Abstract: An optical film structure includes a first substrate having a first surface and a second surface, an optical component includes a micro-lens array and disposed on the first surface of the first substrate, a micro-lens array including a plurality of micro-lens units each of which has a round concentrated area with a projected radius R formed on the first surface, a planarization layer disposed on the optical component, a light absorbing layer disposed on the planarization layer and including a plurality of light absorbing units each of which has a width W. Light incident from the second surface of the first substrate and passing through the micro-lens array is focused on the light absorbing units. The micro-lens array and the planarization layer have a difference in refractive index greater than or equal to 0.2; and W is less than or equal to R/2.

Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the system is used to monitor how organ systems respond to agents such as toxins or medications. The system enables the precise and controlled delivery of these agents, which, in some implementations, enables the biomimetic dosing of drugs in humans to be mimicked.

Abstract: Disclosed are an amphipathic peptide-lipase conjugate with enhanced lipase activity, a polynucleotide coding for the conjugate, an expression vector carrying the polynucleotide, a transformant anchoring the expression vector therein, a method for preparing the conjugate, a lipolysis method using the conjugate, and a method for producing biodiesel using the lipase.

Abstract: The present invention relates to a bidirectional voice transmission system and a method thereof, wherein the system timing of the system is divided into three time slots for carrying a control signal, a broadcast voice signal and a mobile device voice signal. The bidirectional voice transmission system is able to carry out the signal transmission by way of frequency frogging, so as to effectively avoid the signal interference from occurring between any two different signal transmitting and receiving devices. Besides, all of the mobile devices can be added into the bidirectional voice transmission system by way of dynamic building, without using any specific communication interface. The most important is that, the number of node routers can be expanded to about 65,000 in order to apply the bidirectional voice transmission system in a huge range network communication or a wild rescue field.

Abstract: The present invention relates to identification of Zinc-ZIP8-MTF1 axis that plays an important role to OA (osteoarthritis) pathogenesis process and a novel use thereof. According to the present invention, ZIP8 and MTF1 of the present invention increase in the expression in joint disease induced cells or cartilage tissue, and induce the expression of various matrix-degrading enzymes (e.g., MMP-3, MMP-9, MMP-12, MMP-13 and ADAMTS-5 etc.). In addition, when the expression of ZIP8 or MTF1 is inhibited in cells or tissues of animals (e.g., human, mouse), OA pathogenesis is inhibited. Therefore, the ZIP8 and MTF1 of the present invention may be applied to the diagnosis or prognosis of joint diseases, and may be used for the development of therapeutics for joint diseases using these.

Abstract: Disclosed is a humanized monoclonal antibody that binds to the human immunoglobulin heavy chain variable region germline gene VHI-69. The antibody is derived from Mab G6 and recognizes the same epitope. Moreover, the antibody is used in combination with vaccines to augment an immune response to the antigen.

Abstract: The invention provides aromatherapy devices that may be used to break a capsule containing a desired aromatic liquid, and then control the release of the aroma as the volatile aromatic liquid evaporates. The devices may be used, for example, in aromatherapy, including to control nausea or to mask unpleasant scents.

Abstract: In an apparatus and a method for liquid transfer imprint lithography, the apparatus includes a roll unit, a plane unit and a control unit. The roll unit includes a roll stamp, a horizontal moving stage, a roll angular compensating stage and a roll rotating part. The plane unit is disposed under the roll unit and includes a first substrate, a first fixing chuck, a first substrate driving part, a second substrate, a second fixing chuck and a second substrate driving part. The control unit controls an operation of the roll unit and the plane unit.

Abstract: The present invention relates to new salts of pyrazolopyrimidinone represented by formula (I), and pharmaceutically acceptable polymorph, solvate, hydrate, dehydrate, co-crystallization, anhydrous, or amorphous form thereof, the pharmaceutical compositions, and a pharmaceutical unit dosage form containing the same, wherein x represents organic or inorganic acids, preferable maleic acid, succinic acid, methanesulfonic acid, hydrochloric acid, etc. The invention further relates to co-crystals or complexes of compounds of pyrazolopyrimidinone and pharmaceutical compositions containing the same. The present invention also relates to a process for the preparation, use thereof and pharmaceutical preparation containing the salts or crystalline forms.

Abstract: The present application discloses a control method of a fire fighting truck for high-rise and super high-rise building firefighting, including: a command control equipment (2), a launch control equipment (3), a turret control apparatus (8), a photoelectric detection equipment (9), wherein the photoelectric detection equipment (9) comprises: an installing shell, a power supply, a white light zoom camera, an infrared camera, a laser rangefinder, and an integrated processing unit, the white light zoom camera is connected to the installing shell by a screw, the infrared camera is connected to the installing shell by a screw, the laser rangefinder is connected to the installing shell by a screw, a power supply interface of the white light zoom camera is connected to the power supply by a wire, a power supply interface of the infrared camera is connected to the power supply by a wire, a power supply interface of the laser rangefinder is connected to the power supply by a wire, a data interface of the white light zo

Abstract: Methods and devices for preparing microscale polymer relief structures from a thin polymer layer on an absorbing substrate are described. The described methods are ultrafast (about 8 nanoseconds) and allow formation of patterned microstructures having complex morphologies and narrow line widths that are an order of magnitude smaller than the masks used in the methods.

Abstract: Provided is a pharmaceutical composition for preventing or treating a cognitive impairment-related disease, the pharmaceutical composition including N-(2-hydroxyethyl)piperazine-N?(3-propane sulfonic acid), a pharmaceutically acceptable salt thereof or a derivative thereof, and donepezil, a pharmaceutically acceptable salt thereof or a derivative thereof. The composition may be used in preventing or treating a cognitive impairment-related disease.

Abstract: The present invention relates to an Aster glehni extract, a fraction thereof and the active compounds isolated therefrom, which are effective for the treatment, prevention and improvement of hyperuricemia or gout. The Aster glehni extract, the fraction thereof and 6?-O-caffeoylampelopsisionoside, 6?-O-caffeoylroseoside, 6?-O-caffeoylsonchuinoside C, 6?-O-caffeoyldihydrosyringin and glehnoside as the active compounds isolated from the fraction according to the present invention have substantial effect of inhibiting production of uric acid and decreasing its concentration. Accordingly, the Aster glehni extract, the fraction thereof and the active compounds isolated therefrom the fraction according to the present invention can be effectively used as an active ingredient of a drug, health food, etc. for the treatment, prevention and improvement of such as hyperuricemia or gout, which are diseases induced by increased level of uric acid.

Abstract: Disclosed herein are compositions, systems and methods for delivery of proteins of interest using adeno-associated virus (AAV) vectors.

Abstract: Embodiments described herein generally relate to compositions comprising a graphene oxide species. In some embodiments, the compositions advantageously have relatively high oxygen content, even after annealing.

Abstract: The present disclosure provides an isolated, engineered or non-naturally occurring protein comprising an antibody light chain variable domain (VL) which may comprise at least one negatively charged amino acid positioned between residues 49 to 56 according to the numbering system of Kabat, the protein capable of binding specifically to an antigen.

Abstract: Systems and methods for monitoring babies with cameras using a centralized computation and storage center that allows using visual output signals for computer vision and machine learning analysis and high-level reasoning of baby movements. The system comprises a camera located at a predefined working point above a baby's crib, and one or more communication networks between components of the system including a web-based network for in-depth computer vision and machine learning analysis of the visual output signals by an analysis server.

Abstract: Polymer microparticles spatially and spectrally encoded using upconversion nanocrystals (UCN) are described for labeling of articles and tissues. UCN having spectrally distinguishable emission spectra are disposed in different portions of an encoding region of each microparticle.

Abstract: This invention relates to a radioisotope battery and a method of manufacturing the same, wherein manufacturing the radioisotope battery and shielding radiation emitted from the radioisotope Ni-63 from the outside are achieved simultaneously. This radioisotope battery includes a semiconductor layer, a seed layer formed on the semiconductor layer, a radioisotope layer formed on the seed layer, and a radiation shielding layer formed on the radioisotope layer and for shielding radiation of the radioisotope layer form the outside.

Abstract: An optical-to-optical inline spatial domain multiplexing (SDM) de-multiplexer for SDM communication comprising a plurality of concentric core layers each having a beveled output end and a cladding layer concentrically surrounding each core layer. The cladding layer has an index that is lower than the index of the core layer it surrounds. Also included is a system for SDM communication comprising at least one optical source to transmit optical energy, an SDM optical carrier fiber to receive optical energy from the source and output a plurality of SDM signals, a SDM de-multiplexer as described above wherein the SDM signals output from the carrier fiber are each incident upon one of the core layers, optical output fibers positioned to couple SDM signals from each cladding layer, and a photodetector communicatively coupled to the outputs of the optical output fibers to couple the SDM signals output from the optical output fibers.