Patents Assigned to INSTITUTE
  • Patent number: 10946447
    Abstract: Systems and methods in accordance with embodiments of the invention fabricate objects including amorphous metals using techniques akin to additive manufacturing. In one embodiment, a method of fabricating an object that includes an amorphous metal includes: applying a first layer of molten metallic alloy to a surface; cooling the first layer of molten metallic alloy such that it solidifies and thereby forms a first layer including amorphous metal; subsequently applying at least one layer of molten metallic alloy onto a layer including amorphous metal; cooling each subsequently applied layer of molten metallic alloy such that it solidifies and thereby forms a layer including amorphous metal prior to the application of any adjacent layer of molten metallic alloy; where the aggregate of the solidified layers including amorphous metal forms a desired shape in the object to be fabricated; and removing at least the first layer including amorphous metal from the surface.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: March 16, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventor: Douglas C Hofmann
  • Patent number: 10948412
    Abstract: Particularly provided is a method and a system for screening nanoparticles which allow effective search of conditions for surface modification of nanoparticles and reduction in the time, the labor, and the amount of a sample required for the surface modification compared with conventional techniques. The method for screening nanoparticles includes the steps of: dividing a nanoparticle suspension for a respective plurality of containers provided in a containment receptacle; performing surface modification on nanoparticles under different conditions for the respective containers; preparing evaluation samples by adding a dispersion medium into each container and mixing the nanoparticles and the dispersion medium; and performing evaluation on the evaluation sample in each container by optical analysis.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: March 16, 2021
    Assignees: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, NS MATERIALS INC.
    Inventors: Hiroyuki Nakamura, Maki Saeki, Masanori Tanaka, Eiichi Kanaumi
  • Patent number: 10947529
    Abstract: The present disclosure relates to the co-expression of an endonuclease with an end-processing enzyme for the purpose of enhanced processing of the polynucleotide ends generated by endonuclease cleavage.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: March 16, 2021
    Assignee: SEATTLE CHILDREN'S RESEARCH INSTITUTE
    Inventors: Andrew M. Scharenberg, Michael T. Certo, Kamila Sabina Gwiazda
  • Patent number: 10948049
    Abstract: A transmission mechanism includes first and second transmission, first and second shafts, a clutch, and a one-way bearing. In the first gear, power is output through the first driving transmission and the one-way bearing; and in the second gear, the power is output through the clutch, the second driving transmission and the one-way bearing.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: March 16, 2021
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Cheng-Ping Yang, Meng-Ru Wu, Ming-Hsien Yang, Peng-Yu Chen, Jui-Tang Tseng
  • Patent number: 10946108
    Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: March 16, 2021
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HAVARD COLLEGE
    Inventors: Feng Zhang, Le Cong, Fei Ran, Matthias Heidenreich, Lukasz Swiech
  • Patent number: 10948296
    Abstract: An optical gyroscope includes, in part, an optical switch, a pair of spiral optical rings and a pair of photodetectors. The optical switch supplies a laser beam. The first spiral optical ring delivers a first portion of the beam in a clockwise direction during the first half of a period, and a first portion of the beam in a counter clockwise direction during the second half of the period. The second spiral optical ring delivers a second portion of the beam in a counter clockwise direction during the first half of the period, and a second portion of the beam in a clockwise direction during the second half of the period. The first photodetector receives the beams delivered by the first and second optical rings during the first half of the period. The second photodetector receives the beams delivered by the first and second optical rings during the second half of the period.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: March 16, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Alexander D. White, Parham Porsandeh Khial, Seyed Ali Hajimiri
  • Patent number: 10948875
    Abstract: Provided is a method for converting a hologram resolution of an apparatus for converting a hologram resolution. The apparatus for converting a hologram resolution includes receiving a hologram data and determining a direction and a height of an envelope for the hologram data based on first information associated with the hologram data. The apparatus for converting a hologram resolution includes converting the resolution of the hologram data from a first resolution into a second resolution based on the envelop having the determined direction and height.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: March 16, 2021
    Assignee: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventor: Kwan-Jung Oh
  • Patent number: 10945708
    Abstract: A medical image registration method and apparatus are described. By performance of a medical image registration method, a highly accurate registered image, in which breathing deformation information is considered, may be obtained by generation of non-real-time medical images in which the breathing deformation information is reflected before a medical procedure is conducted and by rigid registration of a real-time medical image and the generated non-real-time medical images during the medical procedure.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: March 16, 2021
    Assignees: SAMSUNG ELECTRONICS CO., LTD., KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Youngkyoo Hwang, Jungbae Kim, Youngtaek Oh, Wonchul Bang, Jong Beom Ra, Woo Hyun Nam, Chijun Weon
  • Patent number: 10947526
    Abstract: An electroporation device with a volume of varying cross sectional area that as a fast assay device for determining the optimal conditions for plasma membrane electroporation.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: March 16, 2021
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Cullen Richard Buie, Paulo Andres Garcia Dominguez, Zhifei Ge, Jeffrey Lawrence Moran
  • Patent number: 10948348
    Abstract: A mannikin-based optical analyzer for analyzing an exposure of a subject to an environmental lighting condition. The analyzer has a mannikin with an outer surface replicating a facial profile of the subject, an interior inside the outer surface, and at least one pupil for admission of light into the interior of the mannikin. The analyzer has at least one optical detector configured to acquire and wavelength analyze light directed through the at least one pupil.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: March 16, 2021
    Assignee: RESEARCH TRIANGLE INSTITUTE
    Inventors: Kelley Jo Rountree, James Lynn Davis, Karmann Cressman Mills, Georgiy Bobashev, Robert Furberg, Anthony Clint Clayton
  • Patent number: 10948446
    Abstract: This invention relates to a chemiresistor gas sensor using MXene and a method of manufacturing the same, wherein the chemiresistor gas sensor, manufactured in a manner in which a Ti3C2Tx MXene thin film is formed and transferred onto a sensor substrate, can exhibit good response and sensitivity.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: March 16, 2021
    Assignees: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY, DREXEL UNIVERSITY
    Inventors: Hee-Tae Jung, Seon Joon Kim, Hyeong-Jun Koh, Yury Gogotsi
  • Patent number: 10950749
    Abstract: Provided are light emission devices including an output coupler and optical apparatuses having the same. The light emission device may include a QD layer containing quantum dots and a nano-antenna structure including an output coupler configured to control an output characteristic of light emitted from the QD layer. The output coupler may be configured to output an emission wavelength of the QD layer. The nano-antenna structure may include one of a metallic antenna, a dielectric antenna, and a slit-containing structure, or may have a multi-patch antenna structure or a fishbone antenna structure.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: March 16, 2021
    Assignees: SAMSUNG ELECTRONICS CO., LTD., CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Duhyun Lee, Ruzan Sokhoyan, Yu-Jung Lu, Ghazaleh Kafaie Shirmanesh, Harry A. Atwater, Ragip A. Pala, Chan-Wook Baik
  • Patent number: 10948376
    Abstract: An apparatus for detecting a leak sound in plant equipment using time-frequency transformation includes a first microphone measuring an acoustic signal generated in the plant equipment, a second microphone measuring an acoustic signal generated in the plant equipment, and a leak sound detection module detecting a leak sound in the plant equipment using time-frequency transformation of the acoustic signal measured by the first microphone and the acoustic signal measured by the second microphone, wherein a leak sound may be detected even when a transient dispersive noise signal, as well as a periodic noise signal, is large.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: March 16, 2021
    Assignee: KOREA ATOMIC ENERGY RESEARCH INSTITUTE
    Inventors: Doo Byung Yoon, Soon Sung Moon, Bong Su Yang, Jin Ho Park
  • Patent number: 10947303
    Abstract: Specific binding members, particularly antibodies and fragments thereof, which bind to transforming growth factor beta 1 (TGF-?1) are provided, particularly recognizing human and mouse TGF-?1 and not recognizing or binding TGF-?2 or TGF-?3. Particular antibodies are provided which specifically recognize and neutralize TGF-?1. These antibodies are useful in the diagnosis and treatment of conditions associated with activated or elevated TGF-?1, including cancer, and for modulating immune cells and immune response, including immune response to cancer or cancer antigens. The anti-TGF-?1 antibodies, variable regions or CDR domain sequences thereof, and fragments thereof may also be used in therapy in combination with chemotherapeutics, immune modulators, or anti-cancer agents and/or with other antibodies or fragments thereof. Antibodies of this type are exemplified by the novel antibodies hereof, including antibody 13A1, whose sequences are provided herein.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: March 16, 2021
    Assignee: LUDWIG INSTITUTE FOR CANCER RESEARCH, LTD.
    Inventors: Jacques Van Snick, Catherine Uyttenhove, Thierry Boon
  • Patent number: 10947394
    Abstract: The present disclosure provides a radiative cooling functional coating material and application thereof. The radiative cooling functional coating material can be configured for manufacturing a radiative cooling functional layer. The radiative cooling functional layer can be configured for reflecting ultraviolet light and/or visible light and/or near-infrared light in sunlight and emitting heat through an atmospheric window in a form of infrared radiation. The radiative cooling functional coating material can include a granular filler and a radiative cooling functional resin, and the granular filler can be distributed in the radiative cooling functional resin.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: March 16, 2021
    Assignees: NINGBO RADI-COOL ADVANCED ENERGY TECHNOLOGIES CO., LTD., NINGBO RUILING ADVANCED ENERGY MATERIALS INSTITUTE CO., LTD.
    Inventors: Shaoyu Xu, Rongbing Wan, Minghui Wang
  • Publication number: 20210069230
    Abstract: The present disclosure relates to discovery of specific synergistic drug combinations and mechanisms of drug resistance. Compositions involving newly-identified drug combinations as well as diagnostic and therapeutic methods related to such discoveries are provided.
    Type: Application
    Filed: April 12, 2019
    Publication date: March 11, 2021
    Applicant: THE BROAD INSTITUTE, INC.
    Inventors: Matthew Rees, Cory Johannessen
  • Publication number: 20210070657
    Abstract: Provided are a textile reinforced cement composite for suppressing occurrence of slipping and a crack and a manufacturing method thereof.
    Type: Application
    Filed: December 3, 2019
    Publication date: March 11, 2021
    Applicant: KOREA INSTITUTE OF CIVIL ENGINEERING AND BUILDING TECHNOLOGY
    Inventors: Gum Sung RYU, Kyung Taek KOH, Hyeong Yeol KIM, Gi Hong AN, Dong Woo SEO, Seung Seop JIN
  • Publication number: 20210071158
    Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
    Type: Application
    Filed: April 11, 2018
    Publication date: March 11, 2021
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, David Benjamin Turitz Cox
  • Publication number: 20210069666
    Abstract: A built-in micro interfacial enhanced reaction system and process for PTA production with PX are provided. The system includes a reactor and a micro interfacial unit disposed inside reactor. The reactor includes a shell, an inner cylinder concentrically disposed inside shell, and a circulating heat exchange device partially disposed outside shell, inner cylinder having a bottom end connected to inner bottom surface of the shell in closed manner and an open top end, a region between shell and inner cylinder being first reaction zone, inner cylinder containing second reaction zone and third reaction zone from top to bottom, circulating heat exchange device being connected to inner cylinder and micro interfacial unit respectively. The invention can solve problems of large waste of reaction solvent acetic acid under high temperature and high pressure and being unable to take out the product TA in time during existing process of PTA production with PX.
    Type: Application
    Filed: November 18, 2020
    Publication date: March 11, 2021
    Applicant: NANJING YANCHANG REACTION TECHNOLOGY RESEARCH INSTITUTE CO., LTD.
    Inventors: Zhibing ZHANG, Zheng ZHOU, Feng ZHANG, Lei LI, Weimin MENG, Baorong WANG, Gaodong YANG, Huaxun LUO, Guoqiang YANG, Hongzhou TIAN, Yu CAO
  • Publication number: 20210071121
    Abstract: A cell culture vessel for use with a laser processing machine, including: a layer containing an ingredient that generates heat upon laser irradiation; the layer kills specific cells from among a group of cells cultured on a first surface of the layer when a second surface of the layer is irradiated with laser light having an output of 5W or less at a wavelength of 380 nm or greater and a relative movement between a second area on the second surface where the laser light is applied and the layer is at a rate of 2000 mm/sec or less such that the second area absorbs energy of the laser light to generate heat that kills the specific cells that are present on a first area of the first surface and the laser light does not instantly kill the specific cells on the first area upon irradiation with the laser light.
    Type: Application
    Filed: November 24, 2020
    Publication date: March 11, 2021
    Applicants: KATAOKA CORPORATION, NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Masami SUZUKI, Norio NISHI, Junichi MATSUMOTO, Kimio SUMARU, Toshiyuki KANAMORI