Abstract: Disclosed in the present invention is a 3-cyanoanilinoalkylarylpiperazine derivatives and use thereof in preparing drugs; the 3-cyanoanilinoalkylarylpiperazine derivatives disclosed by the present invention has very useful pharmaceutical properties and good tolerance, especially the use as novel analgesic drugs, novel antidepressants, and novel analgesic and antidepressive drugs. This class of compounds are central analgesics regulating 5-hydroxytrptamine, and also are novel antidepressants regulating 5-hydroxytrptamine. This class of compounds also has less toxic and side effects and a higher safety range.
Type:
Grant
Filed:
April 9, 2013
Date of Patent:
January 19, 2016
Assignees:
NHWA Pharma, Corporation, Shanghai Institute of Pharmaceutical Industry
Abstract: A pulse radar ranging apparatus and a ranging algorithm thereof are provided. The pulse radar ranging apparatus includes a radio frequency pulse generator, a radio frequency filter, a radio frequency switch and a transceiver aerial. The radio frequency pulse generator generates a pulse signal. The radio frequency filter receives the pulse signal and generates a high-pass filter signal, wherein the high-pass filter signal includes a radio frequency pulse reference signal. The radio frequency switch controls an output of the radio frequency pulse reference signal. The transceiver aerial transmits the radio frequency pulse reference signal. The radio frequency pulse reference signal contacts an object and generates a return signal, and the transceiver aerial receives the return signal. The ranging algorithm processes and analyzes the signals obtained by the pulse radar ranging apparatus, and calculates a distance between pulse radar ranging apparatus and the object by using polynomial interpolation.
Type:
Grant
Filed:
March 15, 2013
Date of Patent:
January 19, 2016
Assignee:
Industrial Technology Research Institute
Abstract: A multi-channel wireless network acquires reference time information that is commonly applied to all multi-channels and acquires packet receiving time information of a received packet on each channel basis based on the reference time information by spreading and applying the reference time information to each channel.
Type:
Grant
Filed:
October 29, 2013
Date of Patent:
January 19, 2016
Assignee:
Electronics and Telecommunications Research Institute
Inventors:
Tae Joon Park, Chang Sub Shin, Wun-Cheol Jeong, Hoyong Kang, In Hwan Lee, Cheol Sig Pyo
Abstract: Disclosed is a photodetector including an electrically conductive substrate, a first electrode formed on the substrate, a second electrode disposed to be spaced apart from the first electrode, a plasmonic nanostructure positioned between the first electrode and the second electrode and having surface plasmon resonance, and a resistance measuring device or an electrical conductivity measuring device connected to the first electrode and the second electrode.
Type:
Grant
Filed:
December 30, 2013
Date of Patent:
January 19, 2016
Assignee:
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Seung Yong Lee, Jin Dong Song, So-Hye Cho, Jin Ock Park, Jong-Ku Park
Abstract: This application relates to the modulation of host cell factors required for influenza virus replication. The application relates to compounds, including nucleic acid compounds (such as, e.g., small interfering RNAs (siRNAs)) and small molecules, that target human host cell factors involved in influenza virus replication, and the use of such compounds for modulating influenza virus replication and as antiviral agents. The application also relates to methods of treating an influenza virus infection and methods of treating or preventing a symptom or disease associated with influenza virus infection, comprising administering to a subject a composition comprising a compound, such as a nucleic acid compound (e.g., an siRNA) or small molecule, that targets a human host cell factor involved in influenza virus replication.
Type:
Grant
Filed:
December 10, 2010
Date of Patent:
January 19, 2016
Assignees:
Icahn School of Medicine at Mounta Sinai, Salk Institute for Biological Studies, Sanford-Burnham Medical Research Institute
Inventors:
Megan Shaw, Peter Palese, Adolfo Garcia-Sastre, Silke Stertz, John Young, Renate König, Sumit Chanda
Abstract: Disclosed are a method for measuring a acoustic transfer function of a predetermined space to be secured or monitored through a correlation between sound signals acquired from a sound source generating device and a sound measuring device and a method and a system for judging whether there is an intrusion object by using a difference between an initially set acoustic transfer function information and varied acoustic transfer function information by using the method for measuring the transfer function. In the present disclosure, when an object moves or an intrusion object is generated in a predetermined space, intrusion or no intrusion is monitored by variation of the acoustic transfer function varied by the intrusion object even though there is no noise generated by the intrusion object.
Type:
Grant
Filed:
October 11, 2011
Date of Patent:
January 19, 2016
Assignee:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Abstract: Disclosed is a 2-pyrrolidone polymer or copolymer having optionally substituted methylol groups, and a process for producing the 2-pyrrolidone polymer or copolymer having methylol groups, the process comprising reacting a 2-pyrrolidone polymer or copolymer with an aldehyde.
Type:
Grant
Filed:
May 22, 2012
Date of Patent:
January 19, 2016
Assignee:
NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
Abstract: Provided is a pharmaceutical composition containing inorganic nanoparticles selected from titanium oxide nanoparticles or silica nanoparticles as an active ingredient for preventing or treating angiogenesis-related diseases. The pharmaceutical composition for preventing or treating angiogenesis-related diseases according to the present invention may be used as a therapeutic agent for various diseases based on angiogenesis such as age-related macular degeneration, tumors, and diabetes-related complications.
Type:
Grant
Filed:
September 20, 2012
Date of Patent:
January 19, 2016
Assignee:
KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE
Inventors:
Tae Geol Lee, Jeong Hun Kim, Dong Hyun Jo
Abstract: A leakage-current start-up reference circuit is provided which includes a reference circuit unit, a trigger unit, a leakage-current generator and a disable control unit. The trigger unit includes a first transistor. The drain terminal of the trigger unit is connected to a start-up terminal of the reference circuit unit. The leakage-current generator includes a second transistor which is a gate-drain-tied transistor. The disable control unit includes a third transistor. The gate terminal of the disable control unit is connected to a control terminal of the reference circuit unit. The drain terminal of the leakage-current generator, the gate terminal of the trigger unit and the drain terminal of the disable control unit are joined at a node. The reference circuit unit is started up by the trigger unit to generate a reference current. A leakage-current start-up reference circuit having a current mirror is also provided.
Type:
Grant
Filed:
May 23, 2014
Date of Patent:
January 19, 2016
Assignee:
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Abstract: Embedded systems are provided, which includes a processing unit and a memory. The processing unit simultaneously executes first thread having a flag for performing a data acquisition operation and second thread for performing a data process and output operation for the acquired data in the data acquisition operation. The flag is used for indicating whether a state of the first thread is in an execution state or a sleep state. The memory which is coupled to the processing unit provides a shared buffer for the first and second threads. Before executing the second thread, the flag is checked to determine whether to execute the second thread, wherein the second thread is executed when the flag indicates the sleep state while execution of the second thread is suspended when the flag indicates the execution state.
Type:
Grant
Filed:
July 16, 2012
Date of Patent:
January 19, 2016
Assignee:
INSTITUTE FOR INFORMATION INDUSTRY
Inventors:
Hsin-Yi Liu, Chih-Chiang Kao, Cheng-Hung Pan, Chun-Tai Yen
Abstract: A base station for a communication system and a handoff method thereof are provided. The base station comprises a transceiver and a processor. The transceiver receives a measurement report message with a present reference signal received quality from a wireless device. The processor electrically connected to the transceiver calculates a next report period, estimates a next reference signal received quality and adjusts a first threshold according to a variance of a reference signal received quality. The processor further enables the transceiver to transmit a first measurement control message to the wireless device according to the next report period. The handoff decision process is triggered based on the first threshold and the next reference signal received quality.
Abstract: The present disclosure proposes a method and apparatuses for geographical zone based radio resource management. The geographical zone based radio resource management method adapted for a control node would receive from a user equipment a request to communicate in a Device to Device (D2D) mode of communication. The control node would validate the user equipment according to a geographical zone in which the user equipment is located in response to the request of the user equipment to communicate in the D2D mode, wherein the geographical zone is formed by at least three control nodes. The control node would then notify the user equipment whether the user equipment may communicate in the D2D mode after the user equipment is authorized.
Type:
Grant
Filed:
April 16, 2013
Date of Patent:
January 19, 2016
Assignee:
Industrial Technology Research Institute
Abstract: Disclosed is a compound which exhibits a higher effect of preventing wrinkle formation, a higher effect of improving wrinkles, a higher effect of making the skin beautiful, and a higher effect of improving skin quality than conventional retinol and retinol derivatives in a sustained manner. Further disclosed are a method for producing the same, and an external composition for the skin and a sheet-shaped cosmetic each containing the same as an active ingredient. More specifically disclosed are retinol-modified collagen in which a dicarboxylic acid is attached to at least one hydroxyl group of collagen and retinol is attached to a carboxyl group of at least one attached dicarboxylic acid, a method for producing the same, and an external composition for the skin and a sheet-shaped cosmetic each containing the same as an active ingredient.
Type:
Grant
Filed:
June 15, 2011
Date of Patent:
January 19, 2016
Assignees:
NATIONAL UNIVERSITY CORPORATION NARA INSTITUTE OF SCIENCE AND TECHNOLOGY, SUNSTAR INC.
Abstract: Provided are a three-dimensional (3D) interconnection structure and a method of manufacturing the same. The 3D interconnection structure includes a wafer that has one side of an inverted V-shape whose middle portion is convex and a lower surface having a U-shaped groove for mounting a circuit, and a first electrode formed to cover a part of the inverted V-shaped one side of the wafer and a part of the U-shaped groove.
Type:
Grant
Filed:
July 25, 2012
Date of Patent:
January 19, 2016
Assignee:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Abstract: The disclosure provides an interlocking device and a three-phase interlocking device for a DC to AC converter (DAC). The interlocking device includes a first interlocking circuit and a second interlocking circuit. The first interlocking circuit couples with a first switch and a second switch, controls whether to conduct the first switch according to the logic levels of a first signal, a second signal and a third signal, and controls whether to conduct the second switch according to the logic levels of the first signal and the second signal. The second interlocking circuit couples with a third switch and a fourth switch, controls whether to conduct the third switch according to the logic levels of the first signal, the third signal and a fourth signal, and controls whether to turn on the fourth switch according to the logic levels of the third signal and the fourth signal.
Type:
Grant
Filed:
December 20, 2013
Date of Patent:
January 19, 2016
Assignee:
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Abstract: According to the embodiments described herein, a SUMOylation inhibitor compound comprising a singleton scaffold is provided. In some embodiments, a method for inhibiting a SUMOylation enzyme in a cell is provided. Such a method may include administering a SUMOylation inhibitor compound to the cell. In some aspects, the SUMOylation enzyme is SUMO E1 or SUMO E2. In some aspects, the method may be used to inhibit a cancer cell in vitro (e.g., grown in culture) or in vivo (e.g., as part of a tumor in a subject). In other embodiments, a method for treating a cancer, degenerative diseases and viral infection is provided. Such a method may include administering an effective amount of a pharmaceutical composition to a subject having the cancer. The pharmaceutical composition may include a singleton SUMOylation inhibitor compound.
Type:
Grant
Filed:
May 9, 2013
Date of Patent:
January 19, 2016
Assignees:
City of Hope, Sanford-Burnham Medical Research Institute at Lake Nona
Abstract: The present invention relates to a system and method for managing resources, which involve managing a plurality of frequency resources in a communication system including a plurality of systems having no right to use a first frequency band. The system comprises a coexistence manager (CM) which manages, when a frequency band usable by the plurality of systems is found in the first frequency band, the plurality of systems so as to enable the coexistence of the systems and frequency-sharing among the systems in the usable frequency band; a coexistence enabler (CE) which transceives information of the plurality of systems and information of the coexistence manager; and a coexistence discovery and information server which supports the control of the coexistence manager on the plurality of systems. The plurality of systems uses the usable frequency band by means of coexistence and frequency-sharing according to a reference model.
Type:
Grant
Filed:
September 2, 2011
Date of Patent:
January 19, 2016
Assignee:
Electronics and Telecommunications Research Institute
Abstract: A MEMS apparatus comprising composite vibrating unit and the manufacturing method thereof are disclosed. The vibrating unit includes a stiffness element on which a first material is disposed. A second material being a conductive material is disposed on the first material and is extended to the stiffness element to remove electric charge on first material. When a temperature is changed, a variation direction of a Young's modulus of the first material is opposite to a variation direction of a Young's modulus of the stiffness element. The unique attributes above allow vibrating unit of the MEMS apparatus such as resonator and gyroscope to have stable resonance frequency against the change of temperature.
Type:
Grant
Filed:
January 8, 2014
Date of Patent:
January 19, 2016
Assignee:
Industrial Technology Research Institute
Inventors:
Chung-Yuan Su, Chao-Ta Huang, Tzung-Ching Lee, Yu-Wen Hsu
Abstract: An object inspection apparatus includes a terahertz wave supplying unit for generating a terahertz wave and moving a path of the terahertz wave according to time so that the terahertz wave is supplied to an object to be inspected, a focusing lens located between the terahertz wave supplying unit and the object to be inspected to focus the terahertz wave supplied by the terahertz wave supplying unit, a rotating plate having a plate shape and including a plurality of the focusing lenses with different distances from the center thereof, the rotating plate rotating in the circumferential direction so that one of the focusing lenses is located at a path of the terahertz wave according to the path movement of the terahertz wave, and a terahertz wave detecting unit for collecting and detecting a terahertz wave incident to the object to be inspected.