Abstract: The present invention relates to a recombinant herpes simplex virus (HSV) containing an expression cassette capable of expressing a fused protein of a cancer-cell-targeting domain and an extracellular domain of HVEM and the use thereof. When the recombinant HSV infects and enters target cells, which are cancer cells, HSV proliferates, and an adapter, which is the fused protein, is expressed in the cells and is released to the outside of the cells along with the proliferated HSV virion upon cell lysis, or is released even before the virion is released due to cell lysis when the adapter contains a leader sequence, and the fused protein released to the outside of the cells acts to induce the HSV virion to infect surrounding cancer cells expressing a target molecule recognized by the cancer-cell-targeting domain or to increase the infection efficiency thereof.

Abstract: Disclosed are a human body communication receiver and an operating method thereof, which may effectively remove low frequency noise. The human body communication receiver according to the present disclosure includes a receiving electrode, a virtual electrode, a filter circuit that is connected between the receiving electrode and the virtual electrode, and removes low frequency noise from a signal received through the receiving electrode to generate a high frequency signal, a low frequency reconstruction circuit that is connected to a rear end of the filter circuit and reconstructs a low frequency baseband signal by rectifying the high frequency signal, and an amplifying circuit that is connected to a rear end of the low frequency reconstruction circuit, and amplifies the low frequency baseband signal.

Abstract: The disclosure discloses a method, apparatus and system for detecting multi-mode electromagnetic acoustic and magnetic flux leakage and a sensor. The method comprises: S102, receiving an operation instruction for detecting an object to be detected, the operation instruction is used for controlling a detection sensor to enter into any one or more of working modes as follows: magnetic flux leakage detection, ultrasonic bulk wave detection, ultrasonic guided wave detection and surface wave detection; S104, controlling the detection sensor to output a corresponding detection signal according to the operation instruction; and S106, detecting the object to be detected on the basis of the detection signal. The technical solution achieves a purpose of using one sensor to realize various detection modes, such as magnetic flux leakage and electromagnetic acoustic modes, reduces complexity and cost of a detection system, and improves detection efficiency.

Abstract: Disclosed is a cold-resistant and lean-type transgenic pig and a preparation method therefor, which relate to the field of genetic engineering. By transferring a mouse uncoupling protein 1 gene into the genome of a pig, a transgenic pig is obtained which can not only resist the cold but also have an increased lean meat rate by reducing fat deposition. Simultaneous improvement of two important production traits of pigs through the site-directed single gene manipulation not only lays a foundation for the application and basic research of genetic editing for big animals, but also provides with breading researchers a new way of thinking for improving traits of livestock.

Abstract: The training apparatus according to an embodiment includes: a support unit; a guide unit fixed on the support unit and including rails which extend in a front-rear direction; a sliding unit which is movable in the front-rear direction along the rails of the guide unit; a pillar-shaped rotation axis fixed on the support unit; a footrest unit which supports a user's foot; a lower support formed below the footrest unit; and a connection rotating unit formed below the footrest unit and connected to the rotation axis of the support unit through insertion to allow the footrest unit to rotate around the rotation axis. A plurality of springs installed inward from two sidewalls of the sliding unit is configured to come into contact with the lower support of the footrest unit and apply pressure from two sides when the footrest unit rotates.

Abstract: A method for three-dimensional (3D) scene reconstruction by an agent includes estimating an ego-motion of the agent based on a current image from a sequence of images and a previous image from the sequence of images. Each image in the sequence of images may be a two-dimensional (2D) image. The method also includes estimating a depth of the current image via a depth estimation model comprising a group of encoder layers and a group of decoder layers. The method further includes generating a 3D reconstruction of the current image based on the estimated ego-motion and the estimated depth. The method still further includes controlling an action of the agent based on the 3D reconstruction.

Abstract: Provided are anti-infection effects of a heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) and use thereof. In particular, provided are use of hnRNPA2B1, a nucleic acid molecule encoding the protein, and an accelerator thereof or an inhibitor thereof in the preparation of a product for preventing and/or treating infectious diseases and/or diseases and/or conditions associated with infection, and a corresponding pharmaceutical composition or kit thereof. The present disclosure can be used for preventing and inhibiting infections (such as virus infections) and diagnosing and treating autoimmune diseases related to self-nucleic acids, and has wide application prospects.

Abstract: Recombinant polynucleotides and vectors containing an engineered (artificial) exon-intron-exon gene structure in a transgene are provided, which undergoes splicing when it is expressed in a target cell.

Abstract: Disclosed is an optimization decision-making method of an industrial process fusing domain knowledge and multi-source data. The method comprises the steps of: acquiring the domain knowledge of the industrial process by using probability soft logic, and building an domain rule knowledge base of the industrial process; fusing multi-source data semantics and multi-source data features to form a new semantic knowledge representation of the industrial process, and constructing a semantic knowledge base of the industrial process; under a posteriori regularization framework, utilizing the domain rule knowledge base of the industrial process and the semantic knowledge base of the industrial process to obtain an optimization decision-making model embedded with the domain rule knowledge and obtain a posteriori distribution model; and migrating knowledge in the optimization decision-making model embedded with the domain rule knowledge into the posteriori distribution model through the knowledge distillation technology.

Abstract: A peptide aptamer for specific recognition of arginine and its application are provided. The sequence of the peptide aptamer is shown in SEQ ID No. 1. The peptide aptamer is modified by a group that improves stability, or by a fluorescent group, an isotope and an electrochemical group that provide a detection signal, or by an affinity ligand and a mercapto. According to the computer-aided molecular docking simulation prediction, the peptide aptamer that can specifically bind to L-arginine is screened, which is verified by an isothermal titration calorimeter. The peptide aptamer has the advantages of good stability, strong binding ability, high specificity and low production cost.

Abstract: Disclosed herein are a gateway-signaling method for frequency/timing offsets and an apparatus for the same. An apparatus for transmitting a broadcast signal according to an embodiment of the present invention includes a frequency/timing decision unit for determining a center frequency to which a frequency offset is applied using a carrier offset, which is identified using a timing and a management packet transmitted through a Studio-to-Transmitter Link (STL); and an RF signal generation unit for generating an RF signal to be transmitted, which corresponds to the center frequency.

Abstract: Disclosed herein an apparatus for generating hologram and a method for generating hologram using the same. The apparatus includes: a geometric phase modulator disposed to enable incident light from a target object to pass through and configured to modulate the incident light to a plurality of circular polarizations; an image sensor configured to receive the plurality of circular polarizations and to acquire an interference fringe generated by the plurality of circular polarizations as an image; and a polarization selective element equipped with a liquid crystal element, which controls an output polarization angle of the incident light according to an output polarization signal, and configured to sequentially output the incident light at output polarization angles different from each other.

Abstract: An operation method of a relay terminal for relaying radio communication between a base station and a remote terminal may comprise: recognizing a relay request of the remote terminal for system information provided by the base station; acquiring the system information from the base station; and transmitting the system information to the remote terminal.

Abstract: The disclosure provides a miRNA marker for the treatment and/or diagnosis of Alzheimer's disease (AD), and the miRNA marker is a miRNA23 cluster. The disclosure provides use of the miRNA23 cluster in the diagnosis and treatment of AD. The expression of the miRNA23 cluster is detected using primers for the microRNA marker through AD model cells, AD model animals and natural aging animals, and blood of AD patients, and it is found that the expression of the miRNA23 cluster is significantly reduced during the progression of AD, which reduces neuronal apoptosis by inhibiting the GSK-3?-mediated tau protein phosphorylation. Therefore, the miRNA23 cluster can be used as a novel biomarker and therapeutic target for the early, non-invasive diagnosis and treatment of AD.

Abstract: One embodiment provides an offset calibration circuitry configured to compensate an offset voltage of a resistive bridge sensor. The offset calibration circuitry includes a first current digital to analog converter (IDAC) coupled to a first successive approximation register (SAR), a second IDAC coupled to a second SAR and an SAR controller circuitry. The first IDAC is configured to couple to a negative voltage port of a resistive bridge sensor. The first SAR is configured to store a circuitry first digital value. The second IDAC is configured to couple to a positive voltage port of the resistive bridge sensor. The second SAR is configured to store a second digital value. The SAR controller circuitry is configured to adjust each bit of the first SAR and each bit of the second SAR based, at least in part, on an output of a comparator. The comparator is configured to compare a voltage on the negative voltage port or a voltage on the positive voltage port to a common mode voltage.

Abstract: The present invention relates to a method of discovering a marker for predicting a risk of depression or suicide using multi-omics analysis and machine learning, and a marker for predicting a risk of depression or suicide, discovered by the method. According to the method for discovering a marker for predicting a risk of depression or suicide, the marker for predicting the risk of depression or suicide may be discovered with high accuracy and reliability, and the risk of depression or suicide can be diagnosed and prevented at an early stage through genetic testing.

Abstract: This invention is intended to identify a gene cluster involved in biosynthesis of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species and to establish a system for synthesizing such cyclic peptide compound. The gene is composed of a first module to a tenth module and encodes a protein having activity of synthesizing a nonribosomal peptide constituting a basic peptide backbone of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species.

Abstract: A method performed by an autonomous device includes identifying a current movement of an operator based on monitoring the operator of the autonomous device. The method also includes inferring an intended direction of travel for the autonomous device based identifying the current movement. The method further includes identifying one or more objects in a current environment and limitations of the current environment. The method still further includes determining the action to be performed based on inferring the intended direction of travel and also identifying the one or more objects and the limitations of the current environment. The method also includes performing, by the autonomous device, the action.

Abstract: An environmentally-friendly semi-closed loop deep-sea ore hydraulic lifting system, comprises a water injection pump, a water injection riser, a deep-sea multiple high-pressure silo feeding device, a lifting riser, a dewatering device and a pipeline. The water injection pump and the dewatering device are fixed on a mining ship. The water injection pump is connected to the deep-sea multiple high-pressure silo feeding device through the water injection riser. The deep-sea multiple high-pressure silo feeding device is connected to the dewatering device through the lifting riser. The water injection pump is connected to the dewatering device through the pipeline. Seawater is pumped into the water injection riser by the water injection pump, then ore is fed into a high-pressure hydraulic pipeline by the deep-sea multiple high-pressure silo feeding device to be mixed with the seawater, and an obtained ore and seawater mixture is lifted to the mining ship on the sea surface.

Abstract: A host map system for updating a region of a host map based on sensor data received from a plurality of connected vehicles travelling in the region comprises monitoring a host map region for discrepancies, defining a geo-fence around an area of a discrepancy and setting a schedule for activing the geo-fence. When a connected vehicle enters the geo-fence, the host mapping system transmits the geo-fence to the connected vehicle and requests that it share its sensor data while travelling in the geo-fenced area. The host mapping system receives the sensor data and processes the data to update details of the host map. The host mapping system may transmit the updated map to connected vehicles travelling in the map region.