Abstract: Systems and methods in accordance with embodiments of the invention fabricate objects including amorphous metals using techniques akin to additive manufacturing. In one embodiment, a method of fabricating an object that includes an amorphous metal includes: applying a first layer of molten metallic alloy to a surface; cooling the first layer of molten metallic alloy such that it solidifies and thereby forms a first layer including amorphous metal; subsequently applying at least one layer of molten metallic alloy onto a layer including amorphous metal; cooling each subsequently applied layer of molten metallic alloy such that it solidifies and thereby forms a layer including amorphous metal prior to the application of any adjacent layer of molten metallic alloy; where the aggregate of the solidified layers including amorphous metal forms a desired shape in the object to be fabricated; and removing at least the first layer including amorphous metal from the surface.

Abstract: Particularly provided is a method and a system for screening nanoparticles which allow effective search of conditions for surface modification of nanoparticles and reduction in the time, the labor, and the amount of a sample required for the surface modification compared with conventional techniques. The method for screening nanoparticles includes the steps of: dividing a nanoparticle suspension for a respective plurality of containers provided in a containment receptacle; performing surface modification on nanoparticles under different conditions for the respective containers; preparing evaluation samples by adding a dispersion medium into each container and mixing the nanoparticles and the dispersion medium; and performing evaluation on the evaluation sample in each container by optical analysis.

Abstract: The present disclosure relates to the co-expression of an endonuclease with an end-processing enzyme for the purpose of enhanced processing of the polynucleotide ends generated by endonuclease cleavage.

Abstract: A transmission mechanism includes first and second transmission, first and second shafts, a clutch, and a one-way bearing. In the first gear, power is output through the first driving transmission and the one-way bearing; and in the second gear, the power is output through the clutch, the second driving transmission and the one-way bearing.

Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

Abstract: An optical gyroscope includes, in part, an optical switch, a pair of spiral optical rings and a pair of photodetectors. The optical switch supplies a laser beam. The first spiral optical ring delivers a first portion of the beam in a clockwise direction during the first half of a period, and a first portion of the beam in a counter clockwise direction during the second half of the period. The second spiral optical ring delivers a second portion of the beam in a counter clockwise direction during the first half of the period, and a second portion of the beam in a clockwise direction during the second half of the period. The first photodetector receives the beams delivered by the first and second optical rings during the first half of the period. The second photodetector receives the beams delivered by the first and second optical rings during the second half of the period.

Abstract: Provided is a method for converting a hologram resolution of an apparatus for converting a hologram resolution. The apparatus for converting a hologram resolution includes receiving a hologram data and determining a direction and a height of an envelope for the hologram data based on first information associated with the hologram data. The apparatus for converting a hologram resolution includes converting the resolution of the hologram data from a first resolution into a second resolution based on the envelop having the determined direction and height.

Abstract: A medical image registration method and apparatus are described. By performance of a medical image registration method, a highly accurate registered image, in which breathing deformation information is considered, may be obtained by generation of non-real-time medical images in which the breathing deformation information is reflected before a medical procedure is conducted and by rigid registration of a real-time medical image and the generated non-real-time medical images during the medical procedure.

Abstract: An electroporation device with a volume of varying cross sectional area that as a fast assay device for determining the optimal conditions for plasma membrane electroporation.

Abstract: A mannikin-based optical analyzer for analyzing an exposure of a subject to an environmental lighting condition. The analyzer has a mannikin with an outer surface replicating a facial profile of the subject, an interior inside the outer surface, and at least one pupil for admission of light into the interior of the mannikin. The analyzer has at least one optical detector configured to acquire and wavelength analyze light directed through the at least one pupil.

Abstract: This invention relates to a chemiresistor gas sensor using MXene and a method of manufacturing the same, wherein the chemiresistor gas sensor, manufactured in a manner in which a Ti3C2Tx MXene thin film is formed and transferred onto a sensor substrate, can exhibit good response and sensitivity.

Abstract: Provided are light emission devices including an output coupler and optical apparatuses having the same. The light emission device may include a QD layer containing quantum dots and a nano-antenna structure including an output coupler configured to control an output characteristic of light emitted from the QD layer. The output coupler may be configured to output an emission wavelength of the QD layer. The nano-antenna structure may include one of a metallic antenna, a dielectric antenna, and a slit-containing structure, or may have a multi-patch antenna structure or a fishbone antenna structure.

Abstract: An apparatus for detecting a leak sound in plant equipment using time-frequency transformation includes a first microphone measuring an acoustic signal generated in the plant equipment, a second microphone measuring an acoustic signal generated in the plant equipment, and a leak sound detection module detecting a leak sound in the plant equipment using time-frequency transformation of the acoustic signal measured by the first microphone and the acoustic signal measured by the second microphone, wherein a leak sound may be detected even when a transient dispersive noise signal, as well as a periodic noise signal, is large.

Abstract: Specific binding members, particularly antibodies and fragments thereof, which bind to transforming growth factor beta 1 (TGF-?1) are provided, particularly recognizing human and mouse TGF-?1 and not recognizing or binding TGF-?2 or TGF-?3. Particular antibodies are provided which specifically recognize and neutralize TGF-?1. These antibodies are useful in the diagnosis and treatment of conditions associated with activated or elevated TGF-?1, including cancer, and for modulating immune cells and immune response, including immune response to cancer or cancer antigens. The anti-TGF-?1 antibodies, variable regions or CDR domain sequences thereof, and fragments thereof may also be used in therapy in combination with chemotherapeutics, immune modulators, or anti-cancer agents and/or with other antibodies or fragments thereof. Antibodies of this type are exemplified by the novel antibodies hereof, including antibody 13A1, whose sequences are provided herein.

Abstract: The present disclosure provides a radiative cooling functional coating material and application thereof. The radiative cooling functional coating material can be configured for manufacturing a radiative cooling functional layer. The radiative cooling functional layer can be configured for reflecting ultraviolet light and/or visible light and/or near-infrared light in sunlight and emitting heat through an atmospheric window in a form of infrared radiation. The radiative cooling functional coating material can include a granular filler and a radiative cooling functional resin, and the granular filler can be distributed in the radiative cooling functional resin.

Abstract: The present disclosure relates to discovery of specific synergistic drug combinations and mechanisms of drug resistance. Compositions involving newly-identified drug combinations as well as diagnostic and therapeutic methods related to such discoveries are provided.

Abstract: Provided are a textile reinforced cement composite for suppressing occurrence of slipping and a crack and a manufacturing method thereof.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: A built-in micro interfacial enhanced reaction system and process for PTA production with PX are provided. The system includes a reactor and a micro interfacial unit disposed inside reactor. The reactor includes a shell, an inner cylinder concentrically disposed inside shell, and a circulating heat exchange device partially disposed outside shell, inner cylinder having a bottom end connected to inner bottom surface of the shell in closed manner and an open top end, a region between shell and inner cylinder being first reaction zone, inner cylinder containing second reaction zone and third reaction zone from top to bottom, circulating heat exchange device being connected to inner cylinder and micro interfacial unit respectively. The invention can solve problems of large waste of reaction solvent acetic acid under high temperature and high pressure and being unable to take out the product TA in time during existing process of PTA production with PX.

Abstract: A cell culture vessel for use with a laser processing machine, including: a layer containing an ingredient that generates heat upon laser irradiation; the layer kills specific cells from among a group of cells cultured on a first surface of the layer when a second surface of the layer is irradiated with laser light having an output of 5W or less at a wavelength of 380 nm or greater and a relative movement between a second area on the second surface where the laser light is applied and the layer is at a rate of 2000 mm/sec or less such that the second area absorbs energy of the laser light to generate heat that kills the specific cells that are present on a first area of the first surface and the laser light does not instantly kill the specific cells on the first area upon irradiation with the laser light.