Abstract: Provided are a circular RNA construct and application thereof. The circular RNA construct has a structure represented by formula I in the 5?-3? direction: TI-Z1-Z2 (I), wherein TI is a translation initiation element, Z1 is an expression cassette for exogenous protein expression, and Z2 is nothing or another element.
Type:
Application
Filed:
February 27, 2020
Publication date:
June 9, 2022
Applicant:
SHANGHAI INSTITUTE OF NUTRITION AND HEALTH, CHINESE ACADEMY OF SCIENCES
Abstract: Disclosed are compounds and pharmaceutically acceptable salts and stereoisomers thereof that may cause degradation of various proteins e.g., IKZF2 (Helios). Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds to treat diseases and disorders characterized or mediated by aberrant protein activity.
Type:
Application
Filed:
December 3, 2019
Publication date:
June 9, 2022
Applicant:
DANA-FARBER CANCER INSTITUTE, INC.
Inventors:
Alyssa Verano, Eric Wang, Radoslaw Nowak, Jing Ting Christine Yuan, Nathanael Gray, Eric Fischer, Tinghu Zhang, Hu Liu
Abstract: A weakly supervised image semantic segmentation method based on an intra-class discriminator includes: constructing two levels of intra-class discriminators for each image-level class to determine whether pixels belonging to the image class belong to a target foreground or a background, and using weakly supervised data for training; generating a pixel-level image class label based on the two levels of intra-class discriminators, and generating and outputting a semantic segmentation result; and further training an image semantic segmentation module or network by using the label to obtain a final semantic segmentation model for an unlabeled input image. By means of the new method, intra-class image information implied in a feature code is fully mined, foreground and background pixels are accurately distinguished, and performance of a weakly supervised semantic segmentation model is significantly improved under the condition of only relying on an image-level annotation.
Type:
Application
Filed:
July 2, 2020
Publication date:
June 9, 2022
Applicant:
INSTITUTE OF AUTOMATION, CHINESE ACADEMY OF SCIENCES
Inventors:
Zhaoxiang ZHANG, Tieniu TAN, Chunfeng SONG, Junsong FAN
Abstract: A method of cancelling interference signals may comprise: receiving, from a transmitting communication node, a first polarization signal including an interference signal and a second polarization signal that is orthogonal to the first polarization signal and includes the interference signal; generating a combined signal by combining the first polarization signal and the second polarization signal using initial combining coefficients; calculating a correlation between the combined signal and one of the first polarization signal and the second polarization signal; selecting final combining coefficients based on the correlation; and generating an output signal by combining the first polarization signal and the second polarization signal using the final combining coefficients.
Type:
Application
Filed:
December 2, 2021
Publication date:
June 9, 2022
Applicant:
Electronics and Telecommunications Research Institute
Abstract: Disclosed herein is an Artificial Intelligence (AI) processor. The AI processor includes multiple NVM AI cores for respectively performing basic unit operations required for a deep-learning operation based on data stored in NVM; SRAM for storing at least some of the results of the basic unit operations; and an AI core for performing an accumulation operation on the results of the basic unit operation.
Type:
Application
Filed:
December 7, 2021
Publication date:
June 9, 2022
Applicant:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Inventors:
Jin-Ho HAN, Byung-Jo KIM, Ju-Yeob KIM, Hye-Ji KIM, Joo-Hyun LEE, Seong-Min KIM
Abstract: Provided are a system and method for adaptive masking and non-directional language understanding and generation. The system for adaptive masking and non-directional language understanding and generation according to the present invention includes an encoder unit including an adaptive masking block for performing masking on training data, a language generator for restoring masked words, and an encoder for detecting whether or not the restored sentence construction words are original, and a decoder unit including a generation word position detector for detecting a position of a word to be generated next, a language generator for determining a word suitable for the corresponding position, and a non-directional training data generator for decoder training.
Type:
Application
Filed:
December 2, 2021
Publication date:
June 9, 2022
Applicant:
Electronics and Telecommunications Research Institute
Inventors:
Eui Sok CHUNG, Hyun Woo KIM, Gyeong Moon PARK, Jeon Gue PARK, Hwa Jeon SONG, Byung Hyun YOO, Ran HAN
Abstract: The present disclosure relates to compositions and methods for assessing extended length T-cell receptor (TCR) transcript sequences (i.e., TCR transcript sequences that span TCR transcript variable regions) in a spatially-defined manner across a tissue sample, specifically providing for obtaining useful TCR sequences at high spatial resolution while also assessing relative macromolecule abundance (e.g., RNA expression levels) with deep transcriptomic coverage at similarly high-resolution across the tissue sample.
Type:
Application
Filed:
December 6, 2021
Publication date:
June 9, 2022
Applicants:
THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Abstract: An organic-inorganic hybrid resin is formed by reacting a polyol organic resin with a polysilsesquioxane polymer. The organic-inorganic hybrid resin has T0, T1, T2, and T3 signals of 29Si-NMR, wherein a ratio of the sum of 3 times the integral value of T0 signal and 2 times the integral value of T1 signal and the integral value of T2 signal and the integral value of T3 signal ((3T0+2T1+T2)/T3) is from 0.3 to 1.2, wherein the T0 signal range is 35 ppm to 40 ppm, the T1 signal range is 48 ppm to 53 ppm, the T2 signal range is 55 ppm to 62 ppm, and the T3 signal range is 63 ppm to 72 ppm.
Type:
Application
Filed:
December 30, 2020
Publication date:
June 9, 2022
Applicant:
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Abstract: The present invention relates to a neovascular-targeting contrast medium composition and a method for preparing same. The neovascular-targeting contrast medium composition according to the present invention exhibits high binding force to neovascularization-associated ?v?3 integrin, excellent tissue permeability and biostability, enables simple measurement in vitro, in vivo, or ex vivo, and thus is effective in the detection of neovascularization and in diagnosing diseases associated therewith, and therefore may be usefully employed in the relevant industries.
Type:
Application
Filed:
July 24, 2019
Publication date:
June 9, 2022
Applicant:
KOREA BASIC SCIENCE INSTITUTE
Inventors:
Ki-Yuk CHANG, Chan-Woo KIM, Kwan-Soo HONG, Hyun-Seung LEE, Hyun-Min KIM
Abstract: Feedback methods for repetitive uplink transmissions in a communication system are disclosed. An operation method of a terminal may comprise receiving DL data #1 from a base station through a DL data channel #1; receiving DL data #2 from the base station through a DL data channel #2; and when each of a UL control channel #1 on which an HARQ response #1 for the DL data #1 is to be transmitted and a UL control channel #2 on which an HARQ response #2 for the DL data #2 is to be transmitted overlaps with a UL data channel assigned by the base station, transmitting the HARQ response #1 and the HARQ response #2 to the base station through the UL data channel. Therefore, the performance of the communication system can be improved.
Type:
Application
Filed:
February 23, 2022
Publication date:
June 9, 2022
Applicant:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Inventors:
Cheul Soon KIM, Gi Yoon PARK, Ok Sun PARK
Abstract: Novel monolithic reflective spatial heterodyne spectrometers (SHS) interferometer systems are presented. Monolithic systems in accordance with the invention have a single supporting structure wherein input optics, output optics, a flat mirror, a roof mirror, and a symmetric grating are affixed. Embodiments of the invention contain only fixed parts, and the optics do not move in relation to the supporting structure. Embodiments of the present invention enables smaller, lighter, and more robust reflective SHS systems as compared to conventional interferometry. Additionally, embodiments of the present invention require less time and skill for construction and maintenance, and is a better economic option. Additional embodiments can include multiple interferometer systems in a single supporting structure.
Abstract: Disclosed are methods and apparatuses for image data encoding/decoding. A method for decoding a 360-degree image includes the steps of: receiving a bitstream obtained by encoding a 360-degree image; generating a prediction image by making reference to syntax information obtained from the received bitstream; adding the generated prediction image to a residual image obtained by dequantizing and inverse-transforming the bitstream, so as to obtain a decoded image; and reconstructing the decoded image into a 360-degree image according to a projection format. Therefore, the performance of image data compression can be improved.
Abstract: An atomic magnetometer, which operates in a communication system using a magnetic signal in a very low frequency (VLF) band, may comprise: a vapor cell comprising one or more alkaline metal atoms; a pump light source configured to provide circularly polarized pump beams to the vapor cell; an irradiation light source configured to provide linearly polarized irradiation beams to the vapor cell; a magnetic signal detecting unit configured to detect a magnetic signal by measuring a polarization rotation angle from the linearly polarized irradiation beam passing through the vapor cell; and a bias magnetic field control unit configured to control a bias magnetic field applied to the vapor cell.
Type:
Application
Filed:
November 30, 2021
Publication date:
June 9, 2022
Applicant:
Electronics and Telecommunications Research Institute
Inventors:
Hyun Joon LEE, Jang Yeol KIM, Jae Woo LEE, In Kui CHO, Sang Won KIM, Seong Min KIM, Jung Ick MOON, Je Hoon YUN, Dong Won JANG
Abstract: Disclosed herein is a class of molecules termed remodilins that are effective in treating asthma, pulmonary fibrosis, and associated disorders. The molecules ameliorate asthma and pulmonary fibrosis symptoms by various mechanisms, including inhibiting airway smooth muscle contractile protein accumulation, reducing airway constrictor hyperresponsiveness, inhibiting bronchial fibroblast transformation into myofibroblasts, and/or treating or preventing airway or pulmonary fibrosis.
Type:
Application
Filed:
April 2, 2020
Publication date:
June 9, 2022
Applicants:
The University of Chicago, The United States of America,as Represented by the Secretary, Department of Health and Human Servic, President and Fellows of Harvard College, IIT Research Institute, Beth Israel Deaconess Medical Center, Inc.
Inventors:
Julian SOLWAY, Nickolai DULIN, Diane Luci, David MALONEY, Chan Young PARK, Jeffrey FREDBERG, David MCCORMICK, Ramaswamy KRISHNAN
Abstract: Techniques for detecting embolic information for a patient. The techniques may include obtaining data identifying an ultrasound signal associated with the patient, identifying a set of candidate embolic regions in the data, identifying a set of embolic regions from among the set of candidate embolic regions, and outputting embolic information corresponding to the set of embolic regions.
Type:
Application
Filed:
April 8, 2020
Publication date:
June 9, 2022
Applicants:
Massachusetts Institute of Technology, Children's Medical Center Corporation
Inventors:
Thomas Heldt, Syed Muhammad Imaduddin, Kerri Larovere, Barry Kussman
Abstract: Antimicrobial activity exhibited against a wide variety of plant pathogens. A functional peptide consisting of the amino acid sequence: YYGFPAFSERTRKFWRIWKGKTS (SEQ ID NO: 1) or an amino acid sequence having an identity of 85% or more with respect to the amino acid sequence, or consisting of a partial peptide thereof.
Type:
Application
Filed:
March 6, 2020
Publication date:
June 9, 2022
Applicants:
TOYOTA JIDOSHA KABUSHIKI KAISHA, KYUSHU INSTITUTE OF TECHNOLOGY, NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM, CHUBU UNIVERSITY EDUCATIONAL FOUNDATION
Abstract: The objective of the present invention is to provide a method and an apparatus for intra-prediction. In addition, the objective of the present invention is to provide a method and an apparatus for intra-prediction on a subblock unit basis. Furthermore, the objective of the present invention is to provide a method and an apparatus for determining a division and an encoding order of subblock units.
Abstract: Disclosed herein are a method, an apparatus and a storage medium for image encoding/decoding using a binary mask. An encoding method includes generating a latent vector using an input image, generating a selected latent vector component set using a binary mask, and generating a main bitstream by performing entropy encoding on the selected latent vector component set. A decoding method includes generating a selected latent vector component set including one or more selected latent vector components by performing entropy decoding on a main bitstream and generating the latent vector in which the one or more selected latent vector components are relocated by relocating the selected latent vector component set in the latent vector.
Type:
Application
Filed:
December 3, 2021
Publication date:
June 9, 2022
Applicant:
Electronics and Telecommunications Research Institute
Inventors:
Joo-Young LEE, Se-Yoon JEONG, Hyoung-Jin KWON, Dong-Hyun KIM, Youn-Hee KIM, Jong-Ho KIM, Ji-Hoon DO, Jin-Soo CHOI, Tae-Jin LEE
Abstract: Systems and methods for tracking objects are disclosed herein. In one embodiment, a system having a processor merges features of detected objects extracted from a point cloud and a corresponding image to generate fused features for the detected objects, generates a learned distance metric for the detected objects using the fused features, determines matched detected objects and unmatched detected objects, applies prior tracking identifiers of the detected objects at the prior time to the matched detected objects, determines a confidence score for the fused features of the unmatched detected objects, and applies new tracking identifiers to the unmatched detected objects based on the confidence score.
Type:
Application
Filed:
April 28, 2021
Publication date:
June 9, 2022
Applicants:
Toyota Research Institute, Inc., The Board of Trustees of the Leland Stanford Junior University
Inventors:
Hsu-kuang Chiu, Jie Li, Rares A. Ambrus, Christin Jeannette Bohg
Abstract: An information processing device includes: a plurality of linear combination nodes that linearly combine input values; a selection node that is provided to the linear combination node and calculates, according to the input values, a value indicating whether or not a corresponding linear combination node is selected; and an output node that outputs an output value calculated based on a value of the linear combination node and a value of the selection node.
Type:
Application
Filed:
March 23, 2020
Publication date:
June 9, 2022
Applicants:
NEC Corporation, NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY