Abstract: Disclosed herein are protein kinase inhibitors, more particularly novel pyrimidine derivatives and pharmaceutical compositions thereof, and method of use thereof.

Abstract: The invention provides a method and system for developing and using diagnoses of one or more underlying health affections in humans or an animal specie using a plurality of biomarkers. A target one or more affections are defined and a set of biomarkers is selected. An index is computed based on the measured levels of the biomarkers. The biomarkers levels are discretized, and each discrete value is multiplied by a corresponding coefficient. The index scale is divided into ranges that are matched with health statuses. A subject's health affection status is subsequently determined by measuring the level of each biomarker in the set, computing the index and matching the index value to the predefined index scale.

Abstract: The present invention relates to video encoding/decoding methods and device, wherein the video encoding method according to the invention comprises the following steps: acquiring information of peripheral blocks; setting the information about a current block based on the information of the peripheral blocks; and encoding the current block based on the set information, wherein the current block and the peripheral blocks may be a CU (coding unit).

Abstract: A method of processing application security for uses in a platform-as-a-service layer (PAAS layer) includes steps as follows. First, an application program is scanned to find out a vulnerable code segment. Then, when the vulnerable code segment isn't fixed through a security process, a secure code segment is weaved into this unfixed vulnerable code segment, so as to ensure the security of the application program. Moreover, a system of processing application security is also disclosed in specification.

Abstract: Methods and devices for biological sample preparation and analysis are disclosed. A device may have a linear or circular arrangement of containers, with a connecting structure such as a bar or disk. Fluidics channels between containers allow the performance of different techniques for sample preparation, such as lysing, washing and elution. Different functional elements, such as grinders or mixers, may be attached to the containers.

Abstract: A method for quasi-synchronous tuning of wavelength or frequency of grating external-cavity semiconductor laser and a corresponding semiconductor laser are provided. A grating or mirror is rotated around a quasi-synchronous tuning point (Pq) as rotation center, so as to achieve the frequency selections by grating and resonance cavity in quasi-synchronous tuning, wherein the angle of the line between the quasi-synchronous tuning point (Pq) and a conventional synchronous tuning point (P0) with respect to the direction of light incident on the grating is determined according to the angle difference between the incidence angle and diffraction angle of light on the grating. According to present invention, approximately synchronous tuning of laser is achieved with a simple and flexible design.

Abstract: Disclosed is a poly-phase reluctance electric motor with transverse magnetic flux, which electric motor is composed of a stator and a rotor. The stator is composed of a housing (1) and a number m of phase armature units which are arranged within the housing (1) along the axial direction successively, with each of the phase armature units being staggered at an electrical angle of 360°/m along the circumferential direction. Each phase armature unit is composed of a unit armature iron core, an armature coil (2) and permanent magnets (3), with the unit armature iron core being composed of a first annular iron core segment (6), a second annular iron core segment (7) and a third annular iron core segment (8). The armature coil (2) is embedded within an annular space formed among the first to the third annular iron core segments (6, 7, 8).

Abstract: The disclosure provides a white coating composition, and a device employing a coating made of the composition. The white coating composition includes 20-55 parts by weight of silicon dioxide particles, 40-75 parts by weight of inorganic material, and 5-40 parts by weight of silsequioxane, wherein the silsequioxane is prepared from monomers comprising a first monomer represented by the Formula (I) and a second monomer represented by the Formula (II) wherein, R1 is independently the same or different methyl or ethyl, and R2 is independently the same or different C1-6 alkyl.

Abstract: A method for providing collaboration services and a collaboration agent device for implementing the method, which allows the collaboration agent devices to handle common functions necessary for the collaboration services and the applications to indirectly interact with each other using the collaboration agent devices so that applications running executed in two or more smart devices can provide the collaboration services in collaboration with each other.

Abstract: A search apparatus and search method of prediction mode having direction are provided. The apparatus and method can be applied to intra-prediction of video processing. An initial prediction mode is quickly selected based on a distribution of directional energy values. A plurality of first-stage prediction modes are obtained by spreading out from the initial prediction mode. A fine adjustment is processed according to the prediction mode of a neighboring block. The coding costs of the first-stage prediction modes are calculated and then the prediction mode with the lowest coding cost is selected. Therefore, a total calculation amount is reduced.

Abstract: As a result of dedicated studies, the present inventors succeeded in discovering, for the first time, that fibrogenesis could be suppressed at the physiological tissue level by inhibiting sulfation at position 4 or 6 of GalNAc, which is a sugar that constitutes sugar chains. Furthermore, the present inventors conducted studies using various disease model animals, and as a result, successfully demonstrated that inhibitors of sulfation at position 4 or 6 of GalNAc had therapeutic effects on diseases caused by tissue fibrogenesis (tissue fibrogenic disorders).

Abstract: Graphene-carbon nanotube multi-stack three-dimensional architectures (graphene-CNT stacks) are formed by a “popcorn-like” growth method, in which carbon nanotubes are grown throughout the architecture in a continuous step. Alternating layers of graphene and a transition metal are grown by a vapor deposition process. The metal is fragmented and etched to form an array of catalytic sites. Carbon nanotubes grow from the catalytic sites in a vapor-solid-liquid process. The graphene-CNT stacks have applications in electrical energy storage devices, such as supercapacitors and batteries. The directly grown carbon nanotube array between graphene layers provides ease of ion diffusion and electron transfer, in addition to being an active material, spacer and electron pathway.

Abstract: The present invention provides a method for manufacturing a semiconductor structure, which comprises: providing an SOI substrate, forming a gate structure on the SOI substrate; etching an SOI layer of the SOI substrate and a BOX layer of the SOI substrate on both sides of the gate structure to form trenches, the trenches exposing the BOX layer and extending partly into the BOX layer; forming sidewall spacers on sidewalls of the trenches; forming inside the trenches a metal layer covering the sidewall spacers, wherein the metal layer is in contact with the SOI layer which is under the gate structure. Accordingly, the present invention further provides a semiconductor structure formed according to aforesaid method.

Abstract: An original wafer, typically silicon, has the form of a desired end PV wafer. The original may be made by rapid solidification or CVD. It has small grains. It is encapsulated in a clean thin film, which contains and protects the silicon when recrystallized to create a larger grain structure. The capsule can be made by heating a wafer in the presence of oxygen, or steam, resulting in silicon dioxide on the outer surface, typically 1-2 microns. At least one support element supports the wafer at the time the capsule is provided and blocks only minimal surface area from contact with the film forming atmosphere. There may be a plurality of support elements, or a surface may provide such support. The capsule contains the molten material during recrystallization, and protects against impurities. Recrystallization may be in air. After recrystallization, the capsule is removed.

Abstract: A goal-oriented numerical control automatic tuning system is used for a numerical controller of a machine tool to automatically tune the machine tool. The system includes a goal-oriented input module for receiving external goal values; a machining test path selecting module for receiving an external machining path; and an automatic machine-tuning equation module including a control equation with a predetermined equation coefficient for receiving the goal values and the machining path from the goal-oriented input module and the machining test path selecting module, respectively, such that an appropriate control parameter can be obtained by calculating the control equation based on the goal values and the machining path, and then this control parameter passed to a numerical controller in order to control actuation of the machine tool.

Abstract: The present invention provides a method for producing modified stable polypeptides introducing at least one non-natural amino acid into the hydrophobic region of the polypeptide. The thermal and chemical stability of such polypeptides is improved compared to those properties of its corresponding wild type proteins. The invention further provides purified leucine zipper and coiled-coil proteins in which the leucine residues have been replaced with 5,5,5-trifluoroleucines, and the modified proteins so produced demonstrate increased thermal and chemical stability compared to their corresponding wild-type natural proteins.

Abstract: A gas shower device having gas curtain comprises a first gas shower unit for injecting a reaction gas, thereby forming a reaction gas region, and a second gas shower unit. The second gas shower unit arranged around a periphery of the first gas shower unit comprises a buffer gas chamber for providing a buffer gas, and a curtain distribution plate. The curtain distribution plate further comprises a plurality through holes for injecting the buffer gas, thereby forming a gas curtain around a periphery of the reaction gas region. In another embodiment, an apparatus for depositing film is provided by utilizing the gas shower device having gas curtain, wherein the gas curtain prevents the reaction gas in the reaction gas region from being affected directly by a vacuum pressure so that a residence time of reaction gas can be extended thereby increasing the utilization of reaction gas and film-forming efficiency.

Abstract: A testing method for a chip with an embedded non-volatile memory and the chip is provided. A remapping circuit and the non-volatile memory are connected to a processor. The non-volatile memory has a test area and an area under test. The test area stores a test program, and the area under test stores data under test. When the processor tests the chip, the processor outputs an original instruction address, and the remapping circuit remaps the original instruction address to generate a remapped instruction address. The processor reads the test program in the test area, and executes the test program to read the data under test in the area under test and to perform a test of toggling the logic circuit.

Abstract: The invention relates to a method for reprogramming target cells to multipotent progenitor cells capable of differentiating into muscular, skeletal or dermal cell lines. In particular, the invention relates to an ex vivo method for preparing induced presomitic mesoderm (iPSM) cells, said method comprising the steps of: a) providing target cells to be reprogrammed, and, b) culturing said target cells under appropriate conditions for reprogramming said target cells into iPSM cells, wherein said appropriate conditions comprises increasing expression of at least one T-Box transcription factor in said target cells. The invention further relates to the use of said iPSM cells, for example, for regenerating skeletal, muscle, dermal and cartilage tissues.

Abstract: [Problem] Many oxide-ion conductors exhibit high functionality at high temperatures due to the large weight and charge of oxide ions, and it has been difficult to achieve the functionality at low temperatures. [Solution] A perovskite oxide having hydride ion conductivity, at least 1 at % of the oxide ions (O2?) contained in a titanium-containing perovskite oxide being substituted with hydride ions (H?). This oxide, in which negatively charged hydride ions (H?) are used for the ionic conduction, has both hydride ion conductivity and electron conductivity. As a starting material, the titanium-containing perovskite oxide is kept together with a powder of an alkali metal or alkaline-earth metal hydride selected from LiH, CaH2, SrH2, and BaH2 in a temperature range of 300° C. or higher and lower than the melting point of the hydride in a vacuum or an inert gas atmosphere to substitute some of the oxide ions in the oxide with the hydride ions, resulting in the introduction of the hydride ions into oxygen sites.