Abstract: Provided herein are compounds of Formula (I-A), (I-B), or (I-C), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically enriched forms, prodrugs, or mixtures thereof, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing diseases and/or conditions (e.g., neurological disease (e.g., Alzheimer's disease, multiple sclerosis, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis), metabolic disorder (e.g., obesity, diabetes, X-linked adrenoleukodystrophy (X-ALD)), proliferative disease (e.g., cancers), hepatic disease (e.g., liver cirrhosis), conditions associated with autophagy (e.g., neurodegenerative disease, infection, cancer, conditions associated with aging, heart disease), conditions associated with aging, conditions associated with modulating the mPTP, cardiovascular conditions (e.g.

Abstract: Aspects of the disclosure relate to compositions and methods for targeted protein degradation. In some embodiments, the disclosure relates to methods of evolving protein degrons to interact with certain small molecule inducers (e.g., VS-777, PT-179, or PK-1016). In some embodiments, the disclosure relates to compositions (e.g., peptides, nucleic acids encoding the protein degrons, etc.) used for targeted protein degradation. In some embodiments, the disclosure relates to methods of degrading a target polypeptide in a cell.

Abstract: A colon linearizing device installed in an endoscope to linearize a colon by performing translation and expansion motions in the colon may include a ring-shaped proximal member installed to surround an outer circumferential surface of an insertion tube of an endoscope, a fixed end secured to the insertion tube, a ring-shaped distal member positioned between the proximal member and the fixed end and movably installed along a longitudinal direction of the insertion tube, and an elastic member connected between the fixed end and the distal member.

Abstract: A spherical lithium adsorbent, as well as a preparation method and use thereof are provided. The preparation method includes: dry mixing an adsorbent and a forming agent followed by evenly mixing with a first solvent to form a mixed solution, and adding a thickening and pore forming agent to obtain a mixed system; spraying out the mixed system from a nozzle of a spray device and receiving sprayed drips using a second solvent that is incompatible with the forming agent as a receiving solvent so that the drips become particles to obtain a spherical adsorbent with good performance and even granularity. Spray granulation is performed utilizing airflow so that the particles have a larger specific area and are more suitable for industrial absorption column filling. Furthermore, adsorbent powders in the particles are tightly wrapped and difficult to fall off during cyclic use.

Abstract: An automatic transparent soil preparation box includes an AB liquid mixing module, a refractive index measurement module and a solid particle spreading module which are arranged in a box body. The AB liquid mixing module is configured to inject A/B liquid into a model tank and stir and mix the A/B liquid; the refractive index measurement module is able to suck an AB mixture sample from the model tank and measure a refractive index of the AB mixture sample; the solid particle spreading module is configured to spread solid particles into the model tank and stir and mix the solid particles and an AB mixture. The preparation box integrates functional modules such as liquid mixing, refractive index measurement and solid particle spreading into the preparation box, the preparation process is basically fully automated, the test personnel mainly focus on a test, thereby improving the test efficiency.

Abstract: An ingot splitting method and an ingot splitting apparatus are provided. The ingot splitting method includes the following steps. A laser provided from a laser source is focused with a focusing lens group on a plane to be split of an ingot, and a focus point of the laser is used to scan the plane to be split. An opposing first side and second side of the ingot are fixed with a chuck table and an ultrasonic source. The plane to be split is located between the first side and the second side. A pulling force is applied to the second side in a direction away from the ingot with a tensioner, and ultrasonic waves are applied to vibrate the ingot with the ultrasonic source simultaneously, so that the ingot is divided into two parts from the plane to be split.

Abstract: A method for directly preparing a trivalent chromium compound by electrochemical oxidation of ferrochrome is provided. The method includes: putting ferrochrome as an anode, and placing the anode into an electrolyte solution containing a complexing agent together with a cathode, then turning on a power supply for electrolysis reaction so that chromium and iron in ferrochrome are directly converted into free Cr3+ and Fe3+ respectively, allowing one of Cr3+ and fe3+ to form a stable soluble metal complex together with the complexing agent, and allowing the other of Cr3+ and Fe3+ to form a metal hydroxide solid together with OH? generated by electrolysis reaction, so as to obtain an electrolysis completion slurry. Compared with the prior art, the present application has no hexavalent chromium salt stage, thereby shortening the process flow and avoiding the generation of chromium-containing waste residue.

Abstract: An antenna apparatus includes a first radiating patch with slots and a feed module. There are a plurality of feed modules in correspondence with the slots. The feed module includes a ground component and a feed component. The ground component includes a first conductor patch, a second conductor patch, and a conductor column. The feed component includes a second radiating patch and a first feed member, the second radiating patch and the second conductor patch are spaced from each other. When the foregoing structure is used, integration of an antenna radio frequency system can be improved.

Abstract: The disclosure provides materials and methods for permanently labeling cells by transducing cells with viruses comprising a barcode. The disclosure is based on the idea that tracking, selecting and isolating lymphocytes labeled with the barcode can facilitate identification of clonal cells responsible for antibody or antibody fragment production.

Abstract: A reconfigurable intelligent surface (RIS) antenna includes an RIS antenna body and a bias circuit. The RIS antenna body includes a plurality of RIS antenna units. The bias circuit is electrically coupled to the RIS antenna units of the RIS antenna body. Each RIS antenna unit includes: a metal pattern, a dielectric substrate and a control unit. The metal pattern and the control unit are formed on the dielectric substrate. The metal pattern has a resonance frequency. The control unit includes at least one metal oxide resistive element. The control unit is electrically coupled to the metal pattern and the bias circuit for changing the resonance frequency of the metal pattern by adjusting a bias applied by the bias circuit.

Abstract: Disclosed herein are a method, an apparatus, and a storage medium for image encoding/decoding. An intra-prediction mode for the target block is derived, and intra-prediction for the target block that uses the derived intra-prediction mode is performed. The intra-prediction mode for the target block is derived using an artificial neural network, and an MPM list for the target block is derived using information about the target block, pieces of information about blocks adjacent to the target block, and the artificial neural network. The artificial neural network outputs one or more available intra-prediction modes. Further, the artificial neural network outputs match probabilities for one or more candidate intra-prediction modes, and each of the match probabilities for the candidate intra-prediction modes indicates a probability that the corresponding candidate intra-prediction mode matches the intra-prediction mode for the target block.

Abstract: A stretchable insulating film may include a first insulating layer having stretchability and a second insulating layer on the first layer and having non-stretchability. The first insulating layer may include an elastomer and the second insulating layer may include a cyclic siloxane polymer framework. An electronic device may include the stretchable insulating film. A method of manufacturing the stretchable insulating film may include forming the first insulating layer and forming the second insulating layer. The forming the first insulating layer may include coating a composition including the elastomer or depositing the elastomer. The forming the second insulating layer may include injecting a cyclic siloxane monomer and an initiator on the first insulating layer into a reactor equipped with a heat source and performing a polymerization reaction by low-temperature vapor deposition.

Abstract: Systems, methods, and other embodiments described herein relate to generating designs using learning models for analogics that process text and sketch-based inputs. In one embodiment, a method includes estimating analogical suggestions using a transformer model for a text prompt having design parameters. The method also includes generating an image using a learning model for an expression selected from the analogical suggestions and a sketched stroke inputted. The method also includes manipulating a modified sketch by the learning model and the modified sketch is derived from a sketched conversion of the image by an edge model.

Abstract: A slow-light photonic modulator includes a silicon-on-insulator substrate that includes a silicon device layer on top of a silicon dioxide buried layer. A ridge waveguide is formed partially etching the silicon device layer. The ridge waveguide includes a grating arm and a reference arm. A grating waveguide and a grating electrode are in the grating arm. A straight waveguide and a reference electrode are in the reference arm. A lateral junction is formed by doping the ridge waveguide with p-type and n-type dopants. In some embodiments, the slow-light photonic modulator further includes an unequal phase shifter architecture that is configured to set the modulator in quadrature without the use of external waveguide heaters.

Abstract: A recombinant type I allergen of Artemisia annua pollen (Art a 1), a coding gene, an expression method, and a purification method thereof are provided. By different combinations of codon optimization, different signal peptides, expression vectors and strains, the Art a 1 obtained reaches the expression level of more than 200 mg/L, with a purity of more than 99%, and the activity of the Art a 1 is equivalent to that of a native protein, and the Art a 1 can be used for the desensitization immunotherapy and diagnosis of Artemisia pollen allergy.

Abstract: Provided in the present disclosure is a control system for a heat supply apparatus of a nuclear power plant, comprising: a first-stage pressure measurement means configured for measuring a first-stage pressure of a turbine to obtain a first-stage pressure signal; a high-exhaust pressure measurement means configured for measuring an exhaust pressure of a turbine high-pressure cylinder to obtain an exhaust pressure signal; a steam extraction heating flow rate measurement means configured for measuring a steam extraction heating flow rate to obtain a steam extraction heating flow rate signal; a data acquisition module configured for acquiring and transmitting the measured first-stage pressure signal, the measured exhaust pressure signal and the measured steam extraction heating flow rate signal to a core operation processing module; the core operation processing module; and a the signal output module.

Abstract: A lithium salt-free composite solid electrolyte membrane and a preparation method thereof are provided. The composition of the lithium salt-free composite solid electrolyte membrane includes: micro-nanoscale garnet-type solid electrolyte and polymer; where a mass ratio of the micro-nanoscale garnet-type solid electrolyte to the polymer is (60-100):(5-40); a particle size of the micro-nanoscale garnet-type solid electrolyte is 100 nm-2 ?m. The disclosure also provides a preparation method for the lithium salt-free composite solid electrolyte membrane. The lithium salt-free composite solid electrolyte membrane prepared by the disclosure has controllable morphology and thickness, and does not need to add lithium salt and be equipped with anhydrous and inert environment atmosphere, so that the production cost can be significantly reduced, and large-scale production is easy.

Abstract: A method for processing multiple image data sets, each image data set generated by a different ultrasound frequency emitter, to obtain a single merged image data set for use to display a single merged image. The method can also include steps to account for non-ideal alignment between the different ultrasound frequency emitters.

Abstract: Disclosed are a photo-acoustic sensor device and a photo-acoustic sensing method of the same. The sensing method includes providing a source light in a subject and receiving an ultrasonic wave generated in the subject by the source light. The source light may have a wavelength of 1400 nm to 2500 nm in a near-infrared band.

Abstract: Systems and methods are provided for determining vehicle configurations. The system can receive simulation data or actual driving data of a driving track corresponding to a driver and associate the simulation data or actual driving data with one or more driving parameters. A driver style can be determined based on the one or more driving parameters. A vehicle configuration can be determined for a vehicle of the driver based on the determined driver style. The system can display one or more vehicle settings associated with the vehicle configuration on a user interface.