Abstract: Embodiments herein provide fused-pyrido heterocycles such as azaindoles, carboline derivatives, furo[b]pyridines or furo[b]pyridine-isatin hybrids of Formula I. Embodiments also relate to a process for a synthesis of variety of complex pyrido-heterocycles The pyrido-heterocycles can be used for treating cancer (cervix, kidney, lung, breast and epidermal skin) and multi-drug resistant tuberculosis. These heterocycles can also be used as anti-biofilm agents against pathogenic strains, which will minimize the risk of secondary infections.

Abstract: A focusing device includes a substrate and a plurality of scatterers provided at both sides of the substrate. The scatterers on the both sides of the focusing device may correct geometric aberration, and thus, a field of view (FOV) of the focusing device may be widened.

Abstract: An anti-seismic support method for a mine shaft includes: providing a circular support groove in a liquefaction-prone layer of the mine shaft; providing horizontal support holes in a groove wall, and fixing an outer support spring steel cylinder against the groove wall; drilling vertical support holes at a groove bottom, anchoring a vertical anchor rod group into the vertical support holes, and injecting an expansion anchoring slurry into the vertical anchor rod group; making a lower positioning support ring abut against an upper end of the vertical anchor rod group and an inner wall of the outer support spring steel cylinder; fixing an anti-seismic connecting rod group between lower and upper positioning support rings; making an outer wall of an inner support spring steel cylinder abut against the upper and lower positioning support rings; and providing an upper support cover seat atop the outer and inner support spring steel cylinders.

Abstract: A method includes receiving, with a computing device, an image, identifying one or more salient features in the image, and generating a saliency map of the image including the one or more salient features. The method further includes sampling the image based on the saliency map such that the one or more salient features are sampled at a first density of sampling and at least one portion of the image other than the one or more salient features are sampled at a second density of sampling, where the first density of sampling is greater than the second density of sampling, and storing the sampled image in a non-transitory computer readable memory.

Abstract: The present disclosure relates generally to a system and method for detecting or indicating a state of impairment of a test subject or user due to drugs or alcohol, and more particularly to a method, system and application or software program configured to creating a virtual-reality (“VR”) environment that implements drug and alcohol impairment tests, and which utilizes eye tracking technology to detect or indicate impairment.

Abstract: A modular humeral implant for an inverted shoulder prosthesis includes a humeral stem having, on the one hand, a diaphyseal keel of elongate shape, extending along a diaphyseal axis and shaped to be engaged in a medullary cavity of a humerus, and, on the other hand, a metaphyseal portion. A humeral spacer is mounted on the metaphyseal portion of the humeral stem and has a lower face facing the metaphyseal portion, the lower face having a peripheral portion projecting laterally from the metaphyseal portion and covered at least partially with a porous or rough metal surface coating promoting an osseointegration. A humeral insert is fastened on the humeral spacer and has a hemispherical cup shaped to receive a glenosphere of a glenoid implant.

Abstract: A blur compensation system includes: a mirror on which light of an image from a predetermined position is incident and which reflects light of a specific wavelength such that an incidence angle and an emission angle of the light of the specific wavelength are different from each other; a mirror that is disposed at a position on which the light of an image which is reflected by the mirror is incident and reflects the light of the specific wavelength such that an incidence angle and an emission angle of the light of the specific wavelength are different from each other; and a lens that is disposed on an optical axis of the light of an image between the mirror and the mirror and changes a direction of the light of an image which is reflected by the mirror such that light of a wavelength other than the specific wavelength out of the light of an image which is reflected by the mirror is emitted in the same direction as the light of the specific wavelength from an emission position of the light of the specific wave

Abstract: A stable crystal of a salt of N—[(R)-1-{(S)-2-hydroxy-2-phenylpropylamino}propan-2-yl]isoquinoline-6-sulfonamide may have desirable properties for a pharmaceutical drug substance, and more specifically N—[(R)-1-{(S)-2-hydroxy-2-phenylpropylamino}propan-2-yl]isoquinoline-6-sulfonamide dihydrochloride anhydride. A crystal of the anhydride may have characteristic peaks at 2? angles of 6.8±0.1°, 10.0±0.1°, 12.7±0.1°, 14.6±0.1°, 14.8±0.1°, 16.2±0.1°, 17.4±0.1°, 17.8±0.1°, 19.5±0.1°, 20.0±0.1°, 21.6±0.1°, 24.7±0.1°, 25.5±0.1°, 25.8±0.1°, 29.8±0.1°, 39.5±0.1°, and/or 44.9±0.1° in powder X-ray diffraction spectrum.

Abstract: Disclosed is a silicon photonics-based optical transmission apparatus. The apparatus includes an optical modulator chip of a ground-signal-ground (GSG) electrode array including two phase shifters for differential driving, a sub-substrate including a metal electrode of a periodic pattern to connect two ground metal electrodes to each other at a GSG electrode connected to each of the two phase shifters, and a solder bump having a same periodic pattern as the metal electrode of the sub-substrate to connect the ground metal electrodes of the optical modulator chip and the metal electrode of the periodic pattern of the sub-substrate.

Abstract: Disclosed are a heterogeneous stem cell population, a preparation method therefor, and the use thereof. Specifically, disclosed is a heterogeneous stem cell population, characterized in that stem cells in the heterogeneous stem cell population express stemness genes MYC, KLF4, GMNN, SOX2 and NANOG, and in the heterogeneous stem cell population, the ratio of stem cells expressing CD146 is 1%-50%.

Abstract: A complex is provided comprising a conjugate in which a polymer having a boronic acid group and a compound having a diol structure are bonded, and a substance that is complexed with the conjugate.

Abstract: A method for relative quantification of organic and biological compounds by electrochemical mass spectrometry is disclosed. The method involves using electrochemistry (EC) in a mass spectrometry (MS)-based relative quantitative analysis. In this method, isotope-labeled standards or running calibration curves are not employed. A quantification method could include the steps of subjecting a sample analyte to liquid chromatography or electrophoresis separation, followed by an electrochemical oxidation or reduction in an electrochemical cell, and then mass spectrometric detection.

Abstract: The present invention belongs to the field of plant genetic engineering. Specifically, the invention relates to a method for creating novel herbicide resistant plants by base editing techniques and a method for screening endogenous gene mutation sites capable of conferring herbicide resistance in plants. The invention also relates to the use of the identified endogenous gene mutantation sites in crop breeding.

Abstract: A co-culture apparatus includes: a first airtight container; a co-culture device disposed outside of the first airtight container; a first culture medium source disposed in the first airtight container and storing a first culture medium; a second culture medium source storing a second culture medium having a lower dissolved oxygen concentration than that of the first culture medium; and a first conduit connected to the co-culture device and the first culture medium source. The co-culture device includes: a membrane having a first main surface, and a second main surface opposite to the first main surface for culturing cells; a first flow path partially defined by the first main surface and disposed such that the first culture medium flows therethrough; and a second flow path partially defined by the second main surface and disposed such that the second culture medium flows therethrough. The first flow path has an inlet connected to the first conduit.

Abstract: A microelectromechanical heating device includes a substrate, a thermal insulator, and a heater. The thermal insulator includes a plurality of supporting structures and at least one thermal insulation layer. The supporting structures are disposed on the substrate. The thermal insulation layer is located above the substrate and connected to the plurality of supporting structures. The thermal insulation layer is spaced apart from the substrate by a distance. The heater is disposed on the at least one thermal insulation layer.

Abstract: Disclosed is an acquisition method for domain rule knowledge of an industrial process. The method comprises the steps of: establishing a domain rule base, establishing a semantic knowledge base, and combining the domain rule base and the semantic knowledge base so as to realize an augmented update of a domain rule knowledge base; describing the domain knowledge of the industrial process by using weighted first-order logic rules so as to form a training sample set of the first-order logic rules; performing a weight learning by applying probability soft logic and the training sample set of the first-order logic rules so as to realize weight to non-weighted rules; performing rule learning through a machine learning algorithm so as to obtain a first-order logic rule on a change in optimization decision-making semantic when multi-source data semantic information changes.

Abstract: Disclosed is a dialogue emotion correction method based on a graph neural network, including: extracting acoustic features, text features, and image features from a video file to fuse them into multi-modal features; obtaining an emotion prediction result of each sentence of a dialogue in the video file by using the multi-modal features; fusing the emotion prediction result of each sentence with interaction information between talkers in the video file to obtain interaction information fused emotion features; combining, on the basis of the interaction information fused emotion features, with context-dependence relationship in the dialogue to obtain time-series information fused emotion features; correcting, by using the time-series information fused emotion features, the emotion prediction result of each sentence that is obtained previously as to obtain a more accurate emotion recognition result.

Abstract: A grounding segment for a segmented grounding electric device, including a plurality of segment single bodies disposed in a matched manner, wherein a curved concave surface is formed in an outer side surface of each segment single body; a chute is formed in the curved concave surface; an interior of the chute is in sliding connection with an elastic member; two ends of the elastic member are respectively connected to sliders; the sliders are in sliding connection with the interior of the chute; each slider is movably connected to a curved fixing member matching a grounding conductor; the curved fixing member is made of a conductive material applicable to grounding conductors of different sizes; and a locking apparatus is connected between the plurality of segment single bodies. A user conveniently transports and mounts the grounding segment to reduce a land excavation area. Universality of the grounding segment is improved.

Abstract: Provided is a solid electrolyte membrane including a porous frame including a metal or a polymer material, solid electrolyte particles covering both surfaces of the porous frame, and filling pores of the porous frame, and a binder between the solid electrolyte particles.

Abstract: One embodiment provides a broadband signal source. The broadband signal source includes a number, n, signal paths and a combiner circuitry. Each signal path, i, includes a programmable phase shifter circuitry, an amplifier circuitry and a harmonic generation circuitry. The programmable phase shifter circuitry is configured to phase shift a path input signal by a respective phase angle, ?i. The path input signal corresponds to a source input signal having a fundamental frequency, f, and an input signal bandwidth. The amplifier circuitry is configured to amplify the phase shifted path input signal. The harmonic generation circuitry is configured to generate a path output signal including a plurality of harmonics of the amplified phase shifted path input signal.