Patents Assigned to INSTITUTE
  • Publication number: 20200407498
    Abstract: The purpose of the present invention is to provide: a novel polymer which has an electro-optical effect; a method for producing such a polymer; and a light control element which uses such a polymer. The present invention relates to a non-crosslinkable polycarbonate which contains a moiety that has electro-optical characteristics. The present invention also relates to a method for producing a polycarbonate, which comprises a step for reacting a bisphenol compound, a diol compound that has electro-optical characteristics, and a phosgene in the presence of an acid binding agent and solvent. The present invention also relates to a light control element which comprises such polycarbonate.
    Type: Application
    Filed: March 1, 2019
    Publication date: December 31, 2020
    Applicants: TEIJIN LIMITED, NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY
    Inventors: Naoshi TAKAHASHI, Katsuhiro YAMANAKA, Akira OTOMO, Toshiki YAMADA
  • Publication number: 20200405881
    Abstract: Provided herein are engineered cells and methods for engineering cells to deliver a therapeutic agent, e.g., a small molecule, peptide or other drug, to a cell or tissue to be treated.
    Type: Application
    Filed: March 6, 2018
    Publication date: December 31, 2020
    Applicants: UNIVERSITY OF WASHINGTON, SEATTLE CHILDREN'S RESEARCH INSTITUTE, COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
    Inventors: Patrick S. STAYTON, Anthony CONVERTINE, Debobrato DAS, Hye-Nam SON, Selvi SRINIVASAN, Katherine MONTGOMERY, Ian BLUMENTHAL, Courtney CRANE, Michael JENSEN, James MATTHAEI, John CHIEFARI, Maarten DANIAL, Fei HUANG, James MACDONALD, Almar POSTMA, Kathleen TURNER
  • Publication number: 20200408711
    Abstract: Disclosed are a method of manufacturing a sensor for detecting hydrogen peroxide, the method including preparing a substrate; forming a gas sensing part including carbon nanotubes and porphyrin nanofiber on the substrate; and forming an electrode on the substrate on which the gas detector has been formed, and a sensor for detecting hydrogen peroxide manufactured by the method. In accordance with the method of manufacturing a sensor for detecting hydrogen peroxide of the present disclosure, a step of forming a gas detector including carbon nanotubes and porphyrin nanofiber on a substrate is included, whereby a sensor capable of detecting hydrogen peroxide vapor at a sub-ppm level can be manufactured.
    Type: Application
    Filed: December 4, 2019
    Publication date: December 31, 2020
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Young Tae BYUN, Jae Sung LEE, Da Woon JEONG
  • Publication number: 20200411022
    Abstract: Provided are an apparatus and a method for integrally encoding and decoding a speech signal and a audio signal. The encoding apparatus may include: an input signal analyzer to analyze a characteristic of an input signal; a first conversion encoder to convert the input signal to a frequency domain signal, and to encode the input signal when the input signal is a audio characteristic signal; a Linear Predictive Coding (LPC) encoder to perform LPC encoding of the input signal when the input signal is a speech characteristic signal; and a bitstream generator to generate a bitstream using an output.
    Type: Application
    Filed: September 11, 2020
    Publication date: December 31, 2020
    Applicants: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE, KWANGWOON UNIVERSITY INDUSTRY-ACADEMIC COLLABORATION FOUNDATION
    Inventors: Tae Jin LEE, Seung-Kwon BAEK, Min Je KIM, Dae Young JANG, Jeongil SEO, Kyeongok KANG, Jin-Woo HONG, Hochong PARK, Young-cheol PARK
  • Publication number: 20200412353
    Abstract: The present disclosure provides a high-speed and low-noise dynamic comparator, which includes: an input unit, including an input NMOS transistor and an input PMOS transistor; a latch unit, including a latching NMOS transistor and a latching PMOS transistor, where the latching NMOS transistor and the latching PMOS transistor are connected to form a latch structure; a pull-up unit, including a pull-up PMOS transistor connected to the input NMOS transistor; and a substrate bootstrap voltage generation circuit, generating a substrate bootstrap voltage.
    Type: Application
    Filed: July 18, 2018
    Publication date: December 31, 2020
    Applicant: NO.24 RESEARCH INSTITUTE OF CHINA ELECTRONICS TECHNOLOGY GROUP CORPORATIO
    Inventors: Daiguo XU, Gangyi HU, Ruzhang LI, Jian'an WANG, Guangbing CHEN, Dongbing FU, Shiliu XU, Tao LIU, Jie PU, Zhihua FENG
  • Publication number: 20200410338
    Abstract: An artificial intelligence (AI) system capable of simulating functions of a human brain, such as recognition and judgment, by using the machine learning algorithm such as deep learning, and an application thereof are provided. A method of learning multi-modal data according to the AI system and an application thereof includes: obtaining first context information representing a characteristic of a first signal and second context information representing a characteristic of a second signal by using a first learning network model; obtaining hidden layer information based on the first context information and the second context information by using a second learning network model; obtaining a correlation value representing a relation degree between the hidden layer information by using the second learning network model; and learning the hidden layer information in which the correlation value is derived as a maximum value.
    Type: Application
    Filed: November 13, 2018
    Publication date: December 31, 2020
    Applicants: SAMSUNG ELECTRONICS CO., LTD., KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Hyun Soo CHOI, Chang D. YOO, Sung Hun KANG, Jun Yeong KIM, Sung Jin KIM
  • Publication number: 20200412556
    Abstract: Disclosed herein is a method of operating an authentication server based on a Physical Unclonable Function (PUF), which includes transmitting a Challenge-Response Pair (CRP) update request message to a user device when a CRP update event occurs, receiving a CRP update response message from the user device in response to the CRP update request message, generating a secret key corresponding to the CRP update request message, decrypting the CRP update response message with the secret key, and updating a CRP corresponding to the secret key in a database using the decrypted CRP update response message.
    Type: Application
    Filed: March 25, 2020
    Publication date: December 31, 2020
    Applicant: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventors: Seung-Yong YOON, Byoung-Koo KIM, You-Sung KANG, Doo-Ho CHOI, Ik-Kyun KIM, Tae-Sung KIM, Mi-Kyung OH, Sang-Jae LEE
  • Publication number: 20200407223
    Abstract: The present invention relates to a preparation method of trifluoroamine oxide comprising the steps of producing an intermediate product by reacting nitrogen trifluoride and nitrous oxide in the presence of a reaction catalyst; and producing trifluoroamine oxide by reacting the intermediate product with sodium fluoride in vacuum condition up to 100 mmHg.
    Type: Application
    Filed: May 31, 2019
    Publication date: December 31, 2020
    Applicants: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY, SK-MATERIALS CO., LTD., SK-MATERIALS CO., LTD.
    Inventors: Hong Suk Kang, In Joon Park, Soo Bok Lee, Won Wook So, Shin Hong Yook, Eun-ho Sohn, Beom Sik Kim, Junghun Kwak, Byunghyang Kwon
  • Publication number: 20200407346
    Abstract: The purpose of the present invention is to provide a novel compound which has antibacterial activity against Mycobacterium avium and Mycobacterium intracellulare that are causative bacteria of MAC infection and which is different in backbone structure from known drugs for treatment of MAC infection. One aspect of the present invention relates to a compound of Formula (I) [where R1 has the same meaning as described in the specification and claims] or a salt thereof, or a solvate thereof. Another aspect of the present invention relates to a method for producing the compound of Formula (I) or a salt thereof, or a solvate thereof, and a therapeutic agent for Mycobacterium avium complex infection (MAC infection), which comprises the compound or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof as an active ingredient.
    Type: Application
    Filed: August 30, 2018
    Publication date: December 31, 2020
    Applicants: THE KITASATO INSTITUTE, OP BIO FACTORY CO., LTD.
    Inventors: Hiroshi TOMODA, Nobuhiro KOYAMA, Akihiko KANAMOTO, Junko HASHIMOTO, Ikuko KOZONE
  • Publication number: 20200407371
    Abstract: Provided herein are bifunctional compounds that bind a target protein (e.g., a selected protein) and/or induce ubiquitination for degradation of the target protein. In particular, provided are compounds that bind a bromodomain or bromodomain-containing protein (e.g., BET proteins) or histone methyltransferases (HMTs, e.g., enhancer of zeste homolog 1 (EZH1), or FKBP12) and can promote its degradation by recruiting it to the ubiquitin receptor RPN13 (e.g., RA190), for proteasomal degradation. Also provided are pharmaceutical compositions comprising the bifunctional compounds, methods of treating and/or preventing diseases (e.g., proliferative diseases, cancers, benign neoplasms, pathological angiogenesis, inflammatory diseases, and autoimmune diseases) and musculoskeletal diseases, and methods of inducing the degradation of a target (e.g., a target protein) by recruiting it to the ubiquitin receptor RPN13 of the proteasome in a subject by administering a compound or composition described herein.
    Type: Application
    Filed: February 22, 2019
    Publication date: December 31, 2020
    Applicant: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Jun Qi, Lei Wu, Kenneth C. Anderson, Yan Song, Paul Park, Dharminder Chauhan
  • Patent number: 10877021
    Abstract: A device for biological material detection includes a substrate; a through-hole through which a biological material to be tested passes, the through-hole being formed in the substrate; a molecule that interacts with the biological material to be tested passing through, the molecule being formed in the through-hole; a first chamber member that forms, with at least the surface including the through-hole on one surface side of the substrate, a first chamber to be filled with electrolyte; and a second chamber member that forms, with at least the surface including the through-hole on the other surface side of the substrate, a second chamber to be filled with electrolyte. The biological material to be tested is identified by the waveform of the ion current (passage time, shape, etc.) when the biological material to be tested passes through the through-hole.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: December 29, 2020
    Assignees: OSAKA UNIVERSITY, TOKYO INSTITUTE OF TECHNOLOGY, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
    Inventors: Makusu Tsutsui, Kazumichi Yokota, Masateru Taniguchi, Tomoji Kawai, Mina Okochi, Masayoshi Tanaka, Yoshinobu Baba, Noritada Kaji, Takao Yasui, Yuji Miyahara, Yukichi Horiguchi
  • Patent number: 10874621
    Abstract: Nanoparticles containing an aqueous core containing one or more nucleic acids, such as siRNA, and a shell containing one or more hydrophobic cationic materials, one or more amphiphilic materials, and one or more therapeutic, diagnostic, and/or prophylactic agents are. The hydrophobic cationic material and the hydrophobic portion of the amphiphilic material provide a non-polar polymer matrix for loading non-polar drugs, protect and promoting siRNA molecule retention inside the NP core, and control drug release. The hydrophilic portion of the amphiphilic material can form a corona around the particle which prolongs circulation of the particles in the blood stream and decreases uptake by the RES.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: December 29, 2020
    Assignees: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Xiaoyang Xu, Xueqing Zhang, Omid C. Farokhzad, Robert S. Langer
  • Patent number: 10874675
    Abstract: The invention provides compounds effective as inhibitors of monocarboxylate transporters such as MCT1 and MCT4, which can be used for treatment of medical conditions wherein treatment of the condition with a compound having an inhibitor effect on MCT1, MCT4, or both is medically indicated. Compounds of the invention can have antitumor, antidiabetes, anti-inflammatory, or immunosuppressive pharmacological effects, and can be effective for treatment of cancer and of type II diabetes.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: December 29, 2020
    Assignee: THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Thomas D. Bannister, Hui Wang, Chao Wang, John L. Cleveland
  • Patent number: 10880119
    Abstract: The present invention relates to a method for removing data frame redundancy in a network environment and a device for carrying out the method, which can comprise: a data frame reception step of receiving a first data frame from an adjacent node; and a redundant frame determination step of determining whether a reception completion indicator of a second data frame having the same identification information as the first data frame exists, on the basis of a preset redundancy check table, and processing the first data frame according to the determination result. Disclosed is the data frame redundancy removal method, which deletes the first data frame when the reception completion indicator of the second data frame having the same identification information as the first data frame exists in the redundancy check table.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: December 29, 2020
    Assignee: KOREA ELECTROTECHNOLOGY RESEARCH INSTITUTE
    Inventors: Jae Moon Kim, Hui Myoung Oh, Sung Soo Choi, Chang Un Park
  • Patent number: 10874879
    Abstract: A system for monitoring doses from an ionizing radiation source to a treatment region of a patient and immobilizing a body cavity relative to the treatment region, is provided. The system includes a probe body for insertion into the body cavity. The probe body separates the body cavity from the treatment region to reduce exposure to doses from the ionizing radiation source. Radiation detectors are disposed along the probe body to measure at least one dose. A slot disposed adjacent the radiation detectors receives a dosimetry film that, upon exposure to the one or more doses from the ionizing radiation source, indicates a quantification of the doses. A coupling is in fluid communication with a removable sheath having coupled thereto a vacuum or a pump to remove fluid or gas from the body cavity and ensure inner wall of the body cavity is in contact with the sheath.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: December 29, 2020
    Assignee: SUNNYBROOK RESEARCH INSTITUTE
    Inventors: Ananth Ravi, Harry Easton
  • Patent number: 10877178
    Abstract: Disclosed in the present invention is a method for suppressing airborne transient electromagnetic in-band vibration noise, comprising: dividing the data after current turn-off into two segments according to whether the useful signal is attenuated to the system noise level: the segment A is the useful signal segment, and the segment B is the pure noise segment; limiting the bandwidth of the data of the segment B according to the frequency range of the in-band noise, and labeling the result as BL; training a neural network using the BL, utilizing the well trained neural network to predict the in-band vibration noise contained in the data of the segment A, and labeling the prediction result as PNA; and subtracting the PNA from the data of the segment A to suppress the in-band vibration noise contained in the data of the segment A.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: December 29, 2020
    Assignee: INSTITUTE OF GEOLOGY AND GEOPHYSICS, CHINESE ACADEMY OF SCIENCES
    Inventors: Xin Wu, Guoqianq Xue, Qingyun Di
  • Patent number: 10877016
    Abstract: Provided is a sensor which enables detection/identification of various types of fuels for automobiles by using simple devices. According to the present invention, high-octane gas, regular gas, diesel oil, heating oil, gasoline laced with heating oil, and the like can be clearly identified without using a large-scale analysis such as gas chromatography or mass spectroscopy by using a sensor having a structure in which a surface of a sensor body which detects a surface stress or the like is coated with particles modified with a hydrocarbon group such as an alkyl group.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: December 29, 2020
    Assignee: NATIONAL INSTITUTE FOR MATERIALS SCIENCE
    Inventors: Kota Shiba, Genki Yoshikawa, Gaku Imamura
  • Patent number: 10879669
    Abstract: A photonic crystal laser 10 is a laser that has a configuration, in which a light emitting layer (an active layer 12) that generates light including light of wavelength ?L, and a two-dimensional photonic crystal layer 11 including different refractive index regions (holes 111) disposed two-dimensionally on a plate-like base material 112, the different refractive index regions having a refractive index different from a refractive index of the base material, so that a refractive index distribution is formed, are stacked. Each different refractive index region in the two-dimensional photonic crystal layer 11 is disposed at a position shifted from each lattice point of a basic two-dimensional lattice that has periodicity defined to generate a resonant state of light of the wavelength ?L by forming a two-dimensional standing wave and not to emit light of the wavelength ?L to outside.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: December 29, 2020
    Assignees: KYOTO UNIVERSITY, NATIONAL UNIVERSITY CORPORATION KYOTO INSTITUTE OF TECHNOLOGY
    Inventors: Susumu Noda, Kyoko Kitamura, Masako Yone
  • Patent number: 10877037
    Abstract: Presented herein, in certain aspects, are compositions that comprise novel toxin proteins, the nucleic acids that encode them, and/or portions thereof, which toxins are expressed by fungi of the Mucorales order and are thought to contribute to the pathogenesis of Mucormycosis. Also presented herein, in certain aspects, are methods of detecting the presence or absence of novel fungal toxins and/or the nucleic acids that encode them in a sample, which methods can be used to identify the presence of Mucorales in a subject. Methods and/or compositions presented herein can be used to prevent and/or treat a Mucorales infection.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: December 29, 2020
    Assignee: LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER
    Inventors: Ashraf S. Ibrahim, Sameh Soliman, John Edwards, Jr.
  • Patent number: 10875883
    Abstract: Disclosed is a method for synthesizing a novel chiral ligand, a metal chelate, a variety of non-natural amino acids, Maraviroc and a key intermediate thereof. In the invention, (R)-2-methyl proline is selected and used as a starting raw material, (S)-?3-amino acid is obtained by asymmetric resolution induced by using a nickel chelate, and Maraviroc is synthesized by using (S)-3-amino-3-phenylpropionic acid as a key intermediate with a high yield and the ee value reaching 98.2% or more. The method of the present invention has widely available materials, mild synthetic process conditions, is easy to control, and produces a product of a high optical purity.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: December 29, 2020
    Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Hong Liu, Jiang Wang, Shengbin Zhou, Panfeng Peng, Yong Nian, Shuni Wang, Shuangjie Shu, Hao Shen, Hualiang Jiang, Kaixian Chen