Abstract: Isolated immunogens including a HIV-1 gp120 polypeptide or immunogenic fragment thereof stabilized in a CD4 bound confirmation by crosslinked cysteines, and methods of their use are disclosed. The immunogens are useful, for example, for generating an immune response to HIV-1 gp120 in a subject.

Abstract: The present invention relates to compounds of the following formula wherein R3 is a fluorescent tag. Another aspect of the invention provides an assay for determining the inhibitory effect of a test compound on an HDAC protein comprising: incubating the HDAC protein with a substrate of the above formula in the presence of a test compound; and determining the activity of the HDAC protein.

Abstract: Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions, including infection, such as HIV/AIDS, and various types of cancers.

Abstract: A system and method for generating a focused image of an object is provided. The method comprises obtaining a plurality of images of an object, estimating an initial depth profile of the object, estimating a parallax parameter and a blur parameter for each pixel in the plurality of images and generating a focused image and a corrected depth profile of the object using a posterior energy function. The posterior energy function is based on the estimated parallax parameter and the blur parameter of each pixel in the plurality of images.

Abstract: The present invention provides compounds of Formula (A): (Chemical formula should be inserted here as it appears on abstract in paper form) (A) and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19, R22, R23, and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.

Abstract: The present application discloses a MOSFET and a method for manufacturing the same, wherein the MOSFET comprises: an SOI wafer, which comprises a semiconductor substrate, a buried insulator layer, and a semiconductor layer, the buried insulator layer being disposed on the semiconductor substrate, and the semiconductor layer being disposed on the buried insulator layer; a gate stack, which is disposed on the semiconductor layer; a source region and a drain region, which are disposed in the semiconductor layer and on opposite sides of the gate stack; and a channel region, which are disposed in the semiconductor layer and sandwiched by the source region and the drain region, wherein the MOSFET further comprises a back gate disposed in the semiconductor substrate, and wherein the back gate comprises first, second and third compensation doping regions, the first compensation doping region is disposed under the source region and the drain region; the second compensation doping region extends in a direction away fro

Abstract: Disclosed are membranes and methods for making the same, which membranes provide improved permeability, stability, and cost-effective manufacturability, for separating CO2 from gas streams such as flue gas streams. High CO2 permeation flux is achieved by immobilizing an ultra-thin, optionally catalyzed fluid layer onto a meso-porous modification layer on a thin, porous inorganic substrate such as a porous metallic substrate. The CO2-selective liquid fluid blocks non-selective pores, and allows for selective absorption of CO2 from gas mixtures such as flue gas mixtures and subsequent transport to the permeation side of the membrane. Carbon dioxide permeance levels are in the order of 1.0×10?6 mol/(m2sPa) or better. Methods for making such membranes allow commercial scale membrane manufacturing at highly cost-effective rates when compared to conventional commercial-scale CO2 separation processes and equipment for the same and such membranes are operable on an industrial use scale.

Abstract: A method and apparatus for measuring a radio environment of a base station is provided. The method includes respectively selecting one or more frames for measuring a radio environment in a first mode in which an Over-The-Air Receiver (OTAR) of the base station is initialized and a second mode in which the OTAR is active, continuously measuring the radio environment based on the selected one or more frames in the first mode and intermittently measuring the radio environment based on the selected one or more frames in the second mode.

Abstract: Disclosed are methods for producing esterified propoxylated glycerols and eutectic mixtures containing one or more esterified propoxylated glycerols and one or more digestible fats. Food products containing the eutectic mixtures are also disclosed.

Abstract: A method for controlling interference between a plurality of neighboring base stations for a terminal by a serving base station of the terminal in a communication system is provided. The method includes receiving interference amount information on a first region of a downlink frame from the terminal, determining an interference amount estimate for the first region based on the received interference amount information, comparing the determined interference amount estimate with an interference amount tolerance for the first region; and transmitting an interference indicator requesting reduction in transmission power for the first region to the plurality of neighboring base stations when the interference amount estimate exceeds the interference amount tolerance.

Abstract: An inductance-capacitance (LC) oscillator including a first varactor cell, a first transistor, a second transistor and a first pair of differential transformers is provided. The first varactor cell provides a first variable capacitance to adjust/tune the frequency of a first differential oscillation signal generated by the LC oscillator, and outputting the first differential oscillation signal. The first transistor is coupled between a core dc supply voltage and a first terminal of the first varactor cell. The second transistor is coupled between a ground potential and a second terminal of the first varactor cell. The first pair of differential transformers is connected in cascade with the first transistor and the second transistor between the core dc supply voltage and the ground potential, and is used for increasing the output-swing of the first differential oscillation signal, and making a current flowing through the first transistor to be reused by the second transistor.

Abstract: In an orthogonal frequency division multiple access (OFDMA) communication system, a transmission apparatus connects multiple tiles, which have a 4×3 structure, along a time or frequency axis in an uplink 4-layer partial usage of subchannels (PUSC) mode, and designs pilots corresponding to one layer at one of multiple symbol positions adjacent to a first corner of the tiles and one of multiple symbol positions adjacent to a second corner of the tiles that face the first corner in a diagonal direction. In this case, null symbols are designed at the rest of the symbol positions adjacent to the first corner or the second corner where the pilots are not designed. Accordingly, a receiving apparatus can obtain n channel values from n tiles. Further, n estimated channel values are applied to a linear interpolation method, so that it is possible to estimate the entire channel value of n tiles.

Abstract: A prepolymer prepared by condensation reaction between a first compound represented by Formula (1) below: Ar—H??(1), where Ar is composed of a crosslinkable moiety at one end, a moiety selected from the group —O—, —S—, —COO—, —CO—, —COS—, —SO2—, and —NH—, and one or two repeating units selected from the group: where A is carbon or nitrogen, and X is hydrogen or halogen; and a second compound that is an aromatic moiety.

Abstract: An apparatus includes a pulsed laser source that produces a pulsed laser beam at an input repetition rate and an input pulse power; a passive pulse splitter that receives the pulsed laser beam and outputs a signal including a plurality of sub-pulses for each input pulse of the pulsed laser beam, where the sub-pulses have a repetition rate that is greater than the input repetition rate and at least two of the sub-pulses have power less than the input pulse power; a sample accommodating structure configured to accommodate a sample placed in the path of a sample beam that is formed from the beam that exits the pulse splitter; and a detector that receives a signal of interest emitted from a sample accommodated by the sample accommodating structure based on the incident sample beam.

Abstract: A compound of formula I is disclosed. Compounds of formula I are useful as analgesics, anti-inflammatory agents, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.

Abstract: A DNA vaccine suitable for eliciting an immune response against cancer cells comprises a DNA construct operably encoding a cancer-associated Inhibitor of Apoptosis-family protein and an immunoactive gene product, such as a cytokine or a ligand for a natural killer cell surface receptor, in a pharmaceutically acceptable carrier. A preferred cytokine is CCL21. Preferred ligands for a natural killer cell surface receptor include human MICA, human MICB, human ULBP1, human ULBP2, and human ULBP3. The cancer-associated Inhibitor of Apoptosis (IAP)-family protein is preferably a survivin protein or livin protein. Method of inhibiting tumor growth by administering the vaccine of the invention to a mammal is also described.

Abstract: The present invention is based upon the identification of regions within the NOTCH-1 receptor that, when mutated, lead to increase receptor signaling. The mutations are associated with uncontrolled cellular growth and this growth may be arrested using agents that interfere with NOTCH-1 activity, such as inhibitors of gamma-secretase. Assays for the NOTCH-1 mutations may be used diagnostically or as part of a treatment regimen for cancer patients.

Abstract: A method for transmitting, by a transmitting terminal, data to a receiving terminal in a wireless communication system includes: generating a first detection field including symbols modulated by using a BPSK data tone; generating a second detection field including symbols modulated such that an even numbered subcarrier and an odd numbered subcarrier have a phase difference of 90 degrees; generating a data packet including the first detection field, the second detection field, and the data; and transmitting the data packet.

Abstract: The present invention provides a human anti-?9 integrin antibody or an antibody fragment which specifically recognize human ?9 integrin and mouse ?9 integrin, inhibit interaction with their ligands, particularly, the antibody or antibody fragment which recognize loop regions of human and mouse ?9 integrins, a gene encoding the antibody or antibody fragment, a recombinant expression vector containing the gene, a transformant harboring the gene, production method of human anti-?9 integrin antibody or antibody fragment using the transformant, and an agent for the prophylaxis or treatment of rheumatoid arthritis which contains the antibody or antibody fragment.

Abstract: An LED includes a first intermetallic layer, a first metal thin film layer, an LED chip, a substrate, a second metal thin film layer, and a second intermetallic layer. The first metal thin film layer is located on the first intermetallic layer. The LED chip is located on the first metal thin film layer. The second metal thin film layer is located on the substrate. The second intermetallic layer is located on the second metal thin film layer, and the first intermetallic layer is located on the second intermetallic layer. Materials of the first and the second metal thin film layer are selected from a group consisting of Au, Ag, Cu, and Ni. Materials of the intermetallic layers are selected from a group consisting of a Cu—In—Sn intermetallics, an Ni—In—Sn intermetallics, an Ni—Bi intermetallics, an Au—In intermetallics, an Ag—In intermetallics, an Ag—Sn intermetallics, and an Au—Bi intermetallics.