Abstract: The present application provides systems, methods and compositions used for targeted gene modification, targeted insertion, perturbation of gene transcripts, nucleic acid editing. Novel nucleic acid targeting systems comprise components of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems and transposable elements.

Abstract: A device for capturing particles includes a gas-guiding unit, a gas-guiding unit and a mist-elimination unit. The gas-guiding unit has opposing first and second ends. The mist-elimination unit is disposed at the second end. The liquid-circulation unit, disposed under the mist-elimination unit by surrounding the gas-guiding unit, includes through holes below the gas-guiding unit by a gap. A gas containing particles enters the channel via the first end and then the mist-elimination unit via the second end. While the gas flows into the channel, the liquid in the liquid-circulation unit is inhaled into the channel via the gap to form droplets containing particles. After the droplets are captured by the mist-elimination unit, the liquid formed at the mist-elimination unit flows down into the liquid-circulation unit to reform the liquid to be further inhaled back to the channel of the gas-guiding unit via the gap.

Abstract: The present invention relates to compositions and methods for inhibiting DHHC3 palmitoyltransferase for treating cancer. Described herein, are methods of inhibiting expression or activity of programmed death-ligand 1 (PD-L1) in a cell of a subject, e.g., a human subject, in need thereof are carried out by administering to the subject an effective amount of a palmitoyltransferase inhibitor, thereby inhibiting the expression or activity of PD-L1 in the subject. The palmitoyltransferase comprises an Asp-His-His-Cys motif (DHHC)-type protein. Exemplary DHHC-type proteins include DHHC3, DHHC5, DHHC7, and DHHC17.

Abstract: A method for producing metallic silver by electro-deposition, including electrolyzing an electrolyte solution containing Ce(NO3)3 in an anode zone and an electrolyte solution containing AgNO3 in a cathode zone by using an electrolytic cell with a specific diaphragm, wherein the electrolyte solution in the anode zone is not allowed to enter the cathode zone. After the electrolyzing is complete, the metallic silver with a high purity is obtained at the cathode, and a Ce4+-containing solution is obtained in the anode zone.

Abstract: A system that has a plurality of monitors, a control unit, a first object and a second object is provided. The second object has one or more sensors operable to generate data and is remote from the first object. The control unit is configured to determine whether a first user is positioned on a first or on a second location of the first object and display a simulation of a second user onto the plurality of monitors based on the generated data. The second user is located remote from the first user and is displayed as being positioned in a different location on the first object than the first user on the first object. The control unit is further configured to activate the one or more heat generating devices to simulate a presence of the second user being positioned in the different location on the first object.

Abstract: The present invention provides a point cloud data acquisition method and device under a situation of no GNSS signal. The method comprises: re-sampling line data acquired from a topographic map to obtain discrete line data; generating a full-second PPS pulse in a simulating manner; counting by using a distance measuring instrument, sampling the count, when it is detected that the full-second PPS pulse is received, calculating position information at a current moment; simulating a GNSS satellite protocol according to the position information at the current moment; parsing the GNSS satellite protocol by using a point cloud data acquisition module to complete time synchronization, and controlling a LiDAR to acquire point cloud data; parsing the GNSS satellite protocol by using an inertial measurement module, and recording attitude determination positioning data in real time to generate POS data; and optimizing the POS data to obtain accurate point cloud data.

Abstract: A low density parity check (LDPC) encoder, an LDPC decoder, and an LDPC encoding method are disclosed. The LDPC encoder includes first memory, second memory, and a processor. The first memory stores an LDPC codeword having a length of 16200 and a code rate of 3/15. The second memory is initialized to 0. The processor generates the LDPC codeword corresponding to information bits by performing accumulation with respect to the second memory using a sequence corresponding to a parity check matrix (PCM).

Abstract: A query enhancement system for constructing an elastic field based on a time delay, including: dividing a network node to obtain a set of containers composed of several containers, wherein the containers are nested and each container includes a management node for performing node organization, neighbor maintenance and query services within the container. Further, a query enhancement method for constructing an elastic field based on a time delay includes: carrying out same-layer non-intersection full-coverage division on a network node to obtain a set of containers that are nested, and execute a query flow without a given low time delay requirement which uses an existing query technique and a nearby query flow with a given low time delay requirement which uses a distributed nearby querying method to carry out a nearby query; with an actual query time delay index Ti less than the requirement of an upper time delay limit Ts.

Abstract: The present invention provides for a method of converting a depolymerized lignin aromatic compound into a bioproduct, comprising: (a) providing a composition comprising a depolymerized lignin aromatic compound, optionally a depolymerized cellulose, and optionally a depolymerized hemicellulose, and (b) introducing a genetically modified microorganism to the composition, wherein the genetically modified microorganism is capable of converting the depolymerized lignin aromatic compound into a bioproduct; such that the depolymerized lignin aromatic compound is converted into a bioproduct.

Abstract: The present disclosure relates to a maleate salt of a benzothiophene compound, a crystalline form thereof, and a use thereof. Specifically, the present disclosure relates to a compound represented by formula (I-A), a crystalline form A thereof, a preparation method of a pharmaceutical composition including the same, and a use of the pharmaceutical composition in the preparation of drugs for preventing or treating diseases of the central nervous system. The compound represented by formula (I-A) and the crystalline form A thereof in the present disclosure have excellent physical and chemical properties, high oral bioavailability, excellent drugability, and are well-suited for pharmaceutical preparation, application, and preservation.

Abstract: [Object] An object is to provide a brain activity analyzing method for realizing a biomarker using brain function imaging for neurological/mental disorders. [Solution] From data of resting-state functional connectivity MRI obtained by measuring groups of healthy subjects and patients, a correlation matrix of degrees of activities among prescribed brain regions is derived. By a sparse canonical correlation analysis (SCCA) of attributes of subjects and the correlation matrix, elements of correlation matrix that connect to canonical variables corresponding only to the diagnosis label are extracted. By sparse logistic regression (SLR) during Leave-One-Out Cross Validation of a first sum-set of elements of correlation matrix obtained as a result of feature extraction by a sparse regularized canonical correlation analysis, a second sum-set of elements of the correlation matrix is extracted. By discrimination analysis using sparse logistic regression on the second sum-set, a discriminator is generated.

Abstract: The disclosure provides a stage-by-stage measurement, regulation and distribution method for dynamic characteristics of multi-stage components of large-scale high-speed rotary equipment. Firstly, a single-stage rotor circular contour measurement model is established, and the circular contour measurement model is simplified by using a distance from an ith sampling point of an ellipse to a geometry center to obtain a simplified circular contour measurement model. Then, actually measured circular contour data is taken into the simplified circular contour measurement model to determine a relationship between dynamic response parameters after rotor assembly and eccentricity errors as well as the amount of unbalance of all stages of rotors. Finally, a rotor speed is set according to the relationship between the dynamic response parameters after rotor assembly and the eccentricity errors as well as the amount of unbalance of all stages of rotors to obtain a critical speed parameter objective function.

Abstract: The present invention relates to a mannuronic diacid oligosaccharide composition, comprising a mannuronic diacid of Formula (III) or a pharmaceutically acceptable salt thereof, wherein n is an integer from 1 to 9, m is 0, 1 or 2, and m? is 0 or 1, and wherein the total weight of mannuronic diacids wherein n=1-5 is 80-95% of the total weight of the composition, and the ratio of the total weight of mannuronic diacids wherein n=1-3 to the total weight of mannuronic diacids wherein n=4-7 is between 1.0 and 3.5.

Abstract: A method and a system for automatically generating multiple captions of an image are provided. A method for training an auto image caption generation model according to an embodiment of the present disclosure includes: generating a caption attention map by using an image; converting the generated caption attention map into a latent variable by projecting the caption attention map onto a latent space; deriving a guide map by using the latent variable; and training to generate captions of an image by using the guide map and the image. Accordingly, a plurality of captions describing various characteristics of an image and including various expressions can be automatically generated.

Abstract: Disclosed are a target holder assembly of an ion probe and a method for preparing a sample target thereof. Specifically, the target holder assembly includes a body and sheets, a middle part of the body is provided with a sample target hole, and limiting portions are symmetrically arranged at an opening of the sample target hole away from a sample target entry side; and the sheets match the limiting portions in shape and dimension to form recesses on a sample target for receiving the limiting portions.

Abstract: A wireless communication terminal communicating wirelessly with a base wireless communication terminal and unassociated with the base wireless communication terminal is disclosed.

Abstract: Quantitative phase gradient microscopes (QPGM) using metasurface layers including birefringent lenses are disclosed. The birefringent lenses are manufactured by patterning nanoposts on two different transparent substrates or on opposite sides of the same transparent substrate. Methods to generate phase gradient images (PGI) of objects using the described devices are also disclosed.

Abstract: A magnetic field measuring apparatus includes a digital FLL circuit including ADC that converts a periodically changing voltage output from a SQUID according to a change in a magnetic field into a digital value, a digital integrator that integrates the digital value output from the ADC, a DAC that converts an integrated value output from the digital integrator into a voltage, a converter that converts the voltage output from the DAC into a current, and a coil that generates the magnetic field received by the SQUID, based on the current output from the converter. A calculating device calculates a digital value indicating a flux quantum based on the digital value output from the ADC when the ADC converts the periodically changing voltage output from the SQUID upon receiving the magnetic field generated by a current that is obtained by converting a voltage generated by a voltage generator.

Abstract: Provided is an artificial nucleoside or artificial nucleotide capable of composing an artificial oligonucleotide having superior nuclease resistance. The artificial nucleoside or artificial nucleotide is a compound represented by formula (I) or a salt thereof (wherein, Bx represents a pyrimidine base or purine base, R1, R2, R3 and R4 represent hydrogen atoms, C1-6 alkyl groups or the like, Y represents NR5R6 (wherein, R5 and R6, independently of each other, represent a hydrogen atom, C1-6 alkyl group or the like, or R5 and R6, together with a nitrogen atom bound thereto, form a 3- to 11-membered nitrogen-containing non-aromatic heterocyclic group) or an optionally substituted C2-9 aromatic heterocyclic group, Z1 and Z2 represent hydrogen atoms, hydroxyl group-protecting groups, phosphorous-containing groups or the like, and n represents an integer of 1 to 3).

Abstract: A millimeter wave security inspection instrument debugging system and a millimeter wave security inspection instrument debugging method, which are used for debugging the imaging definition of a millimeter wave holographic imaging security inspection system. A main control apparatus is used for generating a millimeter wave detection signal and a reference signal. The main control apparatus is also used for, where a millimeter wave transmitting antenna, a millimeter wave receiving antenna and a detected object are respectively located at different relative positions, transmitting the millimeter wave detection signal to the detected object by means of the millimeter wave transmitting antenna, and receiving an echo signal reflected from the detected object by means of the millimeter wave receiving antenna, and then using a holographic image technique to perform three-dimensional imaging according to the reference signal and the echo signal.