Abstract: The present invention describes linking a therapeutic agent to a compound which is known to be naturally concentrated in a tissue affected by, or that is causing, a disease, to create a prodrug for treatment of the disease. Embodiments of the present invention include a new class of carotenoid-linked drugs to treat such blinding retinal disease such as age-related macular degeneration, retinoblastoma, and diabetic macular edema. For example, the present invention comprises a method for the treatment of a disorder of the eye comprising linking a therapeutic agent to a xanthophyll carotenoid to create a prodrug, and administering a therapeutically effective amount of the prodrug to an individual in need of treatment. Provided are prodrugs for treatment of retinoblastoma, cystoid macular edema (CME), exudative age-related macular degeneration (AMD), diabetic retinopathy, diabetic macular edema, or inflammatory disorders.

Abstract: A vehicle mounted type fuel testing apparatus comprises a fuel chamber; a first fuel pump for supplying fuel in the fuel chamber to a sample holding container and an auxiliary fuel tank; an analyzing device for analyzing constituents of the fuel accommodated in the fuel chamber; the auxiliary fuel tank for storing the fuel when it is determined that the fuel is normal fuel; the sample holding container for keeping the fuel when it is determined that the fuel is not normal fuel; a second fuel pump for supplying the fuel in the auxiliary fuel tank to a main fuel tank when the fuel is normal fuel; a third fuel pump for supplying the fuel in the auxiliary fuel tank to the outside when the fuel is not normal fuel; and a controller for controlling the above component parts.

Abstract: A fully integrated CMOS multi-element phased-array transmitter (transmitter) includes, in part, on-chip power amplifiers (PA), with integrated output matching. The transmitter is adapted to be configured as a two-dimensional 2-by-2 array or as a one dimensional 1-by-4 array. The transmitter uses a two step up-conversion architecture with an IF frequency of 4.8 GHz. Double-quadrature architecture for the up-conversion stages attenuates the signal at image frequencies. The phase selectors in each transmitter path have independent access to all the phases of the VCO. The double quadrature architecture results in two sets of phase selectors for each path, one for the in-phase (I) and one for the quadrature phase (Q) of the LO signal. The phase selection is done in two stages, with the first stage determining the desired VCO differential phase pair and the next stage selecting the appropriate polarity. An on-chip Balun is used for differential to single-ended conversion.

Abstract: Compounds of the following formula: in which R1, R2, A1, A2, X, Y, m, n, p, x and y are as defined herein. Also disclosed are pharmaceutical compositions each containing one or more of these compounds, and use thereof in treating enteroviral infection.

Abstract: When outputs from two vibration detection sensors are measured by a Coriolis flowmeter in a form of phase difference time, a tube must be thinned to increase a sensitivity of the flowmeter to enable measurement and accordingly flow velocity and pressure loss increase, and a thickness of the flowmeter must be reduced and therefore a pressure resistance cannot be readily enhanced. In particular, the sensitivity of signals to flow rate is difficult to increase and, accordingly, a flow rate of a low-density gas cannot be accurately measured. In the present invention, a Coriolis vibration frame 16 carrying a U-shaped tube is swingably fixed to a forced vibration frame 19 fixed to a support base 22 to form a highly rigid frame structure limiting a vibrating direction to one degree of freedom in a Coriolis vibration direction. The forced vibration frame 19 is vibrated by a vibration exciter 20 so that a ratio of a forced vibration frequency to the Coriolis frequency of a pipeline is at least 1 to 10.

Abstract: The present invention relates to an environmental stress-tolerant plant. The invention discloses a transgenic plant containing a gene in which a DNA encodes a protein consisting of the amino acid sequence as shown in SEQ ID NO: 4 with the deletion of amino acids from positions 136-165 thereof, the DNA being operably linked downstream of a stress responsive promoter.

Abstract: Disclosed are polyphosphazenes of Formula 1 showing a sol-gel behavior with a temperature change, a preparation method thereof, and injectable thermosensitive polyphosphazene hydrogels using the same

Abstract: Disclosed is a method for controlling power level of received signal in an ultra wide band transmission system which uses multi frequency bands, and includes a pre-gain controller (PGC) and a voltage gain amplifier (VGA). The method for controlling a power level of a received signal includes the steps of: a) at the PGCs, detecting which multi frequency band is used in a transmitter of the transmission system; b) at the PGCs, obtaining the voltage gain owing to the discrepancy in the power levels of the received signals; and c) at the PGCs, compensating for the power loss based on the voltage gain.

Abstract: An attrition resistant precipitated bulk iron catalyst is prepared from iron oxide precursor and a binder by spray drying. The catalysts are preferably used in carbon monoxide hydrogenation processes such as Fischer-Tropsch synthesis. These catalysts are suitable for use in fluidized-bed reactors, transport reactors and, especially, slurry bubble column reactors.

Abstract: Disclosed herein is a multi-band ZigBee transceiver for supporting IEEE 802.15.4 wireless communications. In the multi-band ZigBee transceiver, a Multi-Mode Modem (MMM) selects any one of a European version standard using 860 MHz band, a US version standard using 920 MHz band, and a worldwide version standard using 2.4 GHz ISM band among IEEE 802.15.4 standards. A frequency synthesizing unit variably adjusts a carrier frequency according to the transmission standard. A transmission unit receives a digital modulated signal, low-pass-filters the digital modulated signal with a bandwidth thereof being variably adjusted, and up-converts the filtered digital modulated signal into an RF modulated signal corresponding to the selected transmission channel.

Abstract: Isolated peptides are disclosed which, when processed, generate a coordinated immune response.

Abstract: A polypeptide (8F4 molecule) with a T-cell costimulating biological activity is disclosed, as well as monoclonal antibodies against said 8F4 molecule and hybridoma cells which produce the monoclonal antibodies, the use as medicaments of substances which inhibit the biological activity of the disclosed 8F4 polypeptide, in particular monoclonal antibodies, natural or synthetic ligands, agonists or antagonists, in particular for preventing or treating diseases which involve the immune system, the use of said 8F4 molecule or cells containing said 8F4 molecule as medicaments, in particular for preventing or treating diseases which involve the immune system, and the use of substances which specifically recognize the disclosed polypeptide, in particular monoclonal antibodies, natural or synthetic ligands, agonists or antagonists, for diagnosing diseases which involve the immune system.

Abstract: The present invention relates to a ?-[2-(polyalkyleneoxy)ethylthio]alkylalkoxysilane derivative and a preparation method thereof, more particularly to a ?-[2-(polyalkyleneoxy)ethylthio]alkylalkoxysilane derivative prepared by transforming a (?-mercaptoalkyl)alkylalkoxysilane compound into a ?-(alkoxysilyl)alkylthiolate metal salt by treating it with a metallic base and performing dehalometallation at low reaction temperature using a poly(alkyleneoxy)alkyl ether halide or a poly(alkyleneoxy)bis(haloalkyl) ether to form a carbon-sulfur bond and a preparation method thereof. The novel compound of the present invention has not only a Si—OR bond but also contains a sulfur atom in the molecule, so that it can be used as monomer for synthesizing hydrophilic functional silicon polymers, source material of silicon-based surfactants and surface modifier of organic/inorganic materials.

Abstract: A system for approximating flux density of light on a human retina. A housing has an opening allowing light to pass to inside the housing. A baffle coupled to the housing replicates a facial cutoff function response for the light inside the housing. Two detectors are positioned to detect the light inside the housing. One detector produces a photopic spectral response function of the light inside the housing that approximately replicates a spectral response of the foveal cones in the retina. Another detector produces a scotopic spectral response function of the light inside the housing that approximately replicates a spectral response of rods in the retina. A processor coupled to the detectors calculates a mesopic flux density of the light inside the housing based on the photopic and scotopic spectral response functions.

Abstract: Of the “four C's,” cut has historically been the most complex to understand and assess. This application presents a three-dimensional mathematical model to study the interaction of light with a fully faceted, colorless, symmetrical round-brilliant-cut diamond. With this model, one can analyze how various appearance factors (brilliance, fire, and scintillation) depend on proportions. The model generates images and a numerical measurement of the optical efficiency of the round brilliant—called DCLR—which approximates overall fire. DCLR values change with variations in cut proportions, in particular crown angle, pavilion angle, table size, star facet length, culet size, and lower girdle facet length. The invention describes many combinations of proportions with equal or higher DCLR than “Ideal” cuts, and these DCLR ratings may be balanced with other factors such as brilliance and scintillation to provide a cut grade for an existing diamond or a cut analysis for prospective cut of diamond rough.

Abstract: A microfluidic device comprises pumps, valves, and fluid oscillation dampers. In a device employed for sorting, an entity is flowed by the pump along a flow channel through a detection region to a junction. Based upon an identity of the entity determined in the detection region, a waste or collection valve located on opposite branches of the flow channel at the junction are actuated, thereby routing the entity to either a waste pool or a collection pool. A damper structure may be located between the pump and the junction. The damper reduces the amplitude of oscillation pressure in the flow channel due to operation of the pump, thereby lessening oscillation in velocity of the entity during sorting process. The microfluidic device may be formed in a block of elastomer material, with thin membranes of the elastomer material deflectable into the flow channel to provide pump or valve functionality.

Abstract: The present invention provides a highly-integrated and compact optical element and further provides an optical element having various functions such as lower driving voltage, chirping suppression and polarization-independency. The optical element has a substrate 1 formed of a material having an electrooptic effect, a plurality of optical waveguides formed on the substrate, and a modulating electrode for applying electric field into the optical waveguides, and is characterized in that the modulating electrode has at least two branching and confluence lines on the same line for applying the same modulating signal into different optical waveguides.

Abstract: Disclosed is a hybrid multi-user interference cancellation method for canceling interference between a plurality of user signals, which comprises: receiving a plurality of external user signals, calculating powers of the user signals, and numbering the calculated signal powers in their intensity orders; sorting the user numbers in descending order; forming at least one user cluster so that the signal powers following the sorted user numbers may differ less from a central value or a mean value in the same cluster; and performing parallel interference cancellation on the respective user signals within the same cluster, and performing successive interference cancellation between the formed clusters.

Abstract: 4-Substituted coumarin compounds having the general formula of where R is H, CHO, OCH3, X, NO2, an alkyl having C1-10, —OCH2O—, an aryl being mono- or poly-substituted with CN or COOCH3 with the aryl being a phenyl, naphthyl, or azaryl, or a coumarin group that is substituted with R1, R2, R3, R4, with R1, R2, R3, and R4 being H, an alkyl having C1-10, X, NO2, CN, OCH3, COOCH3 or OR5, R5 being H or an alkyl having C1-10, and X being a halogen.

Abstract: An AWG device includes a plurality of arrayed waveguides positioned close to each other. An input signal excites one of these coupled waveguides and the power is then transferred to all of the arrayed waveguides so there are enough degrees of freedom in the device to achieve any desired distribution.