Patents Assigned to Instrumentation Laboratory
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Patent number: 10168278Abstract: An optical system and method for quantifying total protein in whole blood or other multi-phase liquids and colloidal suspensions uses refractometry without preliminary steps such as cell separation or centrifugation. A refractometer is integrated with a flow cell to enable the refractive index of a flowing sample to be measured based on a substantially cell free boundary layer of the sample that is present under certain flow conditions. Dimensions of the flow cell are selected to produce a cell-free layer in a flow of whole blood in which the cell free layer is thick enough to reduce scattering of light from the refractometer light source. A numerical method is used to compensate for scattering artifacts. The numerical compensation method is based on the slope and width of a peak in the derivative curve of an angular spectrum image of the flowing sample produced by refractometry.Type: GrantFiled: October 5, 2017Date of Patent: January 1, 2019Assignee: Instrumentation Laboratory CompanyInventors: Ethan Schonbrun, Lara Adib, Gert Blankenstein
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Publication number: 20180345235Abstract: A linear actuator member applies a vertical force to a vessel or to a holding apparatus in which a vessel is contained. A linear to angular motion constraining member such as a cage structure having a helical track translates linearly directed force and motion applied by the linear actuator member into a combined linear and rotational motion of the vessel. The combined vertical and rotational motion of the vessel in response to the vertical force is repeatable according to a predefined agitation pattern for mixing components in the vessel.Type: ApplicationFiled: May 16, 2018Publication date: December 6, 2018Applicant: Instrumentation Laboratory CompanyInventor: Renen Bassik
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Publication number: 20180252633Abstract: A sample cell apparatus for use in spectroscopic determination of an analyte in a body fluid sample includes a first plate member made from an optically clear material and a second plate member made from an optically clear material and opposing the first plate member. A channel extending into a surface of the first plate member and an opposing surface of the second plate member houses a floating seal. The floating seal surrounds a fluid chamber that retains a sample of body fluid for optical measurement. The fluid chamber may be opened for flushing by separating the first plate member from the second plate member. During measurements the fluid chamber is closed to define a repeatable optical path-length therethrough by urging the first plate member against the second plate member without compressing the floating seal between the first plate member and the second plate member.Type: ApplicationFiled: May 4, 2018Publication date: September 6, 2018Applicant: Instrumentation Laboratory CompanyInventors: Brian Joseph Bosy, Josef Kerimo
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Publication number: 20180144259Abstract: An approach for detecting a transient error in a body fluid sample based on the shape of a response curve of a sensor is provided. The response curve is represented by an equation including at least one coefficient describing a curvature or slope of the response curve. The approach includes comparing the coefficient to a range of coefficients which includes coefficients of response curves corresponding to known analyte concentrations. The approach further includes detecting a transient error based on the comparison. In some examples of the approach, the comparison and detection are performed by a processing transient error detector executing computer readable instructions embodied in a non-transitory computer-readable medium. Other examples of the approach determine a concentration of the analyte based on the equation. Advantageously, various examples of the approach can expedite detection of transient errors at the time of measuring and before reporting sample result.Type: ApplicationFiled: January 22, 2018Publication date: May 24, 2018Applicant: Instrumentation Laboratory CompanyInventors: Sohrab Mansouri, Jose Maria Cervera
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Patent number: 9976946Abstract: A sample cell apparatus for use in spectroscopic determination of an analyte in a body fluid sample includes a first plate member made from an optically clear material and a second plate member made from an optically clear material and opposing the first plate member. A channel extending into a surface of the first plate member and an opposing surface of the second plate member houses a floating seal. The floating seal surrounds a fluid chamber that retains a sample of body fluid for optical measurement. The fluid chamber may be opened for flushing by separating the first plate member from the second plate member. During measurements the fluid chamber is closed to define a repeatable optical path-length therethrough by urging the first plate member against the second plate member without compressing the floating seal between the first plate member and the second plate member.Type: GrantFiled: April 21, 2016Date of Patent: May 22, 2018Assignee: Instrumentation Laboratory CompanyInventors: Brian Joseph Bosy, Josef Kerimo
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Publication number: 20180106720Abstract: An optical system and method for quantifying total protein in whole blood or other multi-phase liquids and colloidal suspensions uses refractometry without preliminary steps such as cell separation or centrifugation. A refractometer is integrated with a flow cell to enable the refractive index of a flowing sample to be measured based on a substantially cell free boundary layer of the sample that is present under certain flow conditions. Dimensions of the flow cell are selected to produce a cell-free layer in a flow of whole blood in which the cell free layer is thick enough to reduce scattering of light from the refractometer light source. A numerical method is used to compensate for scattering artifacts. The numerical compensation method is based on the slope and width of a peak in the derivative curve of an angular spectrum image of the flowing sample produced by refractometry.Type: ApplicationFiled: October 5, 2017Publication date: April 19, 2018Applicant: Instrumentation Laboratory CompanyInventors: Ethan Schonbrun, Lara Adib, Gert Blankenstein
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Patent number: 9904890Abstract: An approach for detecting a transient error in a body fluid sample based on the shape of a response curve of a sensor is provided. The response curve is represented by an equation including at least one coefficient describing a curvature or slope of the response curve. The approach includes comparing the coefficient to a range of coefficients which includes coefficients of response curves corresponding to known analyte concentrations. The approach further includes detecting a transient error based on the comparison. In some examples of the approach, the comparison and detection are performed by a processing transient error detector executing computer readable instructions embodied in a non-transitory computer-readable medium. Other examples of the approach determine a concentration of the analyte based on the equation. Advantageously, various examples of the approach can expedite detection of transient errors at the time of measuring and before reporting sample result.Type: GrantFiled: March 13, 2015Date of Patent: February 27, 2018Assignee: Instrumentation Laboratory CompanyInventors: Sohrab Mansouri, Jose Maria Cervera
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Publication number: 20170363538Abstract: A sample cell apparatus for use in spectroscopic determination of an analyte in a body fluid sample includes a first plate member and a second plate member made from an optically clear material. A channel extending into a surface of the first plate member and an opposing surface of the second plate member houses a floating seal, which surrounds a fluid sample chamber. The fluid chamber is closed to define a repeatable optical path-length therethrough by urging the first plate member against the second plate member without compressing the floating seal between the first plate member and the second plate member. The seal channel is vented to prevent fluid pressure from flexing the first plate member or the second plate member. An actuator having an extended foot portion extends over the fluid chamber to help prevent flexing of the first plate member or the second plate member.Type: ApplicationFiled: September 1, 2017Publication date: December 21, 2017Applicant: Instrumentation Laboratory CompanyInventors: Brian Joseph Bosy, Josef Kerimo
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Publication number: 20170336385Abstract: Analyte content in a cell free portion of a body fluid, such as blood, is optically determined without centrifugation or other preliminary steps for separating the cell free portion from the body fluid. A channel is configured for containing a flowing sample of the body fluid along an optical boundary. The channel is configured so that a cell free layer of the fluid naturally forms along the boundary of the channel which coincides with the optical boundary. A light source is directed onto the optical boundary at an angle selected to generate total reflection from the boundary and to generate an evanescent field across the boundary in the cell free layer of fluid. A light detector is configured to detect absorption of the light in the evanescent field. The light source and light detector are matched to the wavelength range of an absorption peak of the analyte being detected.Type: ApplicationFiled: May 15, 2017Publication date: November 23, 2017Applicant: Instrumentation Laboratory CompanyInventors: Ethan Schonbrun, Gert Blankenstein, Josef Kerimo, Hansong Zeng
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Patent number: 9817010Abstract: A clinical diagnostic sample analyzer for analyzing a sample of a patient is disclosed. The analyzer includes a telescoping closed-tube sampling assembly with a sample probe concentrically housed within a piercing probe and a venting mechanism. The closed-tube sampling assembly is used for aspirating a sample from a sample tube for analysis by a clinical diagnostic sample analyzer.Type: GrantFiled: May 8, 2014Date of Patent: November 14, 2017Assignee: Instrumentation Laboratory CompanyInventors: Matthew Blouin, Gregory Murphy, Diana Mackenzie, Alan Weeks, Daniel Kobrenski
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Publication number: 20170307641Abstract: The invention described herein relates to a method and kit for the diagnosis of antiphospholipid syndrome in patients, wherein a coagulation inhibitor and normal pooled plasma mixture reduce the factor deficiency effect of patient plasma, and coagulation inhibitor interference in patient plasma, and increases specificity and the sensitivity for detecting lupus anticoagulants in the patient's blood in a phospholipid-dependent clotting assay.Type: ApplicationFiled: April 19, 2017Publication date: October 26, 2017Applicant: Instrumentation Laboratory CompanyInventors: Ralph E. Bottenus, Zhenghua Cao
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Publication number: 20170254771Abstract: The present invention pertains to a hemolysis sensor, a hemolysis sensor system and methods of utilizing the hemolysis sensor or hemolysis sensor system to monitor or detect hemolysis in a sample, such as a whole blood sample, a plasma sample, a serum sample or hemolyzed blood. The hemolysis sensor responds to extracellular hemoglobin levels, for example, extracellular hemoglobin in a whole blood sample as a method for detecting hemolysis in whole blood.Type: ApplicationFiled: April 21, 2017Publication date: September 7, 2017Applicant: Instrumentation Laboratory CompanyInventors: Shankar Balasubramanian, Paul D'Orazio
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Patent number: 9658181Abstract: The present invention pertains to a hemolysis sensor, a hemolysis sensor system and methods of utilizing the hemolysis sensor or hemolysis sensor system to monitor or detect hemolysis in a sample, such as a whole blood sample, a plasma sample, a serum sample or hemolyzed blood. The hemolysis sensor responds to extracellular hemoglobin levels, for example, extracellular hemoglobin in a whole blood sample as a method for detecting hemolysis in whole blood.Type: GrantFiled: March 10, 2014Date of Patent: May 23, 2017Assignee: Instrumentation Laboratory CompanyInventors: Shankar Balasubramanian, Paul D'Orazio
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Publication number: 20160267389Abstract: An approach for detecting a transient error in a body fluid sample based on the shape of a response curve of a sensor is provided. The response curve is represented by an equation including at least one coefficient describing a curvature or slope of the response curve. The approach includes comparing the coefficient to a range of coefficients which includes coefficients of response curves corresponding to known analyte concentrations. The approach further includes detecting a transient error based on the comparison. In some examples of the approach, the comparison and detection are performed by a processing transient error detector executing computer readable instructions embodied in a non-transitory computer-readable medium. Other examples of the approach determine a concentration of the analyte based on the equation. Advantageously, various examples of the approach can expedite detection of transient errors at the time of measuring and before reporting sample result.Type: ApplicationFiled: March 13, 2015Publication date: September 15, 2016Applicant: INSTRUMENTATION LABORATORY COMPANYInventors: Sohrab Mansouri, Jose Maria Cervera
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Patent number: 9388503Abstract: An electrochemical sensor system and membrane and method thereof for increased accuracy and effective life of electrochemical and enzyme sensors.Type: GrantFiled: April 8, 2013Date of Patent: July 12, 2016Assignee: Instrumentation Laboratory CompanyInventors: Prasad Pamidi, Sohrab Mansouri, Melanie Shin, Vasile Cosofret, Clarke Xu
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Patent number: 9113834Abstract: Technologies for increasing sample throughput by predicting the end point response time of a sensor for the analysis of an analyte in a sample are disclosed. In one aspect, a system includes a sensor that generates data signals associated with the measurement of an analyte within the sample. A processor records appropriate data points corresponding to the signals, converts them to a logarithmic function of time scale, and plots the converted data points. The processor then determines a curve that fits the plotted data points and determines a curve fitting equation for the curve. Once the equation is determined, the processor extrapolates an end point response of the sensor using the equation. A value, such as analyte concentration, is then calculated using the extrapolated end point response.Type: GrantFiled: October 2, 2013Date of Patent: August 25, 2015Assignee: Instrumentation Laboratory CompanyInventors: Sohrab Mansouri, Jose Maria Cervera
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Patent number: 9113833Abstract: Technologies for increasing sample throughput by predicting the end point response time of a sensor for the analysis of an analyte in a sample are disclosed. In one aspect, a system includes a sensor that generates data signals associated with the measurement of an analyte within the sample. A processor records appropriate data points corresponding to the signals, converts them to a logarithmic function of time scale, and plots the converted data points. The processor then determines a curve that fits the plotted data points and determines a curve fitting equation for the curve. Once the equation is determined, the processor extrapolates an end point response of the sensor using the equation. A value, such as analyte concentration, is then calculated using the extrapolated end point response.Type: GrantFiled: August 16, 2012Date of Patent: August 25, 2015Assignee: Instrumentation Laboratory CompanyInventors: Sohrab Mansouri, Jose Maria Cervera, Ashley Moraski
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Patent number: 8802037Abstract: A multiple cuvette strip comprises a plurality of wells and a reversible interlocking device. The well strips can be reversibly interlocked to other well strips to form a sample holder system. One embodiment of a well strip comprises a flange and a slot to form a reversible interlocking device.Type: GrantFiled: March 3, 2011Date of Patent: August 12, 2014Assignee: Instrumentation Laboratory CompanyInventors: Matthew R. Blouin, Robert R. Fisette
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Patent number: 8758702Abstract: A clinical diagnostic sample analyzer for analyzing a sample of a patient is disclosed. The analyzer includes a telescoping closed-tube sampling assembly with a sample probe concentrically housed within a piercing probe and a venting mechanism. The closed-tube sampling assembly is used for aspirating a sample from a sample tube for analysis by a clinical diagnostic sample analyzer.Type: GrantFiled: May 4, 2006Date of Patent: June 24, 2014Assignee: Instrumentation Laboratory CompanyInventors: Matthew Blouin, Gregory Murphy, Diana Mackenzie, Alan Weeks, Daniel Kobrenski
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Patent number: 8728007Abstract: The present invention relates to a method and apparatus for managing patient data. In one aspect, the invention relates to a system for managing patient data having many instruments. The instruments have a sampling member for sampling a body fluid from a patient and are in direct communication with at least one other instrument.Type: GrantFiled: May 16, 2011Date of Patent: May 20, 2014Assignee: Instrumentation Laboratory CompanyInventors: Anwar A Azer, Ramon E Benet