Abstract: The invention relates to the identification of genetic signatures and expression profiles that are a part of the Base Excision Repair (BER) pathway, a major DNA repair pathway that modifies base lesions. In one embodiment, the present invention provides a method of determining responsiveness of treatment by BER inhibitors for malignant glioma by determining the presence of a low level of expression of Apex 1, a low level of expression of Apex 2, and a high level of expression of MPG.

Abstract: The present invention relates to a composition for the prevention and treatment of liver toxicity originated from acetaminophen comprising TNP (N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine) as an active ingredient. The present inventors confirmed that TNP known as a 5-inosito pyrophosphate inhibitor suppressed apoptosis caused by acetaminophen in human embryonic stem cell-derived liver cells, mouse liver cells, and human hepatoma cell lines, up-regulated glutathione converted in liver cells, and inhibited JNK phosphorylation that is a kind of response against stress increased by acetaminophen. The inventors further confirmed that TNP had the activity of protecting liver cells from the toxicity caused by acetaminophen in an animal model. Therefore, TNP can be efficiently used as an active ingredient for a composition for the prevention and treatment of liver toxicity caused by acetaminophen.

Abstract: A computing device identifies outliers. Support vectors, Lagrange constants, a center threshold value, an upper control limit value, and a lower control limit value are received that define a normal operating condition of a system. The center threshold value, the upper control limit value, and the lower control limit value are computed from the vectors and the Lagrange constants. A first plurality of observation vectors is received for a predefined window length. A window threshold value and a window center vector are computed. A window distance value is computed between the window center vector and the support vectors. Based on comparisons between the computed values and the received values, the first plurality of observation vectors is identified as an outlier relative to the normal operating condition of the system. When the first plurality of observation vectors are identified as the outlier, an alert is output.

Abstract: Methods and systems for non-line-of-sight positioning are disclosed for arbitrarily short to long ranges, where positioning is achieved using a single anchor not requiring tri-/multi-lateration or tri-/multi-angulation. Magnetoquasistatic fields can be used to determine position and orientation of a device in two or three dimensions. Two or three axis coils can be used in receivers and transmitters. The magnetoquasistatic equations are solved in different scenarios, taking into consideration the image signals originating from the interaction between the fields and ground/earth.

Abstract: Provided is a communication control apparatus for controlling data transmission performed by a first communication module and a second communication module, each using a different communication scheme, the apparatus including a receiver to receive traffic information associated with the first communication module, an operating unit to calculate, based on the traffic information, a slack time, starting from a first point in time and ending at a second point in time at which traffic relating to the first communication module occurs, and a transmitter to transmit the slack time to the second communication module, wherein the first point in time is a point in time at which the second communication module requests the slack time from the communication control apparatus in order to transmit data.

Abstract: A vaccine for protection against multiple serotypes of Shigella sp., comprising a putative heat shock protein (EL PGI II), and Hypothetical Protein (EL PGIV) is provided.

Abstract: A method for vehicle positioning is provided, which includes the steps of identifying at least one vehicle in an image, obtaining identification information of each vehicle from the image, and transforming coordinates of each vehicle in the image into positioning information of the corresponding vehicle according to mapping information. The positioning information is a position of the corresponding vehicle in real world. Precise lane-level vehicle positioning can be achieved based on comparison with the identification information or the positioning information.

Abstract: A bipolar plate for a fuel cell is provided, which includes: a metal substrate having a flow field structure; a conducting adhesion layer formed on the metal substrate and having a polymeric adhesive and a plurality of conductive particles; and a pure graphite layer formed on the conducting adhesion layer and structurally corresponding to the flow field structure of the metal substrate. The graphite layer including expanded graphite powder is adhered to the metal substrate via the conducting adhesion layer, and a portion of the expanded graphite powder is embedded into the conducting adhesion layer.

Abstract: Methods are described and related devices, compositions, and systems, in which a caged compound is administered to a biological environment, the caged compound being caged with a long wavelength absorber, the long wavelength being a wavelength greater than or equal to 750 nm; and irradiating the biological environment to excite the long wavelength absorber with light at a wavelength in a range from 900-1100 nm, thus decaging the compound.

Abstract: A method and a device for encoding/decoding images are disclosed. The method for encoding images comprises the steps of: deriving a scan type of a residual signal for a current block according to whether or not the current block is a transform skip block; and applying the scan type to the residual signal for the current block, wherein the transform skip block is a block to which transform for the current block is not applied and is specified on the basis of information indicating whether or not transform for the current block is to be applied.

Abstract: This disclosure provides a composite beam generator and a method of performing powder melting or sintering in additive manufacturing process using the same. The composite beam generator comprises: a beam splitter for splitting a beam into a first directed beam and a second directed beam; a beam shaper for shaping a transverse energy distribution profile of the second directed beam to non-circular; at least one beam delivery unit for guiding the first directed beam or the second directed beam; and a beam combiner for receiving the first directed beam and the second directed beam, and respectively generating a first output beam and a second output beam, and combining them into the composite beam.

Abstract: A valve actuator, valve, and method of actuation of a valve are disclosed. The valve actuator includes a shape memory alloy element attachable to a valve body, capable of use with a valve to cause movement of the valve between first and second positions responsive to at least a threshold amount of temperature change of the shape memory alloy element. The valve actuator further includes a negative-differential spring applied to the shape memory alloy element, thereby reducing the threshold amount of temperature change needed to cause movement of the valve between the first and second positions.

Abstract: A method and apparatus for modulating a baseband signal in beam space MIMO are provided. The baseband signal modulation apparatus may calculate a load value of a plurality of antenna elements using a baseband signal. The baseband signal modulation apparatus may change a phase or a magnitude of a baseband signal or a first band signal having a higher frequency than that of the baseband signal to correspond to the calculated load value.

Abstract: The presently claimed invention provides a photocatalytic air purification unit, comprising a fin structure and an UV lamp. The fin structure comprises a plurality of fins coated with a layer of photocatalyst, and said fin structure is able to increase the surface area for photocatalyst coating, ultimately increasing air pollutant removal efficiency with minimum air resistance. The air purification unit of the present invention is preferably installed in a HVAC system.

Abstract: A method for inhibiting xanthine oxidase and for reducing uric acid levels using a composition obtained by culturing Lactobacillus rhamnosus in a medium. Also disclosed is a composition including a metabolite of Lactobacillus rhamnosus for reducing uric acid levels in a subject and a method for producing the composition.

Abstract: Provided in the present invention are a method using in vitro measurement of the content of methylation or demethylation of GFRa1 CpG islands to estimate a risk of tumorigenesis and of tumor metastasis, or postoperative life expectancy, and a nucleotide sequence used.

Abstract: Expansion of the dynamic range was difficult in conventional amplifying photoelectric conversion devices designed to have a large gain because, when used for high input light intensity, the electric current exceeds the electric current capacity of a near-minimum sized transistor obtained with the design rules. Also, in conventional photoelectric conversion devices, techniques for varying the electric signal outputs in real-time at the device level are necessary for real-time import of observation targets or images having a high contrast ratio and for visualization of local areas in real-time. In order to solve this problem, the present invention provides a gain varying method, a variable gain photoelectric conversion device, a photoelectric conversion cell, a photoelectric conversion array, a read-out method thereof, and a circuit therefor in which amplifying photoelectric conversion devices and field-effect transistors are combined.

Abstract: A method of manufacturing a wire grid polarizer includes: preparing a stamp having a nanostructure body at one surface and forming a mask layer with anisotropic vapor deposition at the one surface; forming a metal film on a substrate; transferring a mask layer of an upper portion of a nanostructure body in the mask layer onto the metal film; and patterning the metal film into metal lines by removing a portion that is not covered with the mask layer in the metal film with dry etching.

Abstract: The present disclosure is directed to sulfonic esters of metal oxides including those of formulas I and II: