Abstract: Porous ceramics that meet the demand for bone substitute materials and the like are provided. Solution is provided by porous ceramics and a method for producing the porous ceramics, which are ceramics having pores, the pores including open pores and closed pores, the open pores including a plurality of large-diameter open pores having a pore size within a range of 20 to 600 ?m and a plurality of micro-diameter open pores having a pore size within a range of 1.0 ?m or smaller, wherein the large-diameter open pores are distributed substantially uniformly all over the ceramics.

Abstract: A multi-bit resolution sub-pipeline structure for measuring a jump magnitude of a transmission curve, comprising: a sub-analog-to-digital converter having n-bit resolution configured to quantize input analog voltage signals and output digital voltage signals; a sub-digital-to-analog converter having n-bit resolution configured to convert the digital voltage signals output by the sub-analog-to-digital converter into corresponding analog voltage signals; a decoder having n-bit resolution configured to decode an n-bit binary input signal; and a switched-capacitor amplification unit configured to, when in a normal mode, perform sampling and residue amplification on the input analog voltage signals; and when in a test mode, measure the jump magnitude of the transmission curve corresponding to each decision level. Magnitude measurement of a transmission curve is performed within 2n clock periods, th and a measurement result is sent to a back-end digital domain of the A/D converter for correction.

Abstract: Described herein are non-Class I engineered CRISPR-Cas systems and components thereof, formulations thereof, cells thereof, and organisms thereof. Methods of making and using the CRISPR-Cas system described herein.

Abstract: The presently disclosed subject matter provides cells and compositions for improved immunotherapy and methods of using such cells and compositions. It relates to cells comprising a ligand-recognizing receptor (e.g., an antigen-recognizing receptor, e.g., a chimeric antigen receptor (CAR) or a T-cell Receptor (TCR)) and an IgG-degrading enzyme or a fragment thereof. The IgG-degrading enzyme rapidly cleaves IgG. The IgG-degrading enzyme serves as a biomolecular shield against the host humoral response. The cells have increased resistance to host humoral response (e.g., an antibody-driven host humoral response), which allows for prolonged persistence of the cells, leading to enhanced activity of the cells.

Abstract: Disclosed herein are an apparatus and method for training a low-bit-precision deep neural network. The apparatus includes an input unit configured to receive training data to train the deep neural network, and a training unit configured to train the deep neural network using training data, wherein the training unit includes a training module configured to perform training using first precision, a representation form determination module configured to determine a representation form for internal data generated during an operation procedure for the training and determine a position of a decimal point of the internal data so that a permissible overflow bit in a dynamic fixed-point system varies randomly, and a layer-wise precision determination module configured to determine precision of each layer during an operation in each of a feed-forward stage and an error propagation stage and automatically change the precision of a corresponding layer based on the result of determination.

Abstract: Disclosed are methods and apparatuses for image data encoding/decoding. A method for decoding a 360-degree image includes the steps of: receiving a bitstream obtained by encoding a 360-degree image; generating a prediction image by making reference to syntax information obtained from the received bitstream; adding the generated prediction image to a residual image obtained by dequantizing and inverse-transforming the bitstream, so as to obtain a decoded image; and reconstructing the decoded image into a 360-degree image according to a projection format. Therefore, the performance of image data compression can be improved.

Abstract: Disclosed is a capacitive-coupled comb-line microstrip array antenna including a dielectric substrate, first and second feeding lines formed on one surface of the dielectric substrate and in parallel branched from a feeding line connected to an input port, and microstrip patches intersected and arranged in a way to be partially overlapped within an area where the parallel first and second feeding lines are formed to face each other. The microstrip patches include a first group of microstrip patches formed in a direction orthogonal to the first feeding line with a gap between the microstrip patches and the first feeding line and a second group of microstrip patches formed in a direction orthogonal to the second feeding line with a gap between the microstrip patches and the second feeding line.

Abstract: A needle has a hollow shaft, a tip formed at one end of the shaft, one or more ports in fluid communication with the interior of the hollow shaft, and a closure. The closure and/or the shaft is movable between (i) a first position wherein the closure closes the port(s), and (ii) a second position opening the port(s).

Abstract: The present disclosure provides a substrate-enhanced comparator and electronic device, the comparator including: a cross-coupled latch, for connecting input signals to the gate of a cross-coupled MOS transistor to form a first input of the latch; output buffers, connected to the cross-coupled latch for amplifying output signals of the latch; AC couplers, connected to the output buffers for receiving and amplifying the output signals of the latch, coupling the output signals to substrates of the cross-coupled MOS transistors to form second inputs of the latch. The cross-coupled latch is also for output signal regenerative latching based on input signals sampled at the first inputs and input signals sampled at the second inputs. The present disclosure introduces additional substrate inputs to the cross-coupled structure of the conventional latch as the second inputs of the latch.

Abstract: Apparatus, system and method for medical analysis of a seated individual, includes determining the aortic valve opening; the PTT; and calculating the PWV. Determining the aortic valve opening includes collecting BCG data while sitting on a seat and determining the timing of the aortic valve opening, taking into account posture. Measuring the aortic pulse wave transit time includes collecting BCG data while sitting on a seat capable of measuring changes in apparent weight; determining the timing of the aortic valve opening; detecting the arrival of the pulse wave at the end point; and measuring the relative timings of the two events. Calculating the PWV includes determining a length of the arterial segment through which a pulse wave is to be measured between a start point and an end point; and dividing the determined length of the arterial segment by the PTT.

Abstract: A method of accelerating training of a low-power, high-performance artificial neural network (ANN) includes (a) performing fine-grained pruning and coarse-grained pruning to generate sparsity in weights by a pruning unit in a convolution core of a cluster in a lower-power, high-performance ANN trainer; (b) selecting and performing dual zero skipping according to input sparsity, output sparsity, and the sparsity of weights by the convolution core, and (c) restricting access to a weight memory during training by allowing a deep neural network (DNN) computation core and a weight pruning core to share weights retrieved from a memory by the convolution core.

Abstract: The present disclosure discloses the use of Tegaserod or a pharmaceutically acceptable salt thereof as a JAK-STAT3 signaling pathway inhibitor and an immunomodulator in the preparation of an anti-tumor drug. Tegaserod and the pharmaceutically acceptable salt thereof show a very excellent inhibitory effect on the growth of various tumor cells in vivo and in vitro, and are expected to be used in the treatment of various cancers.

Abstract: A method for generating a transcranial magnetic stimulation (TMS) coil pose atlas based on electromagnetic simulating calculation includes: constructing coil array positions and orientations of a scalp in a standard Montreal Neurological Institute (MNI) space and matching the coil array positions and orientations of the scalp to a brain space of an individual to obtain coil array positions and orientations of the brain space of the individual; using a finite element calculation method to simulate the coil array positions of the brain space of the individual to obtain induced electric field distributions of brain tissue in different coil orientations; obtaining optimal regulation effects based on the induced electric field distributions of the brain tissue; and obtaining a coil position and orientation corresponding to each optimal regulation effect as an optimal coil pose of each divided brain area of the individual, and constructing a TMS coil pose atlas of the individual.

Abstract: Provided is an optical system which may acquire a hyperspectral image by acquiring a spectral image of an object to be measured, which includes, to collect spectral data and train the neural network, an image forming part forming an image from an object to be measured and transmitting collimated light, a slit moving to scan the incident image and passing and outputting a part of the formed image, and a first optical part obtaining spectral data by splitting light of the image received through the slit by wavelength. Also, the system includes, to decompose overlapped spectral data and to infer hyperspectral image data through the trained neural network, an image forming part forming an image from an object to be measured and transmitting collimated light, and a first optical part obtaining spectral data by splitting light of the received image by wavelength.

Abstract: A radar-absorbing fiber-reinforced structure includes a fiber composite discharging part. The fiber composite discharging part includes a first electrode part and a second electrode part, which are spaced apart from each other by a dielectric layer and receive different voltages. The fiber composite discharging part is configured to discharge plasma in response to a voltage difference thereby changing a reflected wave or transmitted wave of a radar incident on the radar-absorbing fiber-reinforced structure to reduce reflectivity of the radar. At least one of the first electrode part and the second electrode part include a conductive fiber having a tensile strength equal to or more than 0.5 GPa.

Abstract: A millimeter wave security inspection instrument debugging system and a millimeter wave security inspection instrument debugging method, which are used for debugging the imaging definition of a millimeter wave holographic imaging security inspection system. A main control apparatus is used for generating a millimeter wave detection signal and a reference signal. The main control apparatus is also used for, where a millimeter wave transmitting antenna, a millimeter wave receiving antenna and a detected object are respectively located at different relative positions, transmitting the millimeter wave detection signal to the detected object by means of the millimeter wave transmitting antenna, and receiving an echo signal reflected from the detected object by means of the millimeter wave receiving antenna, and then using a holographic image technique to perform three-dimensional imaging according to the reference signal and the echo signal.

Abstract: Methods for modification of surface wettability of fluorine-containing polymers by sequential treatments first with gaseous plasma rich in ultraviolet radiation, and then oxidation using neutral reactive oxidative species. The methods are rapid and permit treatment of fluorine-containing polymers of any shape and size including ‘infinite’ materials such as foils. A surface layer of an object made from a fluorine-containing polymer is depleted of fluorine upon interaction with gaseous plasma rich in ultraviolet radiation. The depleted surface layer is then exposed to reactive oxygen species such as neutral oxygen atoms in the ground state. The wettability of objects made from or containing fluorine-containing polymers treated according to the methods of the present disclosure is close to the theoretical limit for smooth polymers well functionalized with polar functional groups.

Abstract: Provided herein are a voltage indicator and a method of measuring voltage. The voltage indicator includes a membrane-localized voltage-sensitive protein coupled to a capture protein. The method of measuring voltage includes administering a voltage indicator including a membrane-localized voltage-sensitive protein coupled to a capture protein, and determining changes in fluorescence of a small-molecule fluorescent dye captured by the capture protein.

Abstract: Methods of modulating the interaction between ?-amyloid and ?7-nAChR are provided. Aspects of the methods include administering to the subject an effective amount of a naphthalene derivative active agent. Compositions and kits for practicing the subject methods are also provided. The methods, compositions and kits find use in treating a variety of applications, such as treating a subject for a neurodegenerative disease, e.g., Alzheimer's disease.

Abstract: The present application provides systems, methods and compositions used for targeted gene modification, targeted insertion, perturbation of gene transcripts, nucleic acid editing. Novel nucleic acid targeting systems comprise components of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems and transposable elements.