Abstract: Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.

Abstract: In illustrative implementations, an imaging system may comprise a lens, an optical cavity and a time-of-flight camera. The imaging system may capture an image of a scene. The image may be formed by light that is from the scene and that passes through the optical cavity and the lens. In some cases, the lens is in front of the optical cavity, enabling the Euclidean distance between the lens and the camera sensor to be less than the nominal focal length of the lens. In some cases, the lens is inside the optical cavity, enabling the camera to acquire ultrafast multi-zoom images without moving or changing the shape of any optical element. In some cases, the lens is behind the optical cavity, enabling the system to perform ultrafast multi-spectral imaging. In other cases, an optical cavity between the scene and time-of-camera enables ultrafast ellipsometry measurements or ultrafast spatial frequency filtering.

Abstract: Engineered Streptococcus canis Cas9 (ScCas9) variants include an ScCas9 protein with its PID being the PID amino acid composition of Streptococcus pyogenes Cas9 (SpCas9)-NG, an ScCas9 protein having a threonine-to-lysine substitution mutation at position 1227 in its amino acid sequence (Sc+), and an ScCas9 protein having a threonine-to-lysine substitution mutation at position 1227 and a substitution of residues ADKKLRKRSGKLATE [SEQ ID No. 4] in position 365-379 in the ScCas9 open reading frame (Sc++). Also included are CRISPR-associated DNA endonucleases with a PAM specificity of 5?-NG-3? or 5?-NNG-3? and a method of altering expression of a gene product by utilizing the engineered ScCas9 variants.

Abstract: In one aspect, the present invention features a method of inhibiting proliferation and/or reducing survival of a cell comprising a GNAQ polynucleotide or polypeptide having a R183Q or Q209L mutation, comprising contacting the cell with puromycin or a puromycin analog, thereby inhibiting proliferation and/or reducing survival of the cell. In another aspect, a method of treating a vascular malformation or related condition in a subject, comprising administering to the subject an effective amount of puromycin or a puromycin analog is featured.

Abstract: Disclosed is a position estimation method for estimating a position of an interference signal source and a position estimation system for performing the method. The position estimation method may implement an indoor delay-space analysis structure by transmitting and receiving a known signal and a virtual array structure-based direction finding algorithm in an indoor environment in which a plurality of reflected waves is present and may increase an estimation probability for the position of the interference signal source.

Abstract: A disc-type three-degree-of-freedom magnetic suspension switched reluctance motor includes a stator and a double-disc rotor. The stator includes an axial stator core, a permanent magnet ring, and a radial stator core coaxially connected to each other in sequence from outside to inside. Axial suspension teeth are distributed on two axial ends of the axial stator core, several axial torque teeth are evenly distributed between adjacent axial suspension teeth by axial magnetic isolation blocks, and axial suspension windings and axial torque windings are respectively wound on the axial suspension teeth and the axial torque teeth. Radial suspension teeth are distributed on the inner circumference of the radial stator core, radial torque teeth are evenly distributed between adjacent radial suspension teeth by a radial magnetic isolation block, and a radial suspension winding and a radial torque winding are respectively wound on the radial suspension teeth and the radial torque teeth.

Abstract: An apparatus and method for broadcast signal frame using layered division multiplexing are disclosed. An apparatus for generating broadcast signal frame according to an embodiment of the present invention includes a combiner configured to generate a multiplexed signal by combining a core layer signal and an enhanced layer signal at different power levels; a power normalizer configured to reduce the power of the multiplexed signal to a power level corresponding to the core layer signal; a time interleaver configured to generate a time-interleaved signal by performing interleaving that is applied to both the core layer signal and the enhanced layer signal; and a frame builder configured to generate a broadcast signal frame including a preamble for signaling, size information of Physical Layer Pipes (PLPs) and time interleaver information shared by the core layer signal and the enhanced layer signal.

Abstract: Provided is an intraocular lens including: an optic portion; and a haptic portion extending from the optic portion, wherein a pattern having ridges and grooves is formed on at least one of the optic portion and the haptic portion, and each of the grooves has a nanostructure roughness. Provided also is a method of manufacturing an intraocular lens, the method including: seating an object to be processed including an optic portion and at least one haptic portion extending from the optic portion, processing a predetermined pattern for guiding cells by performing laser irradiation on the haptic portion and the optic portion, forming grooves having a nanostructure surface roughness in the predetermined pattern formed by laser beams, and the surface of each of the grooves has an average roughness Ra less than 200 nm.

Abstract: In some aspects, described herein are cell culture media that are useful for in vitro culture of mammalian cells. The culture media contain a variety of small organic compounds that are found in normal adult human blood. Also described are methods of using the culture media for a variety of purposes. Also described are methods of treating cancer.

Abstract: An optical deflector includes: a light transmitting portion through which a light passes; and a pair of electrodes arranged to oppose to each other with the light transmitting portion interposed therebetween. The light transmitting portion is a transparent ion conductor made of a single crystal or polycrystal. The pair of electrodes apply a predetermined voltage to the light transmitting portion to move ions inside the transparent ion conductor so as to change a traveling direction of the light passing through the light transmitting portion.

Abstract: An embodiment of the present invention provides a quantization method for weights of a plurality of batch normalization layers, including: receiving a plurality of previously learned first weights of the plurality of batch normalization layers; obtaining first distribution information of the plurality of first weights; performing a first quantization on the plurality of first weights using the first distribution information to obtain a plurality of second weights; obtaining second distribution information of the plurality of second weights; and performing a second quantization on the plurality of second weights using the second distribution information to obtain a plurality of final weights, and thereby reducing an error that may occur when quantizing the weight of the batch normalization layer.

Abstract: Disclosed is an acquisition method for domain rule knowledge of an industrial process. The method comprises the steps of: establishing a domain rule base, establishing a semantic knowledge base, and combining the domain rule base and the semantic knowledge base so as to realize an augmented update of a domain rule knowledge base; describing the domain knowledge of the industrial process by using weighted first-order logic rules so as to form a training sample set of the first-order logic rules; performing a weight learning by applying probability soft logic and the training sample set of the first-order logic rules so as to realize weight to non-weighted rules; performing rule learning through a machine learning algorithm so as to obtain a first-order logic rule on a change in optimization decision-making semantic when multi-source data semantic information changes.

Abstract: The purpose of the present invention is to realize a dew point measurement in which the generation of dew condensation is directly detected and the detection can be performed without using any optical system. In particular, the purpose of the present invention is to realize a dew point measuring device that is compact and has a high sensitivity. According to one embodiment of the present invention, a sudden change in current values before and after the dew point is detected by detecting the dew condensation to detect a galvanic current that flows due to a water droplet attached onto a surface of an insulating substrate on which thin wires of dissimilar metals are juxtaposed, and by controlling the temperature on the surface of the substrate. In this way, the dew point measurement in which the dew point can be directly measured and a measurement with simple configuration and high accuracy can be performed can be realized.

Abstract: A semiconductor device according to the present invention is formed by a plurality of semiconductor chips laminated on a substrate which are connected via a through electrode penetrating in a lamination direction, in which the plurality of semiconductor chips include first semiconductor chips 104 each having memory blocks and a decoder and a second semiconductor chip having a logic circuit, the logic circuit includes one selection circuit connected to the decoder of all the first semiconductor chips 104 and configured to select addresses of a first memory block 106A that stops input/output and a second memory block 106B that performs input/output instead among the plurality of memory blocks, and the addresses of the selected first memory block 106A and the selected second memory block 106B are each common to all the first semiconductor chips.

Abstract: The present invention discloses a UV curing apparatus for a 3D printing product, including a base. A tray is disposed above the base. The tray is horizontally and rotatably connected around a vertical rotating shaft on the base. A hood concentric with the tray is disposed on the base. The tray is located in the hood, and UV light tubes are arranged on an inner wall of the hood. The tray provides a driving force by means of a driving motor. The driving motor is fixed in the base. As can be seen from the foregoing structure, according to the UV curing apparatus for a 3D printing product in the present invention, a UV curing apparatus applicable to a 3D product is provided, and the surface of the 3D product can be automatically and uniformly subjected to UV curing.

Abstract: An optical measurement stability control system includes a case, a circulating flow field, an optical measurement system and a heat dissipation flow field. The case has an airtight space. The circulating flow field is located in the airtight space and adapted to generate an airflow flowing in the airtight space. The optical measurement system is located in the airtight space and located on a flow path of the airflow. The heat dissipation flow field is connected to the case and located at an end of the flow path. The heat dissipation flow field discharges heat out of the airtight space by heat conduction and forced convection.

Abstract: A sensor may include a knitted pocket and loose yarn that is inside a cavity of the pocket. In some cases, this loose yarn is neither woven, nor knit, nor otherwise part of a fabric. A resistive pressure sensor may include a knitted pocket and loose conductive yarn that is inside the pocket. Pressure applied to the pocket may compress the loose yarn, which may increase the number of electrical shorts between different parts of the loose yarn, which in turn may decrease the electrical resistance of the loose yarn. A capacitive sensor may include a knitted pocket and insulative loose yarn that is inside the pocket. A strain sensor may include knitted conductive pleats. Electrical shorts may occur in contact areas where neighboring pleats meet. As the strain sensor stretches, these contact areas may become smaller, causing the electrical resistance of the pleats as a group to increase.

Abstract: A phased array includes, in part, M×N photonic chips each of which includes, in part, an array of transmitters and an array of receivers. At least one of M and/or N is an integer greater than one. The transmitter arrays in each pair of adjacent photonics chips are spaced apart by a first distance and the receiver arrays in each pair of adjacent photonics chips are spaced apart by a second distance. The first and second distances are co-prime numbers. Optionally, at least a second subset of the M×N photonic chips is formed by rotating a first subset of the M×N photonic chips.

Abstract: Vehicles and systems and methods for determining a viewing direction of a user are disclosed. In one embodiment, a system for detecting a viewing direction of a user includes a marker arranged at a fixed location, and an optical assembly. The optical assembly includes a first optical sensor arranged to view the marker, and a second optical sensor arranged to view the user. The first optical sensor detects the marker for determining a spatial location of the optical assembly with respect to the marker, and the second optical sensor detects an eye of the user for determining an eye angle of the user.

Abstract: The present disclosure provides methods to use calcium cobalt zirconium perovskites as oxygen-selective sorbents for the separation of oxygen from a gas mixture such as air. Systems and high temperature oxygen detectors are also provided. In a preferred embodiment, the perovskite is configured as a membrane.