Abstract: The present invention relates to methods, compositions and kits concerning resistance to treatment with an anti-cancer agent, specifically an inhibitor of BRAF. In particular embodiments, the invention concerns mutations in a BRAF sequence that confer resistance to a BRAF inhibitor. Identification of such mutations in a BRAF sequence allows the identification and design of second-generation BRAF inhibitors. Methods and kits for detecting the presence of a mutant BRAF sequence in a sample are also provided.

Abstract: A power monitoring device and a power analysis method are provided. The power monitoring device receives a plurality of pieces of power consumption information from a power meter. The power meter is installed on a power line of an electric device. The power monitoring device stores a piece of power specification information of the power device and a piece of user and environment information associated with the power device, and generates a piece of user behavior feature information according to the plurality of pieces of power consumption information. The power monitoring device retrieves a piece of key feature information from the power specification information, the user and environment information and the user behavior feature information so as to generate an inform message according to the key feature information, and transmit the inform message to a user device associated with the electric device.

Abstract: An object location confirmation system for use in an area is provided. The area includes a first zone and a second zone. The object location confirmation system includes a first retrieving device, a second retrieving device, and a data processing apparatus. The first retrieving device is disposed on a path of the area to retrieve a first datum of an object. The second retrieving device is disposed in a boundary region of the second zone. The data processing apparatus is configured to receive the first datum and identify the first datum so as to generate a piece of identification information related to the object. The data processing apparatus determines and records that the object is located in the first zone when the data processing apparatus receives the identification information related to the object and has not received a second datum of the object retrieved from the second retrieving device.

Abstract: A method and apparatus for allocating a management resource of a channel of a node that is included in a wireless personal area network (WPAN) are provided. A resource of a channel performs communication with a specific node using a multi-superframe including a plurality of superframes, limits a position area of a time slot including a channel that is allocated to communication with a specific node to a predetermined superframe of the plurality of superframes, gives a logical connection ID to the time slot, and is allocated by matching the logical connection ID and a management resource that manages the time slot.

Abstract: A rapidly assembled debris flow sediment storage dam and a construction method are provided. The sediment storage dam has a main dam body with multiple prefabricated reinforced concrete rectangular boxes linked by vertical and horizontal connections. The top surface of each rectangular box is open, and the other five surfaces of the rectangular box are closed. Soil is used to fill each rectangular box. The main dam body is assembled above dam body foundations. Dam abutment foundations of the sediment storage dam and the inside slope of the dam body are filled with cement-laid stone masonry or concrete, while the top surface of the dam crest is also sealed using cement-laid stone masonry or concrete.

Abstract: Provided is an error amplifier. The error amplifier includes: an amplifying unit receiving first and second input signals and amplifying a voltage difference between the received first and second input signals; a first voltage generating unit generating first and second driving voltages for driving the amplifying unit; a second voltage generating unit generating first and second body voltages to implement a body biasing method; a cascode current source including first to fourth PMOS transistors to provide a bias current to the amplifying unit and the first voltage generating unit; and an output unit outputting a signal of the voltage difference amplified by the amplifying unit, wherein the first and third PMOS transistors receive the first body voltage through a body terminal and the second and fourth PMOS transistors receive the second body voltage through a body terminal.

Abstract: Methods and apparatuses for encapsulating inorganic micro- or nanostructures within polymeric microgels are described. In various embodiments, viruses are encapsulated with microgels during microgel formation. The viruses can provide a template for in situ synthesis of the inorganic structures within the microgel. The inorganic structures can be distributed substantially homogeneously throughout the microgel, or can be distributed non-uniformly within the microgel. The inventive microgel compositions can be used for a variety of applications including electronic devices, biotechnological devices, fuel cells, display devices and optical devices.

Abstract: The present invention relates to a formulation and method for the treatment of fungal nail infections, such as those caused by Trichophyton rubrum and/or Aspergillus niger. The formulation of the invention comprises glucose oxidase, D-glucose and hydrogen peroxide in an aqueous solution. Advantageously, the formulation of the invention provides a two-stage hydrogen peroxide release for the treatment of the fungal nail infections.

Abstract: A method of manufacturing semiconductor wafers is provided which facilitates formation of orientation flat lines and allows beveling work without problems. The method of manufacturing semiconductor wafers according to the present invention is a method of manufacturing semiconductor wafers, in which a plurality of small-diameter wafers is cut out from a large-diameter semiconductor wafer, the method including: a marking step of forming straight groove-like orientation flat lines by a laser beam so as to cross the respective small-diameter wafers in each row in the large-diameter semiconductor wafer, wherein cutout positions of the small-diameter wafers are aligned in rows in a specific direction, collectively for each of the rows; and a cutting step of cutting out the small-diameter wafers separately from the large-diameter semiconductor wafer by a laser beam after the marking step.

Abstract: A highly fluorinated photoresist employing a photodimerization chemistry and a method for manufacturing an organic light emitting diode display using the same. The photoresist includes a copolymer that is made from two different monomers. When the copolymer is used as a photoresist, the photoresist has the characteristic that it becomes insoluble when exposed to an ultraviolet light having a wavelength of 365 nm.

Abstract: A power management method for electro-chemical batteries in low capacity state is provided, including: obtaining battery information based on device hardware, to know in advance the maximum allowable current and maximum allowable power when the battery power is low; by detecting the changes in the voltage versus current, updating BCC curve; using BCC curve as power budget to control the ON/OFF of device function thread; and determining whether the minimum battery capacity and the control restriction are reached, and when the minimum battery capacity and the control restriction are reached, turn off the battery through normal shutdown process; otherwise, return to the step of obtaining battery information.

Abstract: In some embodiments, the invention pertains to therapeutic compositions for treating a brain tumor. Such therapeutic compositions generally comprise: (1) a nanovector; (2) an active agent associated with the nanovector with activity against brain tumor cells; and (3) a targeting agent associated with the nanovector with recognition activity for a marker of the brain tumor cells. In some embodiments, the active agent and the targeting agent are non-covalently associated with the nanovector. Additional embodiments of the present invention pertain to methods of treating a brain tumor in a subject (e.g., a human being) by administering the aforementioned therapeutic compositions to the subject. Further embodiments of the present disclosure pertain to methods of formulating therapeutic compositions for treating a brain tumor in a subject in a personalized manner.

Abstract: The present disclosure discloses a method for manufacturing an N-type MOSFET, comprising: forming a part of the MOSFET on a semiconductor substrate, the part of the MOSFET comprising source/drain regions in the semiconductor substrate, a replacement gate stack between the source/drain regions above the semiconductor substrate, and a gate spacer surrounding the replacement gate stack; removing the replacement gate stack of the MOSFET to form a gate opening exposing a surface of the semiconductor substrate; forming an interface oxide layer on the exposed surface of the semiconductor; forming a high-K gate dielectric layer on the interface oxide layer in the gate opening; forming a first metal gate layer on the high-K gate dielectric layer; implanting dopant ions into the first metal gate layer; and performing annealing to cause the dopant ions to diffuse and accumulate at an upper interface between the high-K gate dielectric layer and the first metal gate layer and a lower interface between the high-K gate diel

Abstract: A buffer and output method and a buffer module for a multimedia stream are provided, wherein multimedia stream packets are received and stored into a first buffer, and when an actual remaining time calculated according to an accumulated idle time and a buffer time, is greater than a remaining time threshold value, following steps are performed. A first present time is read, and a sleep instruction is executed, so as to wait for a preset idle time. A second present time is read, and an actual idle time different from the preset idle time is calculated according to the first present time and the second present time. A part of buffer units are enabled according to the accumulated idle time accumulated according to the actual idle time, to output the stored multimedia stream packets to a second buffer of a player.

Abstract: Disclosed is a lithium battery, including a positive electrode plate, a negative electrode plate, and a polyolefin separator disposed therebetween. An organic-inorganic hybrid film disposed between the polyolefin separator and the positive electrode plate, and/or disposed between the polyolefin separator and the negative electrode plate. The organic-inorganic hybrid film includes inorganic oxide particles and a fluorinated polymer binder, wherein the inorganic oxide particles and the fluorinated polymer binder have a weight ratio of about 40:60 to 80:20.

Abstract: Disclosed are a novel resorcyclic acid lactone compound with inhibitory activity against protein kinases, a pharmaceutically acceptable salt thereof, a method for the synthesis thereof, and a pharmaceutical composition for the treatment and prevention of various cancer diseases comprising the same as an active ingredient. The novel resorcyclic acid lactone compound is useful as a therapeutic for cancer diseases, especially blood cancer, inter alia, acute myeloid leukemia (AML).

Abstract: The present invention aims to provide a non-combustible film having excellent flexibility, excellent moisture resistance, and high mechanical strength. The present invention also aims to provide a dispersion liquid for non-combustible films which is used in production of the non-combustible film, a method for producing a non-combustible film using the above dispersion, and a solar cell back sheet and a flexible board each of which is formed from the above non-combustible film. The present invention further aims to provide a solar cell including the solar cell back sheet. The non-combustible film of the present invention includes a water-insoluble inorganic compound and a heat-resistant synthetic resin, the water-insoluble inorganic compound constituting from 30% by weight to 90% by weight inclusive of the total weight of the non-combustible film, the film exhibiting a flammability of VTM-0 in the UL-94 VTM test.

Abstract: A valve actuator, valve, and method of actuation of a valve are disclosed. The valve actuator includes a shape memory alloy element attachable to a valve body, capable of use with a valve to cause movement of the valve between first and second positions at a predetermined temperature and responsive to at least a threshold amount of temperature change of the shape memory alloy element. The valve actuator further includes an expansion element attached to the shape memory alloy element, the expansion element responsive to temperature changes at a rate lower than a rate of change of temperature indicative of a valve leak, the expansion element adjusting tension on the shape memory alloy element, thereby changing the predetermined temperature.

Abstract: A multi-element alloy material consists of Al, Cr, Fe, Mn, Mo and Ni. From an outer surface to a center of the multi-element alloy material exhibits a hardness gradient from high to low. A method of manufacturing a multi-element alloy material with hardness gradient includes melting and casting metals with a metal combination of Al, Cr, Fe, Mn, Mo and Ni to form an alloy body, subjecting the alloy body to a homogenization treatment, and subjecting the homogenized alloy body to a high temperature treatment to perform precipitation hardening at surface of the alloy body by heating, thereby forming a multi-element alloy material having hardness gradient.

Abstract: Fuel injectors of varying modes, shear or thickness, and megahertz are used to reduce the size of fuel droplets. The fuel injector has an expansion chamber and an orifice-containing face plate with a porous PZT material arranged adjacent to the face plate. The fuel passes through the porous PZT material as the PZT material is energized to realize reduced fuel particle size.