Patents Assigned to INSTITUTE
  • CAMPTOTHECIN COMPOUND CONTAINING STABLE 7-MEMBERED LACTONE RING, PREPARATION METHOD AND USE
    Publication number: 20140128421
    Abstract: Provided are a camptothecin compound containing 7-membered lactone ring, as shown in general formula I, and pharmaceutically acceptable salt thereof, as well as the preparation method and use thereof. In general formula I, R1 is H, a C1˜C3 alkyl, acetyl or propionyl; R2 is H, a C1˜C6 alkyl, a C3˜C6 cycloalkyl, piperidyl; or a C1˜C6 alkyl substituted by an amino; R3 is H, a C1˜C3 alkyl, or a C1˜C6 alkyl substituted by an amino; R4 is H, a hydroxyl, or a C1˜C6 alkoxy; R5 is H, or a C1˜C6 alkoxyl; or R4 and R5 are linked to each other to form —OCH2O— or —OCH2CH2O—. The compound has good anti-tumor activity, and can be clinically used via oral administration, intravenous injection, and intramuscular injection, among others.
    Type: Application
    Filed: April 13, 2012
    Publication date: May 8, 2014
    Applicants: EAST CHINA NORMAL UNIVERSITY, NANJING LUYESKIE PHARMACEUTICAL CO., LTD., SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Wei Lv, Shanbao Yu, Yu Luo, Yi Chen, Jian Ding
  • INTER-CELL INTERFERENCE COORDINATION METHOD AND APPARATUS FOR USE IN MOBILE COMMUNICATION SYSTEM
    Publication number: 20140128117
    Abstract: A data transmission and/or reception method of a base station in a wireless communication system is provided. The data transmission/reception method includes receiving information on interference measured by a terminal, allocating a downlink resource to a terminal based on the received interference information, determining per-subband transmit power distributions of the downlink resource allocation, and transmitting the per-subband transmit power distributions of the downlink resource allocation to neighbor base stations.
    Type: Application
    Filed: November 7, 2013
    Publication date: May 8, 2014
    Applicants: Korea Advanced Institute of Science and Technology, Samsung Electronics Co., Ltd.
    Inventors: Jonghyung KWUN, Yeonjea CHO, Dongjo PARK, Sanguk PARK, Wonchul CHOI
  • PROXIMITY SENSING METHOD, PROXIMITY SENSING APPARATUS AND MOBILE PLATFORM USING THE SAME
    Publication number: 20140129029
    Abstract: A proximity sensing apparatus is provided. The proximity sensing apparatus includes an encoded signal transmission unit, an interference signal transmission unit and a reception unit. The encoded signal transmission unit transmits an encoded signal, and the interference signal transmission unit transmits an interference signal. The interference signal interferes with the encoded signal to generate an interfered signal. The reception unit receives a sensing signal and outputs the sensing signal to a signal processing unit. The sensing signal is either the interfered signal or the encoded signal. The signal processing unit is electrically connected to the reception unit, and determines whether the sensing signal matches the encoded signal. The signal processing unit further outputs a proximity signal when the sensing signal does not match the encoded signal.
    Type: Application
    Filed: October 3, 2013
    Publication date: May 8, 2014
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Jia-Hsing Wu, Chun-Hsien Liu, Ya-Hui Tsai, Po-Yi Li
  • WISE/SOST NUCLEIC ACID SEQUENCES AND AMINO ACID SEQUENCES
    Publication number: 20140127751
    Abstract: The present invention relates to nucleic acid sequences and amino acid sequences which influence bone deposition, the Wnt pathway, ocular development, tooth development, and may bind to LRP. The nucleic acid sequence and polypeptides include Wise and Sost as well as a family of molecules which express a cysteine knot polypeptide. Additionally, the present invention relates to various molecular tools derived from the nucleic acids and polypeptides including vectors, transfected host cells, monochronal antibodies, Fab fragments, and methods for impacting the pathways.
    Type: Application
    Filed: December 19, 2013
    Publication date: May 8, 2014
    Applicant: Stowers Institute for Medical Research
    Inventors: Robb KRUMLAUF, Debra ELLIES
  • Synthetically Functionalized Living Cells
    Publication number: 20140127774
    Abstract: Uniform, functional polymer patches can be attached to a fraction of the surface area of living individual cells. These surface-modified cells remain viable after attachment of the functional patch. The patch does not completely occlude the cellular surface from the surrounding environment. Functional payloads carried by the patch may include, for example, drugs or other small molecules, peptides, proteins, thermally responsive polymers, and nanoparticles, or any other material that can be incorporated in a polymer patch of subcellular dimensions. The patch can include one or more polyelectrolyte multilayers (PEMs).
    Type: Application
    Filed: November 2, 2012
    Publication date: May 8, 2014
    Applicant: Massachusetts Institute of Technology
    Inventors: Albert J. Swiston, Michael F. Rubner, Robert E. Cohen, Darrell J. Irvine
  • Composite Separators and Redox Flow Batteries Based on Porous Separators
    Publication number: 20140127542
    Abstract: Composite separators having a porous structure and including acid-stable, hydrophilic, inorganic particles enmeshed in a substantially fully fluorinated polyolefin matrix can be utilized in a number of applications. The inorganic particles can provide hydrophilic characteristics. The pores of the separator result in good selectivity and electrical conductivity. The fluorinated polymeric backbone can result in high chemical stability. Accordingly, one application of the composite separators is in redox flow batteries as low cost membranes. In such applications, the composite separator can also enable additional property-enhancing features compared to ion-exchange membranes. For example, simple capacity control can be achieved through hydraulic pressure by balancing the volumes of electrolyte on each side of the separator.
    Type: Application
    Filed: November 5, 2012
    Publication date: May 8, 2014
    Applicant: BATTELLE MEMORIAL INSTITUTE
    Inventor: Battelle Memorial Institute
  • Semiconductor structure and method for manufacturing the same
    Publication number: 20140124859
    Abstract: The present invention provides a method for manufacturing a semiconductor structure, which comprises: providing an SOI substrate, forming a gate structure on the SOI substrate; etching an SOI layer of the SOI substrate and a BOX layer of the SOI substrate on both sides of the gate structure to form trenches, the trenches exposing the BOX layer and extending partly into the BOX layer; forming sidewall spacers on sidewalls of the trenches; forming inside the trenches a metal layer covering the sidewall spacers, wherein the metal layer is in contact with the SOI layer which is under the gate structure. Accordingly, the present invention further provides a semiconductor structure formed according to aforesaid method.
    Type: Application
    Filed: August 25, 2011
    Publication date: May 8, 2014
    Applicants: BEIJING NMC CO., LTD., INSTITUTE OF MICROELECTRONICS, CHINESE ACADEMY OF SCIENCES
    Inventors: Haizhou Yin, Huilong Zhu, Zhijiong Luo
  • Fourier Ptychographic X-ray Imaging Systems, Devices, and Methods
    Publication number: 20140126691
    Abstract: Methods, systems, and devices of Fourier ptychographic X-ray imaging by capturing a plurality of variably-illuminated, low-resolution intensity X-ray images of a specimen and computationally reconstructing a high-resolution X-ray image of the specimen by iteratively updating overlapping regions in Fourier space with the variably-illuminated, low-resolution intensity X-ray images.
    Type: Application
    Filed: October 28, 2013
    Publication date: May 8, 2014
    Applicant: California Institute of Technology
    Inventors: Guoan Zheng, Changhuei Yang, Roarke Horstmeyer
  • CERTAIN PROTEIN KINASE INHIBITORS
    Publication number: 20140128387
    Abstract: Disclosed herein are protein kinase inhibitors, more particularly novel pyrimidine derivatives and pharmaceutical compositions thereof, and method of use thereof.
    Type: Application
    Filed: November 5, 2013
    Publication date: May 8, 2014
    Applicants: SHANGHAI iNSTITUTE OF MATERIA MEDICA ACADEMY OF SCIENCES, SHANGHAI FOCHON PHARMACEUTICAL CO., LTD.
    Inventors: Weibo WANG, Meiyu Geng, Jian Ding, Xingdong Zhao, Jing Ai, Qiang Tian, Xia Peng, Weipeng Zhang, Hongbin Liu, Haohan Tan, Ling Chen
  • Method And System For Detecting Underlying Health Affections Using Biomarkers in Humans and Animals
    Publication number: 20140127730
    Abstract: The invention provides a method and system for developing and using diagnoses of one or more underlying health affections in humans or an animal specie using a plurality of biomarkers. A target one or more affections are defined and a set of biomarkers is selected. An index is computed based on the measured levels of the biomarkers. The biomarkers levels are discretized, and each discrete value is multiplied by a corresponding coefficient. The index scale is divided into ranges that are matched with health statuses. A subject's health affection status is subsequently determined by measuring the level of each biomarker in the set, computing the index and matching the index value to the predefined index scale.
    Type: Application
    Filed: November 8, 2012
    Publication date: May 8, 2014
    Applicant: VETERINARY DIAGNOSTICS INSTITUTE, INC.
    Inventor: RANDY RINGOLD
  • Low Drop Diode Equivalent Circuit
    Publication number: 20140126260
    Abstract: Embodiments of the disclosure relate to a low drop diode equivalent circuit. Piezoelectric device based vibration energy harvesting requires a rectifier for conversion of input ac to usable dc form. Power loss due to diode drop in rectifier is a significant fraction of the already low levels of harvested power. The low-drop-diode equivalent can replace the rectifier diodes and minimise power loss. The diode equivalent mimics a diode using linear region operated MOSFET. The diode equivalent is powered directly from input signal and requires no additional power supply for its control. Power used by the control circuit is kept at a value which gives an overall output power improvement. The diode equivalent replaces the four diodes in a full wave bridge rectifier, which is the basic full-wave rectifier and is a part of the more advanced rectifiers like switch-only and bias-flip rectifiers.
    Type: Application
    Filed: March 8, 2013
    Publication date: May 8, 2014
    Applicants: Indian Institute of Science, Department of Electronics and Information Technology
    Inventors: Bharadwaj Amrutur, Laxmi Karthikeyan
  • Apparatuses for Making Cathodes for High-temperature, Rechargeable Batteries
    Publication number: 20140127337
    Abstract: The approaches and apparatuses for fabricating cathodes can be adapted to improve control over cathode composition and to better accommodate batteries of any shape and their assembly. For example, a first solid having an alkali metal halide, a second solid having a transition metal, and a third solid having an alkali metal aluminum halide are combined into a mixture. The mixture can be heated in a vacuum to a temperature that is greater than or equal to the melting point of the third solid. When the third solid is substantially molten liquid, the mixture is compressed into a desired cathode shape and then cooled to solidify the mixture in the desired cathode shape.
    Type: Application
    Filed: January 15, 2014
    Publication date: May 8, 2014
    Applicant: BATTELLE MEMORIAL INSTITUTE
    Inventors: Kerry D. Meinhardt, Vincent L. Sprenkle, Gregory W. Coffey
  • Antigen Presenting Cell Targeted Anti-Viral Vaccines
    Publication number: 20140127198
    Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.
    Type: Application
    Filed: August 26, 2013
    Publication date: May 8, 2014
    Applicant: Baylor Research Institute
    Inventors: Gerard Zurawski, Jacques Banchereau, Anne-Laure Flamar, Yves Levy, Monica Montes
  • System and method of selecting white gaussian noise sub-band using singular value decomposition
    Patent number: 8718960
    Abstract: Provided is a method of selecting a white Gaussian noise sub-band using singular value decomposition (SVD). The method includes selecting a first frequency band, verifying whether a signal is included in the selected first frequency band, determining the first frequency band as a target measurement frequency when the signal is not included in the selected first frequency band, and measuring a background radio noise in the determined target measurement frequency.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: May 6, 2014
    Assignees: Electronics and Telecommunications Research Institute, University-Industry Cooperation Group of Kyung Hee University
    Inventors: Mi-Kyung Suk, Sang Tae Kim, Gwangmoon Park, Seong Yun Lee, Haeng Sook Ro, Heung Yong Kang, Yong-Seok Choi, Young Soo Kim, Seung Min Shin
  • Method for reconstruction of urban scenes
    Patent number: 8718393
    Abstract: An urban scenes reconstruction method includes: acquiring digital data of a three-dimensional subject, the digital data comprising a 2D photograph and a 3D scan; fusing the 3D scan and the 2D photograph to create a depth-augmented photograph; decomposing the depth-augmented photograph into a plurality of constant-depth layers; detecting repetition patterns of each constant-depth layer; and using the repetitions to enhance the 3D scan to generate a polygon-level 3D reconstruction.
    Type: Grant
    Filed: July 28, 2010
    Date of Patent: May 6, 2014
    Assignee: Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences
    Inventors: Baoquan Chen, Liangliang Nan, Qian Zheng
  • System and method for providing and transmitting condensed streaming content
    Patent number: 8719442
    Abstract: A stream condense unit coupled to a streaming server and a client player is provided. The stream condense unit includes a streaming data input unit, a stream content analysis unit, a frame timestamp adjust unit, and a streaming data output unit. The streaming data input unit is configured to receive a plurality of streaming content groups sent by the streaming server. The stream content analysis unit is configured to receive the plurality of streaming content groups, execute a content analysis to get importance scores of the source streaming contents. The frame timestamp adjust unit is configured to receive the condensed stream and adjust a timestamp of each frame in the condensed stream. The streaming data output unit is configured to receive the condensed stream and attach content identifying labels and tables to the condensed stream, and send the condensed stream to the client player to display.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: May 6, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Hsin-Hua Lee, Hui-Ping Kuo, Jen-Yu Yu, Wen-Fang Cheng
  • Micro RNAs for identification of exposure to lower aliphatic saturated aldehydes and the method of identification using thereof
    Patent number: 8716192
    Abstract: The present invention relates to a biomarker for the identification of exposure to lower aliphatic saturated aldehydes by using micro RNA and a method for the identification of exposure to lower aliphatic saturated aldehydes using the same. In this invention, the micro RNA at least 1.5 fold up-regulated by exposure to lower aliphatic saturated aldehydes and the micro RNA up to 0.66 fold down-regulated by the same were selected. These two micro RNAs can be effectively used as the biomarker for the monitoring of lower aliphatic saturated aldehydes and for the risk assessment thereby and at the same time as a tool to investigate the mechanism of toxicity caused by such lower aliphatic saturated aldehydes.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: May 6, 2014
    Assignee: Korea Institute of Science and Technology
    Inventors: Jae Chun Ryu, Mee Song, Ji-seong Yoon, Wooin Ryu, Hyo Sun Lee, Chan Young Shin
  • Iron oxyhydroxides and methods of synthesizing the iron oxyhydroxides
    Patent number: 8715611
    Abstract: An iron oxyhydroxide includes a plurality of iron oxyhydroxide octahedra components, a plurality of chloride components and at least one of germanium hydroxide components or germanium oxide components. The iron oxyhydroxide octahedra components form a tunnel-type structure. The chloride components are disposed in a tunnel of the tunnel-type structure and bonded to at least one of the iron hydroxide octahedra components. The germanium hydroxide components or the germanium oxide components substitute for at least one of the chloride components.
    Type: Grant
    Filed: August 22, 2011
    Date of Patent: May 6, 2014
    Assignee: Korea Institute of Geoscience and Mineral Resources
    Inventors: Il-Mo Kang, Yun-Goo Song, Sung-Ja Choi, Myung-Hun Kim, Young-Boo Lee, Bui Hoang Bac
  • Capillary electrophoresis chips
    Patent number: 8715558
    Abstract: A seamless microchannel with aligned microelectrodes structure can be prepared to include a polymeric body defining a surface of a seamless microchannel. The microchannel is seamless in that it is formed by a single body of material having a conduit that is open at one surface and extends to another opening aligned with microelectrodes in another surface of the body. The rest of the microchannel is closed and defined by the single body of material. The seamless microchannel structure can be used in methods that include biosensors, coupling waveguides, capillary electrophoresis chips, microreactors, polymerase chain reaction-chips, and solving mathematical problems.
    Type: Grant
    Filed: October 1, 2010
    Date of Patent: May 6, 2014
    Assignee: Indian Institute of Technology Bombay
    Inventors: Amit Prabhakar, Soumyo Mukherji
  • Electrofluidic device and operation method thereof
    Patent number: 8717281
    Abstract: An electrofluidic device includes first structural layer and second structural layer. First structural layer includes first substrate; and first electrode and second electrode on the first substrate. The second electrode has an indent region surrounding and without contacting first electrode. First hydrophobic layer is at least over the second electrode. Second structural layer at one side of the first structural layer with a gap includes second substrate and groove structure layer. The groove structure layer includes an indent groove, corresponding to the indent region of the second electrode. Second hydrophobic layer is over the groove structure layer. Polar fluid is disposed in the indent groove and remains in contact with the first electrode. Non-polar fluid is disposed in the gap between the first and second structural layers.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: May 6, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Yun-Sheng Ku, Wei-Yuan Cheng, Pei-Ju Su, Shu-Wei Kuo