Young Su JUNG, Yu Sun JEONG, Ji Cheol KIM, Ji Woo CHOI
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Publication number: 20250099577Abstract: The present invention provides a composition for transdermal administration comprising a nucleic acid. Specifically, the present invention provides a composition for transdermal administration comprising a nucleic acid, the nucleic acid comprising RNA, wherein the composition is administered by an administration method comprising spraying the composition to the surface of a target tissue, and the spraying of the composition is performed by pressurization of the composition, whereby the composition is sprayed toward the target tissue and penetrates the surface of the target tissue.Type: ApplicationFiled: January 25, 2023Publication date: March 27, 2025Applicants: KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION, NANO MRNA CO., LTD., EDUCATIONAL FOUNDATION KYORIN GAKUEN, KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATIONInventors: Kazunori KATAOKA, Satoshi UCHIDA, Saed Amjad Yousef ABBASI, Miki MASAI, Akimasa HAYASHI
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Publication number: 20250101456Abstract: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1, or of a nucleic acid sequence of at least 1400 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule leads to the specific expression in mouse cortex of an exogenous gene in a particular population of CNR1-positive cells when a nucleic acid sequence coding for said exogenous gene is operatively linked to said isolated nucleic acid molecule, said particular population of CNR1-positive cells being characterized in that it also expresses EFHD1, ENPP6 and GJC2.Type: ApplicationFiled: January 17, 2023Publication date: March 27, 2025Applicant: FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCHInventors: Georg KELLER, Hassana OYIBO
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Publication number: 20250099614Abstract: The present invention is inter alia directed to artificial nucleic acid constructs, preferably RNA, comprising at least one coding sequence encoding at least one transcription factor inhibitor for reducing or inhibiting the activity of a target transcription factor in a cell. A preferred transcription factor inhibitor according to the invention is a Runt-related transcription factor (RUNX) inhibitor, for example a RUNX trap comprising at least one amino acid sequence for binding a RUNX transcription factor and at least one amino acid sequence for capturing or trapping RUNX. Further provided are pharmaceutical compositions comprising the artificial nucleic acid, preferably formulated in polyethylene glycol/peptide polymers, polymeric carriers, or lipid-based carriers. Also provided are methods of treating or preventing disorders, diseases, or conditions, and medical uses.Type: ApplicationFiled: January 27, 2023Publication date: March 27, 2025Applicants: CureVac SE, The Schepens Eye Research Institute, Inc.Inventors: Joanna REJMAN, Tim SONNTAG, Markus CONZELMANN, Joseph ARBOLEDA-VELASQUEZ, Leo A. KIM
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Publication number: 20250101457Abstract: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1, or of a nucleic acid sequence of at least 500 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule leads to the specific expression in layer 2/3 of mouse cortex of an exogenous gene in a particular population of DLX4-positive cells when a nucleic acid sequence coding for said exogenous gene is operatively linked to said isolated nucleic acid molecule, said particular population of DLX4-positive cells being characterized in that it also expresses VTN, ABCC9 and CLDN5.Type: ApplicationFiled: January 17, 2023Publication date: March 27, 2025Applicant: FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCHInventors: Georg KELLER, Hassana OYIBO
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Publication number: 20250099623Abstract: The present disclosure relates to treating mitochondrial diseases, cancer and other conditions as a result of reduced oxidative phosphorylation (OXPHOS) activity by overexpressing the METTL17 gene, encoding methyltransferase-like 17. Currently, overexpression of METTL17 to increase its copy number and/or intra-mitochondrial activity has not been indicated as a possible therapeutic for treating mitochondrial disease or other diseases such as cancer or aging related to a decline in OXPHOS activity. A variety of gene therapy approaches are presented for overexpression of METTL17 including, but not limited to, AAV, adenovirus and lentiviral vector expression.Type: ApplicationFiled: September 23, 2024Publication date: March 27, 2025Applicants: THE BROAD INSTITUTE, INC., THE GENERAL HOSPITAL CORPORATIONInventors: Vamsi MOOTHA, Tslil AST
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Publication number: 20250101458Abstract: The present application relates to compositions and methods for eliciting an immune response in a subject using an Adeno-Associated Virus (AAV) AAV11 vector comprising an AAV11 capsid protein and a nucleic acid encoding a transgene operably linked to a promoter, wherein the transgene encodes an immunogenic polypeptide. Further disclosed are immunogenic polypeptides that are used for the compositions and methods.Type: ApplicationFiled: January 19, 2022Publication date: March 27, 2025Applicants: Massachusetts Eye and Ear infirmary, The Schepens Eye Research Institute, Inc.Inventors: Luc H. Vandenberghe, Nerea Zabaleta Lasarte, Urja Achal Bhatt
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Publication number: 20250099033Abstract: The present invention provides a method of screening for psychoactive agents comprising the steps of a) simultaneously assessing in a subject, the activity of neurons of at least two regions of the deep cortical layers in the absence of a potential psychoactive agent and correlating these activities, b) simultaneously assessing in said subject, the activity of said neurons of said at least two regions of the deep cortical layers in the presence of the potential psychoactive agent and correlating said activities, and c) comparing the correlations obtained in step a) and b), wherein any significant change in the correlation obtained in step b) as compared to the correlation obtained in step a) is indicative of a potential psychoactive activity of said potential psychoactive agent.Type: ApplicationFiled: January 23, 2023Publication date: March 27, 2025Applicant: FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCHInventors: Matthias HEINDORF, Georg KELLER
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Publication number: 20250101637Abstract: A preparation method of an aerogel fiber and use are provided. The preparation method includes: mixing a solvent and a polymer material to form a spinning solution; driving the spinning solution with a high-speed airflow by using a blow spinning technology to form a jet flow, and forming a gel fiber through sol-gel transition; and performing solvent replacement on the gel fiber and then performing drying treatment to prepare the aerogel fiber. The method for preparing the aerogel fiber through blow spinning has no high requirements on a gelation process of an aerogel material, and can achieve the preparation of the aerogel fiber by using this method after the spinning solution meeting rheological conditions is obtained, thereby avoiding the influence of the inadequate gelation process on fiber properties while promoting the production efficiency of the aerogel fiber and greatly simplifying procedures.Type: ApplicationFiled: April 13, 2023Publication date: March 27, 2025Applicant: SUZHOU INSTITUTE OF NANO-TECH AND NANO-BIONICS (SINANO) , CHINESE ACADEMY OF SCIENCESInventors: Xuetong ZHANG, Zengwei LIU
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Publication number: 20250100916Abstract: A method for removing inorganic substances from wastewater is provided. The method includes: providing a fluidized bed reactor, wherein carriers are added into the fluidized bed reactor, and the carriers includes polyvinylidene fluoride (PVDF), ethylene tetrafluoroethylene (ETFE), alumina (Al2O3) with purity more than 95 wt %, or combinations thereof; introducing the wastewater containing the inorganic substances and a first reagent into the fluidized bed reactor; fluidizing the carriers in the fluidized bed reactor, and making the inorganic substances in the wastewater reacting with the first reagent to form crystals, wherein the crystals are formed on the outer surfaces of the carriers.Type: ApplicationFiled: February 7, 2024Publication date: March 27, 2025Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Mao-Sung LEE, Teh-Ming LIANG, Wang-Kuan CHANG
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Publication number: 20250103241Abstract: A DRAM is configured using a triple-mode memory cell that supports a computation mode, a memory mode, and a data conversion mode by one cell and converts modes as necessary, and an AI accelerator using the same is provided, so that a dataflow may be reconfigured according to a structure and a size of an AI neural network (so-called deep neural network) to be trained.Type: ApplicationFiled: April 24, 2024Publication date: March 27, 2025Applicant: Korea Advanced Institute of Science and TechnologyInventors: Hoi Jun YOO, Sang Jin KIM
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Publication number: 20250100927Abstract: Reaction schemes involving acids and bases; reactors comprising spatially varying chemical composition gradients (e.g., spatially varying pH gradients), and associated systems and methods, are generally described.Type: ApplicationFiled: December 6, 2024Publication date: March 27, 2025Applicant: Massachusetts Institute of TechnologyInventors: Yet-Ming Chiang, Leah Ellis, Andres Badel
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Publication number: 20250103578Abstract: In one example, a system can receive information about a tabular data structure in a memory including a set of data and a first memory allocation. The system can determine a type of the tabular data structure, the type selected from among two types including a native type and a non-native type. The system can, in response to the type being the native type, identify a first proxy data table usable as a proxy for the tabular data structure that shares the first memory allocation. The system can receive a first indication to access the set of data from application code. The system can issue one or more first read commands to the first proxy data table to cause the set of data to be read from the tabular data structure.Type: ApplicationFiled: October 10, 2024Publication date: March 27, 2025Applicant: SAS Institute Inc.Inventors: Yongqiao Xiao, Mary Elizabeth Carter, Arash Dehghan Banadaki, Avery Winston Acierno, Patrick Nathan Koch
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Publication number: 20250101023Abstract: The present invention relates to a heteroaryl derivative, a stereoisomer thereof, a hydrate thereof, a solvate thereof, or a pharmaceutically acceptable salt thereof, a method for preparing the same, and a pharmaceutical composition for preventing or treating cancer comprising the same as an active ingredient. The heteroaryl derivative of the present invention exhibits high inhibitory activity against overexpressed HER2, and thus, a pharmaceutical composition containing the same as an active ingredient can be usefully used for preventing or treating HER-2 positive cancer.Type: ApplicationFiled: January 19, 2023Publication date: March 27, 2025Applicants: IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY), KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Gu KONG, Ratnakar Reddy KUCHUKULLA, Su Min KIM, So Jeong MOON, Woo Young HUR, In Jeong HWANG
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Publication number: 20250104184Abstract: The present invention describes methods and techniques to improve scintigraphic images obtained by using nuclear medicine techniques for diagnostic analysis. The present invention describes a method and technique to up-sample and down-sample nuclear medicine images that models photon counts and noise characteristics of an image at its target resolution.Type: ApplicationFiled: September 20, 2024Publication date: March 27, 2025Applicants: Jubilant Draximage, Inc., Ottawa Hospital Research InstituteInventors: Eric Moulton, Siraj Ghassel, Jochen Lang, Ran Klein, Indranil Nandi
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Publication number: 20250101054Abstract: A binuclear Schiff base-cobalt complex, a preparation method and use thereof, wherein the binuclear Schiff base-cobalt complex has a structure represented by Formula (I): in Formula (I), R1 and R2 are independently selected from a group consisting of hydrogen, nitro, cyano, a halogen, an aliphatic group, a substituted aliphatic group and an aryl group; and X is selected from a group consisting of —F, —Cl, —Br, —I, —NO3, —CH3COO, —CCl3COO, —CF3COO, —ClO4, p-methylbenzoate, p-toluenesulfonate, 2,4-dinitrophenoxy, 3,5-dinitrophenoxy, p-nitrophenoxy and o-nitrophenoxy anions. The present disclosure can provide a binuclear Schiff base-cobalt complex, which can catalyze copolymerization reaction of an epoxide, such as an epoxide with an electron-withdrawing group, with CO2 to prepare a polycarbonate material.Type: ApplicationFiled: March 21, 2022Publication date: March 27, 2025Applicant: CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY CHINESE ACADEMY OF SCIENCESInventors: Xuan PANG, Yanchuan ZHOU, Ranlong DUAN, Zhiqiang SUN, Xuesi CHEN
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Publication number: 20250104249Abstract: The present disclosure relates to a method and apparatus for performing enhanced center-based panoptic segmentation. A method according to an embodiment of the present disclosure may comprise: extracting a plurality of image feature maps based on an input image; extracting first image feature data through a transformer-based encoder; extracting second image feature data through a pixel decoder; selecting a query set through a query selection unit; extracting an updated query set through a transformer-based decoder; and generating a predicted class and a predicted segmented image. In this regard, A selection operation may be performed on predicted classes and predicted segment images for at least one query on the object.Type: ApplicationFiled: September 27, 2024Publication date: March 27, 2025Applicant: Electronics and Telecommunications Research InstituteInventors: Hee Kyung LEE, Hyon Gon CHOO, Yeong Jun KOH, Jong Hyeon BAEK
