Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.

Abstract: Disclosed herein are immunoglobulin constructs comprising at least one immunoglobulin domain or fragment thereof; and a therapeutic polypeptide or derivative or variant thereof attached to or inserted into said immunoglobulin domain. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a knob domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said knob domain of the CDR3H. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a stalk domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said stalk domain of the CDR3H. Also described herein are methods and compositions comprising the immunoglobulin constructs described herein for treatment and prevention of a disease or condition in a subject.

Abstract: The present invention relates to a composition for immunostaining cleared large tissues and a method for immunostaining cleared large biological tissues using the same. The composition for immunostaining cleared large tissues increases antibody permeability in cleared biological tissues, in particular, large biological tissues having a thickness of 3 mm or more, to allow antibodies to penetrate deep into thick tissues, thereby overcoming immunostaining problems associated with limited permeation of antibodies in existing methods, reduces the time required for immunostaining large tissues, thereby enabling simple and rapid three-dimensional bioimaging with high resolution for large biological tissues, and may be beneficially used, through structure images, for identifying the causes of various diseases, developing new treatment methods, and predicting the efficacy and toxicity of drugs.

Abstract: This application relates to a wide band gap (WBG) power semiconductor system. In one aspect, the system includes a controller configured to generate a switching control signal and a gate driver configured to receive the switching control signal and generate a switching drive signal in response to the switching control signal. The system also includes a WBG power semiconductor device coupled to the gate driver, comprising a gate terminal for receiving the switching drive signal, and configured to be switched in response to the switching drive signal. The switching drive signal has one of three signal levels: a first voltage level higher than a zero voltage level, a second voltage level lower than the zero voltage level, and the zero voltage level at an arbitrary instant. As a result, the gate driver drives the WBG power semiconductor device with the three voltage levels.

Abstract: A heat exchanger for a steam generator according to one embodiment of the present invention comprises a plate and channels formed on the plate by an photo-chemical etching method, wherein the channels comprise: a primary heat transmission section formed in a manner of having a bent or curved flow path so as to be extended longer than the length at which one side and the other side are connected in a straight line; and a flow path resistance section, formed having a smaller width than the width of the channels formed on the primary heat transmission section and being connected to the one side of the primary transmission section in a manner of having a bent or curved flow path so as to be extended longer than the length at which an inlet and an outlet are connected in a straight line.

Abstract: A method, a processing device and a display system for information display are provided. The system includes a display being light transmissive, at least one first information extraction device, at least one second information extraction device, and a processing device. The processing device is connected to the display, the first information extraction device and the second information extraction device. The first information extraction device is configured to extract a user's position information and posture information. The second information extraction device is configured to extract a target object's position information and posture information.

Abstract: Systems and methods for determining a pose of an object held by a flexible end effector of a robot are disclosed. A method of determining a pose of the object includes receiving tactile data from tactile sensors, receiving curvature data from curvature sensors, determining a plurality of segments of the flexible end effector from the curvature data, assigning a frame to each segment, determining a location of each point of contact between the object and the flexible end effector from the tactile data, calculating a set of relative transformations and determining a location of each point relative to one of the frames, generating continuous data from the determined location of each point, and providing the continuous data to a pose determination algorithm that uses the continuous data to determine the pose of the object.

Abstract: Spinal correction surgical techniques and methodologies for correction of scoliosis using non fusion anterior scoliosis correction, including soft tissue releases, unique correction techniques such as de-rotation, and unique single and dual anchor screw/cord applications.

Abstract: Provided is an integrated-system simulation system obtained from a simulation system having a command, control, and communication (C3) system of systems (SoS). The integrated-system simulation system includes an abstracted command and control (C2) model including a traffic model including inter-node traffic information transferred according to time, a mobility model including position information of nodes, and an interface model making the traffic model and the mobility model interoperate, and a communication (C) model configured to be combined with the abstracted C2 model so as to interact with the abstracted C2 model in a full-duplex manner. The abstracted C2 model is generated by acquiring traffic and mobility data between the C2 model and the C model of the SoS simulation system, hypothesizing a form of the abstracted C2 model, and learning the traffic and mobility data acquired from the SoS simulation system and determining variables of the abstracted C2 model form.

Abstract: A process for decomposition of sulfuric acid, particularly a process for catalytically decomposing sulfuric acid is used to obtain sulfur dioxide therefrom. Catalysts are used for improving the dissociation efficiency by lowering the activation energy barrier for the reaction.

Abstract: [Object] To provide a thermoelectric generation cell using a safe and inexpensive general-purpose thermoelectric material.

Abstract: The present disclosure provides a buffer circuit and a buffer. The buffer circuit includes: an input follower circuit for following the voltage change of the first input signal; an input follower linearity boosting circuit for improving follower linearity of the input follower circuit; a first voltage bootstrap circuit for bootstrapping the voltage of the first input signal; a second voltage bootstrap circuit for bootstrapping the voltage of the second input signal; a third voltage bootstrap circuit for providing corresponding quiescent operation point voltage; a compensation follower circuit for following the compensation voltage; a compensation follower linearity boosting circuit for improving follower linearity of the compensation follower circuit; a first load for collecting the buffered voltage; a bias circuit for providing a bias current for the buffer; a bias linearity boosting circuit for improving linearity of the bias circuit; a second load for generating a nonlinear compensation current.

Abstract: A organic fertilizer for controlling pollution or accumulation of heavy metal cadmium in rice and a preparation method and an application method thereof are related to the technical field of fertilizers. The fertilizer is, based on 100 kg of organic material with a water content of 15%, added with 0.05-5 kg of iron salt calculated as iron, and is also added with manganese salt, zinc salt and copper salt, wherein a mass ratio of the iron salt calculated as iron, the manganese salt calculated as manganese, the zinc salt calculated as zinc and the copper salt calculated as copper is 1: 0.2-8: 0.08-2: 0.001-0.5.

Abstract: A method for 3D object modeling includes linking 2D semantic keypoints of an object within a video stream into a 2D structured object geometry. The method includes inputting, to a neural network, the object to generate a 2D NOCS image and a shape vector, the shape vector being mapped to a continuously traversable coordinate shape. The method includes applying a differentiable shape renderer to the SDF shape and the 2D NOCS image to render a shape of the object corresponding to a 3D object model in the continuously traversable coordinate shape space. The method includes lifting the linked, 2D semantic keypoints of the 2D structured object geometry to a 3D structured object geometry. The method includes geometrically and projectively aligning the 3D object model, the 3D structured object geometry, and the rendered shape to form a rendered object. The method includes generating 3D bounding boxes from the rendered object.

Abstract: A measuring-robot device for fully mechanized coal mining faces and an automatic measuring system are provided. The measuring robot includes a suspension cage, a total station, a prism and an industrial computer. Firstly, the suspension cage with automatic leveling function is fixed on the top beam of a hydraulic support, then the total station and the industrial computer are fixed in the suspension cage, and finally the prism with a plug connector is installed under the base of the total station, forming a measuring-robot device. According to the fluctuations of the fully mechanized coal mining face, several measuring robots will be deployed along the fully mechanized coal mining face, and the adjacent measuring robots are line of sight to each other, forming the automatic measuring system covering the fully mechanized coal mining.

Abstract: Provided is a method of providing an interpretation result using visual information, and the method includes: acquiring a spatial domain image including line-of-sight information of a user and gaze position information in the spatial domain image; segmenting the acquired spatial domain image into a plurality of images; detecting text areas including text for each of the segmented images; generating text blocks, each of which is a text recognition result for each of the detected text areas, and determining the text block corresponding to the gaze position information; converting a first language included in the determined text block into a second language that is a target language; and providing the user with a conversion result of the second language.

Abstract: Uniformly-sampled, residue-generating analog-to-digital converters (ADCs), such as uniformly-sampled continuous-time pipelined ADCs, suffer from over-ranging of the residue signal, which can lead to severe signal distortion. Conventionally, power consuming techniques and oversampling are used to address the over-ranging problem. To reduce the range of the residue signal and reduce other impairments, an event-driven sub-quantizer (sub-ADC) and a sub-digital-to-analog converter (sub-DAC) can be implemented in at least one of the stages of the residue-generating ADC, to generate a continuous-time residue signal.

Abstract: The invention features pancreatic islet and pancreatic organoids, and cell cultures and methods that are useful for the rapid and reliable generation of pancreatic islet and pancreatic islet organoids. The invention also features methods of treating pancreatic diseases and methods of identifying agents that are useful for treatment of pancreatic diseases, such as type 2 diabetes and pancreatic cancer, using the pancreatic islet and pancreatic organoids of the invention.

Abstract: The present invention relates to an apparatus and method for encoding and decoding an image by skip encoding. The image-encoding method by skip encoding, which performs intra-prediction, comprises: performing a filtering operation on the signal which is reconstructed prior to an encoding object signal in an encoding object image; using the filtered reconstructed signal to generate a prediction signal for the encoding object signal; setting the generated prediction signal as a reconstruction signal for the encoding object signal; and not encoding the residual signal which can be generated on the basis of the difference between the encoding object signal and the prediction signal, thereby performing skip encoding on the encoding object signal.

Abstract: Disclosed is a mixed-phase winding, comprising at least one branch, where each branch is composed of at least one coil ring; the coil ring comprises a set of lap winding coils and a set of combined conductors; each set of lap winding coils comprises P lap winding coils evenly distributed in the circumferential direction, and each set of combined conductors comprises P combined conductors evenly distributed in the circumferential direction, P being the number of pole pairs; and the lap winding coils and the combined conductors are arranged at intervals in a staggered manner in the circumferential direction and sequentially connected in series; each lap winding coil and each combined conductor each comprises a hairpin conductor or at least two hairpin conductors arranged side by side in the thickness direction; each hairpin conductor comprises a hairpin body integrally bent in a U shape.