Patents Assigned to INSTITUTE
  • Patent number: 8685687
    Abstract: The present invention is directed to chimeric recombinases comprising a serine recombinase operatively linked to a zinc finger nucleotide binding domain such that the chimeric recombinase protein catalyzes site-specific recombination at a DNA site specifically bound by the zinc finger nucleotide binding domain. The serine recombinase can be one of several naturally occurring serine recombinases. The invention also includes nucleic acids encoding the chimeric recombinases, vectors including the nucleic acids, host cells transformed or transfected with the vectors, methods of using the chimeric recombinases to carry out recombination, methods of using substrate-linked protein evolution to generate additional chimeric recombinases, methods of using the chimeric recombinases for gene therapy, and pharmaceutical compositions.
    Type: Grant
    Filed: July 5, 2007
    Date of Patent: April 1, 2014
    Assignee: The Scripps Research Institute
    Inventors: Carlos F. Barbas, III, Russell M. Gordley
  • Patent number: 8687063
    Abstract: A method for predicting lane line is provided in the present invention, in which the method is capable of predicting and reconstructing the unidentified lane line according to a predetermined geometry relationship based on the recognized lane line data previously while one side of lane line is unable to be identified. In one embodiment, a lane predicting relationship formula is formed by describing the geometry relationship between the two identified lines defined the lane. When the one side of line of the lane is unable to be identified, a new predicted line can be reconstructed for representing the unidentified line of lane according to the lane predicting relationship curve. In another embodiment, a lane departure warning system utilizing the foregoing method is provided for monitoring vehicle moving status and alerting the driver so as to enhance the vehicle safety.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: April 1, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Hsi-Wen Hsieh, Yung-Sheng Liao, Che-Chung Lin, Chi-Wei Lin, Dau-Chen Huang
  • Patent number: 8687574
    Abstract: Provided is a system and method that may allocate channels with respect to multiple traffic channels. A channel request apparatus may determine a correlation between traffic streams to which channels are allocated, and to determine whether the traffic streams are related to each other, may generate a channel allocation request message that simultaneously requests channel allocation with respect to related traffic streams that are related to each other, and may transmit the channel allocation request message to a channel response apparatus to request the channel allocation with respect to the related traffic channels.
    Type: Grant
    Filed: February 17, 2011
    Date of Patent: April 1, 2014
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Yong Sun Kim, Seung Eun Hong, Kap Seok Chang, Sung Geun Jin, Woo Yong Lee, Hyun Kyu Chung
  • Patent number: 8685665
    Abstract: A method of enhancing an enzymatic activity of a disintegrin-like domain, and metalloprotease, with an isolated human thrombospondin type 1 motif, member 13 (ADAMTS-13) by substituting on or more positions in the isolated human ADAMTS-13.
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: April 1, 2014
    Assignee: The Chemo-Sero-Therapeutic Research Institute
    Inventor: Kenji Soejima
  • Patent number: 8686110
    Abstract: The present invention relates generally to therapeutic molecules which are useful for modulating apoptosis in a target cell or cell population. More particularly, the present invention provides therapeutic agents which inhibit pro-survival molecules and which are capable of inducing or facilitating apoptosis of a target cell or cell population such as cancer cells. The present invention further provides methods for generating or selecting the therapeutic molecules and pharmaceutical compositions comprising the therapeutic molecules.
    Type: Grant
    Filed: June 23, 2006
    Date of Patent: April 1, 2014
    Assignee: The Walter and Eliza Hall Institute of Medical Research
    Inventors: Peter Malcolm Colman, David Ching Siang Huang, Erinna Faith Lee, Walter Douglas Fairlie
  • Patent number: 8685703
    Abstract: A coryneform bacterium transformant prepared by transferring an exogenous gene which encodes a protein having a sugar transporter function into a coryneform bacterium capable of utilizing D-xylose.
    Type: Grant
    Filed: June 10, 2009
    Date of Patent: April 1, 2014
    Assignee: Research Institute of Innovative Technology for the Earth
    Inventors: Hideaki Yukawa, Masayuki Inui
  • Patent number: 8688063
    Abstract: A receiving apparatus in a wireless communication system includes: an antenna configured to receive a wireless frequency signal including a first frequency band signal and a second frequency band signal; a low noise amplifier (LNA) configured to amplify the wireless frequency signal, output the first frequency band signal as a differential phase signal, and output the second frequency band signal as a common phase signal; a differentiator configured to pass only the differential phase signal between the signals outputted from the LNA; and a combiner configured to pass only the common phase signal between the signals outputted from the LNA.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: April 1, 2014
    Assignee: KAIST (Korea Advanced Institute of Science and Technology)
    Inventors: Sang-Gug Lee, Yuna Shim
  • Patent number: 8688274
    Abstract: A robot positioning method includes the following steps. A optical sensing device is configured at a front end of a robot. Then, the optical sensing device captures a calibration plate image, and a relative position of the optical sensing device with respective to a calibration plate is calculated according to a Bundle Adjustment. A robot calibration method includes the following steps. An optical sensing device is driven to rotate around a reference axis of a calibration plate, so as to calculate a translation matrix between the calibration plate and the robot, and the optical sensing device is driven to translate along three orthogonal reference axes of the calibration plate, so as to calculate a rotation matrix between the calibration plate and the robot.
    Type: Grant
    Filed: January 25, 2011
    Date of Patent: April 1, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Po-Huang Shieh, Shang-Chieh Lu, Bor-Tung Jiang, Kuo-Tang Huang, Chin-Kuei Chang
  • Patent number: 8689324
    Abstract: Techniques to explain authorization origins for protected objects in an object domain are disclosed. In one embodiment, for example, an apparatus may comprise a processor circuit, a request processor component operative on the processor circuit to receive and process a request for an authorization origin of a resource object, the authorization origin comprising an access control with a permission arranged to control access to the resource object based on an identity, and a resource origin component operative on the processor circuit to identify the authorization origin of the resource object from a set of interrelated resource objects and associated access controls, retrieve authorization origin information for the authorization origin, and present the authorization origin information in a user interface view. Other embodiments are described and claimed.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: April 1, 2014
    Assignee: SAS Institute, Inc.
    Inventors: Brian Bowman, Elizabeth A. Lyne, Catherine Hitti, Jianping Yang, J. Forest Boozer
  • Patent number: 8688065
    Abstract: An electromagnetic signal receiver and methods for determining the noise level and signal power in a signal of interest while the receiver is operating. In some embodiments, the signal of interest is a GPS signal. The receiver includes a noise source that provides a noise signal of known power during intervals while the signal of interest is observed. By measuring a signal-to-noise ratio for the signal of interest and the noise power in the signal of interest, the noise level and signal power of the signal of interest can be computed. Various methods of making the measurements and computing the power of the signal of interest are described. Applications of the system and method are described.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: April 1, 2014
    Assignee: California Institute of Technology
    Inventors: Lawrence E. Young, Dmitry Turbiner, Stephan X. Esterhuizen
  • Patent number: 8689160
    Abstract: A computer-implemented method for interconnect redundancy of a circuit design comprises the steps of setting Manhattan distance being less than or equal to three pitches; placing a plurality of dummy micro bumps on at least one side of a die including a signal bump formed on the at least one side; determining an interconnecting candidate by selecting from the dummy micro bumps, which is distant from the signal bump by the Manhattan distance; and providing a routing path between the at least one interconnecting candidate and the signal bump.
    Type: Grant
    Filed: June 17, 2013
    Date of Patent: April 1, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Chang Tzu Lin, Ding Ming Kwai
  • Patent number: 8686359
    Abstract: The present invention relates to methods and systems for 4D ultrafast electron microscopy (UEM)—in situ imaging with ultrafast time resolution in TEM. Single electron imaging is used as a component of the 4D UEM technique to provide high spatial and temporal resolution unavailable using conventional techniques. Other embodiments of the present invention relate to methods and systems for convergent beam UEM, focusing the electron beams onto the specimen to measure structural characteristics in three dimensions as a function of time. Additionally, embodiments provide not only 4D imaging of specimens, but characterization of electron energy, performing time resolved electron energy loss spectroscopy (EELS).
    Type: Grant
    Filed: April 16, 2013
    Date of Patent: April 1, 2014
    Assignee: California Institute of Technology
    Inventor: Ahmed H. Zewail
  • Patent number: 8686730
    Abstract: A system for measuring electrical resistivity survey checks a border of bedrock or a thickness of a sedimentary layer in a riverbed of a river or lake within a short time. A method for analysis of an underground structure of a riverbed using the same is also provided. The system for streamer electric resistivity survey using a survey boat includes a streamer cable connected to the survey boat and having a plurality of electrodes attached thereto, a multi-channel resistivity meter loaded on the survey boat to measure electric resistivity from the plurality of electrodes, a first RTK GPS (Real Time Kinematic Global Positioning System) loaded on the survey boat to measure a position of the survey boat in real time, and a second RTK GPS installed to a tail of the streamer cable to measure a position of the tail in real time.
    Type: Grant
    Filed: September 8, 2011
    Date of Patent: April 1, 2014
    Assignee: Korea Institute of Geoscience & Mineral Resources
    Inventors: Seong-Jun Cho, Jung-Ho Kim, Myeong-Jong Yi, Jeong Sul Son
  • Patent number: 8685160
    Abstract: Provided is a fullerene thin wires-attached substrate in which fullerene thin wires are vertically aligned relative to the surface of the substrate and which is applicable to catalysts, column materials, chemical synthesis templates, field emission devices, field effect transistors, photonic crystals, etc.
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: April 1, 2014
    Assignee: National Institute for Materials Science
    Inventors: Cha Seung, II, Kunichi Miyazawa, Jedeok Kim
  • Patent number: 8685851
    Abstract: A manufacturing method of a MOS device with memory function is provided, which includes: providing a semiconductor substrate, a surface of the semiconductor substrate being covered by a first dielectric layer, a metal interconnect structure being formed in the first dielectric layer; forming a second dielectric layer overlying a surface of the first dielectric layer and the metal interconnect structure; forming an opening in the second dielectric layer, a bottom of the opening revealing the metal interconnect structure; forming an alloy layer at the bottom of the opening, material of the alloy layer containing copper and other metal; and performing a thermal treatment to the alloy layer and the metal interconnect structure to form, on the surface of the metal interconnect structure, a compound layer containing oxygen element. The compound layer containing oxygen element and the MOS device formed in the semiconductor substrate constitute a MOS device with memory function.
    Type: Grant
    Filed: January 27, 2011
    Date of Patent: April 1, 2014
    Assignee: Institute of Microelectronics, Chinese Academy of Sciences
    Inventors: Chao Zhao, Wenwu Wang
  • Patent number: 8688612
    Abstract: A method and apparatus for storing a triple and an inference dependency indexing apparatus appropriate to the method and system are provided. The method of storing a triple related to an inference method for creating other triples by applying an inference rule to the triple includes: (a) adding a serial number to each of triples and inference rules related to inference and storing the triples and the inference rules into a plurality of triple tables and inference rule tables; (b) indexing a triple inferred by applying the triple and the inference rule, using a serial number of the triple and a serial number of the inference rule related to inference; and (c) creating a triple view which allows accessing the triples physically distributed and stored in a plurality of triple storage units (tables) as if the triples are stored in a virtual storage unit (table).
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: April 1, 2014
    Assignee: Korea Institute of Science & Technology Information
    Inventors: Seung Woo Lee, Pyung Kim, Han Min Jung, Mi Kyoung Lee, Dong Min Seo, Won Kyung Sung
  • Patent number: 8688739
    Abstract: A system and method for data matching are disclosed. A user terminal included in the system includes a data provider, a data consumer, and a mapper. The data provider receives life log data of a user which is collected by at least one life log collecting apparatus. The data consumer receives the life log data from the data provider, and compares the life log data and reference data received from a service server to determine whether a difference between the life log data and the reference data exceeds a predetermined threshold value. The mapper maps the service server which provides the reference data corresponding to information of the life log data received from the data provider. Accordingly, the usability to of life log apparatuses can increase.
    Type: Grant
    Filed: July 25, 2012
    Date of Patent: April 1, 2014
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Kyu Chang Kang, Chang Seok Bae, Seong Uk Heo, Dong Won Han
  • Patent number: 8685361
    Abstract: Disclosed therein is a method for preparing a polyacrylonitrile-based polymer for preparation of carbon fiber having a melting point controlled by selecting an optimal energy of microwave, and a method for preparing a carbon fiber through melt spinning using the preparation method for polyacrylonitrile-based polymer. The present invention uses microwave to control the properties of the polyacrylonitrile-based polymer in a simplified way and prepare the polymer optimized for preparation of carbon fiber precursor through melt spinning for a short polymerization time, and provides a means for mass production of the polyacrylonitrile-based polymer being suitable for melt spinning at a temperature lower than the stabilization temperature and acquiring properties adequate to preparation of carbon fiber through stabilization. Hence, the present invention is expected to contribute to mass production of high-performance carbon fibers at reduced cost.
    Type: Grant
    Filed: May 1, 2012
    Date of Patent: April 1, 2014
    Assignee: Korea Institute of Science and Technology
    Inventors: Kap-Seung Yang, Sung-Ho Lee, Hyang-Hoon Chae, Dong-Hun Lee
  • Publication number: 20140087359
    Abstract: Disclosed herein are methods and systems for use in preparing a sample. The methods and systems may be used for lysing one or more structures in a sample (e.g., cells, viral particles, etc.). The methods and compositions may comprise a microfluidic chip or use thereof. The microfluidic chips disclosed herein may comprise (a) a substrate comprising a chamber, wherein at least one mechanical element may be located within the chamber; (b) a thermal element in contact with the chamber; and (c) at least one aperture within the surface of the substrate, wherein the aperture may be configured to insulate the chamber.
    Type: Application
    Filed: September 20, 2013
    Publication date: March 27, 2014
    Applicant: California Institute of Technology
    Inventors: Samuel NJOROGE, John GORMAN, George MALTEZOS, Axel SCHERER
  • Patent number: RE44820
    Abstract: Methods for synthesis of nanocrystalline apatites are presented, as well as a series of specific reaction parameters that can be adjusted to tailor, in specific ways, properties in the recovered product. Particulate apatite compositions having average crystal size of less than 150 nm are provided. Products also can have a surface area of at least 40 m2/g and can be of high density. Hydroxyapatite material is investigated in particular detail. Compositions of the invention can be used as prosthetic implants and coatings for prosthetic implants.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: April 1, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Jackie Y. Ying, Edward S. Ahn, Atsuski Nakahira