Patents Assigned to INSTITUTE
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Patent number: 9101618Abstract: The present invention was accomplished for the purpose of developing a method for effectively treating and/or preventing synucleinopathies, and is based on a discovery that an adiponectin receptor agonist suppresses ? (alpha)-synuclein aggregation, tau phosphorylation and a decrease in proteasomal activity. The method of the present invention for treating and/or preventing neurodegenerative diseases includes a step of administering an effective dose of at least one effective element selected from a group consisting of: adiponectin as an adiponectin receptor agonist; a compound inducing expression of adiponectin; globular adiponectin; and a compound inducing expression of globular adiponectin. The present invention further provides a screening method of the adiponectin receptor agonist for treating and/or preventing neurodegenerative diseases.Type: GrantFiled: August 20, 2012Date of Patent: August 11, 2015Assignee: TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCEInventors: Makoto Hashimoto, Kazunari Sekiyama, Yoshiki Takamatsu, Masayo Fujita, Akio Sekigawa
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Patent number: 9107214Abstract: A method of handling hybrid automatic repeat request (HARQ) acknowledgement responses in a network of a wireless communication system is disclosed. The method comprises assigning resources for a plurality of physical hybrid indicator channels (PHICHs) and a plurality of extended physical hybrid indicator channels (ePHICHs); and transmitting a HARQ acknowledgement response to a communication device of the wireless communication system on a channel selected from the plurality of PHICHs and the plurality of ePHICHs, after receiving an uplink transmission from the communication device.Type: GrantFiled: December 27, 2012Date of Patent: August 11, 2015Assignee: Industrial Technology Research InstituteInventors: Chien-Min Lee, Chia-Pang Yen
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Patent number: 9103534Abstract: A scattered photon extraction light fixture includes an optic element having a first surface; a light source for emitting short wavelength radiation, the light source disposed opposite, perpendicular, or tangential to the first surface of the optic element; a wavelength-conversion material, disposed on the first surface of the optic element, for receiving and down converting at least some of the short wavelength radiation emitted by the light source and transferring a portion of the received and down converted radiation; and one or more reflectors positioned opposite the wavelength-conversion material. A scattered photon extraction light system includes a plurality of light emitting fixtures. One or more wavelength-conversion materials, in the embodiments of the present invention, are disposed remotely from the light source(s), and used to absorb radiation in one spectral region and emit radiation in another spectral region.Type: GrantFiled: January 10, 2014Date of Patent: August 11, 2015Assignee: Rensselaer Polytechnic InstituteInventors: Nadarajah Narendran, Yimin Gu, Jean Paul Freyssinier, Yiting Zhu
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Patent number: 9101671Abstract: Disclosed are compositions and methods related to clot binding compounds. For example, disclosed are conjugates comprising a surface molecule and a plurality of clot binding compounds. The clot binding compounds can selectively bind to clotted plasma protein. The conjugate can, for example, cause clotting and amplify the accumulation of the conjugate in tumors. In one example, the conjugate can comprise a sufficient number and composition of clot binding compounds such that the conjugate causes clotting and amplifies the accumulation of the conjugate in tumors. The disclosed targeting is useful for treatment of cancer and other diseases and disorders.Type: GrantFiled: December 31, 2007Date of Patent: August 11, 2015Assignee: Sanford-Burnham Medical Research InstituteInventors: Erkki Ruoslahti, Dmitri Simberg
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Patent number: 9104965Abstract: An anticipatory monitoring and prediction system can include methods for generating effective, accurate predictions of other traffic objects in the vicinity of an ego-car. The invention proposes to combine approximate probability distributions (ADPs) of agent states with Attractor Functions (AFs) for generating distributed probabilistic representations of the potential future states of the observed traffic objects. AFs are selected based on both the current road context, in which the ego-car is situated, and the current states of all participating objects. The generated predictions can be used to filter incoming sensory information for better object state estimations, rate the nature of the behavior of other traffic objects by comparing generated predictions with actual perceived sensor information, or infer accident likelihoods by comparing the predicted state distributions of objects and the ego-car. Warning and information signals or control commands can be issued in a driving assistance system.Type: GrantFiled: January 7, 2013Date of Patent: August 11, 2015Assignee: HONDA RESEARCH INSTITUTE EUROPE GMBHInventors: Jan Fritsch, Martin Butz, Andreas Alin
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Patent number: 9101908Abstract: Provided is a method for preparing a vanadia-titania catalyst, comprising: vaporizing a titanium precursor; conveying the vaporized titanium precursor to a reaction unit together with an oxygen supplying source; reacting the vaporized titanium precursor conveyed to the reaction unit with the oxygen supplying source to produce titania particles; condensing the titania particles, collecting and recovering them; mixing the recovered titania particles with a vanadium precursor solution; drying the mixture of the titania particles with the vanadium precursor solution; and calcining the dried mixture under oxygen atmosphere or air. Provided also is a vanadia-titania catalyst obtained by the method. The vanadia-titania catalyst has a large specific surface area, uniform and fine nano-scaled size, and high dispersibility, thereby providing excellent nitrogen oxide removal efficiency, particularly in a low temperature range of 200° C.-250° C.Type: GrantFiled: November 27, 2012Date of Patent: August 11, 2015Assignee: Korea Institute of Science and TechnologyInventors: Jong Soo Jurng, Sung Min Chin, Eun Seuk Park
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Patent number: 9104644Abstract: An exemplary embodiment provides an operating method of a software fault-tolerant handling system, and more particularly, to an operating method of a fault-tolerant handling system in which a fault recovery is easy in a fault-tolerant technology of copying with various faults which can occur in a computing device.Type: GrantFiled: March 15, 2013Date of Patent: August 11, 2015Assignee: Electronics and Telecommunications Research InstituteInventor: Kwang Yong Lee
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Patent number: 9102919Abstract: The invention provides compositions and methods of use in reprogramming somatic cells. Compositions and methods of the invention are of use, e.g., for generating or modulating (e.g., enhancing) generation of induced pluripotent stem cells by reprogramming somatic cells. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a pluripotent state and/or enhances the speed and/or efficiency of reprogramming. Certain of the compositions and methods relate to modulating the Wnt pathway.Type: GrantFiled: August 29, 2008Date of Patent: August 11, 2015Assignee: Whitehead Institute for Biomedical ResearchInventors: Brett Chevalier, Alexander Marson, Richard A. Young, Ruth Foreman, Rudolf Jaenisch
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Patent number: 9106262Abstract: A computer processor implementable method of decoding low-density parity-check (LDPC) code, comprising: receiving a log-likelihood-ratio (LLR) input bitstream; performing a combined bit-deinterleaving and reordering process on the LLR input bitstream and storing in a physical memory space, comprising: determining a logical memory address for each LLR bit in the LLR input bitstream, determining a physical memory address for each LLR bit in the LLR input bitstream from logical memory address of the LLR bit; decoding the LLR input bitstream stored in the physical memory space; and performing a combined de-reordering and de-mapping process on the decoded LLR input bitstream.Type: GrantFiled: March 24, 2014Date of Patent: August 11, 2015Assignee: Hong Kong Applied Science and Technology Research Institute Company LimitedInventors: Felix Chow, Chun Hang Lee
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Patent number: 9102734Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.Type: GrantFiled: March 4, 2010Date of Patent: August 11, 2015Assignee: Baylor Research InstituteInventors: Gerard Zurawski, Jacques F. Banchereau, Anne-Laure Flamar, Peter Klucar, Keiko Akagawa, Sandra Zurawski, SangKon Oh
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Patent number: 9102520Abstract: The disclosure relates to nanotube composite structures and related methods and systems. In particular, structures, methods and systems are provided herein to allow for precise, tunable separation between nanomaterials such as carbon nanotubes.Type: GrantFiled: August 12, 2009Date of Patent: August 11, 2015Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Si-Ping Han, Hareem Maune, Robert D. Barish, William A. Goddard, III
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Patent number: 9102555Abstract: The present invention provides a method for removing phosphorus and nitrogen contained in sewage or wastewater using iron ore wastewater. According to the method of the present invention, in which the phosphorus and nitrogen contained in sewage or wastewater are crystallized in the form of struvite using iron ore wastewater containing a large amount of Mg2+ produced in a process of upgrading low-grade iron ore and removed, it is possible to reduce the cost of Mg2+ and the cost of iron ore wastewater treatment, thereby earning economic profits. Moreover, it is possible to prevent water pollution by the removal of the phosphorus and nitrogen contained in sewage or wastewater. Furthermore, it is possible to use struvite crystals obtained as a by-product as a time-release compound fertilizer so as to reduce the amount of fertilizer used and the number of fertilizations, thereby reducing soil contamination.Type: GrantFiled: November 29, 2011Date of Patent: August 11, 2015Assignee: Korea Institute of Geosciences and Mineral ResourcesInventors: Yong Jae Suh, Myung Eun Ju, Dae Sup Kil, Hee Dong Jang
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Patent number: 9101556Abstract: Treatment for alleviating ischemia-reperfusion injury which has minimized risk of side effects and which can suppress neutrophilic infiltration and activation of platelets during ischemia reperfusion comprises administration by inhalation of a mixed gas comprising 21%-98% oxygen, 0.1%-4% hydrogen, 40-80 ppm nitrogen monoxide, and a remainder of inert gas such as nitrogen or helium to a patient undergoing reperfusion from immediately before the start of ischemia reperfusion until shortly after the start of reperfusion.Type: GrantFiled: March 2, 2011Date of Patent: August 11, 2015Assignee: The Kitasato InstituteInventors: Hirosuke Kobayashi, Toshihiro Shimbo, Kenichi Kokubo
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Publication number: 20150216975Abstract: Various embodiments of the present invention provide therapeutic compositions for specifically targeting tumor cells. In some embodiments, the therapeutic compositions generally include: (1) a plurality of nanovectors; (2) one or more active agents associated with the nanovectors, where the one or more active agents have activity against the tumor cells; (3) one or more active agent enhancers associated with the nanovectors; and (4) one or more targeting agents associated with the nanovectors, where the one or more targeting agents have recognition activity for one or more markers of the tumor cells. Additional embodiments of the present invention pertain to methods of targeting tumor cells in a subject by administering one or more of the aforementioned therapeutic compositions to the subject. Further embodiments of the present invention pertain to methods of formulating the aforementioned therapeutic compositions for targeting tumor cells in a subject in a personalized manner.Type: ApplicationFiled: March 15, 2013Publication date: August 6, 2015Applicants: William Marsh Rice University, The Methodist Hospital Research InstituteInventors: David S. Baskin, Daniela Marcano, Martyn A. Sharpe, James M. Tour
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Publication number: 20150219180Abstract: A magnetically suspended and plane-drove vibration isolator with zero stiffness comprises an upper mounting plate, a lower mounting plate and a main body. A sleeve of the main body is lubricated and supported against the lower mounting plate by a magnetically suspended planar motor. A piston cylinder fitted in the sleeve is lubricated against the sleeve by a cylindrical air bearing surface. The angle degree of freedom between the upper mounting plate and the lower mounting plate is decoupled by a spherical air bearing. A position close-loop control system is formed to precisely control the relative position between the upper mounting plate and the lower mounting plate.Type: ApplicationFiled: February 19, 2014Publication date: August 6, 2015Applicant: HARBIN INSTITUTE OF TECHNOLOGYInventors: Jiubin Tan, Junning Cui, Lei Wang
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Publication number: 20150219933Abstract: Disclosed herein is a wearable eyeglass device including: an optical communication module receiving a first optical signal and transmitting a second optical signal; a display module displaying information corresponding to at least one of the first and second optical signals; and a control module controlling the display module to display first information corresponding to the first optical signal at the time of receiving the first optical signal and controlling the optical communication module to transmit the second optical signal corresponding to second information.Type: ApplicationFiled: January 30, 2015Publication date: August 6, 2015Applicant: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTEInventors: Dong-Woo LEE, Hyung-Cheol SHIN, Ga-Gue KIM, Sung-Yong SHIN, Gi-Su HEO, Yong-Ki SON, Hyun-Tae JEONG
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Publication number: 20150222479Abstract: Provided are a method of communicating content in a mobile ad-hoc network and a communication node included in a mobile ad-hoc network, the method and communication node intended to efficiently perform communication based on information centric networking (ICN) in a mobile ad-hoc network and reduce the waste of energy resulting from frequent reconfiguration of communication caused by the mobility of a terminal. The method includes receiving an interest packet or a response packet for content; determining a next node to which the received packet will be relayed based on a forwarding information base (FIB) or a pending interest table (PIT), and relaying the packet using a unicast scheme; and when the relay of the packet to the next node fails, restoring a routing path by storing the packet in a relay candidate buffer and broadcasting the packet.Type: ApplicationFiled: January 7, 2015Publication date: August 6, 2015Applicant: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTEInventors: Jong-Hwan KIM, Il-Gu JUNG, Won RYU, Do-Hyung KIM, Ik-Jun YEOM
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Publication number: 20150218645Abstract: The invention relates to methods and related products for treatment and determining modes of treatment for cancer or prognosis of cancer. Preferably the methods are related to the induction of CD80 in p53 responsive cancer cells.Type: ApplicationFiled: February 1, 2013Publication date: August 6, 2015Applicant: Massachusetts Institute of TechnologyInventors: David Feldser, Tyler E. Jacks, Leah Marie Schmidt
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Publication number: 20150219179Abstract: A vibration isolator with zero stiffness whose angle degree of freedom is decoupled with a spherical air bearing has a main body, in which a sleeve and a lower mounting plate, a piston cylinder and the sleeve are both lubricated and supported with air bearing surfaces respectively, and the angle degree of freedom between a upper mounting plate and the lower mounting plate is decoupled with a spherical air bearing; a position close-loop control system comprising voice coil motors, displacement sensors, limit switches, a controller and a driver is introduced, and the relative position between the upper mounting plate and the lower mounting plate is precisely controlled.Type: ApplicationFiled: February 19, 2014Publication date: August 6, 2015Applicant: HARBIN INSTITUTE OF TECHNOLOGYInventors: Junning Cui, Jiubin Tan, Lei Wang
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Publication number: 20150219443Abstract: Under a known pressure is externally applied to a reference member to which an optical fiber is fixed, test light is allowed to enter the optical fiber, and at least one of a reference Brillouin measurement for determining a reference Brillouin frequency shift amount based on the Brillouin scattering phenomenon, and a reference Rayleigh measurement for determining a reference Rayleigh frequency shift amount based on the Rayleigh scattering phenomenon is performed. A Brillouin measurement coefficient or a Rayleigh measurement coefficient is determined from these calculation results. An optical fiber is fixed to a sample member, the volumetric change of which is unknown, and the same sample Brillouin measurement or sample Rayleigh measurement is performed to determine the frequency shift amount. The volumetric change of the sample member is determined from the sample Brillouin or the sample Rayleigh frequency shift amount, and from the Brillouin or the Rayleigh measurement coefficient.Type: ApplicationFiled: August 10, 2012Publication date: August 6, 2015Applicants: NEUBREX CO., LTD., RESEARCH INSTITUTE OF INNOVATIVE TECHNOLOGY FOR THE EARTHInventors: Ziqiu Xue, Yoshiaki Yamauchi, Kinzo Kishida