Abstract: A humanized antibody, or a binding fragment thereof, wherein the humanized antibody binds human ENO1 (GenBank: AAH50642.1), wherein the antibody comprises a light chain variable region (VL) domain comprising a CDR1 having the amino acid sequence LCDR1 (RASENIYSYLT; SEQ ID NO: 6) and a CDR2 having the amino acid sequence LCDR2 (NAKTLPE; SEQ ID NO: 7) and a CDR3 having the amino acid sequence LCDR3 (QHHYGTPYT; SEQ ID NO: 8) and an antibody heavy chain variable region (VH) domain comprising a CDR1 having the amino acid sequence HCDR1 (GYTFTSCVMN; SEQ ID NO: 3), a CDR2 having the amino acid sequence HCDR2 (YINPYNDGTKYNEKFKG; SEQ ID NO: 4) and a CDR3 having the amino acid sequence HCDR3 (EGFYYGNFDN; SEQ ID NO: 5), wherein framework regions in the light chain variable region (VL) domain and the heavy chain variable region (VH) domain comprise amino acid sequences from a human immunoglobulin.

Abstract: A board assembly for transmitting a high-speed signal and a method of manufacturing the same. The board assembly may include a submount board, a base board, and a contact member for a signal line. The submount board may include at least one first high-speed signal line formed on the surface thereof. The base board may include the submount board on one part of the upper surface thereof, and at least second high-speed signal line on the other part of the upper surface thereof, wherein the second high-speed signal lines corresponds to the first high-speed signal lines, respectively. The contact member for the signal line may be installed on the side of the submount board, and have an upper portion contacting the first high-speed signal line and a lower portion contacting the second high-speed signal line such that the first high-speed signal line contacts the second high-speed signal line.

Abstract: Embodiments described herein generally relate to compositions comprising a graphene oxide species. In some embodiments, the compositions advantageously have relatively high oxygen content, even after annealing.

Abstract: In an apparatus and a method for liquid transfer imprint lithography, the apparatus includes a roll unit, a plane unit and a control unit. The roll unit includes a roll stamp, a horizontal moving stage, a roll angular compensating stage and a roll rotating part. The plane unit is disposed under the roll unit and includes a first substrate, a first fixing chuck, a first substrate driving part, a second substrate, a second fixing chuck and a second substrate driving part. The control unit controls an operation of the roll unit and the plane unit.

Abstract: The present invention relates to new salts of pyrazolopyrimidinone represented by formula (I), and pharmaceutically acceptable polymorph, solvate, hydrate, dehydrate, co-crystallization, anhydrous, or amorphous form thereof, the pharmaceutical compositions, and a pharmaceutical unit dosage form containing the same, wherein x represents organic or inorganic acids, preferable maleic acid, succinic acid, methanesulfonic acid, hydrochloric acid, etc. The invention further relates to co-crystals or complexes of compounds of pyrazolopyrimidinone and pharmaceutical compositions containing the same. The present invention also relates to a process for the preparation, use thereof and pharmaceutical preparation containing the salts or crystalline forms.

Abstract: An endoscope robot inserted into a duct to perform a predetermined work includes a flexible first tube body, a joint structure coupled to an end of the first tube body, and an end-effector connected to the joint structure so that location and direction of the end-effector are adjusted by the joint structure. The joint structure includes a fixed arm coupled to an end of the first tube body, and a plurality of pivotal arms arranged in order in a row from the fixed arm and pivotally connected to each other. The first tube body curves and linearly moves in the duct to move the end-effector to a working position. The plurality of pivotal arms is pivoted at the working position to adjust location and direction of the end-effector.

Abstract: The present disclosure provides an isolated, engineered or non-naturally occurring protein comprising an antibody light chain variable domain (VL) which may comprise at least one negatively charged amino acid positioned between residues 49 to 56 according to the numbering system of Kabat, the protein capable of binding specifically to an antigen.

Abstract: An optical-to-optical inline spatial domain multiplexing (SDM) de-multiplexer for SDM communication comprising a plurality of concentric core layers each having a beveled output end and a cladding layer concentrically surrounding each core layer. The cladding layer has an index that is lower than the index of the core layer it surrounds. Also included is a system for SDM communication comprising at least one optical source to transmit optical energy, an SDM optical carrier fiber to receive optical energy from the source and output a plurality of SDM signals, a SDM de-multiplexer as described above wherein the SDM signals output from the carrier fiber are each incident upon one of the core layers, optical output fibers positioned to couple SDM signals from each cladding layer, and a photodetector communicatively coupled to the outputs of the optical output fibers to couple the SDM signals output from the optical output fibers.

Abstract: Provided is a hidden node detection method and apparatus in a wireless communication system, the apparatus including a sensing unit to sense a first communication device transmitting a data signal from among a plurality of communication devices sharing a wireless channel, a transmitter to generate a reception notification signal in response to the sensing, and transmit the reception notification signal to the a plurality of communication devices through a band identical to a transmission band of the data signal, and a controller to prevent a collision with the data signal transmitted from the first communication device through the wireless channel by delaying processing of a data transmission request when the data transmission request is input from a second communication device among the plurality of communication devices while maintaining the transmitting of the reception notification signal.

Abstract: Provided is a method of manufacturing an organic light-emitting device including a graphene layer. The method of manufacturing an organic light-emitting device according to the present invention may include providing a graphene donor unit including a patterned graphene layer, providing a device unit, and attaching the graphene layer of the graphene donor unit to an organic part. The device unit may include a substrate, a lower electrode, and the organic part which are sequentially stacked, and the organic part may include a dopant. The graphene donor unit may include the graphene layer, a release layer, and an elastic stamp layer which are sequentially stacked.

Abstract: The present invention discloses a method for manufacturing a semiconductor device, comprising the steps of: forming a dummy gate stack structure on a substrate, wherein the dummy gate stack structure contains carbon-based materials; forming source/drain region in the substrate on both sides of the dummy gate stack structure; performing etching to remove the dummy gate stack structure until the substrate is exposed, resulting in a gate trench; and forming a gate stack structure in the gate trench. In accordance with the method for manufacturing a semiconductor device of the present invention, the dummy gate made of carbon-based materials is used to substitute the dummy gate made of silicon-based materials, then no oxide liner and/or etch blocking layer needs be added while the dummy gate is removed by etching in the gate last process, thus the reliability of device is ensured while the process is simplified and the cost is reduced.

Abstract: Methods and devices for preparing microscale polymer relief structures from a thin polymer layer on an absorbing substrate are described. The described methods are ultrafast (about 8 nanoseconds) and allow formation of patterned microstructures having complex morphologies and narrow line widths that are an order of magnitude smaller than the masks used in the methods.

Abstract: Various embodiments include a system having interfaces, storage devices, memory, and processing circuitry. The system may be coupled with one or more storage devices and may receive episode information for a patient from a storage device via one or more wired or wireless links, the episode information includes a plurality of episodes associated with the patient, each of the plurality of episodes is a specific instance of a medical condition. The system may generate a candidate episode pairs list comprising a plurality of candidate episode pairs. Embodiments may also include the system generating a transition list comprising episode pairs from the plurality of candidate episode pairs in the candidate episode pairs list and determining attribute relationships between the plurality of episodes for the patient based on episode pairs in the transition list, the attribute relationships used to attribute items between the plurality of episodes.

Abstract: Disclosed are an amphipathic peptide-lipase conjugate with enhanced lipase activity, a polynucleotide coding for the conjugate, an expression vector carrying the polynucleotide, a transformant anchoring the expression vector therein, a method for preparing the conjugate, a lipolysis method using the conjugate, and a method for producing biodiesel using the lipase.

Abstract: A method for producing organic liquid fuels and other valuable products in which an organic compound is provided to an anode electrode having a metal oxide catalyst disposed on an anode side of an electrolyte membrane, thereby producing an organic liquid fuel and/or other valuable organic product and electrons on the anode side. The electrons are conducted to a cathode electrode disposed on a cathode side of the electrolyte membrane, thereby transforming water provided to the cathode side to H2 gas and hydroxide ions. The method is carried out at a temperature less than or equal to about 160° C., preferably at room temperature.

Abstract: A micro-electro mechanical apparatus with interdigitated spring including a substrate, at least one first mass, a movable electrode, a stationary electrode, an anchor and an interdigitated spring is provided. The movable electrode is disposed on the mass along an axial direction. The stationary electrode is disposed on the substrate along the axial direction, and the movable electrode and the stationary electrode have a critical gap there between. The interdigitated springs connects the mass and the anchor along the axial direction. The interdigitated spring includes first folded portions, first connecting portions, second folded portions, and second connecting portions. Each first folded portion includes two first spans and a first head portion. Each second folded portion includes two second spans and a second head portion. A width of the first span and a width of the second span are greater than the critical gap respectively.

Abstract: Three-dimensional patterning methods of a three-dimensional microstructure, such as a semiconductor wire array, are described, in conjunction with etching and/or deposition steps to pattern the three-dimensional microstructure.

Abstract: The present invention relates to an apparatus and method for generating a bidirectional chirp signal by using a phase accumulation polynomial, and the apparatus for generating a bidirectional chirp signal according to an embodiment may include an extraction unit extracting time interval information from the output of a frequency accumulator, a polynomial handling unit applying the phase accumulation polynomial to the extracted time interval information to generate a polynomial output value, and a bidirectional chirp signal output unit outputting a bidirectional chirp signal on the basis of the generated polynomial output value.

Abstract: A system and method for evaluating computational algorithms described in printed publications are provided. The method comprises analyzing a printed publication to identify at least one computational algorithm described in the printed publication; analyzing the at least one identified computational algorithm to identify at least algorithm-indicating information related to the at least one identified computational algorithm; detecting, using the algorithm-indicating information, at least one software container likely to be associated with the at least one identified computational algorithm; and executing the at least one software container in a computing environment, wherein the computing environment includes computing resources configured to support execution of the software container.

Abstract: A method of a nuclear fuel pellet including a thermal conductive metal and a nuclear fuel pellet prepared thereby. The method includes preparing an oxide nuclear fuel granule having about 30%-45% theoretical density, mixing the fuel granule with thermal conductive metal powder, compacting the fuel granule with which the thermal conductive metal powder is mixed to prepare a green pellet, and sintering the green pellet. In the method, the sintering may be performed under a reducing gas atmosphere that is the same as the commercial pellet preparing process. Thus, compatibility compared to existing commercial preparing processes may be superior. Also, since a liquefied oxide formation process and a reducing process are omitted, the distribution uniformity of the metal material within the pellet may be superior. Therefore, the nuclear fuel pellet in which the metal network and fine microstructure are uniformly distributed within the pellet may be prepared.