Patents Assigned to INSTITUTE
  • Patent number: 8980579
    Abstract: Provided herein are methods for stable integration and/or expression of one or more recombinant polynucleotides in a host cell. The recombinant polynucleotides are typically integrated into the host genome at some native chromosomal integration sites. The integration can be mediated by homologous recombination or by using a hybrid recombinase targeting the specific chromosomal locations. The native chromosomal integration sites in the host cells, which support stable integration and strong transcription activities of foreign genes, are present within or adjacent to specific genes in the CHO genome, the ankyrin 2 gene (Ank2), cleavage and polydenylation specific factor 4 gene (Cpsf4), C-Mos gene, and Nephrocystin-1/Mal gene. Also provided are methods and nucleic acid molecules for inserting site-specific recombination sequences (chromosomal landing pads) into these specific chromosomal locations, engineered host cells containing chromosomal landing pads, methods and compositions (e.g., kits) therefore.
    Type: Grant
    Filed: April 5, 2012
    Date of Patent: March 17, 2015
    Assignee: The Scripps Research Institute
    Inventors: Vincent P. Mauro, Wei Zhou, Bruce Cunningham, Gerald M. Edelman
  • Patent number: 8983006
    Abstract: An orthotope sphere decoding method of a multiple antenna system is disclosed. The method includes performing tree search using a depth-first method by performing an OC-test on the nodes on which the tree search of orthotope sphere decoding will be performed and performing an SC-test on nodes passing the OC-test; and selecting a transmission symbol having a smallest PED value as a final signal as a result of the search.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: March 17, 2015
    Assignee: Gwangju Institute of Science and Technology
    Inventors: Heung-No Lee, Hwanchol Jang
  • Patent number: 8983295
    Abstract: The inventive concept relates to an optical line terminal registering optical network terminals having overlapping serial numbers. The optical line terminal may include a memory storing serial number information of optical network terminals of which a registration is completed in a storage region; and a control part that if a serial number by a serial number request is received from optical network terminals, the received serial number is compared with the serial number information of the memory and if they overlap each other, a previously set preliminary identifier is allocated to the optical network terminal having an overlapping serial number.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: March 17, 2015
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Hark Yoo, Geun Yong Kim, Youngsuk Lee, Sung Chang Kim, Dongsoo Lee
  • Patent number: 8981615
    Abstract: A wound stator core disclosed is substantially formed from a spirally piled strip. In an embodiment, the strip with a specific length is formed with a first dentition and a second dentition, whereas the first dentition is featured by a first slot-number ratio and is composed of a first side and a plurality of first teeth in a manner that the plural first teeth are arranged as an array on the first side; which is also same to the second dentition while allowing the second slot-number ratio to be equal to the first slot-number ratio. In addition, each first tooth is formed with a first dental part at a free end thereof, while also each second tooth is formed with a second dental part at a free end thereof, and the first dental part of each first tooth is connected to the second dental part of its corresponding second tooth.
    Type: Grant
    Filed: January 16, 2013
    Date of Patent: March 17, 2015
    Assignee: Industrial Technology Research Institute
    Inventors: Cheng-Hsuan Lin, Wen-Yang Peng, Han-Ping Yang, Jung-Kang Peng
  • Patent number: 8983942
    Abstract: Disclosed are a method for providing a time machine service based on an SNS (social network service), including: extracting keywords based on SNS information input by SNS users and collecting rich contents relating to the SNS information based on the keywords; dividing points of past, present, and future, based on a predetermined present time period and classifying the rich contents into any one of past information, present information, and future information, based on the division result; and providing the classified rich contents to the SNS users.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: March 17, 2015
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Young Ho Jeong, Jin Woo Hong, Chung Hyun Ahn
  • Patent number: 8979510
    Abstract: A micropump includes: a fluid suction tube for suctioning fluid; a pumping tube connected to the fluid suction tube and providing a suction force and a discharge force to surroundings while repeatedly being expanded and contracted by an external signal; a deform tube connected to the pumping tube and having an aperture that is deformed by the suction force and the discharge force of the pumping tube; and a fluid discharge tube connected to the deform tube and discharging fluid.
    Type: Grant
    Filed: November 10, 2011
    Date of Patent: March 17, 2015
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: Soo Jai Shin, Hyung Jin Sung
  • Patent number: 8983874
    Abstract: A micropayment system and method is presented for a payor U to establish payment to payee M for a transaction T, which typically has a very low value TV. The micropayment scheme minimizes the bank's processing costs, while at the same time eliminating the need for users and merchants to interact in order to determine whether a given micropayment should be selected for payment. In one embodiment, the micropayment scheme includes time constraints, which require that an electronic check C for the transaction T be presented to a bank B for payment within a predetermined time/date interval. In another embodiment, the micropayment scheme includes a selective deposit protocol, which guarantees that a user is never charged in excess of what he actually spends, even within a probabilistic framework. In another embodiment, the micropayment scheme includes a deferred selection protocol, which provides the bank with control and flexibility over the payment selection process.
    Type: Grant
    Filed: October 14, 2009
    Date of Patent: March 17, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Silvio Micali, Ronald L. Rivest
  • Patent number: 8981073
    Abstract: Disclosed are an HCV gene having higher replication efficiency and higher reinfection efficiency than the known HCV gene of genotype 1b, an RNA replicon having this gene, a cell infected with this RNA replicon, which cell allows replication of HCV, and an HCV particle. The hepatitis C virus gene encodes an amino acid sequence wherein the 979th amino acid is threonine; the 1804th amino acid is leucine; and the 1966th amino acid is lysine. An HCV gene which can propagate in vitro and has higher replication efficiency and higher reinfection efficiency than the known HCV gene of genotype 1b was provided.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: March 17, 2015
    Assignee: Advanced Life Science Institute, Inc.
    Inventors: Kenichi Mori, Noboru Maki, Hiromi Fukai
  • Patent number: 8980681
    Abstract: The disclosure provides a method for fabricating a solar cell, including: providing a first substrate; forming a light absorption precursor layer on the first substrate; conducting a thermal process to the light absorption precursor layer to form a light absorption layer, wherein the light absorption layer includes a first light absorption layer and a second light absorption layer, and the first absorption layer is formed on the first substrate; forming a second substrate on the second light absorption layer; removing the first substrate to expose a surface of the first light absorption layer; forming a zinc sulfide (ZnS) layer on the surface of the first light absorption layer; and forming a transparent conducting oxide (TCO) layer on the zinc sulfide (ZnS) layer.
    Type: Grant
    Filed: June 27, 2013
    Date of Patent: March 17, 2015
    Assignee: Industrial Technology Research Institute
    Inventor: Wei-Tse Hsu
  • Patent number: 8978340
    Abstract: Provided is a method for fire-proofing a composite slab constructed of beams installed between columns, a deck plate installed between the beams and slab concrete poured on the beams and the deck plate using a wire rope. Fire-proofing performance of the composite slab manufactured according to the present invention can be enhanced by transferring the load transferred from the deck plate to the upper portion of the beam via the wire rope.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: March 17, 2015
    Assignee: Korea Institute of Construction Technology
    Inventors: Heung-Youl Kim, In-Hwan Yeo, Hyung-Jun Kim, Kyung-Hoon Park, Oh-Sang Kweon
  • Patent number: 8982363
    Abstract: Depth information about a scene of interest is acquired by illuminating the scene, capturing reflected light energy from the scene with one or more photodetectors, and processing resulting signals, in at least one embodiment, a pseudo-randomly generated series of spatial light modulation patterns is used to modulate the light pulses either before or after reflection.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: March 17, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Vivek K. Goyal, Ghulam Ahmed Kirmani
  • Patent number: 8979975
    Abstract: Disclosed is a method of producing low oxygen-content molybdenum powders by reducing molybdenum trioxide, which includes charging a first reducing agent and the molybdenum trioxide, which are in the direct contact with each other on a micro-sieve on an upper portion of a bracket in a body, charging a second reducing agent in the bracket under the micro-sieve, coupling the body with a cover to close the body, and performing a reduction reaction by raising an internal temperature of the body by performing the first reduction reaction due to direct contact between the first reducing agent and the molybdenum trioxide, and performing the second reduction reaction due to evaporation of the second reducing agent. The first and second reduction reactions are performed at a temperature in a range of 550° C. to 650° C., and a temperature in a range of 1000° C. to 1200° C., respectively.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: March 17, 2015
    Assignee: Korea Institute of Geoscience and Mineral Resources
    Inventors: Hyung-Seok Kim, Jung-Min Oh, Chang-Youl Suh, Back-Kyu Lee, Jae-Won Lim
  • Patent number: 8980625
    Abstract: A cell culture plate has a plurality of flow channels, uneven pattern areas and through holes. The flow channels are formed between the uneven pattern areas, and culture solution flows from the flow channels into the uneven pattern areas or from the uneven pattern areas into the flow channels. The uneven pattern area has uneven patterns that create a cell culture space.
    Type: Grant
    Filed: February 24, 2006
    Date of Patent: March 17, 2015
    Assignees: National Food Research Institute, Kuraray Co., Ltd.
    Inventors: Yuji Kikuchi, Hiroko Kikuchi, Taiji Nishi, Takenori Kitani, Yukihiro Yanagawa, Motohiro Fukuda
  • Patent number: 8983124
    Abstract: A moving body positioning device includes a sensor group that outputs a motion velocity vector of a moving body, a motion velocity vector estimation processing device that measures a motion velocity vector and outputs an output sequence of the motion velocity vector together with a measured time, a monitoring camera, an image analysis processing device that analyzes the image of the monitoring camera to measure a position of feet of the moving body measures a motion velocity vector at the position of the feet, and outputs an output sequence of the motion velocity vector with a measured time, and a motion velocity vector collation processing device that collates the output sequence of the motion velocity vector estimation processing device with the output sequence of the image analysis processing device and outputs its collation result as a TRUE or a FALSE signal.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: March 17, 2015
    Assignee: National Institute of Advanced Industrial Science and Technology
    Inventors: Masakatsu Kourogi, Tomoya Ishikawa, Takeshi Kurata
  • Patent number: 8980840
    Abstract: The present invention relates to the management of vaginal health. In particular, the present invention relates to pharmaceutical compositions, and methods of use thereof, for treating diseases associated with compromised boundary lubrication at the vaginal epithelium.
    Type: Grant
    Filed: January 13, 2010
    Date of Patent: March 17, 2015
    Assignees: Schepens Eye Research Institute, Lubris LLC
    Inventors: Edward R. Truitt, III, Benjamin Sullivan, David Sullivan
  • Patent number: 8980926
    Abstract: The present invention relates to methods of treating a subject with malaria comprising administering a 2-aminoindole compound represented by Formula: (I)—The values and preferred values of the variables in Structural Formula I are defined herein.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: March 17, 2015
    Assignees: Genzyme Corporation, President and Fellows of Harvard College, Massachusetts Institute of Technology
    Inventors: Ralph Mazitschek, Jon C. Clardy, Dyann Wirth, Roger Wiegand, Sameer Urgaonkar, Mary Lynn Baniecki, Joseph Cortese, Cassandra Celatka, Yibin Xiang, Renato Skerlj, Elyse M. J. Bourque
  • Patent number: 8981391
    Abstract: A display panel including a substrate, a meshed shielding pattern, and a plurality of light-emitting devices is provided. The meshed shielding pattern is disposed on the substrate so as to define a plurality of pixel regions on the substrate. The light-emitting devices are disposed on the substrate. At least one light-emitting device of the light-emitting devices is disposed in each pixel region of the pixel regions, wherein an area of the pixel region is A1, an area of the light-emitting device is A2, and a ratio of A2 to A1 is below 50%.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: March 17, 2015
    Assignee: Industrial Technology Research Institute
    Inventors: Jui-Ying Lin, Chia-Hsin Chao, Kuang-Yu Tai, Wen-Yung Yeh
  • Patent number: 8982442
    Abstract: A wavelength selective polarization controller capable of controlling the polarization plane of optical wavelength multiplexing signals, for each wavelength component, and which does not generate time lag between each component is provided. This wavelength selective polarization controller has: a telecentric optical system to which optical wavelength multiplexing signals are incident; a polarization controller that controls the polarization plane of light output from the telecentric optical system; and an output optical system for outputting to an optical path output from the polarization controller. The telecentric optical system has: a first diffraction grating to which the optical wavelength multiplexing signals are incident; and a first condenser that condenses the optical wavelength multiplexing signals that have passed through the diffraction grating. The polarization controller has a plurality of phase modulators.
    Type: Grant
    Filed: June 12, 2012
    Date of Patent: March 17, 2015
    Assignees: National Institute of Information and Communications Technology, Optoquest Co., Ltd.
    Inventors: Naoya Wada, Seitetsu Boku, Hiroyuki Yamazaki, Yusaku Tottori
  • Patent number: 8981083
    Abstract: The invention features compositions and methods for treating or preventing a neoplasia. More specifically, the invention provides compositions and methods for disrupting the interaction of a BET family polypeptide comprising a bromodomain with chromatin (e.g., disrupting a bromodomain interaction with an acetyl-lysine modification present on a histone N-terminal tail).
    Type: Grant
    Filed: May 16, 2011
    Date of Patent: March 17, 2015
    Assignee: Dana Farber Cancer Institute, Inc.
    Inventors: James Elliott Bradner, Jun Qi
  • Patent number: 8982793
    Abstract: A method for controlling channel access performed by an access point (AP) in a wireless system is provided. The method includes: receiving at least one frame from at least one station (STA), respectively, for a specific time period, each frame including information on a contention window (CW) used when the frame is transmitted; processing information one at least one CW for each STA; determining whether to control the channel access based on the processed information on the CW; selecting an abnormal STA candidate group if it is determined that the channel access control is performed; and controlling the channel access to each STA included in the abnormal candidate STA group.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: March 17, 2015
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Hyun Gu Park, Sok Kyu Lee