Patents Assigned to INSTITUTE
  • Patent number: 9637798
    Abstract: The invention relates to the identification of genetic signatures and expression profiles that are a part of the Base Excision Repair (BER) pathway, a major DNA repair pathway that modifies base lesions. In one embodiment, the present invention provides a method of determining responsiveness of treatment by BER inhibitors for malignant glioma by determining the presence of a low level of expression of Apex 1, a low level of expression of Apex 2, and a high level of expression of MPG.
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: May 2, 2017
    Assignees: Dignity Health, The Translational Genomics Research Institute
    Inventors: Shwetal V. Mehta, Michael E. Berens, Harshil Dineshkumar Dhruv
  • Patent number: 9636343
    Abstract: The present invention relates to a composition for the prevention and treatment of liver toxicity originated from acetaminophen comprising TNP (N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine) as an active ingredient. The present inventors confirmed that TNP known as a 5-inosito pyrophosphate inhibitor suppressed apoptosis caused by acetaminophen in human embryonic stem cell-derived liver cells, mouse liver cells, and human hepatoma cell lines, up-regulated glutathione converted in liver cells, and inhibited JNK phosphorylation that is a kind of response against stress increased by acetaminophen. The inventors further confirmed that TNP had the activity of protecting liver cells from the toxicity caused by acetaminophen in an animal model. Therefore, TNP can be efficiently used as an active ingredient for a composition for the prevention and treatment of liver toxicity caused by acetaminophen.
    Type: Grant
    Filed: July 3, 2015
    Date of Patent: May 2, 2017
    Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Seyun Kim, Yong-Mahn Han, Young-Ran Kim, Seulgi Lee
  • Patent number: 9639809
    Abstract: A computing device identifies outliers. Support vectors, Lagrange constants, a center threshold value, an upper control limit value, and a lower control limit value are received that define a normal operating condition of a system. The center threshold value, the upper control limit value, and the lower control limit value are computed from the vectors and the Lagrange constants. A first plurality of observation vectors is received for a predefined window length. A window threshold value and a window center vector are computed. A window distance value is computed between the window center vector and the support vectors. Based on comparisons between the computed values and the received values, the first plurality of observation vectors is identified as an outlier relative to the normal operating condition of the system. When the first plurality of observation vectors are identified as the outlier, an alert is output.
    Type: Grant
    Filed: December 23, 2016
    Date of Patent: May 2, 2017
    Assignee: SAS Institute Inc.
    Inventors: Deovrat Vijay Kakde, Sergiy Peredriy, Arin Chaudhuri, Anya M. McGuirk
  • Patent number: 9638521
    Abstract: Methods and systems for non-line-of-sight positioning are disclosed for arbitrarily short to long ranges, where positioning is achieved using a single anchor not requiring tri-/multi-lateration or tri-/multi-angulation. Magnetoquasistatic fields can be used to determine position and orientation of a device in two or three dimensions. Two or three axis coils can be used in receivers and transmitters. The magnetoquasistatic equations are solved in different scenarios, taking into consideration the image signals originating from the interaction between the fields and ground/earth.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: May 2, 2017
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventor: Darmindra D. Arumugam
  • Patent number: 9641412
    Abstract: Provided is a communication control apparatus for controlling data transmission performed by a first communication module and a second communication module, each using a different communication scheme, the apparatus including a receiver to receive traffic information associated with the first communication module, an operating unit to calculate, based on the traffic information, a slack time, starting from a first point in time and ending at a second point in time at which traffic relating to the first communication module occurs, and a transmitter to transmit the slack time to the second communication module, wherein the first point in time is a point in time at which the second communication module requests the slack time from the communication control apparatus in order to transmit data.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: May 2, 2017
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Hong Soog Kim, Sok Kyu Lee
  • Patent number: 9636390
    Abstract: A vaccine for protection against multiple serotypes of Shigella sp., comprising a putative heat shock protein (EL PGI II), and Hypothetical Protein (EL PGIV) is provided.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: May 2, 2017
    Assignees: Indian Council of Medical Research, Post Graduate Institute of Medical Education and Research (PGIMER)
    Inventors: Neelam Taneja, Sapna Pahil, Meera Sharma
  • Patent number: 9639939
    Abstract: A method for vehicle positioning is provided, which includes the steps of identifying at least one vehicle in an image, obtaining identification information of each vehicle from the image, and transforming coordinates of each vehicle in the image into positioning information of the corresponding vehicle according to mapping information. The positioning information is a position of the corresponding vehicle in real world. Precise lane-level vehicle positioning can be achieved based on comparison with the identification information or the positioning information.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: May 2, 2017
    Assignee: Industrial Technology Research Institute
    Inventors: Yu-Chee Tseng, Lien-Wu Chen, Chia-Chen Chang, Yin-Chih Lu, Pei-Chuan Tsai
  • Patent number: 9640806
    Abstract: A bipolar plate for a fuel cell is provided, which includes: a metal substrate having a flow field structure; a conducting adhesion layer formed on the metal substrate and having a polymeric adhesive and a plurality of conductive particles; and a pure graphite layer formed on the conducting adhesion layer and structurally corresponding to the flow field structure of the metal substrate. The graphite layer including expanded graphite powder is adhered to the metal substrate via the conducting adhesion layer, and a portion of the expanded graphite powder is embedded into the conducting adhesion layer.
    Type: Grant
    Filed: October 19, 2016
    Date of Patent: May 2, 2017
    Assignee: Industrial Technology Research Institute
    Inventors: Ho-Yen Hsieh, Wen-Lin Wang, Ching-Ying Huang
  • Patent number: 9636656
    Abstract: Methods are described and related devices, compositions, and systems, in which a caged compound is administered to a biological environment, the caged compound being caged with a long wavelength absorber, the long wavelength being a wavelength greater than or equal to 750 nm; and irradiating the biological environment to excite the long wavelength absorber with light at a wavelength in a range from 900-1100 nm, thus decaging the compound.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: May 2, 2017
    Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, University of Southern California
    Inventors: Dennis A. Dougherty, Robert H. Grubbs, Mark Humayun, Clinton J. Regan, Azita Emami
  • Patent number: 9641845
    Abstract: A method and a device for encoding/decoding images are disclosed. The method for encoding images comprises the steps of: deriving a scan type of a residual signal for a current block according to whether or not the current block is a transform skip block; and applying the scan type to the residual signal for the current block, wherein the transform skip block is a block to which transform for the current block is not applied and is specified on the basis of information indicating whether or not transform for the current block is to be applied.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: May 2, 2017
    Assignees: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE, UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY
    Inventors: Hui Yong Kim, Sung Chang Lim, Jin Ho Lee, Jin Soo Choi, Jin Woong Kim, Gwang Hoon Park, Kyung Yong Kim
  • Patent number: 9636775
    Abstract: This disclosure provides a composite beam generator and a method of performing powder melting or sintering in additive manufacturing process using the same. The composite beam generator comprises: a beam splitter for splitting a beam into a first directed beam and a second directed beam; a beam shaper for shaping a transverse energy distribution profile of the second directed beam to non-circular; at least one beam delivery unit for guiding the first directed beam or the second directed beam; and a beam combiner for receiving the first directed beam and the second directed beam, and respectively generating a first output beam and a second output beam, and combining them into the composite beam.
    Type: Grant
    Filed: December 26, 2014
    Date of Patent: May 2, 2017
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Wei-Chin Huang, Ping-Han Wu, Kuang-Po Chang
  • Patent number: 9638343
    Abstract: A valve actuator, valve, and method of actuation of a valve are disclosed. The valve actuator includes a shape memory alloy element attachable to a valve body, capable of use with a valve to cause movement of the valve between first and second positions responsive to at least a threshold amount of temperature change of the shape memory alloy element. The valve actuator further includes a negative-differential spring applied to the shape memory alloy element, thereby reducing the threshold amount of temperature change needed to cause movement of the valve between the first and second positions.
    Type: Grant
    Filed: December 11, 2012
    Date of Patent: May 2, 2017
    Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, CHEVRON U.S.A. INC.
    Inventors: Eric Wright Gilbertson, Franz Hover, Donald Bryan Freeman, Jose Arellano
  • Patent number: 9641231
    Abstract: A method and apparatus for modulating a baseband signal in beam space MIMO are provided. The baseband signal modulation apparatus may calculate a load value of a plurality of antenna elements using a baseband signal. The baseband signal modulation apparatus may change a phase or a magnitude of a baseband signal or a first band signal having a higher frequency than that of the baseband signal to correspond to the calculated load value.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: May 2, 2017
    Assignee: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventors: Duk Hyun You, Seung Eun Hong
  • Patent number: 9636432
    Abstract: The presently claimed invention provides a photocatalytic air purification unit, comprising a fin structure and an UV lamp. The fin structure comprises a plurality of fins coated with a layer of photocatalyst, and said fin structure is able to increase the surface area for photocatalyst coating, ultimately increasing air pollutant removal efficiency with minimum air resistance. The air purification unit of the present invention is preferably installed in a HVAC system.
    Type: Grant
    Filed: January 29, 2014
    Date of Patent: May 2, 2017
    Assignee: NANO AND ADVANCED MATERIALS INSTITUTE LIMITED
    Inventor: Lok Hang Keung
  • Patent number: 9636368
    Abstract: A method for inhibiting xanthine oxidase and for reducing uric acid levels using a composition obtained by culturing Lactobacillus rhamnosus in a medium. Also disclosed is a composition including a metabolite of Lactobacillus rhamnosus for reducing uric acid levels in a subject and a method for producing the composition.
    Type: Grant
    Filed: August 11, 2015
    Date of Patent: May 2, 2017
    Assignee: Food Industry Research and Development Institute
    Inventors: Siao-Jhen Chen, Yen-Lin Chen, Hsun-Yin Hsu, Shy-Yunn Wann, Mei-Huei Chen, Li-Wen Yu
  • Patent number: 9637797
    Abstract: Provided in the present invention are a method using in vitro measurement of the content of methylation or demethylation of GFRa1 CpG islands to estimate a risk of tumorigenesis and of tumor metastasis, or postoperative life expectancy, and a nucleotide sequence used.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: May 2, 2017
    Assignee: Beijing Institute For Cancer Research
    Inventors: Dajun Deng, Jun Zhang, Zhaojun Liu, Jing Zhou, Liankun Gu, Baozhen Zhang
  • Patent number: 9641782
    Abstract: Expansion of the dynamic range was difficult in conventional amplifying photoelectric conversion devices designed to have a large gain because, when used for high input light intensity, the electric current exceeds the electric current capacity of a near-minimum sized transistor obtained with the design rules. Also, in conventional photoelectric conversion devices, techniques for varying the electric signal outputs in real-time at the device level are necessary for real-time import of observation targets or images having a high contrast ratio and for visualization of local areas in real-time. In order to solve this problem, the present invention provides a gain varying method, a variable gain photoelectric conversion device, a photoelectric conversion cell, a photoelectric conversion array, a read-out method thereof, and a circuit therefor in which amplifying photoelectric conversion devices and field-effect transistors are combined.
    Type: Grant
    Filed: September 16, 2013
    Date of Patent: May 2, 2017
    Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Yutaka Hayashi, Yasushi Nagamune, Toshitaka Ota
  • Patent number: 9638851
    Abstract: A method of manufacturing a wire grid polarizer includes: preparing a stamp having a nanostructure body at one surface and forming a mask layer with anisotropic vapor deposition at the one surface; forming a metal film on a substrate; transferring a mask layer of an upper portion of a nanostructure body in the mask layer onto the metal film; and patterning the metal film into metal lines by removing a portion that is not covered with the mask layer in the metal film with dry etching.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: May 2, 2017
    Assignee: KOREA INSTITUTE OF MACHINERY & MATERIALS
    Inventors: Jun-Ho Jeong, Junhyuk Choi, Dae-Guen Choi, So Hee Jeon, Ji Hye Lee, Joo Yun Jung, Soon-Hyoung Hwang, Sang Keun Sung
  • Patent number: 9636428
    Abstract: The present disclosure is directed to sulfonic esters of metal oxides including those of formulas I and II:
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: May 2, 2017
    Assignees: California Institute of Technology, Children's Hospital of Los Angeles
    Inventors: Carl M. Blumenfeld, Karn Sorasaenee, Harry B. Gray, Robert H. Grubbs
  • Patent number: D785781
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: May 2, 2017
    Assignee: DNA Medicine Institute, Inc.
    Inventor: Eugene Y. Chan