Abstract: Described herein are methods and uses thereof for in vivo evaluating functions of multiple genes in parallel by combining in utero genetic perturbation of progenitor cells and single-cell transcriptomic profiling of progeny cells in animals. These methods can be used, among other things, to reveal in vivo gene functions in a cell type-specific manner.

Abstract: The disclosure relates to methods for treating cancers (e.g., cancers having a BRCA1 and/or BRCA2 mutation(s)) by administering to the subject an effective amount of a ubiquitin-specific protease 1 (USP1) inhibitor.

Abstract: A magnetron sputtering device according to the present disclosure includes a chamber having a vacuum state therein, a gas supply pipe configured to supply argon (Ar) gas into the chamber, a sputtering head provided within the chamber and including a sputtering target and a magnetic body disposed on a bottom end of the sputtering target to generate a magnetic field, a power supply configured to supply current to the sputtering target to generate plasma, a cooling device including a refrigerant pipe, through which refrigerant circulating from outside the chamber to the sputtering head, flows and configured to cool the sputtering head to a low temperature, a sputtering shield surrounding an area of the refrigerant pipe located outside the chamber and including a refrigerant inlet and a refrigerant outlet communicating with the refrigerant pipe, wherein the sputtering shield including a communication hole communicating with the chamber to have a vacuum state therein and the refrigerant pipe delivers the refrigera

Abstract: A multiscale composite materials with few or no void defects are described. The composite materials include a network of porous materials. Methods and systems for the fabrication of the composite materials are generally described. According to certain embodiments, composite materials are fabricated without the use of an autoclave or low pressure environments.

Abstract: A method of manufacturing a composite anode for a lithium ion battery and a composite anode for a lithium ion battery manufactured thereby. According to the method provide herein, since a metal catalyst precursor is reduced using Joule heating to obtain a carbon-metal catalyst composite layer, composite anode for a lithium ion battery having a large area in a short period of time can be provided, which is excellent in terms of economic feasibility. Further, since it is possible to manufacture a composite anode for a lithium ion battery with the improved lithium electrodeposition density and reversibility of lithium ions, a composite anode for a lithium ion battery having high capacity and improved life stability can be obtained.

Abstract: The present invention relates to the technical field of power generation of power systems, in particular to an offshore integrated power supply system based on clean energy. The integrated power supply system comprises a power generation unit for providing energy, an energy storage unit for storing energy, a load unit for consuming energy, an energy management system, and a fuel cell, wherein the power generation unit comprises a photovoltaic power generation system, a wind power generation system, and a tidal power generation system; the energy storage unit comprises hydrogen storage and a battery pack; and the energy management system connects the power generation unit, the load unit, and the energy storage unit, and allocates the surplus energy from the power generation unit to the hydrogen storage and the battery pack after satisfying the load unit.

Abstract: A vertically integrated micro-bolometer includes an integrated circuit chip, an infrared sensing film, and a metal bonding layer. The integrated circuit chip includes a silicon substrate, a circuit element, and a dielectric layer disposed on the silicon substrate. The infrared sensing film includes a top absorbing layer, a sensing layer, and a bottom absorbing layer. The sensing layer is disposed between the top absorbing layer and the bottom absorbing layer. Materials of the top absorbing layer, the sensing layer, and the bottom absorbing layer are materials compatible with a semiconductor manufacturing process. The metal bonding layer connects the dielectric layer on the silicon substrate in the integrated circuit chip and the bottom absorbing layer of the infrared sensing film to form a vertically integrated micro-bolometer. In one embodiment, the infrared sensing film is divided into a central sensing film, a surrounding sensing film, and a plurality of connecting portions by a plurality of slots.

Abstract: Methods, apparatuses, and systems related to the electrochemical separation of target gases from gas mixtures are provided. In some cases, a target gas such as carbon dioxide is captured and optionally released using an electrochemical cell (e.g., by bonding to an electroactive species in a reduced state). Some embodiments are particularly useful for selectively capturing the target gas while reacting with little to no oxygen gas that may be present in the gas mixture. Some such embodiments may be useful in applications involving separations from gas mixtures having relatively low concentrations of the target gas, such as direct air capture and ventilated air treatment.

Abstract: The present invention provides compositions and methods that allow lipid membranes to be imaged optically at nanoscale resolution via a lipid-optimized form of expansion microscopy, also referred to as membrane expansion microscopy (mExM). mExM, via a post-expansion antibody labeling protocol, enables protein-lipid relationships to be imaged in organelles such as mitochondria, the endoplasmic reticulum, the nuclear membrane, and the Golgi apparatus. mExM may be of use in a variety of biological contexts, including the study of cell-cell interactions, intracellular transport, and neural connectomics.

Abstract: A ultraviolet detector includes a substrate; a first epitaxial layer that is a heavily doped epitaxial layer and located on the substrate, a second epitaxial layer located on the first epitaxial layer, where the second epitaxial layer is a lightly doped epitaxial layer, or a double-layer or multi-layer structure composed of at least one lightly doped epitaxial layer and at least one heavily doped epitaxial layer; an ohmic contact layer located on the second epitaxial layer or formed in the second epitaxial layer, where the ohmic contact layer is a graphical heavily doped layer; and a first metal electrode layer located on the ohmic contact layer.

Abstract: The invention provides a method for producing sulfated polysaccharides by reacting a PAPS production/regeneration system utilizing the metabolic activity of a microorganism or a treated matter thereof with a microorganism expressing a sulfation enzyme or a treated matter or extract thereof upon mixing of inexpensive raw materials such as magnesium sulfate. The invention also provides a method for producing PAPS from inexpensive raw materials. The methods involve preparing a transformant (a) of a bacterium of the genus Corynebacterium, which contains a gene encoding an ATP sulfurylase and a gene encoding an APS kinase, which are expressible, and in which a cell plasma membrane of the transformant (a) is substance-permeable, or a treated matter of the transformant (a), and conducting a reaction for producing PAPS by using a reaction solution containing ATP or an ATP source, a sulfate ion source, and the transformant (a) or the treated matter thereof.

Abstract: Disclosed are a 3D non-volatile memory, an operating method thereof, and a manufacturing method thereof. The 3D non-volatile memory includes a bit line formed to extend in a vertical direction and horizontal structures contacting the bit line while being formed to extend in a horizontal direction and being space in the vertical direction. Each of the horizontal structures includes a ferroelectric layer contacting the bit line, a middle metal layer surrounded by the ferroelectric layer, a dielectric layer surrounded by the middle metal layer, and a word line surrounded by the dielectric layer.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. Methods for making and using and uses of such systems, methods, and compositions and products from such methods and uses are also disclosed and claimed.

Abstract: An in-situ stress measurement device for ultra-deep non-vertical drilling adopts a technical route of single channel and bidirectional rolling of in-hole equipment, and its related functions are mainly realized by a bidirectional rolling device and a split-type axial-force-free circuit switching valve. The bidirectional rolling device can drive the in-hole equipment to move freely in a circumferential direction and back and forth, which changes sliding friction between the in-hole equipment and a hole wall into rolling friction during an in-situ stress measurement of non-vertical drilling. The split-type axial-force-free circuit switching valve provides a technical solution for a single-pipe test in the non-vertical drilling.

Abstract: In an embodiment, there is provided a light guide for an edge-lit light panel. The light guide includes a first light coupling surface; a second light coupling surface; a first light output surface; and a second light output surface. The second light coupling surface opposes the first light coupling surface. The second light output surface opposes the first light output surface. The first light output surface and the second light output surface are coupled between the first light coupling surface and the second light coupling surface. Each light coupling surface is configured to receive incident light from a respective light source and to produce at least a portion of a batwing light beam inside the light guide. The at least a portion of the batwing light beam is concentrated adjacent the first light output surface, the first light output surface corresponding to a first light extraction surface.

Abstract: The disclosure relates to gene therapy vectors, such as AAV vectors, comprising a polynucleotide encoding ?-sarcoglycan (SGCG) and methods of using such gene therapy vectors to treat subjects suffering from a muscular dystrophy, e.g. limb girdle dystrophy type 2C (LGMD2C).

Abstract: The present disclosure relates to an apparatus for enhancing contrast sensitivity and resolution in a grating interferometer by machine learning, which can improve both image contrast sensitivity and spatial resolution in a grating interferometer by machine learning, the apparatus including: an image acquisition unit; a numerical phantom generation unit, a convolution layer generation unit to extract features from input data; an activation function application calculation unit that can apply a rectified linear activation function to an output value of the convolution calculation to perform smooth repetitive machine learning; a CNN repetitive machine learning unit that corrects a convolution calculation factor while repeatedly performing forward propagation and backward propagation processes; and an image matching output unit that matches and outputs features extracted by repetitive machine learning of the CNN repetitive machine learning unit.

Abstract: A photochromic polypropylene fiber is provided. The photochromic polypropylene fiber includes about 98 to 99 parts by weight of polypropylene, about 0.2 to 0.8 parts by weight of a photochromic agent, about 0.1 to 1 parts by weight of an ultraviolet absorber, and about 0.1 to 1 parts by weight of a light stabilizer. The ultraviolet absorber includes and the light stabilizer includes wherein n is 10-14. A preparation method of the photochromic polypropylene fiber is further provided.

Abstract: A composite coating layer for a solid oxide fuel cell member according to the present disclosure includes a nickel layer that coats at least a portion of the surface of the solid oxide fuel cell member, and a lanthanum oxide layer that coats at least a portion of the surface of the nickel layer, and thereby, has an effect of suppressing the volatilization of chromium from the solid oxide fuel cell member even under high temperature and long-term conditions.

Abstract: Provided are an odorant receptor marker of microglia and a use thereof, and according to the odorant receptor marker of microglia and a use thereof according to one aspect, microglia may be detected by measuring an activity or expression level of a protein of an odorant receptor (OR) Olfr110 or Olfr111, and OR ligands of microglia may be selected using them, and an inhibitor or activator against the interaction between the OR and 2-pentylfuran is effectively used in treatment of a neuroinflammatory disease or meningitis.