Abstract: Provided herein are compounds of the formula (IV) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful as MITF inhibitors, MITF pathway inhibitors and for the treatment of cancer.

Abstract: A method and apparatus for generating a sampling frequency are provided. A signal is generated, of which frequency is a predetermined multiple of a reference clock, and a frequency offset in a channel is extracted from the entire frequency offset. The amount of shift is calculated by dividing the extracted frequency offset by a predetermined value, and a final sampling frequency is obtained by shifting the frequency of the generated signal by the amount of shift.

Abstract: The assay device (10) comprises a micro flow path (76); a porous medium provided near the distal end portion (80) of the micro flow path (76); and a space (82) provided between the micro flow path (76) and the porous medium for controlling the flow rate of a fluid moving from the micro flow path (76) to the space (82). After a fluid moved along the micro flow path (76) based on a lateral flow is brought into contact with the porous medium beyond the space (82) and is absorbed to the porous medium, the fluid is divided by the space (82) so that the fluid stays in the micro flow path (76). With this structure, it is possible to perform solution exchange in the micro flow path without using an external device such as a pump.

Abstract: Provided is an operation command generation device configured to generate an operation command, which is a collection of jobs to be carried out by a process system including a robot based on a protocol chart including a process symbol representing a process to be carried out on a container containing a process subject, the operation command generation device including: a process job generation unit configured to generate, based on the process symbol, a job for causing the process system to carry out the process on the container at a work area; and a transfer job generation unit configured to generate, when the process represented by the process symbol is not a process to be carried out on the same container, a job to transfer the container from the work area to a retreat area after the process represented by the process symbol has been carried out.

Abstract: In some aspects, the invention provides methods of identifying, detecting, and/or measuring protein-protein interactions. In some aspects, the invention provides methods of identifying and/or characterizing modulators of protein-protein interactions. In some aspects, the invention provides methods of identifying and/or characterizing modulators of protein activity, wherein the methods are based at least in part on measuring interaction between a chaperone and client protein. In some aspects, the invention provides methods for identifying and/or characterizing compounds and/or for assessing compound specificity, wherein the methods are based at least in part on measuring interaction between a chaperone and client protein. In some embodiments, a client protein is a kinase. In some embodiments, a compound is a kinase inhibitor. In some aspects, the invention provides methods of profiling kinase inhibitor specificity.

Abstract: The present invention provides neuroprotective polyphenol compounds, which can be synthetic analogs of fisetin, baicalein or chlorogenic acid, that maintain neuroprotective, anti-inflammatory, glutathione promoting, and/or antioxidant properties. The neuroprotective polyphenol compounds are useful for promoting, enhancing and/or increasing neuron protection, growth and/or regeneration. The polyphenol compounds further find use for increasing and or maintaining intracellular glutathione (GSH) levels. The polyphenol compounds are also useful for treating, preventing, mitigating and/or delaying neurodegenerative conditions, including diabetes, Parkinson's disease, Huntington's disease, Alzheimer's disease, non-Alzheimer's dementias, multiple sclerosis, traumatic brain injury, spinal cord injury or ALS.

Abstract: Systems, apparatus, and methods of asynchronous digital communication include at least one transmitter and/or at least one receiver communicatively coupleable to at least one communication interface for encoding and transmitting digital information as and/or receiving and decoding digital information from a transition between a first symbol and a second symbol, based on a predetermined relationship between the first symbol and the second symbol in such a way that the timing of the symbols is no longer relevant.

Abstract: A front installation node is suitable for integral forming with a front end frame of an aircraft pylon and includes a first lug and a second lug, each respectively protruding outwardly from one of the two sides of the frond end frame; a first connecting rod and a second connecting rod, one end thereof being respectively connected to the first lug and the second lug, and the other end thereof being respectively suitable for connecting to an aircraft engine. The first connecting rod can pivotally connect to the first lug at a first connection point. The second connecting rod and the second lug are respectively connected at a second connecting point and a third connecting point. Using the front installation node to transmit torque is beneficial in reducing the external width of a rear installation node, reducing engine fuel consumption.

Abstract: A method of preparing a fluoroelastomer capable of being vulcanized by using peroxide, the method comprising: in the presence of an initiator and a chain transfer agent, conducting emulsion polymerization reaction on comonomers to obtain a fluoroelastomer. The preparation method utilizes alkyl iodide RIx as the chain transfer agent, and introduces the atom I into the molecular structure of the polymer during the reaction, the atom I acting as a crosslinking point during peroxide vulcanization. The fluoroelastomer obtained via the preparation method greatly improves the performance after being vulcanized; in addition, due to the low cost and extensive sources of alkyl iodide, the preparation method also simplifies the manufacturing process, reduces cost, and has wide application prospects.

Abstract: A zoom lens is provided, which includes an electrode pattern on a substrate, and a liquid-crystal material on the electrode pattern. The electrode pattern includes a plurality of concentric ring electrodes surrounding an innermost electrode. Each of the concentric ring electrodes has an opening. A first trace extends from a first electrode out of an outermost concentric ring electrode to the innermost electrode. The first trace has greater resistance than the concentric ring electrodes and the innermost electrode. A second trace connecting the innermost electrode and a second electrode out of the outermost concentric ring electrode through the openings. The liquid-crystal material includes a liquid-crystal compound with a chemical structure of wherein R is C4-10 alkyl group, n=1 or 2, and each of X is independently H or F.

Abstract: Provided is a stabilizing circuit structure using a sense field effect transistor (sense-FET). A power semiconductor module includes a depletion-mode field effect transistor (D-mode FET) and the sense FET that has same structure as the D-mode FET and varies in area. Also the power semiconductor module includes not only an enhancement-mode field effect transistor (E-mode FET), but also the stabilizing circuit including circuit elements such as a resistor, a capacitor, an inductor, or a diode.

Abstract: The present invention relates to an apparatus for detecting photons according to an atmospheric condition, using a function of adjusting light quantity that can significantly improve reliability of an atmospheric condition analysis result by minimizing noise in a spectrum by maintaining the quantity of incident light uniform within a predetermined range regardless of atmospheric conditions and changes, and to a method of adjusting light quantity. The apparatus for detecting photons in accordance with atmospheric conditions using a function of adjusting light quantity includes: an apparatus case having a light inlet; a light quantity adjuster disposed under the light inlet and adjusting quantity of incident light such that a predetermined quantity of light travels inside; and a controller controlling operation of the light quantity adjuster in accordance with intensity of light detected by the light quantity adjuster.

Abstract: A variable inference system and a variable inference method for a software program are provided. The variable inference system and method calculate a first variable type output corresponding to an unknown variable for a plurality of first basic blocks of a software program. The variable inference system and method calculate a second variable type input corresponding to the unknown variable for a second basic block of the software program. The variable inference system and method calculate a second variable type generation when the second basic block includes a primitive instruction corresponding to the unknown variable. The variable inference system and method calculate a second variable type kill. The variable inference system and method calculate a second variable output corresponding to the unknown variable for the second basic block according to the second variable type input, the second variable type generation and the second variable type kill.

Abstract: Provided is a method for designing a current supply device for wirelessly supplying power to a vehicle having a current collection device. In the design method, the gap between the two adjacent magnetic poles of the current supply device is received as input and then the gap between the current supply device and the current collection device is determined based on the gap between the two magnetic poles. Next, the magnitude of the power to be supplied to the current supply device is determined based on the value required with respect to the magnitude of the magnetic field and the gap between the current supply device and the current collection device. According to the design method, current supply device can easily be designed since various functional requirements are decoupled from each other.

Abstract: A physical unidirectional communication apparatus and method intended to utilize a structure that exploits an electrical signal by which data cannot be transmitted and to guarantee the reliability of data transmission via a transmission method that uses the structure.

Abstract: A phase locked loop includes a signal receiver configured to generate a mixed signal based on the received signal and an oscillator signal, and a frequency control circuit configured to compare the mixed signal to a reference signal, and adjust the oscillator signal based on a result of the comparing.

Abstract: Security guards at big facilities, such as airports, monitor multiple screens that display images from individual surveillance cameras dispersed throughout the facility. If a guard zooms with a particular camera, he will lose image resolution, along with perspective on the surrounding area. Embodiments of the inventive Imaging System for Immersive Surveillance (ISIS) solve these problems by combining multiple cameras in one device. When properly mounted, example ISIS systems offer 360-degree, 100-megapixel views on a single screen. (Other resolutions may also be employed.) Image-stitching software merges multiple video feeds into one scene. The system also allows operators to tag and follow targets, and can monitor restricted areas and sound an alert when intruders breach them.

Abstract: The invention relates to methods for the identification of compounds, peptides and proteins that can act as substrates for histone deacetylases. The invention further relates to compounds of Formula I: F1-X1-L1-X2-P1-X3-G1??(Formula I) The invention relates to the treatment of diseases or disorders mediated by ARID1A (BAF250A).

Abstract: A light fixture includes a light source, a wavelength-conversion material, and a reflector. The light source is configured to emit a first radiation, and has a front surface and a back surface. The wavelength-conversion material is arranged under the front surface and configured to convert the first radiation to a second radiation which has a first portion not able to reach the reflector and a second portion able to reach the reflector. The reflector is arranged over the back surface and configured to reflect the second portion away from the light source without passing through the wavelength-conversion material. The reflector has an end distant from the light source and is arranged in an elevation different from that of the wavelength-conversion material.

Abstract: A receiving terminal in a hybrid network receives a video stream through a broadcasting network. The receiving terminal receives a high speed video stream streamed at a high speed for a defined first period from a first time when switching from the broadcasting network to a communication network depending on a receiving state of the broadcasting network is determined, receives a live video stream streamed in a live form from any one time of the first period, and generates a continuous video stream using the video stream received through the broadcasting network, the high speed video stream, and the live video stream.