Abstract: The present invention relates to novel hydrogenases isolated from novel hyperthermophilic strains belonging to Thermococcus spp., genes encoding the hydrogenases, and methods of producing hydrogen using strains having the genes. According to the hydrogen production methods of the invention, a large amount of hydrogen can be produced merely by culturing the strains in specific culture conditions. Thus, the methods of the invention have advantages in that they are more economic and efficient than existing hydrogen production methods and can produce hydrogen even at high temperature.

Abstract: Exemplary embodiments provide diagnostic devices, systems and methods for determining the presence or absence of one or more markers or characteristics in one or more samples. An exemplary diagnostic device may display a first two-dimensional machine-readable output to indicate the presence or absence of a first characteristic in a sample. Similarly, the exemplary diagnostic device may display a second two-dimensional machine-readable output to indicate the presence or absence of a second characteristic in a sample. An image capture device may be used to automatically detect the two-dimensional machine-readable output appearing in the diagnostic device. A computational device may be used to automatically determine whether the presence or absence of the first characteristic and/or the second characteristic based on the two-dimensional machine-readable output displayed in the diagnostic device.

Abstract: The present invention provides methods of contacting a protein kinase C (PKC) activator with a PKC activator in a manner sufficient to stimulate the synthesis of proteins sufficient to consolidate long-term memory. The present invention also provides methods of contacting a protein kinase C (PKC) activator with a PKC activator in a manner sufficient to downregulate PKC.

Abstract: This disclosure provides replication-incompetent adenoviral vectors useful in vaccine development and gene therapy. The disclosed vectors comprise a selective deletion of E3 and are particularly useful for preparation of vaccines development and for gene therapy using toxic transgene products that result in vector instability that occurs when the entire E3 domain is deleted.

Abstract: Disclosed is a method for preparing optically pure (+)-ambrisentan and (+)-darusentan, comprising: firstly catalyzing the asymmetric epoxidation of a ?-unsaturated alkene using a chiral ketone derived from fructose or a hydrate thereof as a catalyst, and then subjecting the product to an epoxy compound ring-opening reaction and substitution reaction successively to obtain optically pure (+)-ambrisentan and (+)-darusentan.

Abstract: A reflection-type light control element according to the present invention is provided with a light control layer configured to exhibit a reversible change between a transparent state and a reflection state in a reversible reaction with a hydrogen and a catalyst layer configured to accelerate the reversible reaction of the light control layer, wherein the reflection-type light control element is such that the light control layer includes an alloy that contains at least one kind of element selected from a group composed of group 2 elements and at least two kinds of elements selected from a group composed of group 3 elements and rare earth elements, or a hydride of the alloy.

Abstract: Methods and reagents for the installation of click chemistry handles on target proteins are provided, as well as modified proteins comprising click chemistry handles. Further, chimeric proteins, for example, bi-specific antibodies, that comprise two proteins conjugated via click chemistry, as well as methods for their generation and use are disclosed herein.

Abstract: A computer-implemented method of determining actions outside of a norm is provided. The method comprises: generating an actor state vector and a peer group state vector, wherein the actor state vector identifies a characteristic for an actor in each of a plurality of categories and the peer group state vector identifies a characteristic for a peer group in each of the plurality of categories, transforming the actor state vector into a first sampled wave series representation using a first wave series transformation, transforming the population state vector into a second sampled wave series representation using a second wave series transformation, and filtering the first sampled wave series representation and the second sampled wave series representation to identify a deviation of the first wave series representation from the second wave series representation in a phase or a magnitude.

Abstract: A solar panel device is provided which can be simply attached to an existing fluorescent lamp or LED lamp to construct a power-generating lamp.

Abstract: Diagnostic assays for facilitating the diagnosis of lymphoplasmacytic lymphoma (LPL) are provided. The method comprises assessing a biological sample of the subject for the presence of a mutation at position 38182641 in chromosome 3p22.2, wherein presence of the mutation is indicative that the subject has LPL. Also, provided are targeted therapies, methods for monitoring the progression or recurrence of LPL, and a sensitive and inexpensive real-time allele specific polymerase chain reaction assay for reliable and quantitative assessments of the mutation.

Abstract: Disclosed are a method of manufacturing a graphene-carbon nanotube nanostructure which includes mixing graphite, a catalytic metal, and an ionic liquid, and then radiating microwaves on the mixture, and a graphene-carbon nanotube nanostructure manufactured using the method.

Abstract: A data storage unit of a data editing apparatus stores both a base indicating a data attribute and a data value in association with each other as data to be edited. A code acquisition unit acquires a user code, which is a code described in a first program language for describing data editing details by intensive notation and which describes editing details for the data to be edited that are based on the base. A code generation unit generates, in accordance with a predetermined correspondence relationship between a second program language for describing data editing details by extensive notation and the first program language, an execution code described in the second program language based on the user code. An editing processing unit edits the data to be edited in accordance with the execution code.

Abstract: Techniques to automatically generate simulated information are described. A method comprises receiving, by a program builder component executed on a processor, a structured input file comprising one or more data libraries and one or more directive files to generate simulated data for a simulation database. The method further comprising producing, by the program builder component executed on the processor, a data generator program based on the structured input file, the data generator program arranged to generate the simulated data for the simulation database using multiple data generating sessions executed concurrently or sequentially. Other embodiments are described and claimed.

Abstract: This invention provides the use of AChE as nuclease. The use of AChE in regulating the stability of nucleic acid and cell apoptosis, as well as a series of agents based on the use, including the agents for promoting or inhibiting cell apoptosis, the agents for inhibiting tumors, and the agents for protecting nucleic acid from impairing, are provided.

Abstract: The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. The nanoparticle has a range of diameters including between about 0.1 nm and about 100 nm, between about 0.5 nm and about 50 nm, between about 1 nm and about 25 nm, between about 1 nm and about 15 nm, or between about 1 nm and about 8 nm. The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound. The nanoparticle also exhibits high biostability and biocompatibility. To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as poly(ethylene glycol) (PEG). The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo.

Abstract: Embodiments of the present invention relate to unifying augmented reality technology and big data. An interactive operation element may be defined. The interactive operation element is associated with an event and a location on an augmented reality (AR) screen. An action may be performed based on the event using a predefined communication protocol. The action may be associated with an information artifact which is derived from big data.

Abstract: A system and methods for transcranial magnetic stimulation, the system including a helmet, a positioning portion, a stimulator and a cooling system, are disclosed. The helmet includes a coil for deep brain magnetic stimulation. The coil has a base portion, and return portions, which may include a protruding return portion and a contacting return portion. The coil is designed to minimize unintended stimulation of portions of the brain, while reducing accumulation of surface charges. The coil is stimulated at several locations and/or at different times so as to focus the electrical field on a specific deep neuronal structure.

Abstract: The present invention provides a system and method of strategic learning and, in particular, to a system and method that allows evaluation to occur in real-time, shifts evaluation from the researcher to the program manager, and provides a feedback loop regarding evaluation findings. In one embodiment, the method comprises steps of: 1) learning preparation, wherein a team is established to implement a model, 2) roadmap development, wherein tangible outcomes are created and identified, 3) focused learning, wherein a plurality of outcomes from step 2) are identified and then considered critical, 4) systematic data collection wherein one asks how to collect data that is meaningful, and 5) strategies improvement, wherein data collection is used to change strategy.

Abstract: A topical applicator composition and process are described that decorporate radionuclides from radiologically-contaminated dermal surfaces and that further promote healing. The topical applicator includes a decorporation agent mixed with a plasticizing agent that forms a covering when applied to the dermal surface that decorporates radionuclides and minimizes their systemic migration. The topical applicator formulations can be delivered in conjunction with bandages and other application dressings.

Abstract: In general, the invention relates to electrode materials, e.g., novel cathode materials with high density, low cost, and high safety. A voltage design strategy based on the mixing of different transition metals in crystal structures known to be able to accommodate lithium in insertion and delithiation is presented herein. By mixing a metal active on the +2/+3 couple (e.g., Fe) with an element active on the +3/+5 or +3/+6 couples (e.g., V or Mo), high capacity multi-electron cathodes are designed in an adequate voltage window.