Abstract: The present invention relates to dihydrofolate reductase inhibitors having an aromatic group and a heteroaromatic group linked by a methylene group; methods of preparation of dihydrofolate reductase inhibitors that include metal mediated cross coupling of an aromatic halide or heteroaromatic halide with an organozinc reagent; and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such dihydrofolate reductase inhibitors.

Abstract: A beam splitter includes a substrate. A thin film layer stack is formed on the substrate to achieve the same group delay dispersion (GDD) for both reflection and transmission from any input port and output port of said beam splitter.

Abstract: The present invention relates generally to a method for regulating cytokine signaling and agents useful for same. The method of the present invention is predicated in part on the identification of the molecular target of suppressor of cytokine signaling (SOCS) interaction in controlling cytokine signaling. The identification of the molecular target permits the development of assays to screen for a range of agonists and antagonists useful in modulating cytokine function. The present invention further provides, therefore, screening assays and more particularly high through-put screening assays for agonists and antagonists of SOCS-receptor interaction. Such agonists and antagonists are useful in the manufacture of medicaments for controlling cytokine signaling. Control of cytokine signaling is important for the treatment of a range of conditions including cancer, inflammatory conditions, immunological disorders and any other conditions involving aberrations of signal transduction.

Abstract: Effective stimulation of immune responses is achieved through the use of a group A streptococcal antigen combined with proteosome adjuvant. The compositions are provided in particular for intranasal administration. The vaccine compositions are provided for use in inducing an immune response in an individual for the treatment or prophylaxis of group A streptococcal infection in an individual, preferably via prevention or reduction of colonisation of the throat following intranasal administration.

Abstract: Apparatus for outputting a sequence of vectors includes a first storage that stores vector x having a dimension of at least 1. A first calculator calculates vector function x?=f(x) which utilizes a first rational vector map f to which the stored vector x is input. A second storage stores vector y having a dimension of at least 1. A second calculator calculates vector function y?=g(x, y) which utilizes a second rational vector map g to which the stored vectors x and y are input. An output outputs vector z? which is an association of the resultant vectors x? and y?. A first update updates the first storage by storing the resultant vector x? and a second update updates the second storage by storing the resultant vector y?.

Abstract: The present invention relates to the method for tagging of carbohydrates with active methylene compound. Particularly, it relates to the method for tagging of carbohydrates with active methylene compound comprising the step of preparing carbohydrate conjugate in which carbohydrate and methylene compound are combined by mixing carbohydrate mixture and methylene compound under aqueous polar aprotic solvent containing amine base catalyst. The tagging method of the present invention does not need many kinds of chemical reagent and the reactions can be taken even in the presence of certain amount of impurities. So, it can be used for the analysis of oligosaccharide present in the various kinds of samples.

Abstract: Transflective liquid crystal display devices and fabrication methods thereof. A single cell gap transflective liquid crystal display device includes a first substrate with a reflective region and a transmissive region. A second substrate opposes the first substrate. A liquid crystal layer is disposed between the first and second substrates. A reflective structure is disposed on the first substrate, thereby forming a recess at the transmissive region. A first alignment layer is conformably formed on the first substrate covering the reflective structure, thereby forming a second recess at the reflective region. The second recess is filled with a second alignment, wherein the first and second alignment layers provide different orientations and pre-tilt angles for the liquid crystal layer.

Abstract: This invention provides a sputtering system providing large area sputtering and plasma-assisted reactive gas dissociation. A plurality of plasma sources is provided in a reaction chamber to dissociate at least one reactive gas. The dissociated reactive gas is doped in a film during the deposition of the film so as to control the composition of the film. The property of the film is thus improved. A composite film can be formed on the substrate by the present sputtering system. The present sputtering system is suitable for film deposition on a large-area hard substrate and flexible substrate.

Abstract: Various phenylamine derivatives are described as well as the use of compounds to inhibit BID protein for controlling apoptotic cascade.

Abstract: An ultra high-density recordable optical data recording media that which adds a near-field electromagnetic field enhancement layer between a substrate and a recording layer, by using the resonance enhancement effect produced between the near-field electromagnetic field enhancement layer and the recording layer to read very small recording marks (less than 100 nm) and increase the carrier to noise ratio and the recording density of the disks.

Abstract: A medicament for the preventive and/or therapeutic treatment of allergic diseases and/or endometriosis and/or hysteromyoma which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein X represents a connecting group whose number of atoms in the main chain is 2 to (said connecting group may be substituted), A represents hydrogen atom or acetyl group, E represents an aryl group which may be substituted or a hetero aryl group which may be substituted, ring Z represents an arene which may have one or more substitutents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above, or a heteroarene which may have one or more substitutents in addition to the group represent

Abstract: At least one embodiment of the inventive technology relates to a frozen environmental sample temperature control system that comprises a frozen formulation having water in an amount from substantially 87% to 78% by weight of the formulation, and salt in an amount from substantially 13% to 22% by weight of the formulation, the system further including at least one container containing the frozen formulation; and a cooler having insulating material disposed between an outer wall and an inner surface that defines an inner chamber into which the at least one container and the at least one frozen environmental sample may be placed for storage and/or transport. Various embodiments may incorporate specific types of insulating material and/or adaptations to an inner surface of the cooler to enhance the insulation effected thereby.

Abstract: The present invention relates to a method and device for estimating a timing error and a frequency offset in the MIMO mobile communication system. In a system including a plurality of transmit antennas and a plurality of receive antennas, a predetermined preamble symbol is inserted into a frame to be transmitted by a transmitting device, and pseudo noise is multiplied to the preamble symbol, and result signal is transmitted through each transmit antenna. A receiving device receives the signal through each receive antenna, extracts a preamble symbol from the OFDM symbol, and multiplies local pseudo noise that corresponds to the pseudo noise used by the transmitting device and is shifted by the extracted preamble symbol. A timing error is estimated and compensated according to the correlation of the pseudo noise of the transmitting device and the local pseudo noise of the receiving device. A frequency offset is estimated and compensated according to the phase difference between the preamble symbols.

Abstract: There is disclosed a knitting machine comprising: at least one knitting needle; at least one positive yarn feed device for feeding yarn to said at least one knitting needle; needle monitoring means for providing information relating to the at least one knitting needle during the course of a knitting operation; and a controller for controlling the operation of the positive yarn feed device; in which the controller is adapted to: receive information from the needle monitoring means during the course of a knitting operation; use said information to calculate a desired amount of yarn to be fed to a knitting needle; and control the positive yarn feed device so that the positive yarn feed device feeds the desired amount of yarn to the knitting needle during the course of the knitting operation.

Abstract: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.

Abstract: The invention provides caspase recruitment domain (CARD)-containing polypeptides, CARD, NB-ARC, ANGIO-R, LRR and SAM domains therefrom, as well as encoding nucleic acid molecules and specific antibodies. The invention also provides related screening, diagnostic and therapeutic methods.

Abstract: The invention discloses a MRAM (Magnetoresistive RAM) based on vertical current writing and its control method, the operation of information writing in the MRAM unit is completed by the corporate effect of the magnetic field generated by the current parallel to the MFC unit and the other current vertical to the MFC unit and passing through this unit. The advantage of such structure is: eliminating a word line (WL) of the prior art especially for information writing, reducing the number of the metal wiring layers and the contact holes, and reducing the complexity of MRAM's structure, and difficulty and cost of manufacturing process.

Abstract: A medicament for the preventive and/or therapeutic treatment of allergic diseases and/or endometriosis and/or hysteromyoma which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein X represents a connecting group whose number of atoms in the main chain is 2 to 5 (said connecting group may be substituted), A represents hydrogen atom or acetyl group, E represents an aryl group which may be substituted or a hetero aryl group which may be substituted, ring Z represents an arene which may have one or more substitutents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above, or a heteroarene which may have one or more substitutents in addition to the group represe

Abstract: It is an object of the present invention to provide a polymer material, the histocompatibility of which has been improved by irradiation of ion beam, which prevents an aneurysm having a risk of rupture from actually rupturing. The present invention provides a material for treating aneurysms, which is composed of a polymer material containing carbon as a constitutional element, and which is produced by modifying at least a portion of the surface thereof by ion bombardment.

Abstract: A business method or design created specifically to transition cultural and community services organizations from grant and donation-dependent Title 26, U.S.C. §501(c)(3) organizations to self-sufficient enterprises. In an exemplary method, the business method or design transitions a plurality of grant and/or donation-dependent organizations to self-sufficient enterprises by determining a group of grant and/or donation-dependent organizations in a substantially common field; selecting a model organization from the group; developing an Incubator business for transitioning the model organization; transitioning the model organization, using the Incubator business, to a self-sufficient enterprise; transitioning at least one other organization in the group, using the Incubator business, to a self-sufficient enterprise.