Abstract: Disclosed herein are methods of determining the sequence and/or positions of modified bases in a nucleic acid sample present in a circular molecule with a nucleic acid insert of known sequence comprising obtaining sequence data of at least two insert-sample units. In some embodiments, the methods comprise obtaining sequence data using circular pair-locked molecules. In some embodiments, the methods comprise calculating scores of sequences of the nucleic acid inserts by comparing the sequences to the known sequence of the nucleic acid insert, and accepting or rejecting repeats of the sequence of the nucleic acid sample according to the scores of one or both of the sequences of the inserts immediately upstream or downstream of the repeats of the sequence of the nucleic acid sample.

Abstract: Methods for diagnosing and treating cancer associated with an oncogenic Kras mutation in a subject are provided.

Abstract: A heterogeneous storing server and a file storing method thereof are provided. The heterogeneous storing server has a file storing priority table which records different device type groups. The heterogeneous storing server determines the device type group to which a file belongs according to attributes of the file. The heterogeneous storing server stores the file into appropriate storing devices dynamically and adjusts the number of backups of the file in the storing devices dynamically according to a definition of the device type group.

Abstract: Provided is an information processing system configured to: receive a plurality of images; select a standard image; search, in extracting partial images for complementing a too bright region/too dark region in the standard image from a reference images, using correction images obtained by subjecting each of the images to multivalued processing for each division of luminance components, for regions having matching shapes of respective regions included in the correction image of the standard image and the correction images of the other images; and complement image portions corresponding to the too bright region and/or too dark region in the correction image of the standard image using image portions, which are matching regions and correspond to appropriately bright regions, to thereby generate a synthetic image.

Abstract: A scanning method performed by a station (STA) in a wireless LAN system is provided. The method comprises: transmitting a probe request frame; and receiving a short probe response frame from an access point (AP) as a response to the probe request frame. The short probe response frame includes service set ID (SSID) information or compressed SSID information of the AP.

Abstract: Aspects of the present invention relate to a method for manufacturing a high-performance and low-power field effect transistor (FET) element of which surface roughness scattering is minimized or removed, comprising: a first step of etching a strained silicon substrate into a pin structure; a second step of stacking undoped SiGe thereon; a third step of etching the undoped SiGe; a fourth step of etching after performing lithography; a fifth step of stacking doped SiGe thereon; a sixth step of etching the doped SiGe after performing lithography; and a step of forming a transistor element by sequentially stacking an oxide and a gate metal on the doped SiGe and there is an effect of enabling the implementation of a Fin HEMT capable of having all of good channel controllability and a high on-current, which are advantages of a FinFET, and high electron mobility, which is an advantage of an HEMT.

Abstract: Disclosed is a flat plate pulsating heat pipe (FP-PHP) serving as a power-free high efficiency heat transfer system for small electronic devices such as mobile phones and laptop computers. The FP-PHP is manufactured using MEMS technology and configured to have a single-turn loop or a multi-turn loop, each having a single diameter channel or a dual diameter channel. Further, since a working fluid used in a flat plate pulsating heat pipe exhibits different characteristics according to the main working temperature, provided is a flat plate pulsating heat pipe which includes a working fluid having optimum efficiency in the main working temperature.

Abstract: Light-emitting diode (LED) driver systems that are scalable and can be used for N-color LED systems are provided. An LED system having N LED strings of different color can be efficiently driven with independently controllable constant current sources for each string from a single power source. The driver system can include a power converter having an inductor.

Abstract: The present invention relates to a method for a user to adjust the contents of the closed-captioning based on a user's language skill and other needs. The method comprises the steps of: receiving closed captioning contents; determining sub-difficulty levels of the closed captioning contents by comparing the closed captioning contents with at least one classification database; grouping sub-difficulty levels based on preset ranges into difficulty levels; and displaying and adjusting closed captioning contents at difficulty levels chosen by the user.

Abstract: The present invention relates to a compound inhibiting HF-1 activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention demonstrates anticancer activity not by non-selective cytotoxicity but by inhibiting the activity of HIF-1, the transcription factor playing an important role in cancer cell growth and metastasis. Accordingly, the compound or the pharmaceutically acceptable salt thereof according to the present invention inhibits HIF-1 activity, and therefore can be used as a therapeutic agent for solid tumors such as colon cancer, liver cancer, stomach cancer and breast cancer. In addition, the compound or the pharmaceutically acceptable salt thereof according to the present invention can be used as an active ingredient for a therapeutic agent for diabetic retinopathy or arthritis which may become worse when hypoxia-induced VEGF expression by HIF-1 increases.

Abstract: The invention provides materials and methods for producing coreless fruit, or plants that produce coreless fruit. The invention involves combining reduced expression of AGAMOUS (AG) with parthenocarpy. Parthenocarpy can be induced by hormone treatment, or can be provided by reduced or eliminated expression of PISTILATA (PI) or APETALA3 (AP3). The invention provides methods and materials for producing the plants and coreless fruit by genetic modification (GM) and non-GM means. The invention also provides the plants and coreless fruit.

Abstract: Provided is an apparatus and method for frontal audio rendering in interaction with a screen size, the method including measuring playback environment information used to play back input content; and correcting an audio signal to be output based on the measured playback environment information and production environment information included in the input content.

Abstract: Provided are a MapReduce apparatus and a MapReduce control apparatus and method. The MapReduce apparatus includes a map calculator configured to perform a map calculation, a combiner configured to aggregate and summarize map calculation results of the map calculator, a rack combiner configured to aggregate and summarize map calculation results of MapReduce apparatuses connected to the same rack switch according to a policy of a MapReduce control apparatus, and a reduce calculator configured to receive the aggregated and summarized results of the combiner or the rack combiner and perform a reduce calculation.

Abstract: A novel adjuvant composition is provided that is excellent in safety and convenience as compared to the conventional adjuvant such as Alum. An adjuvant composition comprising citrullines, which are water soluble substance present in the living body, and/or a salt thereof; a vaccine composition comprising said adjuvant composition and an antigen; a process for preparing said adjuvant composition and said vaccine composition; and a method for administering said adjuvant composition and said vaccine composition are provided.

Abstract: A feed of at least one of (a) a source liquid including a solvent with a dissolved impurity and (b) a retentate of the source liquid is pumped in a substantially closed loop through a liquid-separation module. The liquid-separation module includes a membrane that passes at least partially purified solvent to a permeate side of the membrane while diverting the impurity in a retentate on the retentate side of the membrane. The purified solvent is extracted from the permeate side of the membrane; and the retentate from the liquid-separation module is pumped to or through a pressurized reservoir with a variable volume for the feed component and recirculated as a component of the feed. Over time, the volume for the feed is reduced and the pressure applied to the feed in the reservoir is increased to balance against an increasing difference in osmotic pressure across the membrane.

Abstract: Provided are an apparatus, method, and system for relaying trading of a distributed energy resource. A distributed energy resource trading relay method performed at a distributed energy resource trading relay apparatus may include receiving an auction request for a plurality of distributed energy resource chunks; calculating an availability probability and a trading probability of each of the auction-requested distributed energy resource chunks; assigning a weight to each of the distributed energy resource chunks based on the calculated availability probability and trading probability; and determining a purchaser having bid for distributed energy resource chunks corresponding to a greatest weight sum as a successful bidder in response to a plurality of purchasers bidding for the distributed energy resource chunks. Since a distributed energy resource may be divided based on a size available at a consumer and thereby traded, the availability of the distributed energy resource may be enhanced.

Abstract: An isolated peptide for inhibiting melanogenesis in a mammal subject is provided. The isolated peptide consisting of an amino acid sequence of SSASTTED (SEQ ID NO: 1). Also provided are methods and compositions for inhibiting melanogenesis in a mammal subject.

Abstract: The present invention includes methods and compositions for enhancing the efficacy of SMCs in the treatment of cancer. In particular, the present invention includes methods and compositions for combination therapies that include an SMC and at least a second agent that stimulates one or more apoptotic or immune pathways. The second agent may be, e.g., an immunostimulatory compound or oncolytic virus.

Abstract: A method for self-tuning a computing system is presented. The method comprises mapping a current workload of the computing system to at least one bucket; measuring a current operation metric representing a current operation of the computing system; determining, based on the current operation metric, at least one optimization scheme for each of the at least one bucket, wherein the at least one optimization scheme includes at least a list of system knobs having optimal values configured to adjust the operation of the computing device to meet at least one predefined target metric; and setting each of the system knobs listed in the at least one determined optimization scheme to its respective value.

Abstract: A solar cell according to embodiments of the inventive concept includes a back electrode on a substrate, a first light absorbing layer including gallium (Ga) and indium (In) on the back electrode, a first buffer layer on the first light absorbing layer, a first window layer on the first buffer layer, a second light absorbing layer including Ga on the first window layer, a second buffer layer on the second light absorbing layer, and a second window layer on the second buffer layer, wherein a composition ratio of (Ga)/(Ga+In) of the first light absorbing layer is lower than that of the second light absorbing layer.