Abstract: The invention relates to global transcription machinery engineering to produce altered cells having improved phenotypes.

Abstract: The following disclosure provides compositions and methods for the repairing of a diseased or disordered retina, for example, in patients suffering from age-related macular degeneration (AMD).

Abstract: Systems and methods for the activation of species and/or the delivery of species to a target environment using harmonic generation materials are generally described.

Abstract: A delivery device for topical and systemic delivery of agents to targeted oral locations, such as mouth cancer cells, has been developed. The formulation includes a mucoadhesive polymeric matrix such as chitosan, which contains one or more therapeutic and/or diagnostic agents, taste masking agents, permeation enhancers, the therapeutic or diagnostic agent to be delivered, and a hydrophilic polymeric coating such as polyethyleneglycol (“PEG”). In the preferred embodiment, the matrix is formulated with one side having the PEG-mucoadhesive polymer exposed for topical placement onto epithelial or cancer cells in the mouth or other mucosal area and the side(s) facing the inside of the oral cavity being covered with a biocompatible, inert membrane that is impermeable to the therapeutic and/or diagnostic agent(s) to be delivered.

Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.

Abstract: A danger sensing apparatus includes a data collecting unit disposed at each of a side rear-view mirror of the vehicle and an inner portion of the vehicle to collect image data of a side region of the vehicle and a situation of a door region of the inner portion of the vehicle as data; a data analyzing unit analyzing the data collected from the data collecting unit to analyze a danger object approaching an outer side of the vehicle and the situation of the door region of the inner portion of the vehicle; and a controlling unit controlling operations of a drive train of the vehicle and the door based on a signal analyzed from the data analyzing unit.

Abstract: Visual prosthesis apparatus includes an image receiver, a processor coupled to the image receiver, a stimulation device coupled to the processor, and an eye monitoring device coupled to the processor. The image receiver receives a sequence of images and the processor produces a stimulation signal at least partially in accordance with the received images. The stimulation device receives the stimulation signal and stimulates visual neurons of a user accordingly to provide the user with a visual percept. The eye monitoring device monitors one or more ocular parameters at an eye region of the user, wherein one or more control functions are associated with the monitored ocular parameters. The processor controls the visual prosthesis apparatus in accordance with the monitored ocular parameters and the associated control functions. The one or more ocular parameters can include pupil size, state of closure of the user's eyelid and direction of eye gaze.

Abstract: Neuroinvasive and neurovirulent strain of the West Nile virus, named IS-98-ST1, nucleic acid molecules derived from its genome, proteins and peptides encoded by said nucleic acid molecules, and uses thereof.

Abstract: Disclosed are methods for manufacturing bio-based epoxy resins. The raw materials of the resins include lignin, polyol, solvent, catalyst, acid anhydride, and multi-epoxy compound. The methods of manufacturing the resins include evenly mixing the lignin, the polyol, the catalyst, and the solvent together to form a mixture. The acid anhydride is added to the mixture to process esterification for forming an intermediate product. The multi-epoxy compound is added to the intermediate product to process epoxidation for forming the bio-based epoxy resins. The bio-based epoxy resin has excellent compatibility with the solvent, such that the solvent can be added to the bio-based epoxy resins to form coatings having a tunable solid content. As a result, the coating can be applied to the surfaces of every type of base material.

Abstract: The object of the present invention is achieved by providing a copolymer, in particular, a block copolymer which has excellent coating formation ability, adhesive properties to a substrate, and does not adsorb protein; an antithrombotic coating agent which has superior antithrombotic properties and adhesive properties to a substrate to those of the conventional antithrombotic coating agent; and a medical instrument which is obtained by coating the antithrombotic coating agent, and the block copolymer includes a polymer (A) containing a (meth)acrylic ester monomer and a polymer (B) containing a (meth)acrylamide monomer and has excellent coating formation ability and high adhesive properties to a substrate.

Abstract: Provided is a novel lithium silicate-based material useful as a positive electrode material for lithium ion secondary battery. The lithium silicate-based compound is represented by Li1.5FeSiO4.25 The lithium silicate-based compound is a compound including: lithium (Li); iron (Fe); silicon (Si); and oxygen (O), and expressed by a composition formula, Li1+2?FeSiO4+??c(?0.25???0.25, 0?c?0.5). The lithium silicate-based compound, of which iron (Fe) is trivalent, exerts a remarkable chemical stability as compared to Li2FeSiO4.

Abstract: Novel methods and systems for encoding cryptographic information are disclosed. A message can be encoded through a sequence of nucleic acids by assigning a binary value to a pair of nucleic acids, while other nucleic acids can be used for spacing. Unique organisms can also be used for identification. The nucleic acids can be encapsulated in organic materials such as saccharide-based desiccants.

Abstract: An apparatus and method for recommending contents based on a metadata graph are provided. The apparatus includes a contents metadata acquirer configured to acquire metadata of contents, a contents-related data acquirer configured to acquire contents-related data from the Web, a metadata graph generator configured to analyze acquired contents metadata and contents-related data to generate a metadata graph, a metadata graph DB configured to store a metadata graph generated by the metadata graph generator, and a contents recommender configured to search for contents that are similar to specific contents viewed by a user through a contents output terminal using the metadata graph stored in the metadata graph DB, and recommend the searched contents to the user through the contents output terminal.

Abstract: Provided are an apparatus and a method for soft-sensing a vehicle or stationary fuel cell system capable of predicting a quality variable based on a process variable and providing the predicted quality variable in real time.

Abstract: A FinFET and a method for manufacturing the same are disclosed. In one aspect, the method comprises forming a semiconductor fin having trapezoid cross-section. The method also includes forming one of a source region and a drain region. The method also includes forming a sacrificial spacer. The method also includes forming another one of the source region and the drain region using the sacrificial spacer as a mask. The method also includes removing the sacrificial spacer. The method also includes forming a gate stack in place of the sacrificial spacer, the gate stack comprising a gate conductor and a gate dielectric isolating the gate conductor from the semiconductor fin.

Abstract: Exemplary embodiments provide dispensers and delivery devices that release their contents at sustained rates. An exemplary device may include one or more reservoirs for holding a solid, semisolid, liquid or gaseous substance that may be released outside the device. Exemplary devices enable sustained release of their contents over a predetermined period of time, for example, up to a month or more. Exemplary devices also enable release of the contents according to, for example, predetermined release rates and profiles customized for the use of the device. Each reservoir of the device may include one or more apertures through which the contents may be released outside the reservoir. Each aperture may be covered by one or more porous membranes to allow sustained release of the contents of the reservoir.

Abstract: In an apparatus for manufacturing a scaffold and a scaffold manufactured by the apparatus, a collector is disposed under a dispensing head that dispenses melted bio materials (polymer) for manufacturing the scaffold. The collector has a cylindrical tube shape. Both sides of the tube shape are fixed. Thus, the tube is securely fixed and bending of the tube is prevented. Also, accuracy and preciseness of the scaffold are improved.

Abstract: The present invention provides a method for identifying animal species, said method comprises a step of amplifying a DNA fragment by PCR using a DNA in a sample as a template and animal-specific DNA sequences as a primer pair, wherein the animal-specific DNA sequences are derived from a ATP synthase subunit 8 gene or a region proximal thereto of a mitochondrial genome; and a step of detecting the amplified DNA fragment.

Abstract: This invention relates to a highly functional graft copolymer and a method of preparing the same, and more particularly, to a highly functional graft copolymer including a main chain of a highly elastic ethylene-based terpolymer including, at a predetermined molar ratio, an ethylene unit, an ?-olefin unit having 6 to 12 carbon atoms, and at least one functional unit selected from the group consisting of divinylbenzene and p-methylstyrene, and a side chain of a polar polymer for imparting functionality, and to a method of preparing the highly functional graft copolymer by performing anionic polymerization after catalytic polymerization using a metallocene catalyst.

Abstract: Disclosed in the disclosure are a method and a device for processing geological information. The method for processing the geological information comprises: acquiring multiple geological image graphs; determining the relation between the image coordinate and the ground coordinate of each of the multiple geological image graphs by an imaging mode of geological images; and joining the multiple geological image graphs together according to the relation between the image coordinate and the ground coordinate of each of the multiple geological image graphs. The large-scale ground images can be acquired by processing the geological images according to the present disclosure.