Abstract: The present invention provides aminohydantoin anti-malarial agents. In some embodiments, these agents have the property of functions of targeting malarial aspartic proteases while at the same time having low activity against human BACE. Methods of employing such agents are also provided.

Abstract: Light to ultra-light cement compositions with modified rheological properties. The cement composition includes cement, hydrophobic nano-silica, at least one additive and a sufficient amount of water to make a cement slurry with high compressive strength, low porosity, low free water, and low fluid loss with a quick thickening time.

Abstract: A display panel comprising a substrate, a meshed shielding pattern, a plurality of light-emitting devices and a solar cell is provided. The substrate has a first surface and a second surface opposite to the first surface, the substrate comprises a first circuit layer disposed over the first surface and a second circuit layer disposed over the second surface. The meshed shielding pattern is disposed on first surface of the substrate to define a plurality of pixel regions over the substrate. The light-emitting devices are disposed on the first surface of the substrate and electrically connected to the first circuit layer, and at least one of the light-emitting devices is disposed in one of the pixel regions. The solar cell is disposed on the second surface of the substrate and electrically connected to the second circuit layer.

Abstract: A cell-penetrating peptide is described. Also described is a pro-apoptotic agent including the cell-penetrating peptide and a pro-apoptotic peptide linked thereto. The pro-apoptotic agent is useful for inhibition of in vitro cell proliferation and for treatment of tumors.

Abstract: A window cleaning apparatus includes a first cleaning unit and a second cleaning unit that is attached to both sides of a window, respectively, by a magnetic force and moved on the sides, and a method of controlling a movement of the window cleaning apparatus. The method includes detecting the first initial attachment position of the window cleaning apparatus and moving the window cleaning apparatus close to the detected initial attachment position after cleaning.

Abstract: Systems and methods for the annotation of source data using confidence labels in accordance embodiments of the invention are disclosed. In one embodiment of the invention, a method for determining confidence labels for crowdsourced annotations includes obtaining a set of source data, obtaining a set of training data representative of the set of source data, determining the ground truth for each piece of training data, obtaining a set of training data annotations including a confidence label, measuring annotator accuracy data for at least one piece of training data, and automatically generating a set of confidence labels for the set of unlabeled data based on the measured annotator accuracy data and the set of annotator labels used.

Abstract: Biological metabolites LysoPC (18:0), LysoPC (20:3), fatty acid (16:1), fatty acid (18:0), fatty acid (18:1), fatty acid (18:2) and fatty acid (22:6) according to the present disclosure allow for simple and accurate diagnosis of a cardiovascular disease since their level in the blood of a subject increases or decreases if the subject has a cardiovascular disease such as myocardial infarction or angina. In addition, whereas the existing biomarkers can diagnose only whether myocardial infarction occurs or not, the biological metabolites according to the present disclosure can diagnose not only myocardial infarction but also unstable angina occurring prior to the onset of myocardial infarction stage by stage.

Abstract: The invention relates to a system and method for lane relative position estimation. The environment of a vehicle is first sensed, and spatial features are then extracted and classified from information obtained from the sensing. The spatial features capture lateral position information within a lane, and an output signal including the result of the classification, which represents the relative lateral positioning of a road location with respect to the overall lane shape, is generated.

Abstract: An electric field-induced carrier generation layer including a p-type material and an n-type material is provided. The p-type material and the n-type material are alternately distributed in at least one direction different from a thickness direction of the electric field-induced carrier generation layer. An organic electronic device is also provided.

Abstract: Functionalized second harmonic nanoprobes for imaging samples and a method of using such probes to monitor the dynamics different processes using a variety of imaging techniques are provided. The functionalized second harmonic generating (SHG) nanoprobes are comprised of various kinds of nanocrystalline materials that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy, and are provided with functional surface modifications that allow for targeted imaging of a variety of biological and non-biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, DNA conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging.

Abstract: A method of treating a medical condition in which suppression of effector T cells is beneficial in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of a CCL1 polypeptide, thereby treating the medical condition in the subject.

Abstract: Systems and methods for the crowdsourced clustering of data items in accordance embodiments of the invention are disclosed. In one embodiment of the invention, a method for determining categories for a set of source data includes obtaining a set of source data, determining a plurality of subsets of the source data, where a subset of the source data includes a plurality of pieces of source data in the set of source data, generating a set of pairwise annotations for the pieces of source data in each subset of source data, clustering the set of source data into related subsets of source data based on the sets of pairwise labels for each subset of source data, and identifying a category for each related subset of source data based on the clusterings of source data and the source data metadata for the pieces of source data in the group of source data.

Abstract: In a computing device supporting distributed stream processing, a request is received from a controller device to redistribute blocks storing streamed data. The request indicates that a number of blocks stored on the computing device be sent to a second computing device. The controller device controls distribution of analytic results to a data access system. The analytic results are computed from the streamed data. The indicated number of blocks are selected from the blocks storing the streamed data. The selected blocks are sent to the second computing device. Pointers to remaining blocks of the blocks storing the streamed data are updated.

Abstract: The present application provides, among other things, a compound of Formula I-a and/or I-b, or a pharmaceutically acceptable salt thereof, wherein the variables are defined in the specification. The compounds of the invention are useful for treating various diseases including cancer.

Abstract: Communication methods for aggregation of heterogeneous component carriers and communication devices and wireless communication stations using the same methods are proposed. In one embodiment, the proposed communication method is adapted to a wireless communication station and includes aggregating physical channel resources respectively corresponding to heterogeneous access technologies in a Layer 2 or below the Layer 2 in a protocol stack; and communicating with at least one wireless terminal communication device through the physical channel resources respectively corresponding to the heterogeneous access technologies, wherein the physical channel resources respectively corresponding to heterogeneous access technologies are heterogeneous component carriers. The physical channel resources may be heterogeneous component carriers, such as radio component carrier(s), optical component carrier(s), and/or acoustic component carrier(s).

Abstract: Reformer-enhanced alcohol engine system. The engine system includes a spark-ignited alcohol engine having a compression ratio in the range of 13-15 and includes a turbocharger or supercharger operatively connected to the engine to provide a pressure boost of at least about 2.5 times atmospheric pressure to cylinders of the engine. A source of alcohol is provided for injection into the engine. A reformer is provided including a low-temperature reforming catalyst in a heat transfer relation with exhaust gas from the engine and arranged to receive alcohol from the alcohol source for reforming the alcohol into a hydrogen-rich gas. Means are provided for injecting the hydrogen-rich gas into the engine and a knock sensor detects knock in the engine. A fuel management control unit is provided which is responsive to the knock sensor to apportion the ratio of alcohol injected into the engine to hydrogen-rich gas injected into the engine.

Abstract: In order to produce metallurgical grade silicon and solar cell grade polysilicon in batches, a method of the present invention comprises: a step of reduction in an arc furnace, consisting of removing C and CO in a silicon reduction atmosphere using silica stone and carbon black by an arc so as to produce metallurgical grade silicon; a step of refining by slag consisting of removing phosphorus (P) and boron (B) by slag; a step of refining by unidirectional solidification consisting of removing metal impurities (Fe, Al, Ti, Mn, etc.) by means of unidirectional solidification; and a step of steam plasma-electromagnetism continuous refining consisting of charging a furnace with the unidirectionally solidified silicon and removing boron (B) by a steam plasma torch.

Abstract: A compound III/V optoelectronic device and method associated with such a device is disclosed. In one aspect, a method for an improved III/V compound optoelectronic device is disclosed. The method comprises applying a sulfur surfactant on the III/V compound optoelectronic device to improve passivation of the III/V compound optoelectronic device. In a second aspect, a III/V compound optoelectronic device is disclosed. The III/V compound optoelectronic device comprises a thin film device with a III/V compound semiconductor absorbing material, and a sulfur surfactant on the III/V compound thin film device to improve passivation of the III/V compound optoelectronic device.

Abstract: Methods and compositions for the diagnosis of cancer susceptibilities, defective DNA repair mechanisms and treatments thereof are provided. Among sequences provided here, the FANCD2 gene has been identified, and probes and primers are provided for screening patients in genetic-based tests and for diagnosing Fanconi Anemia and cancer. The FANCD2 gene can be targeted in vivo for preparing experimental mouse models for use in screening new therapeutic agents for treating conditions involving defective DNA repair. The FANCD2 polypeptide has been sequenced and has been shown to exist in two isoforms identified as FANCD2-S and the monoubiquinated FANCD-L form. Antibodies including polyclonal and monoclonal antibodies have been prepared that distinguish the two isoforms and have been used in diagnostic tests to determine whether a subject has an intact Fanconi Anemia/BRCA pathway.